Page last updated: 2024-08-16

terfenadine and midazolam

terfenadine has been researched along with midazolam in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (10.53)	18.2507
2000's	12 (31.58)	29.6817
2010's	19 (50.00)	24.3611
2020's	3 (7.89)	2.80

Authors

Authors	Studies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cerimele, B; DeSante, K; Goldberg, MJ; Hatcher, B; Ring, B; Sides, G; Wrighton, S	1
Hall, SD; Mäenpää, J; Ring, BJ; Strom, SC; Wrighton, SA	1
Atkins, WM; Liu, N; Lu, AY; Newton, DJ; Wang, RW	1
Emoto, C; Iketaki, H; Nakajima, M; Satoh, T; Shimada, N; Shimizu, R; Suzuki, S; Yamasaki, S; Yamazaki, H; Yokoi, T	1
Dresser, GK; Kim, RB; Schwarz, UI; Wilkinson, GR	1
Antal, EJ; Arakawa, T; Gordi, T; Hong, C; Knuth, DW; Nickens, DJ; Polasek, EC; Sharma, A; Tan, LH; Teillol-Foo, M; Xie, R	1
Kazama, E; Kume, T; Ogasawara, A	1
Alfaro, RM; Davey, RT; Formentini, E; Penzak, SR; Robertson, SM; Voell, J	1
Higashi, R; Matsumoto, I; Miyata, Y; Nakade, S; Nunoya, K; Ogawa, M; Sutoh, F; Yoneda, K	1
Chupka, J; Feng, B; Fenner, KS; Frederick, KS; Kalgutkar, AS; Kempshall, S; Mireles, RJ; Troutman, MD	1
Frye, RF; Himmelfarb, J; Le, P; Leblond, FA; Naud, J; Nolin, TD; Pichette, V; Sadr, H	1
Aohara, F; Fujimura, Y; Harakawa, N; Hasegawa, R; Katori, N; Kim, SR; Maekawa, K; Naito, M; Niwa, T; Okuda, H; Sai, K; Saito, Y; Sawada, J; Tohkin, M; Yoshimura, T	1
Imai, H; Imanaga, J; Kotegawa, T; Ohashi, K; Ohyama, T; Shirasaka, Y; Tamai, I; Tateishi, T; Tsutsumi, K; Yoshizato, T	1
Alfaro, RM; Chairez, C; Hunt, JD; Kovacs, JA; Malati, CY; Penzak, SR; Robertson, SM	1
Banba, H; Takayama, K; Takeda-Morishita, M; Tomaru, A	1
Ando, Y; Deguchi, M; Hirota, T; Ieiri, I; Irie, S; Izumi, N; Kanda, E; Kimura, M; Kotani, N; Kusuhara, H; Maeda, K; Matsuguma, K; Matsuki, S; Morishita, M; Okuzono, T; Sugiyama, Y; Tsunemitsu, S; Yamane, N	1
Chang, SY; Grubb, MF; Isoherranen, N; Peng, CC; Rodrigues, AD; Shirasaka, Y; Thummel, KE	1
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Staub, C; Walder, B	1
Bosilkovska, M; Daali, Y; Dayer, P; Déglon, J; Desmeules, JA; Rebsamen, M; Samer, CF; Staub, C; Walder, B	1
Asher, LJ; Feere, DA; House, AA; Knauer, MJ; Nolin, TD; Thomson, BK; Urquhart, BL; Velenosi, TJ	1
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Thomas, A; Walder, B	1
Jeon, JY; Kim, DS; Kim, MG; Kim, Y	1
Kim, RB; Tirona, RG; Wilson, A	1
Annaert, P; Bouillon, T; de Loor, H; Kuypers, D; Vanhove, T	1
Abe, K; Ando, O; Imaoka, T; Karibe, T	1
Cintra, MACT; Coelho, EB; Cusinato, DAC; Filgueira, GCO; Lanchote, VL; Rocha, A	1
Kawachi, T; Kume, S; Miwa, H; Takahashi, K; Yoshida, S	1
Åsberg, A; Christensen, H; Egeland, EJ; Robertsen, I; Witczak, BJ; Zaré, HK	1
da Costa César, I; de Araújo, LL; de Castro, WV; de Lima Nascimento, M; de Oliveira, FM; Derendorf, H; do Carmo Vieira, M; do Nascimento, SB; Duarte-Almeida, JM; Siqueira, JM	1

