terfenadine has been researched along with loratadine in 155 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (7.10) | 18.7374 |
| 1990's | 54 (34.84) | 18.2507 |
| 2000's | 68 (43.87) | 29.6817 |
| 2010's | 21 (13.55) | 24.3611 |
| 2020's | 1 (0.65) | 2.80 |
| Authors | Studies |
|---|---|
| Almansa, C; Balsa, D; Bartrolí, J; Carceller, E; Forn, J; García-Rafanell, J; Giral, M; Merlos, M | 1 |
| Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Sen, S; Sinha, N | 1 |
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Hitchcock, SA | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Small, P | 1 |
| Kaliner, MA | 1 |
| Barkley, AS; Millard, LG; Shall, L; Thompson, DA | 1 |
| Naclerio, RM | 2 |
| Berger, U; Horak, F; Jäger, S | 1 |
| Hindberg Rasmussen, W; Høi, L; Lorentzen, KA; Nüchel Petersen, L; Olsen, OT; Svendsen, UG | 1 |
| Hill, S; Lever, LR; Marks, R; Rosenberg, R; Thompson, D | 1 |
| Abu Shareeah, AM | 1 |
| Buscaglia, S; Canonica, GW; Ciprandi, G; Iudice, A; Ruffoni, S; Tosca, MA | 1 |
| Becker, AB; Lukowski, JL; Simons, FE; Simons, KJ | 1 |
| Fletcher, MP; Ryhal, BT | 1 |
| Soter, NA | 1 |
| Gillardin, JM; Gommeren, W; Janssen, PA; Janssen, PF; Leysen, JE; Sanz, G; Schotte, A | 1 |
| Chapman, RW; Egan, RW; Kreutner, W; Mauser, PJ | 1 |
| Belaich, S; Bruttmann, G; DeGreef, H; Lachapelle, JM; Paul, E; Pedrali, P; Tennstedt, D | 1 |
| McMillan, JL; Simons, FE; Simons, KJ | 1 |
| Woodward, JK | 2 |
| Kaiser, HB | 1 |
| Simons, FE | 1 |
| Chapman, RW; Gulbenkian, A; Kreutner, W; Siegel, MI | 1 |
| Bousquet, J; Chanal, I; Lebel, B; Michel, FB; Morel, A | 1 |
| Bruttmann, G; Charpin, D; Germouty, J; Horak, F; Kunkel, G; Wittmann, G | 1 |
| Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M | 1 |
| Bedard, PM; Del Carpio, J; Gutkowski, A; Hebert, J; Kabbash, L; Nedilski, M; Prevost, M; Schulz, J; Turenne, Y | 1 |
| Bruttmann, G; Christophers, E; Frølund, L; Horak, F; Pedrali, P; Weeke, B; Wolff, HH | 1 |
| Bedard, P; Del Carpio, J; Gutkowski, A; Hebert, J; Prevost, M; Schulz, J; Turenne, Y; Yeadon, C | 1 |
| O'Hanlon, JF | 1 |
| Barnett, A; Cohen-Winston, M; Iorio, LC | 1 |
| de Jong, R; Gaillard, AW; Gruisen, A | 1 |
| O'Hanlon, JF; Ramaekers, JG | 1 |
| Elsayed, S; Holen, E; Nyfors, A | 1 |
| Bahmer, FA | 1 |
| Katelaris, CH | 1 |
| Darrow, WR; Woosley, R | 1 |
| Dowd, PM; Goldsmith, P | 1 |
| Belloni, PA; Folco, G; Letari, O; Miozzo, A; Nicosia, S; Rovati, GE; Sala, A | 1 |
| Carlsen, KH; Fagertun, HE; Kramer, J; Larsen, S | 1 |
| Holdcroft, C | 1 |
| Cerio, R; Chieira, ML; deGroot, LJ; Giannetti, A; Gonçalves, HM; Guillot, B; Lutsky, BN; Lynde, CW; Schuller, JL; Vareltzides, A | 1 |
| Cartier, A; Ghezzo, H; L'Archevêque, J; Labrecque, M; Malo, JL; Trudeau, C | 1 |
| Cuss, FM; Del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Lin, CC; Sherwood, J | 1 |
| Baroody, FM; Kagey-Sobotka, A; Lichtenstein, LM; Lim, MC; Naclerio, RM; Proud, D | 1 |
| Cabanis, MJ; Caplain, H; Chaufour, S; Rosenzweig, P; Thebault, JJ; Ulliac, N | 1 |
| Woosley, RL | 1 |
| DeMora, F; Ferrer, L; García, G; Puigdemont, A | 1 |
| Clark, S | 1 |
| Edwards, IR; Lindquist, M | 1 |
| Ducic, I; Ko, CM; Morad, M; Shuba, Y | 1 |
| Briscoe, MP; Clark, RH; Day, JH; Ellis, AK; Gervais, P | 1 |
| Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D | 1 |
| Wroblewski, BA | 1 |
| Crawford, WW; Klaustermeyer, WB; Lee, PH; Placik, IM | 1 |
| Estes, KS; González, MA | 1 |
| Annunziato, L; Castaldo, P; Genovese, A; Giorgio, G; January, CT; Marone, G; Pannaccione, A; Taglialatela, M; Zhou, Z | 1 |
| Burtin, B; Donnelly, F; Rihoux, JP | 1 |
| Christian, S; Jensen, M; Kind, P; Ricard, N; Stewart, J | 1 |
| de Abajo, FJ; Rodríguez, LA | 1 |
| Mattila, MJ; Paakkari, I | 1 |
| Fairweather, DB; Hindmarch, I; Shamsi, Z; Stanley, N | 1 |
| Danielson, L; DeVos, C; Grant, JA; Rihoux, JP | 1 |
| Collart, P; Nicolas, JM; Roba, J; Whomsley, R | 1 |
| Crumb, WJ | 1 |
| Dunn, N; Mann, RD; Pearce, GL; Shakir, S | 1 |
| Abdelaziz, MM; Devalia, JL; Khair, OA | 1 |
| Juniper, EF; Van Cauwenberge, P | 1 |
| Capano, D; Harris, AG; Prenner, BM | 1 |
| Benedetto, SR; Duncan, BS; Sloan, AS | 1 |
| Abernethy, DR; Barbey, JT; Brown, KS; Feirrera, I; Ford, N; Franc, J; Salazar, DE | 1 |
