Page last updated: 2024-08-16

terfenadine and piperidines

terfenadine has been researched along with piperidines in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (10.00)	18.7374
1990's	29 (36.25)	18.2507
2000's	25 (31.25)	29.6817
2010's	14 (17.50)	24.3611
2020's	4 (5.00)	2.80

Authors

Authors	Studies
Blockhuys, S; Janssens, M; Parys, W	1
Kalasinsky, KS; Klette, KL; Kuhlman, JJ; Levine, B; Magluilo, J; Smith, ML	1
Franzyshen, SK; Walsh, DA; Yanni, JM	1
Barnett, A; Cohen-Winston, M; Iorio, LC	1
Brandon, ML; Weiner, M	1
Dabrowicki, E; Huddlestone, L; Kagan, G; Kapur, TR; Wolstencroft, P	1
Cook, CE; Leeson, GA; Myers, M; Okerholm, RA; Tallent, CR; Williams, DL; Wright, GJ	1
Nicholson, AN; Stone, BM	1
Lundberg, PK	1
Andrade García, JL; Fuentes González, VM; Ortega Gómez, H; Pérez Martín, J	1
Imano, K; Ishii, K; Karasawa, T; Nakamura, H; Seto, Y; Takeyama, K; Yakuo, I	1
O'Hanlon, JF; Ramaekers, JG	1
Bahmer, FA	1
Abe, T; Matsuda, K; Nagai, H; Omata, T; Segawa, Y; Yoshida, K	1
Blockhuys, S; Janssens, M	1
Bahmer, FA; Ruprecht, KW	1
Khalil, SK; Surapaneni, S	1
Freng, BA; Garud, O; Korsrud, FR; Kramer, J; Olsen, AK; Poppe, S; Rebo, R; Søhoel, P; Woxen, OJ	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W	2
Martens, J	1
Kalis, B	1
Llenas, J; Roberts, DJ	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J	1
Delpón, E; Franqueza, L; Gay, P; Tamargo, J; Valenzuela, C; Vicente, J	1
Ducic, I; Ko, CM; Morad, M; Shuba, Y	1
Brown, AM; Dennis, A; Rampe, D; Roy, ML	1
Roberts, DJ	2
Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y	1
Mattila, MJ; Paakkari, I	1
Artursson, P; Hidalgo, IJ; Raeissi, SD; Segura-Aguilar, J	1
Gong, Q; January, CT; Vorperian, VR; Zhang, S; Zhou, Z	1
Danielson, L; DeVos, C; Grant, JA; Rihoux, JP	1
Hanada, E; Hirota, M; Iga, T; Kotaki, H; Nakaya, H; Ohtani, H; Sato, H; Sawada, Y; Uemura, H	1
López, M; Palacios, JM; Roberts, DJ; Ryder, H; Segarra, V	1
Abdelaziz, MM; Devalia, JL; Khair, OA	1
Chaikin, P; Gillen, MS; Miller, B; Morganroth, J	1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM	1
Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE	1
Paakkari, I	1
Avery, MJ; DePasquale, MJ; Fossa, AA; Leishman, DJ; Raunig, DL	1
Malik, M	1