Trials

9 trial(s) available for terfenadine and midazolam

Article	Year
Effect of dirithromycin on human CYP3A in vitro and on pharmacokinetics and pharmacodynamics of terfenadine in vivo. Journal of clinical pharmacology, 1996, Volume: 36, Issue:12 Topics: Adult; Anti-Anxiety Agents; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Half-Life; Histamine H1 Antagonists; Humans; Hydroxylation; Macrolides; Male; Microsomes, Liver; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Spectrophotometry, Ultraviolet; Terfenadine	1996
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:1 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Enzyme Induction; Female; Gene Expression Regulation; Genes, MDR; Humans; Hypericum; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Plant Preparations; Reference Values; Terfenadine	2003
CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations. Journal of clinical pharmacology, 2005, Volume: 45, Issue:3 Topics: Adult; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black or African American; Cytochrome P-450 CYP3A; Female; Genotype; Herb-Drug Interactions; Hispanic or Latino; Humans; Hypericum; Male; Midazolam; Middle Aged; Phenotype; Plant Preparations; Terfenadine; White People	2005
Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Current medical research and opinion, 2008, Volume: 24, Issue:2 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Ginkgo biloba; HIV Protease Inhibitors; Humans; Lopinavir; Male; Midazolam; Phytotherapy; Plant Extracts; Protease Inhibitors; Pyrimidinones; Ritonavir; Terfenadine	2008
The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. Pharmacogenetics and genomics, 2011, Volume: 21, Issue:2 Topics: Adult; Animals; Anti-Allergic Agents; Area Under Curve; Beverages; Biological Transport; GABA Modulators; Humans; Male; Malus; Midazolam; Organic Anion Transporters; Polymorphism, Single Nucleotide; Terfenadine; Xenopus laevis; Young Adult	2011
Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. Journal of clinical pharmacology, 2012, Volume: 52, Issue:6 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Monitoring; Drugs, Chinese Herbal; Female; Half-Life; Herb-Drug Interactions; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Midazolam; Panax; Plant Roots; Terfenadine; Young Adult	2012
Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs. Journal of clinical pharmacology, 2013, Volume: 53, Issue:6 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; HIV Protease Inhibitors; Humans; Intestines; Liver; Liver-Specific Organic Anion Transporter 1; Male; Midazolam; Organic Anion Transporters; Pravastatin; Ritonavir; Saquinavir; Tandem Mass Spectrometry; Terfenadine; Young Adult	2013
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method. Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:3 Topics: Adolescent; Adult; Bupropion; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Dried Blood Spot Testing; Drug Interactions; Female; Flurbiprofen; Genotyping Techniques; Humans; Male; Midazolam; Omeprazole; Phenotype; Terfenadine; Young Adult	2016
Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. Clinical pharmacology and therapeutics, 2017, Volume: 102, Issue:6 Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Female; Humans; Kidney Transplantation; Liver-Specific Organic Anion Transporter 1; Male; Midazolam; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Polymorphism, Single Nucleotide; Solute Carrier Organic Anion Transporter Family Member 1B3; Tacrolimus; Terfenadine; Young Adult	2017

