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tert-butyl beta-carboline-3-carboxylate and 2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one

tert-butyl beta-carboline-3-carboxylate has been researched along with 2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one in 6 studies

Compound Research Comparison

Studies
(tert-butyl beta-carboline-3-carboxylate)
Trials
(tert-butyl beta-carboline-3-carboxylate)
Recent Studies (post-2010)
(tert-butyl beta-carboline-3-carboxylate)
Studies
(2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one)
Trials
(2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one)
Recent Studies (post-2010) (2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one)
45073307

Protein Interaction Comparison

ProteinTaxonomytert-butyl beta-carboline-3-carboxylate (IC50)2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0003
Translocator proteinRattus norvegicus (Norway rat)0.0001
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0001
GABA theta subunitRattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0003
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0001

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allen, MS; Codding, PW; Hagen, TJ; Koehler, KF; Martin, MJ; Narayanan, K; Schindler, LR; Schultz, C; Tan, YC; Trudell, ML1
Good, AC; Peterson, SJ; Richards, WG1
Platt, DE; Silverman, BD1
Karplus, M; So, SS1
Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W1
Cook, JM; Hagen, T; Katz, JL; Suzuki, T; Takada, K1

Other Studies

6 other study(ies) available for tert-butyl beta-carboline-3-carboxylate and 2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one

ArticleYear
Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Binding Sites; Carbolines; Chemical Phenomena; Chemistry; Computer Simulation; Ligands; Models, Chemical; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship

1990
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
    Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11

    Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone

1996
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Cholinesterase Inhibitors; Dopamine beta-Hydroxylase; Drug Design; Enzyme Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Conformation; Molecular Structure; Neural Networks, Computer; Phosphorylases; Receptors, Aryl Hydrocarbon; Static Electricity; Structure-Activity Relationship

1997
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis

2008
Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats.
    Life sciences, 1989, Volume: 44, Issue:4

    Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred F344

1989