| Affrime, M; Banfield, C; Batra, V; Clement, R; Gupta, S; Kantesaria, B; Marino, M | 1 |
| Cummins, G; Lee, J; Okamoto, L | 1 |
| Benko, LB | 1 |
| Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M | 1 |
| Cummins, G; Leahy, M; Liao, E | 1 |
| Annunziato, L; Castaldo, P; Fresi, A; Giorgio, G; Pannaccione, A; Rosati, B; Secondo, A; Taglialatela, M; Wanke, E | 1 |
| DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM | 1 |
| Wilson, AM | 1 |
| Affrime, M; Banfield, C; Gupta, S; Lim, J; Marino, M | 1 |
| Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE | 1 |
| Coutie, WJ; Lipworth, BJ; Orr, LC; Sims, EJ; Wilson, AM | 1 |
| Paakkari, I | 1 |
| Spencer, HM | 1 |
| Haggart, K; Lipworth, BJ; Sims, EJ; Wilson, AM | 1 |
| Gu, X; Silver, NA; Simons, FE; Simons, KJ | 1 |
| Bates, CE; Currie, GP; Lee, DK; Lipworth, BJ | 1 |
| Jackson, CM; Lee, DK; Lipworth, BJ | 1 |
| Boyce, M; Carey, W; Luria, X; Warrington, S | 1 |
| Christian, CD; Crisalida, T; Economides, A; Georges, GC; Hale, M; Kaliner, MA; Liao, Y; Meeves, SG; White, MV; Woodworth, TH | 1 |
| Glass, DJ; Harper, AS | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Appajosyula, S; Gelfand, EW; Meeves, S | 1 |
| Baroody, FM; deTineo, M; Maleckar, B; Moinuddin, R; Naclerio, RM | 1 |
| Glass, D; Harper, A | 1 |
| Fujihara, S; Gardiner, M; Haggart, K; Lee, DK; Lipworth, BJ | 1 |
| Fooanant, S; Roongapinun, S; Wajajamreon, S | 1 |
| Benedetti, MS; Diquet, B; Molimard, M | 1 |
| Fujieda, S; Hyo, S; Kawada, R; Kitazawa, S; Takenaka, H | 1 |
| Conboy-Ellis, K | 1 |
| Boyle, J; Hindmarch, I; Johnsen, S; Meadows, R; Ridout, F | 1 |
| Baltes, E; Benedetti, MS; Chatelain, P; Gillard, M | 1 |
| Ebert, SN; Katchman, AN; Koerner, J; Tosaka, T; Woosley, RL | 1 |
| Green, GR | 1 |
| Brunton, S; Spangler, DL | 1 |
| Elad, S; Heisler, S; Shalit, M | 1 |
| Cohen, AD; Gan-El, U; Lieberman, N; Reuvni, H; Vardy, DA | 1 |
| Camelo-Nunes, IC | 1 |
| Blaiss, MS; Lehman, JM | 1 |
| Aragane, Y; Ashenager, MS; Grgela, T; Kawada, A | 1 |
| Kruszewski, J; Kłos, K; Sułek, K | 1 |
| Kruszewski, J; Kruszewski, R; Kłos, K; Sułek, K | 1 |
| Devillier, P; Faisy, C; Roche, N | 1 |
| Ikezawa, Z; Inomata, N; Tatewaki, S | 1 |
| Bachert, C | 1 |
| dos Santos, RV; Lima, HC; Magerl, M; Mlynek, A | 1 |
| Bagad, AS; Bahekar, PC; Chidrewar, GU; Mandhane, SN; Mehetre, SV; Pawar, CA; Rajamannar, T; Rao, CT; Shah, JH | 1 |
| Moeller, ML; Nahata, MC; Phan, H | 1 |
| Gleixner, KV; Hadzijusufovic, E; Mirkina, I; Peter, B; Pickl, WF; Schuch, K; Thaiwong, T; Valent, P; Willmann, M; Yuzbasiyan-Gurkan, V | 1 |
| Crowe, A; Wright, C | 1 |
| Church, MK; Maurer, M | 1 |
| Anoopkumar-Dukie, S; Grant, GD; Kavanagh, JJ; Naicker, P | 1 |
| Atia, NN; El-Gizawy, SM; El-Kommos, ME; Hosny, NM | 1 |
| Plichta, D; Spiewak, R | 1 |
| Chen, M; Chen, W; Chen, X; Guo, A; He, Y; Li, J; Liu, Z; Su, J; Wen, S; Yan, S; Zhang, C; Zhang, J; Zhao, Y; Zhou, H; Zhu, W | 1 |
| Enk, CD; Levi, A | 1 |
| Kannappan, V; Kanthiah, S | 1 |
| Ji, Q; Liu, Y; Ye, XJ; Zhao, CL | 1 |
| Apfelbacher, CJ; Böhmer, MM; Carter, B; Jupiter, A; Matterne, U; Weisshaar, E | 1 |
| Enk, CD; Hodak, E; Lapidoth, M; Levi, A; Mazor, S; Snast, I; Uvaidov, V | 1 |
| Dell'Orco, PC; Floyd, PD; Skrdla, PJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
27 review(s) available for terfenadine and loratadine
| Article | Year |
|---|---|
Structural modifications that alter the P-glycoprotein efflux properties of compounds.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Central Nervous System Agents; Central Nervous System Diseases; Drug Design; Humans; Models, Molecular; Permeability; Structure-Activity Relationship | 2012 |
Nonsedating antihistamines: pharmacology, clinical efficacy and adverse effects.
Topics: Astemizole; Cyproheptadine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Terfenadine | 1992 |
Comparative effects of terfenadine and loratadine in the treatment of hay fever.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Safety; Terfenadine | 1991 |
The second-generation antihistamines. What makes them different?
