Page last updated: 2024-09-03

tert-butyl beta-carboline-3-carboxylate and beta-carboline-3-carboxylic acid methyl ester

tert-butyl beta-carboline-3-carboxylate has been researched along with beta-carboline-3-carboxylic acid methyl ester in 8 studies

Compound Research Comparison

Studies
(tert-butyl beta-carboline-3-carboxylate)
Trials
(tert-butyl beta-carboline-3-carboxylate)
Recent Studies (post-2010)
(tert-butyl beta-carboline-3-carboxylate)
Studies
(beta-carboline-3-carboxylic acid methyl ester)
Trials
(beta-carboline-3-carboxylic acid methyl ester)
Recent Studies (post-2010) (beta-carboline-3-carboxylic acid methyl ester)
450714506

Protein Interaction Comparison

ProteinTaxonomytert-butyl beta-carboline-3-carboxylate (IC50)beta-carboline-3-carboxylic acid methyl ester (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.005
Translocator proteinRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0115
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.005
GABA theta subunitRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.005
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.005

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's5 (62.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allen, MS; Cook, JM; Costantino, G; Dorn, LJ; Hagen, TJ; Koehler, KF; LaLoggia, AJ; Martin, MJ; Skolnick, P1
Allen, MS; Codding, PW; Hagen, TJ; Koehler, KF; Martin, MJ; Narayanan, K; Schindler, LR; Schultz, C; Tan, YC; Trudell, ML1
Good, AC; Peterson, SJ; Richards, WG1
Platt, DE; Silverman, BD1
Karplus, M; So, SS1
Ahmad, K; Beg, Y; Cho, SJ; Muddassar, M; Pasha, FA1
Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W1
Cook, JA; Guzman, F; Hagen, TJ; Shannon, HE1

Other Studies

8 other study(ies) available for tert-butyl beta-carboline-3-carboxylate and beta-carboline-3-carboxylic acid methyl ester

ArticleYear
Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach.
    Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22

    Topics: Animals; Binding, Competitive; Carbolines; Cerebral Cortex; Convulsants; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Mice; Models, Molecular; Models, Statistical; Molecular Conformation; Rats; Receptors, GABA-A; Regression Analysis; Structure-Activity Relationship

1992
Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Binding Sites; Carbolines; Chemical Phenomena; Chemistry; Computer Simulation; Ligands; Models, Chemical; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship

1990
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
    Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11

    Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone

1996
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Cholinesterase Inhibitors; Dopamine beta-Hydroxylase; Drug Design; Enzyme Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Conformation; Molecular Structure; Neural Networks, Computer; Phosphorylases; Receptors, Aryl Hydrocarbon; Static Electricity; Structure-Activity Relationship

1997
3D and quantum QSAR of non-benzodiazepine compounds.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Benzodiazepines; Carbolines; Imaging, Three-Dimensional; Imidazoles; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Pyrimidines; Quantitative Structure-Activity Relationship; Software

2008
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis

2008
Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Animals; Carbolines; Diazepam; Discrimination Learning; Harmine; Male; Picrotoxin; Rats; Rats, Inbred F344

1988