Page last updated: 2024-09-03

tert-butyl beta-carboline-3-carboxylate and flunitrazepam

tert-butyl beta-carboline-3-carboxylate has been researched along with flunitrazepam in 4 studies

Compound Research Comparison

Studies
(tert-butyl beta-carboline-3-carboxylate)
Trials
(tert-butyl beta-carboline-3-carboxylate)
Recent Studies (post-2010)
(tert-butyl beta-carboline-3-carboxylate)
Studies
(flunitrazepam)
Trials
(flunitrazepam)
Recent Studies (post-2010) (flunitrazepam)
45072,697298130

Protein Interaction Comparison

ProteinTaxonomytert-butyl beta-carboline-3-carboxylate (IC50)flunitrazepam (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0016
GABA theta subunitRattus norvegicus (Norway rat)0.0016
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0016

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Cox, ED; Diaz-Arauzo, H; Harris, B; Huang, Q; Ma, C; McKernan, R; Reddy, MS; Skolnick, P1
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W1
Cook, JM; Lelas, S; Rowlett, JK; Spealman, RD; Yin, W1

Other Studies

4 other study(ies) available for tert-butyl beta-carboline-3-carboxylate and flunitrazepam

ArticleYear
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423)
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Carbolines; Cell Line; Cerebral Cortex; Drug Design; GABA Agonists; Humans; Male; Mice; Muscle Relaxation; Rats; Receptors, GABA-A; Recombinant Proteins; Seizures; Structure-Activity Relationship

1998
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis

2008
Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors.
    Psychopharmacology, 2003, Volume: 165, Issue:3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Discrimination Learning; Dose-Response Relationship, Drug; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; Injections, Intravenous; Male; Pyridazines; Pyridines; Receptors, GABA-A; Saimiri; Zolpidem

2003