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Cetirizine; Cyproheptadine; Education, Medical, Continuing; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity; Loratadine; Terfenadine | 1991 |
H1-receptor antagonist treatment of seasonal allergic rhinitis.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Ketotifen; Loratadine; Rhinitis, Allergic, Seasonal; Terfenadine | 1990 |
Recent advances in H1-receptor antagonist treatment.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Receptors, Histamine H1; Rhinitis, Allergic, Perennial; Terfenadine; Urticaria | 1990 |
Pharmacology and toxicology of nonclassical antihistamines.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cyproheptadine; Drug Administration Schedule; Histamine H1 Antagonists; Humans; Loratadine; Sleep Stages; Terfenadine | 1988 |
Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis.
Topics: Administration, Oral; Administration, Topical; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine | 1995 |
The new H1 antihistamines. Treatment of urticaria and other clinical problems.
Topics: Astemizole; Cetirizine; Dermatitis, Atopic; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine; Urticaria | 1993 |
Cardiac actions of antihistamines.
Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Torsades de Pointes | 1996 |
Pharmacokinetic overview of oral second-generation H1 antihistamines.
Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure-Activity Relationship; Terfenadine; Therapeutic Equivalency; Torsades de Pointes | 1998 |
Variations among non-sedating antihistamines: are there real differences?
Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine | 1999 |
[The effect of second generation histamine antagonists on the heart].
Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes | 2001 |
Are antihistamines useful in managing asthma?
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropanes; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Loratadine; Mannitol; Quinolines; Rhinitis; Sulfides; Terfenadine | 2002 |
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine | 2002 |
[Clinical aspects of anti-inflammatory action of antihistamines].
Topics: Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Piperazines; Terfenadine | 2003 |
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine | 2004 |
Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.
Topics: Absorption; Animals; Area Under Curve; Benzimidazoles; Biological Availability; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Metabolic Clearance Rate; Piperazines; Terfenadine; Tissue Distribution | 2004 |
Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.
Topics: Adolescent; Adult; Cetirizine; Child; Child, Preschool; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nurse Practitioners; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome | 2005 |
Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.
Topics: Central Nervous System; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Quality of Life; Rhinitis, Allergic, Seasonal; Terfenadine | 2006 |
New antihistamines: a critical view.
Topics: Anti-Allergic Agents; Blood-Brain Barrier; Central Nervous System Diseases; Cetirizine; Child; Cyproheptadine; Heart Diseases; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Mast Cells; Piperazines; Receptors, Histamine H1; Terfenadine | 2006 |
Selecting the optimal oral antihistamine for patients with allergic rhinitis.
Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Long QT Syndrome; Loratadine; Piperazines; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome | 2006 |
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.
Topics: Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria | 2008 |
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Clinical Trials as Topic; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Young Adult | 2009 |
H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?
Topics: Anti-Allergic Agents; Cetirizine; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Predictive Value of Tests; Skin Tests; Terfenadine; Urticaria | 2012 |
[Pharmacotherapy of urticaria--an analysis of the discrepancies between guidelines of expert bodies, registration documents and evidence for the effectiveness of drugs].
