Page last updated: 2024-08-16

terfenadine and ketoconazole

terfenadine has been researched along with ketoconazole in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	31 (44.29)	18.2507
2000's	21 (30.00)	29.6817
2010's	15 (21.43)	24.3611
2020's	3 (4.29)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Giordanetto, F; Leach, AG; Zachariae, U	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Lockey, RF	1
Bloch, A; Broccard, O; Duruz, H; Guinand, O; Lacatis, D; Levy, P; Zimmermann, M	1
Flicker, M; Mathews, DR; McBride, G; McNutt, B; Okerholm, R	1
Cantilena, LR; Ferguson, CL; Killeavy, ES; Lloyd, BK; Monahan, BP; Troy, J	1
Ciummo, PE; Katz, NL	1
Burmaster, SD; Cheng, LK; Hook, RH; Leeson, GA; Ling, KH; Reith, MK	1
Estabrook, RW; Ferrero, JL; Kukulka, MJ; Lee, RD; Mulford, DJ; Rodrigues, AD; Shet, MS; Surber, BW; Thomas, SB	1
Guanci, R; Lilley, LL	1
Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL	1
Kivistö, KT; Klotz, U; Neuvonen, PJ	1
Pohjola-Sintonen, S	1
Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD	1
Cantilena, LR; Honig, PK	1
Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J	1
Diamond, JM	1
Neuvonen, P; Pohjola-Sintonen, S; Toivonene, L; Viitasalo, M	1
Sabbah, A	1
Oster, G; Thompson, D	1
Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL; Wright, CE	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W	1
Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; von Moltke, LL	1
Carlson, AM; Morris, LS	1
Burkhart, GA; Honig, PK; Sevka, MJ; Temple, R	1
Collins, JM; Fitzsimmons, ME	1
Ishizaki, T	1
Llenas, J; Roberts, DJ	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J	1
Artursson, P; Dobson, GL; Guo, Z; Hidalgo, IJ; Raeissi, SD	1
Brown, AM; Dumaine, R; Roy, ML	1
Artursson, P; Hidalgo, IJ; Raeissi, SD; Segura-Aguilar, J	1
Chen, CF; Chen, CH; Chen, LC; Ho, YS; Liang, YC; Lin, CH; Lin, JK; Lin, SY; Wang, YJ; Yu, CF	1
Knutson, L; Knutson, T; Lennernäs, H; Tannergren, C	1
Gotoh, Y; Kamada, N; Momose, D	1
Kikuchi, A; Maeda, T; Nozawa, T; Tamai, I; Wakasawa, T	1
Kazama, E; Kume, T; Ogasawara, A	1
Bate, A; Edwards, IR; Norén, GN; Sundberg, R	1
Chiba, M; Ishii, Y; Shibata, Y; Takahashi, H	1
Higashi, R; Matsumoto, I; Miyata, Y; Nakade, S; Nunoya, K; Ogawa, M; Sutoh, F; Yoneda, K	1
Constantinescu, C; Gripeos, D; Lilja, Y; Mercolini, L; Mukherjee, J; Ozdemir, V; Raggi, MA; Reist, C; Wu, JC	1
Chang, SY; Grubb, MF; Isoherranen, N; Peng, CC; Rodrigues, AD; Shirasaka, Y; Thummel, KE	1
Badyra, B; Kudolo, J; Lisowski, B; Polak, S; Wiśniowska, B	1
Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A	1
da Costa César, I; de Araújo, LL; de Castro, WV; de Lima Nascimento, M; de Oliveira, FM; Derendorf, H; do Carmo Vieira, M; do Nascimento, SB; Duarte-Almeida, JM; Siqueira, JM	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Chen, CH; De Clercq, E; Feng, D; Ginex, T; Kang, D; Lee, KH; Liu, X; Luque, FJ; Murugan, NA; Pannecouque, C; Steitz, TA; Wang, Z; Wei, F; Wu, G; Yang, Y; Zhan, P; Zhang, H; Zhang, J; Zhao, T	1
Adebesin, AM; Falck, JR; Fischer, R; Konkel, A; Lossie, J; Paudyal, MP; Puli, N; Schunck, WH; Vijaykumar, J; Wesser, T; Westphal, C; Zhu, C	1
Consoli, V; D'Agata, V; D'Amico, AG; Fallica, AN; Floresta, G; Intagliata, S; Pittalà, V; Rescifina, A; Romeo, G; Salerno, L; Sorrenti, V; Vanella, L	1

