terikalant has been researched along with piperidines in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (70.97) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brugada, J; Cavero, I; Escande, D; Kirchhof, C; Mestre, M | 1 |
| Chinn, K; Martin, CL | 1 |
| Beregi, JP; Chemla, D; Coudray, N; Escande, D; Lecarpentier, Y; Mery, P; Mestre, M | 1 |
| McLarnon, JG; Wang, XP | 1 |
| Allessie, M; Boersma, L; Brugada, J; Brugada, P; Havenith, M; Kirchhof, C; Wellens, HJ | 1 |
| McLarnon, JG; Xu, R | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM | 1 |
| Beregi, JP; Chemla, D; Coudray, N; Escande, D; Lecarpentier, Y; Mestre, M; Péry, N | 1 |
| Escande, D | 1 |
| Curtis, MJ; Rees, SA | 3 |
| Allessie, M; Boersma, L; Brugada, J; Navarro-Lopez, F | 1 |
| Fermini, B; Jurkiewicz, NK; Salata, JJ; Sanguinetti, MC; Wang, J | 1 |
| Edwards, G; Högestätt, ED; Larsson, B; Weston, AH; Zygmunt, PM | 1 |
| Chiba, S; Furukawa, Y; Lakhe, M; Nagashima, Y; Yonezawa, T | 1 |
| Gross, GJ; Hsu, AK; Kwok, WM; Schultz, JE | 1 |
| Kocić, I; Konstański, Z | 1 |
| Beatch, GN; Dickenson, DR; Williams, BA | 1 |
| Shi, H; Wang, H; Wang, Z | 1 |
| Konstański, Z; Korolkiewicz, RP; Petrusewicz, J; Rekowski, P; Ruczyński, J; Szczepańska, R; Szyk, A | 1 |
| Allessie, MA; Brandts, B; Trappe, HJ; Tüttelmann, F; Van Bracht, M | 1 |
| Li, GR; Nattel, S; Xu, CQ; Yang, BF | 1 |
| Adamantidis, MM; Bastide, M; Dumotier, BM | 1 |
| Dorian, P; Mamalias, N; Newman, D; Qi, X; Varma, P | 1 |
| Li, YR; Sun, MZ; Xu, CQ; Yang, BF; Yang, YB; Zhang, JY; Zhou, J | 1 |
| Coker, SJ; Farkas, A | 1 |
| Hirano, Y; Hiraoka, M; Kocic, I | 1 |
| Chen, QW; Dong, DL; Du, ZM; Gong, DM; Xu, CQ; Yang, BF | 1 |
| Acsai, K; Biliczki, A; Biliczki, P; Jost, N; Papp, JG; Tálosi, L; Varró, A; Virág, L | 1 |
1 review(s) available for terikalant and piperidines
| Article | Year |
|---|---|
RP 58866 and its active enantiomer RP 62719 (terikalant): blockers of the inward rectifier K+ current acting as pure class III antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Chromans; Chromones; Electrophysiology; Humans; Models, Cardiovascular; Piperidines; Potassium Channels | 1992 |
30 other study(ies) available for terikalant and piperidines
| Article | Year |
|---|---|
Contribution of delayed rectifier and inward rectifier to repolarization of the action potential: pharmacologic separation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzopyrans; Chromans; Chromones; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Membrane Potentials; Microelectrodes; Papillary Muscles; Piperidines; Potassium Channels; Pyridines | 1992 |
Positive inotropic effects of RP 62719, a new pure class III antiarrhythmic agent, on guinea pig myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Chromans; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Potassium Channels; Stimulation, Chemical | 1992 |
Temperature dependence of drug blockade of a calcium-dependent potassium channel in cultured hippocampal neurons.
Topics: Animals; Anti-Arrhythmia Agents; Biophysical Phenomena; Biophysics; Calcium; Cells, Cultured; Chromans; Electrophysiology; Hippocampus; Kinetics; Neurons; Piperidines; Potassium Channels; Temperature; Thermodynamics | 1991 |
Double-wave reentry as a mechanism of acceleration of ventricular tachycardia.
Topics: Animals; Anti-Arrhythmia Agents; Chromans; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart Ventricles; Male; Myocardium; Piperidines; Rabbits; Tachycardia | 1990 |
Actions of the benzopyran compound terikalant on macroscopic currents in rat ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels; Cells, Cultured; Chromans; Heart; Heart Ventricles; Male; Myocardium; Piperidines; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Ventricular Function | 1995 |
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil | 1995 |
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium | 1995 |
[Positive inotropic and lusitropic effect of RP 62719, a new class III antiarrhythmia agent].
Topics: Animals; Anti-Arrhythmia Agents; Chromans; Guinea Pigs; Heart Failure; Humans; Isometric Contraction; Isotonic Contraction; Male; Myocardial Contraction; Papillary Muscles; Piperidines; Potassium Channels | 1994 |
Commentaries on the IK1 blockade controversy (March issue)
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Chromans; Dogs; Guinea Pigs; Humans; Piperidines; Potassium Channels; Rabbits; Rats; Species Specificity | 1994 |
IK1 blockade is a potentially useful antiarrhythmic mechanism.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Chromans; Ion Channel Gating; Piperidines; Potassium Channels; Rats | 1994 |
Class III actions in an experimental model of ventricular tachycardia.
