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tert-butyl beta-carboline-3-carboxylate and zolpidem

tert-butyl beta-carboline-3-carboxylate has been researched along with zolpidem in 16 studies

Compound Research Comparison

Studies
(tert-butyl beta-carboline-3-carboxylate)
Trials
(tert-butyl beta-carboline-3-carboxylate)
Recent Studies (post-2010)
(tert-butyl beta-carboline-3-carboxylate)
Studies
(zolpidem)
Trials
(zolpidem)
Recent Studies (post-2010) (zolpidem)
45071,825368683

Protein Interaction Comparison

ProteinTaxonomytert-butyl beta-carboline-3-carboxylate (IC50)zolpidem (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.048
Translocator proteinRattus norvegicus (Norway rat)4.7
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.048
GABA theta subunitRattus norvegicus (Norway rat)0.048
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.048

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's10 (62.50)29.6817
2010's4 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Cox, ED; Diaz-Arauzo, H; Harris, B; Huang, Q; Ma, C; McKernan, R; Reddy, MS; Skolnick, P1
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Clayton, T; Cook, JM; Cromer, BA; Ma, C; Majumder, S; Namjoshi, OA; Petrou, S; Platt, DM; Roth, BL; VanLinn, ML; Yin, W1
Avenet, P; Granger, P; Griebel, G; Letang, V; Perrault, G; Sanger, DJ; Schoemaker, H1
Cook, JM; Ma, C; Miczek, KA; Rowlett, JK; Tornatzky, W1
Bergman, J; Cook, JM; Cox, ED; Paronis, CA1
Carter, L; Cook, JM; France, CP; Gerak, LR; Ma, C; McMahon, LR1
Cook, J; Ma, C; Platt, DM; Rowlett, JK; Spealman, RD1
Cook, JM; Lelas, S; Rowlett, JK; Spealman, RD; Yin, W1
Cook, JM; de Almeida, RM; Miczek, KA; Rowlett, JK; Yin, W1
Bokonjić, DR; Cook, JM; Obradović, DI; Savić, MM; Ugresić, ND; Yin, W1
Bokonjić, DR; Cook, JM; Obradović, DI; Sarma, PV; Savić, MM; Ugresić, ND1
Cook, JM; Groenink, L; Hopkins, SC; Klanker, M; Korte, SM; Olivier, B; Van Linn, ML; Vinkers, CH1
Atack, JR; Cook, JM; Dawson, GR; Licata, SC; Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Van Linn, ML1
Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML1
Cook, JM; Makaron, L; Moran, CA; Namjoshi, O; Rallapalli, S; Rowlett, JK1

Other Studies

16 other study(ies) available for tert-butyl beta-carboline-3-carboxylate and zolpidem

ArticleYear
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423)
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Carbolines; Cell Line; Cerebral Cortex; Drug Design; GABA Agonists; Humans; Male; Mice; Muscle Relaxation; Rats; Receptors, GABA-A; Recombinant Proteins; Seizures; Structure-Activity Relationship

1998
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Alcoholism; Animals; Benzodiazepines; Binding Sites; Carbolines; Cell Line; Computer Simulation; GABA-A Receptor Antagonists; Humans; Protein Subunits; Rats; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship

2010
New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (omega) receptor subtypes.
    Psychopharmacology, 1999, Volume: 146, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Binding, Competitive; Carbolines; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Male; Mice; Mice, Inbred BALB C; Motor Activity; Muscle Relaxants, Central; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem

1999
Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and beta-Carboline-3-carboxylate-t-butyl ester (beta-CCt).
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Body Temperature; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Antagonists; Mice; Pyridines; Receptors, GABA-A; Triazolam; Vocalization, Animal; Zolpidem

2001
Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys.
    Psychopharmacology, 2001, Volume: 156, Issue:4

    Topics: Acetamides; Animals; Carbolines; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Midazolam; Pyridines; Pyrimidines; Reaction Time; Receptors, GABA-A; Saimiri; Zolpidem

2001
Discriminative stimulus effects of benzodiazepine (BZ)(1) receptor-selective ligands in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Acetamides; Animals; Carbolines; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Macaca mulatta; Midazolam; Pyridines; Pyrimidines; Receptors, GABA-A; Zolpidem

2002
Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys.
    Psychopharmacology, 2002, Volume: 164, Issue:2

    Topics: Animals; Ataxia; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Motor Activity; Pyridines; Receptors, GABA-A; Saimiri; Social Behavior; Triazolam; Zolpidem

2002
Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors.
    Psychopharmacology, 2003, Volume: 165, Issue:3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Discrimination Learning; Dose-Response Relationship, Drug; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; Injections, Intravenous; Male; Pyridazines; Pyridines; Receptors, GABA-A; Saimiri; Zolpidem

2003
GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice.
    Psychopharmacology, 2004, Volume: 172, Issue:3

    Topics: Aggression; Animals; Behavior, Animal; Carbolines; Drug Synergism; Ethanol; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Locomotion; Male; Mice; Pyridines; Receptors, GABA-A; Self Administration; Zolpidem

2004
Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Carbolines; Drug Interactions; Flumazenil; GABA Modulators; Ligands; Male; Maze Learning; Mice; Midazolam; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Zolpidem

2004
Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt.
    Psychopharmacology, 2005, Volume: 180, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Benzodiazepines; Binding Sites; Carbolines; Convulsants; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Habituation, Psychophysiologic; Injections, Intraperitoneal; Ligands; Male; Midazolam; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Retention, Psychology; Zolpidem

2005
Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.
    Psychopharmacology, 2009, Volume: 204, Issue:2

    Topics: Acute Disease; Anesthetics; Animals; Anti-Anxiety Agents; Body Temperature; Carbolines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA Agents; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Psychological; Telemetry; Zolpidem

2009
Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.
    Neuropharmacology, 2010, Volume: 58, Issue:2

    Topics: Animals; Barbiturates; Carbolines; Catheterization; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Antagonists; GABA Modulators; Neuropsychological Tests; Pyridines; Receptors, GABA-A; Saimiri; Triazoles; Zolpidem

2010
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
    Behavioural pharmacology, 2012, Volume: 23, Issue:2

    Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hand Strength; Imidazoles; Male; Muscle Relaxation; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Zolpidem

2012
Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 104

    Topics: Acetamides; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbolines; Cognition; Executive Function; Female; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Imidazoles; Macaca mulatta; Pyridines; Pyrimidines; Receptors, GABA-A; Triazolam; Zolpidem

2013