Reviews

4 review(s) available for terfenadine and ketoconazole

Article	Year
Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences. Clinical pharmacokinetics, 1994, Volume: 27, Issue:1 Topics: Cytochrome P-450 Enzyme System; Drug Interactions; Fluconazole; Heart; Humans; Itraconazole; Ketoconazole; Prodrugs; Terfenadine	1994
[Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia]. Duodecim; laaketieteellinen aikakauskirja, 1993, Volume: 109, Issue:2 Topics: Drug Interactions; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Pointes	1993
The clinician and drug interactions--an update. Journal of clinical psychopharmacology, 1996, Volume: 16, Issue:3 Topics: Antifungal Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Histamine H1 Antagonists; Humans; Ketoconazole; Microsomes, Liver; Selective Serotonin Reuptake Inhibitors; Terfenadine	1996
Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction. The Journal of toxicological sciences, 1996, Volume: 21, Issue:5 Topics: Drug Design; Drug Interactions; Humans; Ketoconazole; Risk Assessment; Terfenadine; Torsades de Pointes	1996

Trials

1 trial(s) available for terfenadine and ketoconazole

Article	Year
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. The American journal of cardiology, 1993, Aug-26, Volume: 72, Issue:6 Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; Heart Diseases; Humans; In Vitro Techniques; Ketoconazole; Membrane Potentials; Middle Aged; Prospective Studies; Retrospective Studies; Terfenadine	1993

Article

Year

Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.

The American journal of cardiology, 1993, Aug-26, Volume: 72, Issue:6

Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; Heart Diseases; Humans; In Vitro Techniques; Ketoconazole; Membrane Potentials; Middle Aged; Prospective Studies; Retrospective Studies; Terfenadine

