Page last updated: 2024-08-16

terfenadine and itraconazole

terfenadine has been researched along with itraconazole in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (30.30)	18.2507
2000's	14 (42.42)	29.6817
2010's	8 (24.24)	24.3611
2020's	1 (3.03)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bergström, CA; Hubatsch, I; Johansson, K; Wassvik, CM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Kivistö, KT; Klotz, U; Neuvonen, PJ	1
Pohjola-Sintonen, S	1
Cantilena, LR; Honig, PK; Hull, R; Smith, JE; Wortham, DC; Zamani, K	1
Crane, JK; Shih, HT	1
Neuvonen, P; Pohjola-Sintonen, S; Toivonen, L; Viitasalo, M	1
Neuvonen, P; Pohjola-Sintonen, S; Toivonene, L; Viitasalo, M	1
Oster, G; Thompson, D	1
Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF	1
de Wildt, SN; van den Anker, JN	1
Broekmans, AW; Lekkerkerker, JF	1
Avdeef, A; Ruell, JA; Tsinman, O	1
Cha, IJ; Choi, YG; Hong, WS; Lee, SS; Nguyen, PM; Shin, JG; Shon, JH; Yoon, YR	1
Nieber, K; Rufke, C	1
Shimizu, M; Sugawara, K; Tateishi, T; Uno, T	3
Chroust, K; Floriánová, A; Kadlecová, J; Papousek, I; Sisáková, M; Spinar, J; Toman, O	1
Miura, M; Suzuki, T; Tateishi, T; Uno, T	1
Bate, A; Edwards, IR; Norén, GN; Sundberg, R	1
Miura, M; Uno, T	1
Chang, SY; Grubb, MF; Isoherranen, N; Peng, CC; Rodrigues, AD; Shirasaka, Y; Thummel, KE	1
Srinivas, NR	1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N	1

Reviews

4 review(s) available for terfenadine and itraconazole

Article	Year
Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences. Clinical pharmacokinetics, 1994, Volume: 27, Issue:1 Topics: Cytochrome P-450 Enzyme System; Drug Interactions; Fluconazole; Heart; Humans; Itraconazole; Ketoconazole; Prodrugs; Terfenadine	1994
[Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia]. Duodecim; laaketieteellinen aikakauskirja, 1993, Volume: 109, Issue:2 Topics: Drug Interactions; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Pointes	1993
[Long QT interval. Interaction of terfenadine and itraconazole]. Medizinische Monatsschrift fur Pharmazeuten, 2006, Volume: 29, Issue:1 Topics: Antifungal Agents; Histamine H1 Antagonists; Humans; Itraconazole; Long QT Syndrome; Onychomycosis; Rhinitis, Allergic, Seasonal; Terfenadine	2006
Clinical pharmacokinetics of fexofenadine enantiomers. Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:1 Topics: Antifungal Agents; Calcium Channel Blockers; Drug Interactions; Histamine H1 Antagonists; Humans; Itraconazole; Stereoisomerism; Terfenadine; Verapamil	2010

Trials

6 trial(s) available for terfenadine and itraconazole

Article	Year
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:2 Topics: Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Genes, MDR; Haplotypes; Histamine H1 Antagonists; Humans; Itraconazole; Male; Polymorphism, Genetic; Terfenadine	2005
Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein. British journal of clinical pharmacology, 2006, Volume: 61, Issue:5 Topics: Adult; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Diltiazem; Drug Administration Schedule; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Itraconazole; Male; Terfenadine; Time Factors	2006
Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein. British journal of clinical pharmacology, 2006, Volume: 62, Issue:3 Topics: Adult; Antifungal Agents; Cross-Over Studies; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Japan; Male; Terfenadine	2006
Lack of dose-dependent effects of itraconazole on the pharmacokinetic interaction with fexofenadine. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:11 Topics: Administration, Oral; Adult; Aged; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Male; Middle Aged; Terfenadine	2006
The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers. British journal of clinical pharmacology, 2008, Volume: 65, Issue:5 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Combinations; Drug Interactions; Female; Humans; Itraconazole; Male; Terfenadine	2008
Prediction of area under the curve for a p-glycoprotein, a CYP3A4 and a CYP2C9 substrate using a single time point strategy: assessment using fexofenadine, itraconazole and losartan and metabolites. Drug development and industrial pharmacy, 2016, Volume: 42, Issue:6 Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Itraconazole; Losartan; Polypharmacy; Terfenadine	2016