Boyce, M; Carey, W; Luria, X; Warrington, S	1
Antonijoan, RM; Barbanoj, MJ; Esbrí, R; Garcia, E; García-Gea, C; Gich, I; Gispert, J; Luria, X; Morte, A	1
Fernandez, D; Ghanta, A; Kauffman, GW; Sanguinetti, MC	1
Appajosyula, S; Gelfand, EW; Meeves, S	1
Avery, M; Fermini, B; Fossa, AA; Raunig, DL; Wang, E; Wisialowski, T; Wolfgang, E	1
Iizuka, H; Ishida-Yamamoto, A; Takahashi, H	1
Buisson, D; Jaouen, M; Mazier, C; Sari, MA	1
Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M	1
Fukuda, H; Kamikozawa, Y; Ohashi, R; Sugiura, M; Tamai, I; Yabuuchi, H	1
Berisa, A; Corcóstegui, R; Innerárity, A; Labeaga, L; Orjales, A	1
Codreanu, A; de Chillou, C; Moneret-Vautrin, DA	1
Cox, BF; Fischer, C; Gintant, GA; Limberis, JT; Long, MA; Martin, RL; Mikhail, A; Patel, A; Su, Z	1
Cheng, J; Jiang, H; Li, W; Liu, H; Tang, Y; Zhu, W	1
Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H	1
Brun, ME; Funk, C; Grimm, HP; Kansy, M; Lavé, T; Poirier, A; Portmann, R; Senner, F	1
Imai, YN; Oiki, S; Ryu, S	1
Ikezawa, Z; Inomata, N; Tatewaki, S	1
Horak, F; Lemell, P; Zieglmayer, P; Zieglmayer, R	1
Aqvist, J; Boukharta, L; de Groot, BL; Karimi-Nejad, Y; Stary, A; Vriend, G; Wacker, SJ; Zachariae, U	1
Han, HK; Jin, MJ	1
Laguna Martínez, JJ; Reaño Martos, M; Rojas Pérez-Ezquerra, P; Sánchez Morillas, L; Sanz, ML	1
Fukui, H; Hattori, M; Kitamura, Y; Kuroda, W; Mizuguchi, H; Ogishi, H; Takeda, N	1
Fukuoka, M; Ikoma, A; Kabashima, K; Miyachi, Y; Tanizaki, H	1
Fujii, M; Imaizumi, Y; Ohya, S; Yamamura, H	1
Bekkali, N; Boeckxstaens, GE; de Jonge, WJ; Shi, J; Stanisor, OI; van den Wijngaard, RM; van Diest, SA; Welting, O; Yu, Z	1
Plichta, D; Spiewak, R	1
Asako, M; Gotoh, M; Honda, T; Nomura, Y; Ohashi, Y; Okubo, K; Saito, A; Togawa, M	1
Bedada, SK; Boga, PK	1
Bosma, R; Labeaga, L; Leurs, R; van den Bor, J; Vischer, HF	1
Bal, R; Yildirim, C	1
Claydon, TW; Genge, CE; Gunawan, M; Hobbs, Y; Hull, CM; Lin, E; Rayani, K; Shafaattalab, S; Tibbits, GF	1
Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K	1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N	1
Abe, M; Ishii, M; Kikuchi, T; Morimoto, K; Ogihara, T; Oikawa, E; Sasaki, M; Tomita, M	1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H	1