Topics: Administration, Oral; Administration, Topical; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Glucocorticoids; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Poland; Practice Guidelines as Topic; Terfenadine; Treatment Outcome; Urticaria | 2013 |
Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.
Topics: Administration, Oral; Administration, Topical; Adult; Cetirizine; Chemotherapy, Adjuvant; Child; Eczema; Histamine H1 Antagonists; Humans; Loratadine; Outcome Assessment, Health Care; Pruritus; Randomized Controlled Trials as Topic; Terfenadine | 2019 |
54 trial(s) available for terfenadine and loratadine
| Article | Year |
|---|---|
Suppression of epicutaneous reactivity by terfenadine and loratadine.
Topics: Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Rhinitis, Allergic, Seasonal; Skin; Skin Tests; Terfenadine | 1992 |
Comparative inhibition profiles of three non-sedating antihistamines assessed by an extended Lewis model.
Topics: Adult; Analysis of Variance; Cetirizine; Cyproheptadine; Female; Histamine Antagonists; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Models, Biological; Single-Blind Method; Skin; Skin Tests; Terfenadine | 1992 |
Inhibition of mediator release during the early reaction to antigen.
Topics: Albumins; Antigens; Cetirizine; Esterases; Histamine; Humans; Kinins; Loratadine; Nasal Mucosa; Nasal Provocation Tests; Terfenadine; Tosylarginine Methyl Ester | 1992 |
Onset and duration of the effects of three antihistamines in current use--astemizole, loratadine and terfenadine forte--studied during prolonged, controlled allergen challenges in volunteers.
Topics: Adult; Allergens; Astemizole; Double-Blind Method; Female; Humans; Loratadine; Male; Nasal Mucosa; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Time Factors | 1992 |
Comparison of loratadine and terfenadine in allergic seasonal rhinoconjunctivitis with emphasis on nasal stuffiness and peak flow.
Topics: Adolescent; Adult; Aged; Conjunctivitis, Allergic; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Nasal Mucosa; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Terfenadine | 1992 |
Effects of cetirizine, loratadine and terfenadine on histamine weal and flare reactions.
Topics: Administration, Oral; Adult; Cetirizine; Cyproheptadine; Double-Blind Method; Erythema; Female; Histamine; Histamine Antagonists; Humans; Hydroxyzine; Loratadine; Male; Middle Aged; Random Allocation; Skin; Terfenadine | 1992 |
Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
Topics: Adult; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Male; Pruritus; Remission Induction; Terfenadine; Time Factors; Urticaria | 1992 |
Comparative effects of terfenadine and loratadine in the treatment of hay fever.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Safety; Terfenadine | 1991 |
Comparison of the effects of single doses of the new H1-receptor antagonists loratadine and terfenadine versus placebo in children.
Topics: Benzhydryl Compounds; Child; Cyproheptadine; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Patch Tests; Rhinitis, Allergic, Perennial; Terfenadine | 1991 |
Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Chronic Disease; Clinical Trials as Topic; Cyproheptadine; Histamine Antagonists; Histamine H1 Antagonists; Humans; Loratadine; Middle Aged; Terfenadine; Urticaria | 1990 |
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects.
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadine; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Placebos; Skin Tests; Terfenadine; Time Factors; Urticaria | 1990 |
Antiallergic activity of H1-receptor antagonists assessed by nasal challenge.
Topics: Adult; Benzhydryl Compounds; Cyproheptadine; Double-Blind Method; Histamine H1 Antagonists; Histamine Release; Humans; Loratadine; Nasal Provocation Tests; Pollen; Prostaglandin D2; Rhinitis, Allergic, Seasonal; Terfenadine | 1988 |
Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis.
Topics: Adolescent; Adult; Benzhydryl Compounds; Child; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Mucosa; Placebos; Rhinitis, Allergic, Perennial; Terfenadine | 1989 |
Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Benzhydryl Compounds; Cyproheptadine; Double-Blind Method; Drug Administration Schedule; Female; Histamine Antagonists; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine | 1989 |
A multicentric study of loratadine, terfenadine and placebo in patients with seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Clinical Trials as Topic; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Random Allocation; Rhinitis, Allergic, Seasonal; Terfenadine | 1988 |
Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Benzhydryl Compounds; Clinical Trials as Topic; Cyproheptadine; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Middle Aged; Placebos; Random Allocation; Rhinitis, Allergic, Seasonal; Terfenadine | 1988 |
Antihistamines and driving safety.
Topics: Automobile Driving; Benzhydryl Compounds; Cyproheptadine; Double-Blind Method; Ethanol; Histamine H1 Antagonists; Humans; Loratadine; Male; Psychomotor Performance; Sleep Stages; Terfenadine | 1988 |
The influence of antihistamines on human performance.
Topics: Administration, Oral; Adult; Benzhydryl Compounds; Clemastine; Cyproheptadine; Diazepam; Double-Blind Method; Humans; Loratadine; Male; Psychomotor Performance; Pyrrolidines; Reaction Time; Terfenadine; Time Factors | 1988 |
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94.
Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine | 1995 |
Effects of antihistamines on inflammatory mediators.