Other Studies

23 other study(ies) available for terfenadine and itraconazole

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Poorly soluble marketed drugs display solvation limited solubility. Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23 Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Tandem Mass Spectrometry; Thermodynamics	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics. Journal of clinical pharmacology, 1993, Volume: 33, Issue:12 Topics: Adult; Drug Interactions; Electrocardiography; Female; Heart; Humans; Itraconazole; Male; Terfenadine	1993
Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine. The American journal of medicine, 1993, Volume: 95, Issue:4 Topics: Bradycardia; Drug Interactions; Humans; Itraconazole; Male; Middle Aged; Syncope; Terfenadine	1993
Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia. European journal of clinical pharmacology, 1993, Volume: 45, Issue:2 Topics: Adult; Drug Interactions; Electrocardiography; Female; Humans; Itraconazole; Risk Factors; Terfenadine; Torsades de Pointes	1993
Torsades de pointes after terfenadine-itraconazole interaction. BMJ (Clinical research ed.), 1993, Jan-16, Volume: 306, Issue:6871 Topics: Adult; Drug Interactions; Female; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Pointes	1993
Use of terfenadine and contraindicated drugs. JAMA, 1996, May-01, Volume: 275, Issue:17 Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin	1996
[Syncopes during simultaneous use of terfenadine and itraconazole]. Nederlands tijdschrift voor geneeskunde, 1997, May-10, Volume: 141, Issue:19 Topics: Adult; Anti-Allergic Agents; Antifungal Agents; Cardiotonic Agents; Female; Humans; Isoproterenol; Itraconazole; Long QT Syndrome; Mycoses; Rhinitis, Allergic, Seasonal; Syncope; Terfenadine	1997
[Syncopes with simultaneous use of terfenadine and itraconazole]. Nederlands tijdschrift voor geneeskunde, 1997, Sep-06, Volume: 141, Issue:36 Topics: Anti-Allergic Agents; Antifungal Agents; Drug Interactions; Humans; Itraconazole; Syncope; Terfenadine	1997
[Syncopes with simultaneous use of terfenadine and itraconazole. Drug Monitoring Board]. Nederlands tijdschrift voor geneeskunde, 1997, Sep-06, Volume: 141, Issue:36 Topics: Anti-Allergic Agents; Antifungal Agents; Drug Monitoring; Humans; Itraconazole; Syncope; Terfenadine	1997
Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:5 Topics: Acids; Amiodarone; Hydrogen-Ion Concentration; Itraconazole; Permeability; Solubility; Solvents; Tamoxifen; Terfenadine; Water	2004
[Extension of QT interval as a consequence of risk factor accumulation--case study]. Vnitrni lekarstvi, 2006, Volume: 52, Issue:3 Topics: Adult; Anthracyclines; Antifungal Agents; Antineoplastic Agents; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Itraconazole; Long QT Syndrome; Terfenadine; Torsades de Pointes; Ventricular Dysfunction, Left	2006
A statistical methodology for drug-drug interaction surveillance. Statistics in medicine, 2008, Jul-20, Volume: 27, Issue:16 Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral; Diuretics; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Itraconazole; Ketoconazole; Models, Statistical; Product Surveillance, Postmarketing; Terfenadine	2008
Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:8 Topics: Biocatalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Genotype; Humans; Itraconazole; Ketoconazole; Male; Microsomes, Liver; Midazolam; Terfenadine; Testosterone; Vincristine	2013
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4 Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil	2020