1993

Other Studies

65 other study(ies) available for terfenadine and ketoconazole

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14 Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Special drug communication teleconference. August 7, 1992. Ear, nose, & throat journal, 1992, Volume: 71, Issue:9 Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Drug Interactions; Electrocardiography; Humans; Ketoconazole; Liver Diseases; Macrolides; Terfenadine; United States; United States Food and Drug Administration	1992
Medic alert! Nursing management, 1992, Volume: 23, Issue:9 Topics: Cardiovascular System; Drug Interactions; Erythromycin; Humans; Ketoconazole; Terfenadine	1992
Torsades de Pointes after treatment with terfenadine and ketoconazole. European heart journal, 1992, Volume: 13, Issue:7 Topics: Adult; Cardiac Pacing, Artificial; Dermatomycoses; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Ketoconazole; Long QT Syndrome; Rhinitis, Allergic, Seasonal; Terfenadine; Torsades de Pointes	1992
Torsades de pointes occurring in association with terfenadine use. JAMA, 1991, Nov-06, Volume: 266, Issue:17 Topics: Drug Interactions; Electrocardiography; Humans; Ketoconazole; Terfenadine; Torsades de Pointes	1991
Torsades de pointes occurring in association with terfenadine use. JAMA, 1990, Dec-05, Volume: 264, Issue:21 Topics: Adult; Benzhydryl Compounds; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Ketoconazole; Terfenadine; Torsades de Pointes	1990
Interactions and drug-metabolizing enzymes. American pharmacy, 1995, Volume: NS35, Issue:9 Topics: Adolescent; Adult; Anti-Allergic Agents; Antidepressive Agents, Second-Generation; Antifungal Agents; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Erythromycin; Female; Fluoxetine; Humans; Isoenzymes; Ketoconazole; Liver; Male; Middle Aged; Pharmaceutical Preparations; Terfenadine; Theophylline; Torsades de Pointes	1995
Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:6 Topics: Alcohols; Biotransformation; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Reagent Kits, Diagnostic; Terfenadine; Troleandomycin	1995
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:7 Topics: Adult; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ketoconazole; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Rats; Recombinant Fusion Proteins; Terfenadine	1995
Med errors: the new antihistamines. The American journal of nursing, 1995, Volume: 95, Issue:5 Topics: Adult; Drug Interactions; Female; Humans; Ketoconazole; Terfenadine	1995
In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction. Journal of clinical pharmacology, 1994, Volume: 34, Issue:12 Topics: Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Models, Biological; Terfenadine	1994
Possible interactions with terfenadine or astemizole. The Western journal of medicine, 1994, Volume: 160, Issue:4 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescriptions; Erythromycin; Female; Humans; Ketoconazole; Male; Middle Aged; Retrospective Studies; Terfenadine	1994
Ketoconazole and fluconazole drug interactions. Archives of internal medicine, 1994, May-09, Volume: 154, Issue:9 Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketoconazole; Terfenadine	1994
TCA toxicity. Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:6 Topics: Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Female; Humans; Ketoconazole; Macrolides; Male; Terfenadine	1993
Torsades de pointes after terfenadine-itraconazole interaction. BMJ (Clinical research ed.), 1993, Jan-16, Volume: 306, Issue:6871 Topics: Adult; Drug Interactions; Female; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Pointes	1993
[Teldane update. Interview with Dr. Alfred Sabbah, chief of the immuno-allergology laboratory of the C.H.U. d'Angers. Interview by Dr. Pierre Ceddaha]. Allergie et immunologie, 1993, Volume: 25, Issue:2 Topics: Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Contraindications; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Humans; Hypersensitivity; Inactivation, Metabolic; Incidence; Infant; Josamycin; Ketoconazole; Microsomes, Liver; Retrospective Studies; Risk; Terfenadine	1993
Use of terfenadine and contraindicated drugs. JAMA, 1996, May-01, Volume: 275, Issue:17 Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin	1996
Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. Journal of clinical psychopharmacology, 1996, Volume: 16, Issue:2 Topics: Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Culture Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Histamine H1 Antagonists; Humans; Ketoconazole; Metabolic Clearance Rate; Microsomes, Liver; Oxidoreductases, N-Demethylating; Selective Serotonin Reuptake Inhibitors; Terfenadine	1996
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. Arzneimittel-Forschung, 1996, Volume: 46, Issue:2 Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes	1996
Coprescription of terfenadine and erythromycin or ketaconazole: an assessment of potential harm. Journal of the American Pharmaceutical Association (Washington, D.C. : 1996), 1996, Volume: NS36, Issue:4 Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Antifungal Agents; Clinical Pharmacy Information Systems; Drug Interactions; Erythromycin; Health Maintenance Organizations; Insurance Claim Review; Ketoconazole; Retrospective Studies; Terfenadine	1996
Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin. Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Bacterial Agents; Antifungal Agents; Child; Child, Preschool; Drug Prescriptions; Erythromycin; Female; Health Maintenance Organizations; Humans; Infant; Ketoconazole; Male; Medicaid; Michigan; Middle Aged; Ohio; Terfenadine; United States	1997
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:2 Topics: Anti-HIV Agents; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Histamine H1 Antagonists; HIV Protease Inhibitors; Humans; Indinavir; Intestine, Small; Ketoconazole; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Saquinavir; Terfenadine	1997
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharmaceutical research, 1997, Volume: 14, Issue:8 Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxylation; Intestinal Mucosa; Jejunum; Ketoconazole; Microsomes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Steroid Hydroxylases; Terfenadine; Troleandomycin	1997