Reviews

8 review(s) available for terfenadine and piperidines

Article	Year
New trends in the treatment of allergic conjunctivitis. Documenta ophthalmologica. Advances in ophthalmology, 1992, Volume: 82, Issue:4 Topics: Animals; Antazoline; Conjunctivitis, Allergic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Naphazoline; Ophthalmic Solutions; Piperidines; Placebos; Terfenadine	1992
Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:3 Topics: Administration, Oral; Administration, Topical; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine	1995
Towards the optimal antihistamine: studies with ebastine. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Piperidines; Potassium Channels; Rats; Structure-Activity Relationship; Terfenadine	1998
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
[The effect of second generation histamine antagonists on the heart]. Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4 Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes	2001
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research. Current medical research and opinion, 2004, Volume: 20, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine	2004
[Pharmacotherapy of urticaria--an analysis of the discrepancies between guidelines of expert bodies, registration documents and evidence for the effectiveness of drugs]. Przeglad lekarski, 2013, Volume: 70, Issue:12 Topics: Administration, Oral; Administration, Topical; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Glucocorticoids; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Poland; Practice Guidelines as Topic; Terfenadine; Treatment Outcome; Urticaria	2013

Trials

18 trial(s) available for terfenadine and piperidines

Article	Year
New trends in the treatment of allergic conjunctivitis. Documenta ophthalmologica. Advances in ophthalmology, 1992, Volume: 82, Issue:4 Topics: Animals; Antazoline; Conjunctivitis, Allergic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Naphazoline; Ophthalmic Solutions; Piperidines; Placebos; Terfenadine	1992
Clinical investigation of terfenadine, a non-sedating antihistamine. Annals of allergy, 1980, Volume: 44, Issue:2 Topics: Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperidines; Placebos; Pollen; Terfenadine	1980
A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders. The Journal of international medical research, 1980, Volume: 8, Issue:6 Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Placebos; Rhinitis, Allergic, Seasonal; Terfenadine	1980
Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine. British journal of clinical pharmacology, 1982, Volume: 13, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cognition; Emotions; Female; Histamine H1 Antagonists; Humans; Mental Processes; Motor Skills; Piperidines; Terfenadine; Time Factors; Triprolidine	1982
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94. Allergy, 1995, Volume: 50, Issue:3 Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine	1995
A comparison of topical levocabastine and oral terfenadine in the treatment of allergic rhinoconjunctivitis. The Livostin Study Group. Allergy, 1993, Volume: 48, Issue:7 Topics: Administration, Intranasal; Administration, Oral; Adult; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine	1993
Tolerability of levocabastine eye drops. Documenta ophthalmologica. Advances in ophthalmology, 1993, Volume: 84, Issue:2 Topics: Adolescent; Adult; Conjunctivitis, Allergic; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Terfenadine; Visual Acuity	1993
Safety and efficacy of topical levocabastine compared with oral terfenadine. Annals of allergy, 1994, Volume: 72, Issue:5 Topics: Administration, Oral; Administration, Topical; Adult; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine	1994
Topical levocabastine compared with orally administered terfenadine for the prophylaxis and treatment of seasonal rhinoconjunctivitis. The Journal of allergy and clinical immunology, 1993, Volume: 92, Issue:1 Pt 1 Topics: Administration, Oral; Adult; Aerosols; Conjunctivitis, Allergic; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Humans; Male; Norway; Ophthalmic Solutions; Piperidines; Remission Induction; Rhinitis, Allergic, Seasonal; Terfenadine	1993
Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs, 1996, Volume: 52 Suppl 1 Topics: Adult; Anti-Allergic Agents; Butyrophenones; Chronic Disease; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine; Urticaria	1996
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. Allergy, 1999, Volume: 54, Issue:7 Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria	1999
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. British journal of clinical pharmacology, 2001, Volume: 52, Issue:2 Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines; Terfenadine	2001
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:2 Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria	2002
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. Drugs under experimental and clinical research, 2002, Volume: 28, Issue:6 Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine	2002
A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity. International archives of allergy and immunology, 2003, Volume: 132, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Butyrophenones; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Terfenadine	2003
Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance. Clinical and experimental dermatology, 2004, Volume: 29, Issue:5 Topics: Adult; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Dibenzoxepins; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Male; Olopatadine Hydrochloride; Piperidines; Psychomotor Performance; Pyridines; Sleep Stages; Terfenadine	2004
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5 Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies; Double-Blind Method; Eye Diseases; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Nasal Mucosa; Nose Diseases; Ophthalmic Solutions; Piperidines; Placebos; Rhinitis, Allergic, Seasonal; Terfenadine	2010
Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study. Allergology international : official journal of the Japanese Society of Allergology, 2017, Volume: 66, Issue:1 Topics: Adult; Asian People; Benzimidazoles; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine	2017