Topics: Animals; Anti-Arrhythmia Agents; Chromans; Dose-Response Relationship, Drug; Female; Heart Conduction System; Male; Perfusion; Piperidines; Rabbits; Tachycardia, Ventricular | 1993 |
Specific IK1 blockade: a new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Callithrix; Cardiac Pacing, Artificial; Chromans; Electrocardiography; Heart; Male; Myocardial Reperfusion Injury; Piperidines; Potassium Channels; Rabbits; Rats; Rats, Wistar; Tachycardia, Ventricular; Ventricular Fibrillation | 1993 |
Further investigations into the mechanism of antifibrillatory action of the specific IK1 blocker, RP58866, assessed using the rat dual coronary perfusion model.
Topics: Animals; Anti-Arrhythmia Agents; Chromans; Coronary Circulation; Male; Myocardial Ischemia; Perfusion; Piperidines; Potassium; Potassium Channels; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Chromans; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart; Mice; Myocardium; Oocytes; Osmolar Concentration; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Reaction Time; Stereoisomerism; Trans-Activators; Xenopus | 1996 |
Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Anti-Arrhythmia Agents; Apamin; Binding, Competitive; Biological Factors; Cerebral Cortex; Charybdotoxin; Chromans; Cyclooxygenase Inhibitors; Drug Interactions; Female; Hepatic Artery; Indoles; Indomethacin; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Chronotropic and inotropic effects of terikalant on isolated, blood-perfused atrial and ventricular preparations of dogs.
Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Chromans; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Heart Rate; Male; Muscle Contraction; Norepinephrine; Pinacidil; Piperidines; Potassium Channels; Propranolol; Vasodilator Agents; Ventricular Function | 1997 |
Terikalant, an inward-rectifier potassium channel blocker, does not abolish the cardioprotection induced by ischemic preconditioning in the rat.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Cells, Cultured; Chromans; Electrophysiology; Guinea Pigs; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Myocardial Infarction; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar | 1998 |
The effects of potassium channel modulators on the simulated ischaemia-induced changes in contractility and responsiveness to phenylephrine of rat-isolated papillary muscle.
Topics: Animals; Chromans; Female; Galanin; Glyburide; Male; Myocardial Contraction; Myocardial Ischemia; Papillary Muscles; Phenylephrine; Piperidines; Potassium Channels; Rats; Rats, Wistar | 1998 |
Kinetics of rate-dependent shortening of action potential duration in guinea-pig ventricle; effects of IK1 and IKr blockade.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; Kinetics; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Sensitivity and Specificity; Sulfonamides; Time Factors; Ventricular Function | 1999 |
Inactivation block of the HERG human cardiac K+ channels by RP58866.
Topics: Animals; Anti-Arrhythmia Agents; Chromans; Dose-Response Relationship, Drug; Heart; Humans; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Xenopus | 1999 |
The inhibitory effects of terikalant on the contractile activity of galanin in isolated rat fundus strips.
Topics: Animals; Chromans; Dose-Response Relationship, Drug; Female; Galanin; Gastric Fundus; In Vitro Techniques; Male; Muscle Contraction; Piperidines; Potassium Channels; Rats; Rats, Wistar | 2000 |
Inhibition of muscarinic potassium current by the class III antiarrhythmic drug RP58866 in guinea-pig atrial myocytes.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Chromans; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Myocardium; Patch-Clamp Techniques; Phosphorylcholine; Piperidines; Potassium; Receptor, Muscarinic M2; Receptors, Muscarinic; Sphingosine | 2000 |
Effects of RP58866 on transmembrane K+ currents in mammalian ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Chromans; Dogs; Female; Guinea Pigs; Heart Ventricles; Inhibitory Concentration 50; Male; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels | 1999 |
"Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Cisapride; Dose-Response Relationship, Drug; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Male; Phenethylamines; Piperidines; Rabbits; Sulfonamides; Time Factors; Ventricular Function | 2001 |
Terikalant and barium decrease the area of vulnerability to ventricular fibrillation induction by T-wave shocks.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Barium Compounds; Chlorides; Chromans; Dogs; Electric Countershock; Electrocardiography; Female; Infusions, Intravenous; Male; Piperidines; Ventricular Fibrillation; Ventricular Function | 2002 |
[Inhibition of transmembrane K(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719].
Topics: Animals; Anti-Arrhythmia Agents; Cell Separation; Chromans; Dogs; Guinea Pigs; Heart Ventricles; Inhibitory Concentration 50; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying | 2000 |
Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Body Temperature; Chromans; Electrocardiography; Erythromycin; Heart Rate; Male; Piperidines; Quaternary Ammonium Compounds; Rabbits; Torsades de Pointes | 2002 |
The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes.
Topics: Animals; Chromans; Female; Glyburide; Guinea Pigs; Heart Ventricles; Hypotonic Solutions; Male; Membrane Potentials; Myocytes, Cardiac; Piperidines; Potassium Channels; Ventricular Function | 2004 |
[Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866].
Topics: Aconitine; Alkaloids; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzylisoquinolines; Chromans; Dogs; Female; Guinea Pigs; Male; Matrines; Piperidines; Potassium Channels; Quinolizines; Rabbits; Rats | 2004 |
Cellular electrophysiological effect of terikalant in the dog heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Dogs; Electrophysiology; Female; Heart; In Vitro Techniques; Kinetics; Male; Papillary Muscles; Piperidines; Purkinje Fibers | 2005 |