Topics: Cetirizine; Chymases; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Humans; Loratadine; Nasal Provocation Tests; Prostaglandin D2; Serine Endopeptidases; Terfenadine; Tryptases | 1993 |
Loratadine and terfenadine in perennial allergic rhinitis. Treatment of nonresponders to the one drug with the other drug.
Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin E; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome | 1993 |
Comparative study of the efficacy and safety of loratadine syrup and terfenadine suspension in the treatment of chronic allergic skin diseases in a pediatric population.
Topics: Child; Chronic Disease; Dermatitis, Contact; Humans; Loratadine; Skin; Solutions; Suspensions; Terfenadine | 1993 |
Duration of effect of loratadine and terfenadine administered once a day for one week on cutaneous and inhaled reactivity to histamine.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchoconstriction; Dose-Response Relationship, Drug; Drug Interactions; Female; Forced Expiratory Volume; Histamine; Humans; Loratadine; Male; Middle Aged; Single-Blind Method; Skin; Terfenadine; Time Factors; Vital Capacity | 1993 |
Effects of loratadine and terfenadine on the induced nasal allergic reaction.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Eosinophilia; Female; Histamine H1 Antagonists; Humans; Inflammation Mediators; Loratadine; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Nasal Lavage Fluid; Nasal Mucosa; Nasal Provocation Tests; Rhinitis, Allergic, Perennial; Statistics, Nonparametric; Terfenadine | 1996 |
Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers.
Topics: Adult; Benzimidazoles; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Male; Terfenadine | 1995 |
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis.
Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental Exposure; Female; Humans; Loratadine; Male; Middle Aged; Pruritus; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sneezing; Terfenadine; Treatment Outcome | 1997 |
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug Interactions; Electrocardiography; Erythromycin; Female; Heart; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Male; Terfenadine | 1998 |
Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis.
Topics: Adrenergic Agents; Allergens; Ambulatory Care; Analysis of Variance; Anti-Allergic Agents; Astemizole; Bronchodilator Agents; Chlorpheniramine; Confidence Intervals; Cross-Over Studies; Ephedrine; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Nasal Mucosa; Nose; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome | 1998 |
Link between patient preferences and treatment outcomes in seasonal allergic rhinitis: an empiric investigation.
Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Patient Satisfaction; Rhinitis, Allergic, Perennial; Surveys and Questionnaires; Terfenadine; Treatment Outcome | 1999 |
A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function.
Topics: Adult; Cognition; Cross-Over Studies; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Male; Middle Aged; Promethazine; Psychomotor Performance; Reaction Time; Terfenadine; Wrist | 1999 |
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria | 1999 |
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Terfenadine; Treatment Outcome | 2000 |
Efficacy and tolerability of loratadine versus fexofenadine in the treatment of seasonal allergic rhinitis: a double-blind comparison with crossover treatment of nonresponders.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine | 2000 |
Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Linear Models; Loratadine; Male; Middle Aged; Piperazines; Terfenadine; Triazoles | 2001 |
Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Terfenadine | 2001 |
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.
Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria | 2002 |
Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.
Topics: Administration, Oral; Adult; Area Under Curve; Beverages; Biological Availability; Citrus; Confidence Intervals; Cross-Over Studies; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Terfenadine | 2002 |
A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis.
Topics: Acetates; Adult; Anti-Allergic Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Humans; Leukotriene Antagonists; Loratadine; Nasal Cavity; Poaceae; Pollen; Pulmonary Ventilation; Quinolines; Rhinitis, Allergic, Seasonal; Single-Blind Method; Skin Tests; Sulfides; Terfenadine | 2002 |
Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.
Topics: Adult; Air Pollutants; Allergens; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Lung; Male; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine | 2002 |
Clinical pharmacology of H1-antihistamines in the skin.
Topics: Adult; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Skin; Skin Tests; Terfenadine | 2002 |
Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.
Topics: Acetates; Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Provocation Tests; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperazines; Respiratory Hypersensitivity; Terfenadine | 2003 |
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine | 2002 |
Relative potency of fexofenadine HCl 180 mg, loratadine 10 mg, and placebo using a skin test model of wheal-and-flare suppression.
Topics: Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Histamine H1 Antagonists; Histamine Release; Humans; Loratadine; Male; Middle Aged; Reference Values; Skin Tests; Terfenadine; Time Factors; Treatment Outcome | 2003 |
Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis.
Topics: Acetates; Adolescent; Adult; Ambrosia; Anti-Allergic Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Quality of Life; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides; Surveys and Questionnaires; Terfenadine; Treatment Outcome; Vasoconstrictor Agents | 2004 |
Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Provocation Tests; Piperazines; Rhinitis, Allergic, Perennial; Terfenadine; Treatment Outcome | 2004 |
Comparative efficacy of wheal-and-flare suppression among various non-sedating antihistamines and the pharmacologic insights to their efficacy.
Topics: Adolescent; Adult; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Terfenadine; Urticaria | 2004 |
The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen.