Other Studies

55 other study(ies) available for terfenadine and piperidines

Article	Year
Measurement of azacyclonol in urine and serum of humans following terfenadine (Seldane) administration using gas chromatography-mass spectrometry. Journal of chromatography, 1992, Jul-24, Volume: 578, Issue:2 Topics: Adult; Fourier Analysis; Gas Chromatography-Mass Spectrometry; Humans; Male; Piperidines; Spectrophotometry, Infrared; Terfenadine	1992
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds. Journal of medicinal chemistry, 1989, Volume: 32, Issue:1 Topics: Anaphylaxis; Animals; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Guinea Pigs; Hypersensitivity; Male; Passive Cutaneous Anaphylaxis; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Terfenadine	1989
Interaction studies in mice of SCH 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents. Agents and actions, 1986, Volume: 18, Issue:5-6 Topics: Animals; Benzhydryl Compounds; Diphenhydramine; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Histamine Antagonists; Loratadine; Male; Mice; Motor Activity; Piperidines; Reflex; Seizures; Stereotyped Behavior; Terfenadine; Vocalization, Animal	1986
Radioimmunoassay for terfenadine in human plasma. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:12 Topics: Benzhydryl Compounds; Histamine H1 Antagonists; Humans; Kinetics; Piperidines; Radioimmunoassay; Terfenadine	1980
Assessment of drugs' side effects: Visual Analogue Scale versus check-list format. Perceptual and motor skills, 1980, Volume: 50, Issue:3 Pt 2 Topics: Adult; Benzhydryl Compounds; Diphenhydramine; Humans; Male; Mental Processes; Piperidines; Self Disclosure; Terfenadine	1980
[Terfenadine in allergic rhinitis in children]. Alergia, 1981, Volume: 28, Issue:1 Topics: Benzhydryl Compounds; Chemical Phenomena; Chemistry; Child; Child, Preschool; Female; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Terfenadine	1981
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:3 Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Male; Phenothiazines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Terfenadine	1994
Effect of ZCR-2060, an antiallergic agent, on antigen-induced immediate- and late-phase increases in airway resistance in sensitized guinea pigs. International archives of allergy and immunology, 1995, Volume: 106, Issue:1 Topics: Airway Resistance; Anaphylaxis; Animals; Benzoates; Bronchi; Cetirizine; Female; Guinea Pigs; Ketotifen; Metyrapone; Ovalbumin; Piperidines; Prednisolone; Terfenadine	1995
A preliminary pharmacokinetic study of the enantiomers of the terfenadine acid metabolite in humans. Chirality, 1994, Volume: 6, Issue:6 Topics: Administration, Oral; Adult; Chromatography; Chromatography, High Pressure Liquid; Humans; Male; Piperidines; Stereoisomerism; Structure-Activity Relationship; Terfenadine	1994
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5 Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine	1996
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. Arzneimittel-Forschung, 1996, Volume: 46, Issue:2 Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes	1996
Determination of the terfenadine metabolite azacyclonol in human serum using gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical applications, 1996, Apr-12, Volume: 678, Issue:2 Topics: Anti-Anxiety Agents; Gas Chromatography-Mass Spectrometry; Humans; Piperidines; Sensitivity and Specificity; Terfenadine	1996
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels. European journal of pharmacology, 1997, May-20, Volume: 326, Issue:2-3 Topics: Animals; Butyrophenones; Cells, Cultured; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Terfenadine	1997
Comparative effects of loratadine and terfenadine on cardiac K+ channels. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:1 Topics: Animals; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Gene Expression; Guinea Pigs; Heart Ventricles; Histamine H1 Antagonists; In Vitro Techniques; Loratadine; Male; Membrane Potentials; Myocardium; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Terfenadine; Xenopus laevis	1997
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS letters, 1997, Nov-03, Volume: 417, Issue:1 Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; Cisapride; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart; Humans; Kv1.5 Potassium Channel; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured	1997
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; Piperidines; Rats; Rats, Sprague-Dawley; Terfenadine	1999
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers. Pharmaceutical research, 1999, Volume: 16, Issue:5 Topics: Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Catalytic Domain; Cell Polarity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Histamine H1 Antagonists; Humans; Hydroxylation; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Oligonucleotide Probes; Oxidoreductases, N-Demethylating; Piperidines; RNA, Messenger; Terfenadine; Tritium; Verapamil	1999
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:6 Topics: Astemizole; Benzimidazoles; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG	1999