Other Studies

29 other study(ies) available for terfenadine and midazolam

Article	Year
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharmaceutical research, 1999, Volume: 16, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity	1999
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Grapefruit juice interactions with drugs. The Medical letter on drugs and therapeutics, 1995, Aug-18, Volume: 37, Issue:955 Topics: Beverages; Caffeine; Citrus; Cyclosporine; Estrogens; Felodipine; Food-Drug Interactions; Humans; Midazolam; Nifedipine; Terfenadine	1995
Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone. Pharmacogenetics, 1998, Volume: 8, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Benzoflavones; Buffers; Calcium Chloride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Magnesium Chloride; Microsomes, Liver; Midazolam; NADP; Oxidoreductases, N-Demethylating; Terfenadine; Testosterone	1998
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hydroxylation; Kinetics; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Nifedipine; Recombinant Proteins; Substrate Specificity; Terfenadine; Testosterone	2000
Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Animals; Benzoflavones; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; GABA Modulators; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Intestines; Kinetics; Mice; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Nifedipine; Oxygen; Protein Binding; Steroid Hydroxylases; Terfenadine; Testosterone; Vasodilator Agents	2001
Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3 Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Ketoconazole; Liver; Macaca fascicularis; Male; Microsomes; Midazolam; Terfenadine	2007
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:4 Topics: Anti-Asthmatic Agents; Antibodies, Blocking; Antifungal Agents; Cell Line, Tumor; Chromones; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Ketoconazole; Leukotriene Antagonists; Microsomes, Liver; Midazolam; Oxygenases; Terfenadine; Tolbutamide	2009
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat. Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:12 Topics: Animals; Anti-Allergic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estradiol; Hypnotics and Sedatives; Intestinal Absorption; Isoquinolines; Male; Midazolam; Pharmaceutical Preparations; Prazosin; Quinazolines; Rats; Rats, Sprague-Dawley; Sympatholytics; Terfenadine	2009
ESRD impairs nonrenal clearance of fexofenadine but not midazolam. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:10 Topics: Adult; Aged; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Urea Nitrogen; Cytochrome P-450 CYP3A; Enterocytes; Female; Hepatocytes; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Organic Anion Transporters; Prospective Studies; Rats; Rats, Sprague-Dawley; Terfenadine	2009
CYP3A416 and CYP3A418 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Alleles; Animals; Asia, Eastern; Atorvastatin; Biocatalysis; Camptothecin; Carbamazepine; Cytochrome P-450 CYP3A; Docetaxel; Heptanoic Acids; Humans; Irinotecan; Midazolam; Models, Molecular; Paclitaxel; Pyrroles; Spodoptera; Substrate Specificity; Taxoids; Terfenadine	2010
Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice. Drug metabolism and pharmacokinetics, 2013, Volume: 28, Issue:2 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Female; HIV Protease Inhibitors; Inactivation, Metabolic; Mice; Microsomes; Midazolam; Pravastatin; Ritonavir; Saquinavir; Terfenadine	2013
Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:8 Topics: Biocatalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Genotype; Humans; Itraconazole; Ketoconazole; Male; Microsomes, Liver; Midazolam; Terfenadine; Testosterone; Vincristine	2013
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma. Bioanalysis, 2014, Volume: 6, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Flurbiprofen; Half-Life; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2014
Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots. Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:3 Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Capsules; Carbonated Beverages; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Enzyme Inhibitors; Feasibility Studies; Flurbiprofen; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenotype; Pilot Projects; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult	2014
Effect of CKD and dialysis modality on exposure to drugs cleared by nonrenal mechanisms. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015, Volume: 65, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Anti-Anxiety Agents; Cytochrome P-450 CYP3A; Female; Humans; Kidney; Male; Midazolam; Middle Aged; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency, Chronic; Severity of Illness Index; Terfenadine	2015
Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach. British journal of clinical pharmacology, 2016, Volume: 82, Issue:6 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Fermented Foods; Healthy Volunteers; Humans; Losartan; Male; Midazolam; Middle Aged; Omeprazole; Panax; Pharmaceutical Preparations; Terfenadine; Young Adult	2016
CYP3A4 Activity is Markedly Lower in Patients with Crohn's Disease. Inflammatory bowel diseases, 2017, Volume: 23, Issue:5 Topics: Adult; Aged; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Crohn Disease; Cytochrome P-450 CYP3A; Female; Follow-Up Studies; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Prognosis; Substrate Specificity; Terfenadine	2017
Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys. Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Curcumin; Cytochrome P-450 CYP3A; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Lapatinib; Macaca fascicularis; Male; Midazolam; Neoplasm Proteins; Pantoprazole; Quinazolines; Rosuvastatin Calcium; Sulfasalazine; Terfenadine	2018
LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses. Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Variation, Population; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Healthy Volunteers; Humans; Isoenzymes; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine	2019
Generation of intestinal organoids derived from human pluripotent stem cells for drug testing. Scientific reports, 2020, 04-06, Volume: 10, Issue:1 Topics: Cell Line; Humans; Induced Pluripotent Stem Cells; Intestines; Midazolam; Organoids; Terfenadine	2020
Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End-Stage Renal Disease. Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:4 Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Midazolam; Middle Aged; Organic Anion Transporters; Prospective Studies; Renal Dialysis; Renal Elimination; Terfenadine; Time Factors; Treatment Outcome	2020
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein. Current drug metabolism, 2020, Volume: 21, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Male; Maytenus; Midazolam; Plant Extracts; Quinolines; Rats; Rats, Wistar; Terfenadine	2020