Blockade of HERG and Kv1.5 by ketoconazole. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:2 Topics: Action Potentials; Animals; Antifungal Agents; Cation Transport Proteins; DNA-Binding Proteins; Electric Stimulation; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart; Histamine H1 Antagonists; Humans; Ketoconazole; Kv1.5 Potassium Channel; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Xenopus	1998
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers. Pharmaceutical research, 1999, Volume: 16, Issue:5 Topics: Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Catalytic Domain; Cell Polarity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Histamine H1 Antagonists; Humans; Hydroxylation; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Oligonucleotide Probes; Oxidoreductases, N-Demethylating; Piperidines; RNA, Messenger; Terfenadine; Tritium; Verapamil	1999
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. Journal of cellular biochemistry, 2002, Volume: 87, Issue:2 Topics: Animals; Apoptosis; Baculoviridae; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA Fragmentation; Drug Interactions; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Insecta; Ketoconazole; Liver Neoplasms; Microsomes; Recombinant Proteins; Terfenadine; Tumor Cells, Cultured	2002
The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. British journal of clinical pharmacology, 2003, Volume: 55, Issue:2 Topics: Adult; Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Intestinal Absorption; Jejunum; Ketoconazole; Male; Permeability; Terfenadine	2003
The advantages of the Ussing chamber in drug absorption studies. Journal of biomolecular screening, 2005, Volume: 10, Issue:5 Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Cell Membrane; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Jejunum; Ketoconazole; Kinetics; Mass Spectrometry; Permeability; Protein Binding; Rats; Terfenadine; Time Factors	2005
Transporter-mediated intestinal absorption of fexofenadine in rats. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:4 Topics: Animals; Anti-Allergic Agents; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Dose-Response Relationship, Drug; Estrone; Intestinal Absorption; Ketoconazole; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Wistar; Terfenadine; Xenopus	2006
Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3 Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Ketoconazole; Liver; Macaca fascicularis; Male; Microsomes; Midazolam; Terfenadine	2007
A statistical methodology for drug-drug interaction surveillance. Statistics in medicine, 2008, Jul-20, Volume: 27, Issue:16 Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral; Diuretics; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Itraconazole; Ketoconazole; Models, Statistical; Product Surveillance, Postmarketing; Terfenadine	2008
A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method. Drug metabolism and pharmacokinetics, 2008, Volume: 23, Issue:5 Topics: Area Under Curve; Cryopreservation; Cytochrome P-450 Enzyme System; Desipramine; Drug Interactions; Hepatocytes; Humans; Indinavir; Ketoconazole; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests; Quinidine; Technology, Pharmaceutical; Terfenadine	2008
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:4 Topics: Anti-Asthmatic Agents; Antibodies, Blocking; Antifungal Agents; Cell Line, Tumor; Chromones; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Ketoconazole; Leukotriene Antagonists; Microsomes, Liver; Midazolam; Oxygenases; Terfenadine; Tolbutamide	2009
Ketoconazole-associated preferential increase in dopamine D2 receptor occupancy in striatum compared to pituitary in vivo: role for drug transporters? Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:1 Topics: Administration, Oral; Adult; Anti-Allergic Agents; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Binding, Competitive; Blood-Brain Barrier; Corpus Striatum; Drug Therapy, Combination; Humans; Injections, Intramuscular; Ketoconazole; Male; Neoplasm Proteins; Pituitary Gland; Positron-Emission Tomography; Psychotic Disorders; Receptors, Dopamine D2; Risperidone; Schizophrenia; Terfenadine	2012
Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:8 Topics: Biocatalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Genotype; Humans; Itraconazole; Ketoconazole; Male; Microsomes, Liver; Midazolam; Terfenadine; Testosterone; Vincristine	2013
How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction. Folia medica Cracoviensia, 2015, Volume: 55, Issue:4 Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Dextromethorphan; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; In Vitro Techniques; Ketoconazole; Models, Cardiovascular; Patch-Clamp Techniques; Pilot Projects; Quinidine; Terfenadine	2015
Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes. Journal of pharmacological sciences, 2020, Volume: 142, Issue:4 Topics: Animals; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Drug Synergism; Ketoconazole; Macaca fascicularis; Polypharmacy; Terfenadine; Torsades de Pointes	2020
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein. Current drug metabolism, 2020, Volume: 21, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Male; Maytenus; Midazolam; Plant Extracts; Quinolines; Rats; Rats, Wistar; Terfenadine	2020
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3 Topics: Animals; Anti-HIV Agents; Binding Sites; Cell Line, Tumor; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Male; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Structure; Pyrimidines; Rats, Wistar; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2019
Development of Robust 17( Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Dose-Response Relationship, Drug; Drug Stability; Epoxide Hydrolases; Esterification; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Rats, Wistar	2019
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Male; Molecular Docking Simulation; Molecular Structure; Protein Binding; Rats, Sprague-Dawley; Structure-Activity Relationship	2021