Topics: Adult; Cetirizine; Cryptomeria; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Japan; Loratadine; Male; Middle Aged; Pollen; Quality of Life; Rhinitis, Allergic, Seasonal; Sneezing; Surveys and Questionnaires; Terfenadine | 2005 |
Suppression of the histamine-induced wheal and flare response by fexofenadine HCl 60 mg twice daily, loratadine 10 mg once daily and placebo in healthy Japanese volunteers.
Topics: Adult; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Japan; Loratadine; Male; Middle Aged; Placebos; Prospective Studies; Terfenadine; United Kingdom; Urticaria | 2005 |
[Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].
Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Placebos; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2006 |
[The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].
Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Drug Administration Schedule; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Regional Blood Flow; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2006 |
Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.
Topics: Adult; Allergens; Animals; Dermatophagoides pteronyssinus; Dibenzazepines; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hydroxyzine; Imidazoles; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2009 |
The effects of antihistamines with varying anticholinergic properties on voluntary and involuntary movement.
Topics: Adult; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Promethazine; Reaction Time; Sleep Stages; Terfenadine; Tremor; Young Adult | 2013 |
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
Topics: Adult; Asian People; Benzimidazoles; China; Female; Genotyping Techniques; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Loratadine; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Receptors, IgE; Terfenadine; Urticaria; Young Adult | 2015 |
[The effect of combined therapy on seasonal allergic rhinitis].
Topics: Administration, Intranasal; Budesonide; Double-Blind Method; Glucocorticoids; Humans; Leukotriene Antagonists; Loratadine; Quality of Life; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Terfenadine | 2016 |
75 other study(ies) available for terfenadine and loratadine
| Article | Year |
|---|---|
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Topics: Anaphylaxis; Animals; Benzocycloheptenes; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Muscle Contraction; Muscle, Smooth; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water | 1998 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Treatment of urticaria and angioedema: low-sedating H1-type antihistamines.
Topics: Angioedema; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Urticaria | 1991 |
[Non-sedative antihistaminics and binding to central and peripheral H1 histamine receptors].
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cerebellum; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Hydroxyzine; Kinetics; Loratadine; Lung; Organ Specificity; Protein Binding; Receptors, Histamine H1; Terfenadine | 1991 |
Selective inhibition of peripheral histamine responses by loratadine and terfenadine.
Topics: Animals; Benzhydryl Compounds; Bronchi; Cyproheptadine; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine Release; Injections, Intravenous; Injections, Intraventricular; Loratadine; Lung; Lung Compliance; Male; Methacholine Compounds; Terfenadine | 1990 |
Pharmacology of antihistamines.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Time Factors | 1990 |
Antiallergic activity of loratadine, a non-sedating antihistamine.
Topics: Animals; Benzhydryl Compounds; Bronchial Spasm; Calcium; Cyproheptadine; Guinea Pigs; Histamine Antagonists; Histamine Release; Hypersensitivity; In Vitro Techniques; Loratadine; Male; Mast Cells; Rats; SRS-A; Terfenadine | 1987 |
Effects of nonsedating histamine H1-antagonists on EEG activity and behavior in the cat.
Topics: Animals; Astemizole; Behavior, Animal; Benzhydryl Compounds; Benzimidazoles; Cats; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Histamine Antagonists; Histamine H1 Antagonists; Loratadine; Male; Phenothiazines; Sleep; Terfenadine | 1989 |
Interaction studies in mice of SCH 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents.
Topics: Animals; Benzhydryl Compounds; Diphenhydramine; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Histamine Antagonists; Loratadine; Male; Mice; Motor Activity; Piperidines; Reflex; Seizures; Stereotyped Behavior; Terfenadine; Vocalization, Animal | 1986 |
The effect of H1 receptor antagonists on peripheral blood mononuclear cells, adenoid cells and primary cell lines.
Topics: Adenoids; Adult; Cell Division; Cell Line; Chlorpheniramine; Dermatitis, Atopic; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Leukocytes, Mononuclear; Loratadine; Male; Middle Aged; Terfenadine | 1995 |
Non sedating antihistamines.
Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Psychomotor Performance; Terfenadine | 1993 |
Analysis of potential adverse drug reactions--a case of mistaken identity.
Topics: Astemizole; Atrial Fibrillation; Drug Interactions; Electrocardiography; Humans; Loratadine; Quinidine; Tachycardia, Ventricular; Terfenadine | 1994 |
Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity.
Topics: Animals; Blood Platelets; Bronchi; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Leukotrienes; Loratadine; Macrophages, Peritoneal; Male; Rats; Receptors, Histamine H1; Terfenadine; Terpenes; Thapsigargin | 1994 |
Terfenadine, astemizole and loratadine: second generation antihistamines.
Topics: Astemizole; Humans; Loratadine; Terfenadine | 1993 |
Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs.
Topics: Animals; Cardiovascular System; Central Nervous System; Diphenhydramine; Electrocardiography; Electroencephalography; Guinea Pigs; Histamine H1 Antagonists; Hypnotics and Sedatives; Loratadine; Male; Promethazine; Quinidine; Terfenadine | 1995 |
Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells.
Topics: Animals; Calcimycin; Cell Survival; Cetirizine; Concanavalin A; Dermatitis, Atopic; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; Ketotifen; Loratadine; Mast Cells; Skin; Substance P; Terfenadine | 1997 |
Dangers of non-sedating antihistamines.
Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legislation, Drug; Liver Diseases; Loratadine; Terfenadine; United Kingdom | 1997 |
Risks of non-sedating antihistamines.
Topics: Adverse Drug Reaction Reporting Systems; Astemizole; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine | 1997 |
Comparative effects of loratadine and terfenadine on cardiac K+ channels.
Topics: Animals; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Gene Expression; Guinea Pigs; Heart Ventricles; Histamine H1 Antagonists; In Vitro Techniques; Loratadine; Male; Membrane Potentials; Myocardium; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Terfenadine; Xenopus laevis | 1997 |
Antihistamines.
Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis; Terfenadine | 1998 |
Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines.
Topics: Animals; Astemizole; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Histamine H1 Antagonists; Humans; Loratadine; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured; Xenopus laevis | 1998 |
The clinical efficacy of H1 antagonists in urticaria and rhinitis.
Topics: Anti-Allergic Agents; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Mathematical Computing; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria | 1998 |
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; Child, Preschool; Cohort Studies; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Information Systems; Loratadine; Male; Middle Aged; Risk Factors; Tachycardia, Ventricular; Terfenadine; Triprolidine | 1999 |
In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines.
Topics: Astemizole; Benzimidazoles; Cetirizine; Cytochrome P-450 Enzyme Inhibitors; Dimethyl Sulfoxide; Enzyme Inhibitors; Glucuronosyltransferase; Histamine H1 Antagonists; Humans; Isoenzymes; Kinetics; Loratadine; Microsomes, Liver; Terfenadine | 1999 |
Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions.
Topics: Adult; Aged; Cells, Cultured; Dose-Response Relationship, Drug; Heart Atria; Histamine H1 Antagonists; Humans; Loratadine; Middle Aged; Patch-Clamp Techniques; Potassium Channel Blockers; Terfenadine; Transfection | 2000 |
Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Cetirizine; Child; Child, Preschool; Consciousness Disorders; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Loratadine; Male; Middle Aged; Product Surveillance, Postmarketing; Sleep Stages; Terfenadine; Triprolidine | 2000 |
The potential of active metabolites of antihistamines in the management of allergic disease.
Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases | 2000 |
Impact of interventions designed to increase market share and prescribing of fexofenadine at HMOs.
Topics: Analysis of Variance; Astemizole; Cetirizine; Cost Savings; Drug Costs; Drug Utilization; Health Maintenance Organizations; Histamine H1 Antagonists; Humans; Loratadine; Marketing of Health Services; Practice Patterns, Physicians'; Retrospective Studies; Terfenadine; United States | 2000 |
Newer antihistamines.
Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Somnambulism; Terfenadine | 2001 |
[Seasonal allergic rhinitis. Nasal obstruction can also beh improved].
Topics: Anti-Allergic Agents; Double-Blind Method; Humans; Loratadine; Multicenter Studies as Topic; Nasal Obstruction; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine | 2001 |
A descriptive analysis of the use and cost of new-generation antihistamines in the treatment of allergic rhinitis: a retrospective database analysis.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Databases as Topic; Drug Utilization Review; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Retrospective Studies; Rhinitis, Allergic, Perennial; Terfenadine; United States | 2001 |
Ugly wait at the counter. Insurer pushes to make allergy drugs nonprescription.
Topics: Anti-Allergic Agents; Health Services Accessibility; Humans; Insurance Carriers; Legislation, Drug; Loratadine; Nonprescription Drugs; Terfenadine; United States; United States Food and Drug Administration | 2001 |
The costs of nonsedating antihistamine therapy for allergic rhinitis in managed care: an updated analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Cetirizine; Child; Cohort Studies; Drug Costs; Economics, Pharmaceutical; Female; Health Care Costs; Histamine H1 Antagonists; Humans; Loratadine; Male; Managed Care Programs; Middle Aged; Retrospective Studies; Rhinitis, Allergic, Perennial; Terfenadine; United States | 2001 |
Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs).
Topics: Astemizole; Calcium; Calcium Channel Blockers; Calcium Channels; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Neuroblastoma; Norepinephrine; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Tritium; Tumor Cells, Cultured | 2001 |
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].
Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine | 2002 |
The Rx-to-OTC switch of Claritin, Allegra, and Zyrtec: an unprecedented FDA response to petitioners and the protection of public health.
Topics: Anti-Allergic Agents; Cetirizine; Drug Approval; Drug Costs; Drug Labeling; Drug Prescriptions; Gatekeeping; Humans; Legislation, Drug; Loratadine; Nonprescription Drugs; Public Health Practice; Terfenadine; United States; United States Food and Drug Administration | 2002 |
Decongestant effects of antihistamines: a class effect?
Topics: Controlled Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Loratadine; Nasal Decongestants; Rhinitis, Allergic, Seasonal; Terfenadine | 2003 |
Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.
Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Patient Satisfaction; Rhinitis, Allergic, Seasonal; Sleep Wake Disorders; Terfenadine; Treatment Outcome | 2003 |
Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.