Cardiotoxicity of second-generation antihistamines. Drugs, 1999, Volume: 57, Issue:6 Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	1999
Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9 Topics: Animals; Butyrophenones; Dibenzazepines; Electrophysiology; Heart Ventricles; Histamine H1 Antagonists; Imidazoles; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley; Terfenadine	1999
Computer-assisted comparison of the structural and electronic dispositions of ebastine and terfenadine. Drug safety, 1999, Volume: 21 Suppl 1 Topics: Butyrophenones; Histamine H1 Antagonists; Models, Molecular; Molecular Conformation; Piperidines; Signal Processing, Computer-Assisted; Terfenadine	1999
The potential of active metabolites of antihistamines in the management of allergic disease. Allergy, 2000, Volume: 55, Issue:5 Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases	2000
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations]. Terapevticheskii arkhiv, 2002, Volume: 74, Issue:3 Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine	2002
The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Butylamines; Cisapride; Disease Models, Animal; Dogs; Female; Heart Rate; Long QT Syndrome; Male; Piperidines; Pyridines; Terfenadine; Verapamil	2002
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. British journal of clinical pharmacology, 2002, Volume: 54, Issue:6 Topics: Butyrophenones; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	2002
Physicochemical features of the HERG channel drug binding site. The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzopyrans; Binding Sites; Biophysical Phenomena; Biophysics; Cation Transport Proteins; Cisapride; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Inhibitory Concentration 50; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Oocytes; Phenylalanine; Piperidines; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Structure, Tertiary; RNA, Complementary; Sequence Homology, Amino Acid; Serotonin Receptor Agonists; Temperature; Terfenadine; Tyrosine; Xenopus	2004
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig. European journal of pharmacology, 2004, Feb-20, Volume: 486, Issue:2 Topics: Animals; Antipsychotic Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cisapride; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Humans; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Risperidone; Terfenadine; Verapamil	2004
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine. Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21 Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine	2004
Practical application of guinea pig telemetry system for QT evaluation. The Journal of toxicological sciences, 2005, Volume: 30, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine	2005
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5 Topics: Adenosine Triphosphatases; Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Biological Transport, Active; Brain; Chromatography, Liquid; Intestinal Absorption; Kinetics; LLC-PK1 Cells; Male; Mass Spectrometry; Mice; Mice, Knockout; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Swine; Terfenadine; Verapamil	2006
In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist. Drugs in R&D, 2006, Volume: 7, Issue:4 Topics: Animals; Benzimidazoles; Bradykinin; Bronchial Spasm; Capillary Permeability; Cetirizine; Dermatitis; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Antagonists; Hypersensitivity; Male; Mice; Molecular Structure; Oxazolone; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H1; Serotonin; Structure-Activity Relationship; Terfenadine; Time Factors	2006
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:10 Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunctivitis, Allergic; Cromolyn Sodium; Diabetes Mellitus, Type 1; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Piperazines; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine	2006
Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay. Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:5 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; beta-Cyclodextrins; Biological Assay; Cisapride; Dose-Response Relationship, Drug; Electrophysiology; Ether-A-Go-Go Potassium Channels; Excipients; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Pyridines; Solubility; Terfenadine; Time Factors	2007
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking. Proteins, 2008, May-01, Volume: 71, Issue:2 Topics: Amino Acid Sequence; Binding Sites; Butyrophenones; Computer Simulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Oxygenases; Piperidines; Protein Interaction Domains and Motifs; Sequence Alignment; Structural Homology, Protein; Substrate Specificity; Terfenadine	2008
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria	2008
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Algorithms; Animals; Biological Transport, Active; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Diffusion; Estrone; Fatty Acids, Monounsaturated; Fluvastatin; Hepatocytes; Indoles; Kinetics; Male; Membranes, Artificial; Models, Biological; Naphthalenes; Oligopeptides; Organic Anion Transporters; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Piperidines; Quinolines; Rats; Rats, Wistar; Sincalide; Temperature; Terfenadine	2008
Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cisapride; Dimerization; Ether-A-Go-Go Potassium Channels; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Piperidines; Pyridines; Sequence Homology, Amino Acid; Terfenadine	2009
Multiple H1-antihistamine-induced urticaria. The Journal of dermatology, 2009, Volume: 36, Issue:4 Topics: Administration, Oral; Adult; Drug Eruptions; Female; Histamine; Histamine H1 Antagonists; Humans; Immunologic Tests; Leukotriene B4; Loratadine; Piperidines; Pyridines; Skin Tests; Terfenadine; Urticaria	2009
Toward a consensus model of the HERG potassium channel. ChemMedChem, 2010, Mar-01, Volume: 5, Issue:3 Topics: Amino Acid Sequence; Benzopyrans; Cisapride; Crystallography, X-Ray; Ether-A-Go-Go Potassium Channels; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Piperidines; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Alignment; Terfenadine	2010
Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction. Journal of food science, 2010, Volume: 75, Issue:3 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Food-Drug Interactions; Gastric Emptying; Half-Life; Histamine H1 Antagonists, Non-Sedating; Intestinal Absorption; Male; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Terfenadine	2010
Urticaria due to antihistamines. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:1 Topics: Administration, Oral; Butyrophenones; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Piperidines; Terfenadine; Urticaria	2011
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen. Acta oto-laryngologica, 2012, Volume: 132, Issue:4 Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; Interleukins; Male; Middle Aged; Nasal Mucosa; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine	2012
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch. International archives of allergy and immunology, 2012, Volume: 158, Issue:2 Topics: Adult; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Pruritus; Pyridines; Skin; Terfenadine; Urticaria	2012
Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates. Journal of biomolecular screening, 2012, Volume: 17, Issue:6 Topics: Action Potentials; Biological Assay; Cell Line; Cisapride; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; Pyrimidinones; Sodium Channels; Terfenadine; Transfection; Verapamil	2012
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists. PloS one, 2013, Volume: 8, Issue:6 Topics: Animals; Blotting, Western; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Irritable Bowel Syndrome; Mast Cells; Maternal Deprivation; Occludin; Piperidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; Terfenadine	2013
The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers. European journal of clinical pharmacology, 2017, Volume: 73, Issue:3 Topics: Adult; Alkaloids; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Half-Life; Healthy Volunteers; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Polyunsaturated Alkamides; Terfenadine	2017
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H European journal of pharmacology, 2018, Nov-05, Volume: 838 Topics: Benzimidazoles; Diphenhydramine; HeLa Cells; Histamine H1 Antagonists, Non-Sedating; Humans; Piperidines; Receptors, Histamine H1; Terfenadine; Time Factors	2018
ERG Channels Regulate Excitability in Stellate and Bushy Cells of Mice Ventral Cochlear Nucleus. The Journal of membrane biology, 2018, Volume: 251, Issue:5-6 Topics: Action Potentials; Animals; Auditory Pathways; Cochlear Nucleus; Electrophysiology; Ether-A-Go-Go Potassium Channels; Membrane Potentials; Mice; Piperidines; Pyridines; Stellate Ganglion; Terfenadine	2018
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. American journal of physiology. Regulatory, integrative and comparative physiology, 2019, 12-01, Volume: 317, Issue:6 Topics: Animals; Chlorobenzenes; Cresols; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Heart; Histamine H1 Antagonists, Non-Sedating; Oocytes; ortho-Aminobenzoates; Phenethylamines; Phenylurea Compounds; Piperidines; Potassium Channel Blockers; Quinolines; Sulfonamides; Terfenadine; Xenopus laevis; Zebrafish; Zebrafish Proteins	2019
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis. European journal of pharmacology, 2020, May-15, Volume: 875 Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Morpholines; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Piperidines; Prostaglandin D2; Pyrroles; Quality of Life; Quinolines; Rats; Rhinitis, Allergic; Sulfides; Terfenadine	2020
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4 Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil	2020
Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter. Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:5 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Administration, Oral; Animals; Caco-2 Cells; Citrus paradisi; Citrus sinensis; Diabetes Mellitus, Type 2; Food-Drug Interactions; Fruit and Vegetable Juices; Half-Life; HEK293 Cells; Humans; Intestinal Absorption; Male; Malus; Organic Anion Transporters; Piperidines; Rats; Terfenadine; Uracil	2021
Cytochrome Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11 Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine	2022