Topics: Anti-Allergic Agents; Cetirizine; Choice Behavior; Data Collection; Humans; Loratadine; Managed Care Programs; Nonprescription Drugs; Patient Satisfaction; Terfenadine; United States | 2004 |
Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.
Topics: Animals; Cetirizine; CHO Cells; Cricetinae; Cricetulus; Histamine H1 Antagonists; Humans; Loratadine; Piperazines; Predictive Value of Tests; Receptors, Histamine H1; Recombination, Genetic; Terfenadine; Urticaria | 2005 |
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cells, Cultured; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Loratadine; Lovastatin; Methadone; Oxides; Pentamidine; Potassium Channel Blockers; Rabbits; Terfenadine; Torsades de Pointes | 2006 |
Treatment of ear pain in pilots in flight.
Topics: Aerospace Medicine; Anti-Allergic Agents; Humans; Loratadine; Pain; Rhinitis, Allergic, Seasonal; Steroids; Terfenadine | 2005 |
Saliva secretion in patients with allergic rhinitis.
Topics: Adolescent; Adult; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Patient Satisfaction; Pilot Projects; Rhinitis; Saliva; Salivary Glands; Terfenadine; Xerostomia | 2006 |
Marketing of a new non-sedating antihistamine (fexofenadine) puts an additional burden on healthcare system resources in Israel.
Topics: Commerce; Cost-Benefit Analysis; Cross-Sectional Studies; Delivery of Health Care; Drug Prescriptions; Histamine H1 Antagonists, Non-Sedating; Humans; Israel; Loratadine; Marketing of Health Services; Terfenadine | 2006 |
Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines.
Topics: Cells, Cultured; Cetirizine; Dibenzoxepins; Histamine H1 Antagonists, Non-Sedating; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Loratadine; Olopatadine Hydrochloride; RNA, Messenger; T-Lymphocytes; Terfenadine | 2007 |
Multiple H1-antihistamine-induced urticaria.
Topics: Administration, Oral; Adult; Drug Eruptions; Female; Histamine; Histamine H1 Antagonists; Humans; Immunologic Tests; Leukotriene B4; Loratadine; Piperidines; Pyridines; Skin Tests; Terfenadine; Urticaria | 2009 |
Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.
Topics: Acetates; Alcohols; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Cetirizine; Drug Interactions; Female; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Hydroxyzine; Hypersensitivity; Immunoglobulin G; Interleukin-4; Leukocytes; Loratadine; Male; Mice; Mice, Inbred BALB C; Nasal Lavage Fluid; Nasal Mucosa; Pentobarbital; Piperazines; Sneezing; Terfenadine | 2010 |
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Cetirizine; Child; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Leukotriene Antagonists; Loratadine; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Sulfides; Tablets; Terfenadine; Treatment Outcome | 2009 |
H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cats; Cell Line, Tumor; Cell Proliferation; Dasatinib; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Loratadine; Mastocytoma; Mastocytosis, Systemic; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Terfenadine; Thiazoles; Tumor Cells, Cultured | 2010 |
The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cetirizine; Chromatography, High Pressure Liquid; Drug Interactions; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Loratadine; Mass Spectrometry; Permeability; Terfenadine | 2012 |
Thin layer chromatography-densitometric determination of some non-sedating antihistamines in combination with pseudoephedrine or acetaminophen in synthetic mixtures and in pharmaceutical formulations.
Topics: Acetaminophen; Chromatography, Thin Layer; Densitometry; Histamine H1 Antagonists, Non-Sedating; Limit of Detection; Linear Models; Loratadine; Pseudoephedrine; Reproducibility of Results; Tablets; Terfenadine | 2014 |
Treatment of solar urticaria using antihistamine and leukotriene receptor antagonist combinations tailored to disease severity.
Topics: Acetates; Adolescent; Adult; Cetirizine; Child; Child, Preschool; Cyclopropanes; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Photosensitivity Disorders; Quinolines; Remission Induction; Remission, Spontaneous; Severity of Illness Index; Sulfides; Sunlight; Terfenadine; Ultraviolet Rays; Urticaria; Young Adult | 2015 |
D-Optimal mixture design optimization of an HPLC method for simultaneous determination of commonly used antihistaminic parent molecules and their active metabolites in human serum and urine.
Topics: Anti-Allergic Agents; Chromatography, High Pressure Liquid; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Limit of Detection; Loratadine; Solid Phase Extraction; Terfenadine | 2017 |
Real-life experience in the treatment of solar urticaria: retrospective cohort study.
Topics: Acetates; Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Cohort Studies; Cyclopropanes; Disease Management; Female; Histamine Antagonists; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Omalizumab; Photosensitivity Disorders; Quinolines; Retrospective Studies; Sulfides; Terfenadine; Urticaria; Young Adult | 2019 |
Modeling Recrystallization Kinetics Following the Dissolution of Amorphous Drugs.
Topics: Chemistry, Pharmaceutical; Crystallization; Glyburide; Indomethacin; Kinetics; Loratadine; Models, Chemical; Pharmaceutical Preparations; Solubility; Terfenadine | 2020 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |