Page last updated: 2024-08-16

terfenadine and fexofenadine

terfenadine has been researched along with fexofenadine in 616 studies

Research

Studies (616)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's45 (7.31)18.2507
2000's318 (51.62)29.6817
2010's213 (34.58)24.3611
2020's40 (6.49)2.80

Authors

AuthorsStudies
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Chen, XL; Hendrix, J; Kang, J; Korolev, AM; Lysenkova, LN; Miroshnikova, OV; Pearlstein, RA; Preobrazhenskaya, M; Rampe, D; Shchekotikhin, AE; Vaz, RJ1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Eddy, P; Goldman, E; Huang, W; Jia, ZJ; Kadambi, V; Scarborough, RM; Sinha, U; Song, Y; Su, T; Tumas, D; Zhang, P; Zhu, BY1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Caron, G; Ermondi, G; Visentin, S1
Imai, YN; Oiki, S; Ryu, S1
Aslanian, R; Du, XY; Hey, JA; McLeod, RL; Piwinski, JJ; Priestley, T; Sorota, S; West, RE; Williams, SM; Zhang, XS; Zhu, X1
Conradi, R; Lee, PH; Shanmugasundaram, V1
Abu Khalaf, R; Abu Sheikha, G; Bustanji, Y; Taha, MO1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Sen, S; Sinha, N1
Hitchcock, SA1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, JL; Chen, X; Dai, K; Fan, P; Fu, Y; Jaen, J; Li, L; Liang, L; Lindstrom, M; Mihalic, JT; Motani, A; Tang, L1
Colquhoun, JM; Dunman, PM; Ebsworth-Mojica, K; Flaherty, DP; Forbes, LT; Krysan, DJ; Perlmutter, JI; Wang, JL1
Rankovic, Z1
Coutant, JE; Nardella, PA; Okerholm, RA; Walter, SM; Westmark, PA1
Blaschke, G; Terhechte, A1
Ido, T; Ito, K; Itoh, M; Iwata, R; Ryu, JH; Sawai, Y; Watanabe, T; Yanai, K1
Bergman, JN; Simons, FE; Simons, KJ; Watson, WT1
Nightingale, SL1
Ashworth, L1
Arumugham, T; Bhargava, V; Eller, M; Lippert, C; Stoltz, M; Weir, S; Yu, D1
Paul, E1
Merk, HF1
Ahlbrandt, R; Bernstein, DI; Mason, J; Nathan, RA; Schoenwetter, WF; Storms, W1
Simons, FE; Simons, KJ1
Briscoe, MP; Clark, A; Day, JH; Ellis, AK; Mason, J; Smith, JN; Welsh, A1
Markham, A; Wagstaff, AJ1
O'Hanlon, JF; Vermeeren, A1
Abdelaziz, MM; Bayram, H; Davies, RJ; Devalia, JL; Khair, OA; Prior, AJ1
Estes, KS; González, MA2
Olson, SC; Smithers, JA; Stern, RH1
Bhargava, VO; Castles, MA; Pack, DJ; Robbins, DK; Weir, SJ1
Russell, T; Stoltz, M; Weir, S1
Bagnasco, M; Battifora, M; Bertolini, C; Bloom, M; Canonica, GW; Ciprandi, G; Cutolo, M; Paolieri, F; Riccio, AM1
Christian, S; Jensen, M; Kind, P; Ricard, N; Stewart, J1
Philpot, E1
Ahlbrandt, R; Mason, J; Pratt, CM; Reynolds, R; Russell, T1
Mattila, MJ; Paakkari, I1
Fellrath, JM; Rahm, F; Spertini, F; Terrien, MH1
Giraud, T1
Compton, D; Mason, J; Ricard, N; Stewart, J; Sussman, GL1
Fairweather, DB; Hindmarch, I; Shamsi, Z; Stanley, N1
Cvetkovic, M; Fromm, MF; Kim, RB; Leake, B; Wilkinson, GR1
Danielson, L; DeVos, C; Grant, JA; Rihoux, JP1
Mason, J; Rao, N; Reynolds, R1
Ahlbrandt, R; Brown, AM; Mason, J; Pratt, C; Rampe, D; Reynolds, R; Russell, T1
Crijns, HJ; Heeringa, M; Pinto, YM; van Gelder, IC1
Kendall, MJ; Po, AL1
Shuster, J1
Casale, TB; Meltzer, EO; Nathan, RA; Thompson, AK1
Bousquet, J; Howarth, PH; Reynolds, R; Roi, L; Stern, MA1
Finn, AF; Fretwell, R; Kaplan, AP; Long, J; Qu, R1
Coletta, D; Di Giacomo, B; Natalini, B; Ni, MH; Pellicciari, R1
Kashyap, AS; Kashyap, S1
Mills, SL; Nicholson, AN; Stone, BM; Turner, C1
Baker, TW; Bloomfield, JR; Brown, TL; Grant, AR; Layton, TA; McKenzie, DR; Watson, GS; Weiler, JM; Woodworth, GG1
Hennessy, S; Strom, BL1
Jarvis, B; Simpson, K1
Craig-McFeely, PM; Freemantle, SL; Pearce, GL; Shakir, SA1
Dunn, N; Mann, RD; Pearce, GL; Shakir, S1
Mason, J; Nelson, HS; Reynolds, R1
Abdelaziz, MM; Devalia, JL; Khair, OA1
Hari, Y; Müller, U; Reimers, A1
Dhar, S; Hazra, PK; Malakar, S; Mistri, G1
Juniper, EF; Van Cauwenberge, P1
Finn, AF; Schoenwetter, WF; Thompson, AK1
Amon, S; Amon, U; Gibbs, BF1
Irman-Florjanc, T1
Capano, D; Harris, AG; Prenner, BM1
Benedetto, SR; Duncan, BS; Sloan, AS1
Brookhuis, KA; de Waard, D1
Demonaco, HJ; Dudley, J; Lee, TH1
Angello, JT; Druce, HM1
Shaikh, WA1
Bazex, J; Journé, F; Loche, E; Marguery, MC; Schwarze, HP1
D'Oronzio, L; Dambra, P; Ferrannini, A; Loria, MP; Nettis, E; Tursi, A1
Gu, X; Johnston, L; Simons, FE; Simons, KJ1
Gu, X; Silver, NA; Simons, FE; Simons, KJ2
Bruce, MA; Haehner-Daniels, BD; Hall, SD; Hamman, MA1
Dagenais, C; Ducharme, J; Pollack, GM1
Bunnag, C; Chochaipanichnon, L; Jareoncharsri, P; Kongpatanakul, S; Limprasertsiri, S; Pumhirun, P; Supiyaphun, P; Tunsuriyawong, P1
Amichai, B; Brenner, L; Grunwald, MH1
Bastlund, J; Evans, AM; Jørgensen, KL; Larsen, LA; Milne, RW; Stretch, GR1
Affrime, M; Banfield, C; Batra, V; Clement, R; Gupta, S; Kantesaria, B; Marino, M1
Aunhachoke, K; Charuwichitratana, S; Gherunpong, N; Gritiyarangsan, P; Janjumratsang, P; Jiamton, S; Korkij, W; Krisadapong, J; Kullavanijaya, P; Kulthanan, K; Kuntiranont, M; Sitakalin, C1
Duvernelle, C; Frossard, N; Melac, M; Pauli, G; Purohit, A1
Anderson, SD; Brannan, JD; Chan, HK; Gomes, K; King, GG; Seale, JP1
Burtin, B; De Vos, C; Donnelly, F; Horak, F; Kavina, A; Stübner, P; Zieglmayer, R1
Cummins, G; Lee, J; Okamoto, L1
Bernstein, DI; Goldsobel, A; Graft, DF; Long, J; Meltzer, EO; Portnoy, J1
Choo, EF; Dresser, GK; Kim, RB; Kubba, SV; Lan, LB; Leake, BF; McKinsey, J; Schuetz, EG; Schuetz, JD; Schwarz, UI; Taylor, A; Wilkinson, GR; Xie, HG; Zhou, S1
Benko, LB1
Acharya, NV; Craig-McFeely, PM; Shakir, SA1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M1
Cummins, G; Leahy, M; Liao, E1
Canonica, GW; Ciprandi, G; Cosentino, C; Milanese, M; Mondino, C1
Asghar, A; Gorski, JC; Haehner-Daniels, B; Hall, SD1
Bailey, DG; Dawson, PA; Dresser, GK; Freeman, DJ; Kim, RB; Leake, BF; Schwarz, UI1
Drescher, S; Fromm, MF; Hofmann, U; Seiler, M1
DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM1
Wilson, AM1
Affrime, M; Banfield, C; Gupta, S; Lim, J; Marino, M1
Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE1
Brinkmann, U; Drescher, S; Eichelbaum, M; Fromm, MF; Hitzl, M; Hofmann, U; Schaeffeler, E; Schwab, M1
Coutie, WJ; Lipworth, BJ; Orr, LC; Sims, EJ; Wilson, AM1
Hindmarch, I; Kimber, S; Shamsi, Z1
Bircher, A; Degonda, M; Helbling, A; Pichler, WJ1
Bensch, GW; Borish, LC; Nelson, HS1
Anderson, CL; Anson, BD; January, CT; Rajamani, S1
Abbasi, AA; Dempsey, JA; Haverkamp, HC; Meyer, KC; Rice, AJ; Sonetti, DA; Wetter, TJ; Xiang, Z1
Stein, CM1
Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z1
Om Reddy, G; Radhakrishna, T1
Cui, ZH; Gelfand, EW; Joetham, A; Kanehiro, A; Takeda, K2
Chowdhury, BA1
Berkowitz, RB; Lutz, C; Meeves, S; Moss, M; Weiler, J; Weiler, K; Woodworth, GG1
Abelson, MB; Berger, WE; D'Arienzo, PA; Granet, DB; Kägi, MK; Lanier, BQ; Spangler, DL1
Cassano, N; Coviello, C; D'Argento, V; Filieri, M; Filotico, R; Vena, G1
Addison, T; Jiang, X; Maleki, S; Naidong, W; Shou, WZ1
Haggart, K; Lipworth, BJ; Sims, EJ; Wilson, AM1
Harada, S; Kawashima, M; Tango, T1
Koop, A; Mösges, R1
Busch, AE; Decher, N; Dennis, AT; Ficker, E; Lerche, C; Maier, P; Scherer, CR; Steinmeyer, K; Wollnik, B1
Greenblatt, DJ; Perloff, MD; von Moltke, LL1
Harvey, P; Meeves, SG; Miura, Y; Mohler, SR; Nicholson, A1
Inoue, T; Katoh, N; Kishimoto, S; Matsunaga, K1
Itoh, M; Iwabuchi, K; Mochizuki, H; Sakurada, Y; Tashiro, M; Watanabe, T; Yanai, K1
Abraham, D; Saltoun, CA1
Allocco, FT; Baroody, FM; deTineo, M; Naclerio, RM; Votypka, V1
Akbay, E; Apa, DD; Cayan, S1
Kinoshita, H; Koizuka, I; Kuroda, H; Miyabe, S; Ochi, K; Sugiyama, Y; Takatsu, M; Tanaka, K1
Dresser, GK; Kim, RB; Schwarz, UI; Wilkinson, GR1
Cheung, BS; Heskin, R; Hofer, KD1
Chee, P; Lum, G; Sojo, LE1
Knutson, L; Knutson, T; Lennernäs, H; Tannergren, C1
Bates, CE; Currie, GP; Lee, DK; Lipworth, BJ1
Austin, M; Bower, EA; Meeves, S; Moore, JL; Moss, M; Selby, KA1
Jackson, CM; Lee, DK; Lipworth, BJ2
de Vries, HJ; Kammeyer, A; Mekkes, JR1
Bachert, C; Baena-Cagnani, C; Decosta, P; Finn, AF; Hedlin, G; Kowalski, ML; Meltzer, EO; Potter, P; Rosado Pinto, JE; Ruuth, E; Scheinmann, P; Simons, FE; Wahn, U1
Grzelewska-Rzymowska, I; Kroczyńska-Bednarek, J; Pietrzkowicz, M1
Hindmarch, I; Ridout, F1
Hagan, LL; More, DR; Napoli, DC1
Flores, J; Mansfield, L; Meeves, SG; Mendoza, C1
Boyce, M; Carey, W; Luria, X; Warrington, S1
Alexander, M; Allegro, S; Hicks, A; Patel, P1
Goritz, SS; J Semus, M; Simons, FE; Simons, KJ1
Duchateau, J; Heenen, M; Sternon, J1
Harada, S; Inagi, M; Kawashima, M; Nakagawa, H; Noguchi, T; Tango, T1
Christian, CD; Crisalida, T; Economides, A; Georges, GC; Hale, M; Kaliner, MA; Liao, Y; Meeves, SG; White, MV; Woodworth, TH1
Hindmarch, I; Johnson, S; Meadows, R; Ridout, F; Shamsi, Z1
Glass, DJ; Harper, AS1
Casale, T; Chervinsky, P; Fowler-Taylor, A; Fox, H; Hedgecock, S; Shen, H; Townley, R; Tripathy, I1
Potter, PC; Schepers, JM; Van Niekerk, CH1
Abelson, MB; Gotnes, PJ; Ober, A; Spangler, DL1
Grzelewska-Rzymowska, I1
Appajosyula, S; Meeves, SG1
Canonica, GW; Ciprandi, G; Cosentino, C; Passalacqua, G; Riccio, AM; Tosca, MA1
Portnoy, JM; Simon, SD1
Georges, G; Hampel, F; Liao, Y; Mansfield, L; Meeves, S; Ratner, P1
Bondesson, U; Hedeland, M; Knutson, L; Lennernäs, H; Petri, N; Tannergren, C1
Antonijoan, RM; Barbanoj, MJ; Esbrí, R; Garcia, E; García-Gea, C; Gich, I; Gispert, J; Luria, X; Morte, A1
Dicpinigaitis, PV; Gayle, YE1
Furue, M; Morita, K; Moroi, Y; Nakahara, T; Urabe, K1
Hasegawa, Y; Hindmarch, I; Ishikawa, K; Kamei, H; Muraoka, I; Nabeshima, T; Noda, Y; Senzaki, K1
Appajosyula, S; Gelfand, EW; Meeves, S1
Dogra, S; Handa, S; Kumar, B1
Baroody, FM; deTineo, M; Maleckar, B; Moinuddin, R; Naclerio, RM1
Asano, K; Kanai, K; Suzaki, H2
Masuda, A; Matsuda, E; Nariai, K; Shibasaki, T; Watanabe, N1
Glass, D; Harper, A1
Haggart, K; Jackson, CM; Lee, DK; Lipworth, BJ1
Fujihara, S; Gray, RD; Lee, DK; Lipworth, BJ; Robb, FM1
Fujihara, S; Gardiner, M; Haggart, K; Lee, DK; Lipworth, BJ1
Adesanya, H1
Sugawara, K; Takahata, T; Tateishi, T; Uno, T; Yasui-Furukori, N; Yoshiya, G1
Fardon, TC; Jackson, CM; Lee, DK; Lipworth, BJ; Soutar, PC1
Ciprandi, G; Cirillo, I; Vizzaccaro, A1
Fu, I; Matuszewski, BK; Woolf, EJ1
Sugawara, K; Takahata, T; Tateishi, T; Uno, T; Yasui-Furukori, N1
Bachert, C; Finn, AF; Hedlin, G; Meltzer, EO; Rosado Pinto, JE; Ruuth, E; Scheinmann, P; Wahn, U1
Fooanant, S; Roongapinun, S; Wajajamreon, S1
Przybilla, B; Ruëff, F1
Aoki, M; Funaki, Y; Itoh, M; Iwabuchi, K; Iwata, R; Kato, M; Mochizuki, H; Sakurada, Y; Tashiro, M; Wong, DF; Yanai, K1
Benedetti, MS; Diquet, B; Molimard, M1
Leahy, MJ; Lennox, RD1
Berger, WE; Corren, J; LaForce, CF; Wheeler, WJ1
Iizuka, H; Ishida-Yamamoto, A; Takahashi, H1
Abbas, MN; Abdel Fattah, AA; Zahran, E1
Lennernäs, H; Petri, N; Rungstad, D; Tannergren, C1
Buisson, D; Jaouen, M; Mazier, C; Sari, MA1
Jensen, BK; Kittner, B; Krishna, R; Krishnaswami, S; Sankoh, AJ1
Cho, JY; Chung, JY; Hong, KS; Jang, IJ; Jung, HR; Kim, JR; Lim, HS; Oh, DS; Shin, SG; Yi, SY; Yu, KS1
Chong, S; Kamath, AV; Yao, M; Zhang, Y1
Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A1
Deslandes, B; Frossard, N; N'Gom, AS; Pauli, G; Purohit, A1
Halliwill, JR; Lockwood, JM; Wilkins, BW1
Sugawara, K; Tateishi, T; Uno, T; Yasui-Furukori, N1
Crawford, B; Gotoh, M; Okubo, K; Okuda, M; Ritsu, M; Shimada, K1
Asano, K; Kanai, KI; Suzaki, H1
Antal, EJ; Arakawa, T; Gordi, T; Hong, C; Knuth, DW; Nickens, DJ; Polasek, EC; Sharma, A; Tan, LH; Teillol-Foo, M; Xie, R1
Bailey, DG; Dresser, GK; Kim, RB1
Kobayashi, M; Tokura, Y1
Fuse, E; Kusuhara, H; Sugiyama, Y; Tahara, H1
Eichelbaum, M; Fromm, MF; Hofmann, U; Kivistö, KT; Niemi, M; Schwab, M1
Fujieda, S; Hyo, S; Kawada, R; Kitazawa, S; Takenaka, H1
Harding, G; Leahy, M; Lennox, RD; Shikiar, R1
Horak, F; Kavina, A; Lemell, P; Zieglmayer, PU; Zieglmayer, R1
Agrawala, P; Haribhakti, R; Howard, DR; Kittner, B1
Georges, G; Kaplan, AP; Liao, Y; Meeves, S; Spector, SL; Varghese, ST1
Fuse, K; Kusuhara, H; Maeda, K; Nishigaki, R; Okudaira, K; Shimizu, M; Sugiyama, Y1
Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y1
Conboy-Ellis, K1
Cha, IJ; Choi, YG; Hong, WS; Lee, SS; Nguyen, PM; Shin, JG; Shon, JH; Yoon, YR1
Hindmarch, I; Horikawa, E; Inokuchi, T; Kato, M; Mochizuki, H; Ridout, F; Sakurada, Y; Tashiro, M; Yanai, K1
Chung, SJ; Kim, DD; Lee, MK; Lin, H; Roh, HJ; Shim, CK; Yoo, JW1
Gotoh, Y; Kamada, N; Momose, D1
Dhar, S; Georges, G; Varghese, ST1
Breier, AR; Paim, CS; Schapoval, EE; Steppe, M1
Jonkman, LM; Kuypers, KP; Ramaekers, JG; Theunissen, EL1
Boyle, J; Hindmarch, I; Johnsen, S; Meadows, R; Ridout, F1
Fardon, TC; Hodge, MR; Lee, DK; Lipworth, BJ1
Havránek, E; Mikus, P; Valásková, I1
Darlath, W; Gillissen, A; Juergens, UR; Racké, K; Stober, M; Tasci, S; Vetter, H1
Baltes, E; Benedetti, MS; Chatelain, P; Gillard, M1
Green, GR1
Ciebiada, M; Górska-Ciebiada, M; Górski, P; Grzelewska-Rzymowska, I; Zakrzewska, A1
Goldberg, I; Tessler, L1
Izu, K; Tokura, Y1
Fujita, H; Ikezawa, Z; Inomata, N; Kanbara, T; Osuna, H1
Fuse, E; Koepsell, H; Kusuhara, H; Maeda, K; Sugiyama, Y; Tahara, H1
Fukuda, H; Kamikozawa, Y; Ohashi, R; Sugiura, M; Tamai, I; Yabuuchi, H1
Berkowitz, RB; Braker, S; Georges, G; Jones, P; Lutz, C; Meeves, S; Qiu, C; Varghese, ST1
Bondesson, U; Borga, O; Hedeland, M; Lennernas, H; Nyberg, L; Petri, N1
Gorski, JC; Hall, SD; Hamman, MA; Lemma, GL; Wang, Z; Zaheer, NA1
Bondesson, U; Broström, H; Ingvast-Larsson, C; Larsson, P; Olsén, L; Sundqvist, M; Tjälve, H1
Arakawa, S; Fujiwara, S; Hatano, Y; Katagiri, K1
Direkwattanachai, C; Ngamphaiboon, J; Tiensuwan, M; Vangveeravong, M; Visitsunthorn, N1
Bergman, E; Bondesson, U; Forsell, P; Hedeland, M; Knutson, L; Lennernäs, H; Petri, N1
Mansfield, LE2
Shimizu, M; Sugawara, K; Tateishi, T; Uno, T3
Murata, K; Nakai, Y; Ohashi, Y1
Saraswat, A; Saraswat, M1
Brouwer, KL; Hoffmaster, KA; Kalvass, JC; Pollack, GM; Turncliff, RZ1
Blom-Coenjaerts, C; Ramaekers, JG; Theunissen, EL; van Deursen, JA; van Kroonenburgh, MJ1
Berisa, A; Corcóstegui, R; Innerárity, A; Labeaga, L; Orjales, A1
Brunton, S; Spangler, DL1
Bourbeau, M; Cameron, DW; Campbell, P; Chauhan, BM; Foster, BC; Seguin, I; van Heeswijk, RP1
Boyle, J; Eriksson, M; Fujita, T; Kumagi, Y; Stanley, N1
Burtin, B; Hohlfeld, JM; Krug, N; Larbig, M; Luettig, B; Martin, L; Stamm, H1
Cousineau, M; Danser, E; Dewire, R; Floden, J; Peng, SX; Ritchie, DM1
Davey, AK; Ngo, SN; Tong, Y; Zhang, R1
Elad, S; Heisler, S; Shalit, M1
Miura, M; Suzuki, T; Tateishi, T; Uno, T3
Kamei, J; Takahashi, Y1
Hahn, EG; Müller, S; Raithel, M; Weidenhiller, M; Winterkamp, S1
Cohen, AD; Gan-El, U; Lieberman, N; Reuvni, H; Vardy, DA1
Kikuchi, A; Maeda, T; Nozawa, T; Tamai, I; Wakasawa, T1
Magen, E; Mishal, J; Viskoper, RJ; Yosefy, C1
Kandikere, VN; Komarneni, P; Maurya, S; Mudigonda, K; Nirogi, RV; Shukla, M2
Bian, S; Chung, SJ; Gebhardt, M; Kim, DD; Kwon, KA; Lin, H; Shim, CK1
Darlath, W; Gillissen, A; Juergens, UR; Racké, K; Stöber, M; Uen, S; Vetter, H1
Couderc, JP1
Cinca, J; Farré, J; Hove-Madsen, L; Llach, A; Molina, CE; Prat-Vidal, C; Roura, S1
Camelo-Nunes, IC1
Kazama, E; Kume, T; Ogasawara, A1
Bazelmans, D; Berkowitz, RB; Georges, G; Godfrey, P; Liao, Y; Lutz, C; McCafferty, F; Meeves, S1
Chegini, S; Hamilos, DL; Oren, E1
Blaiss, MS; Lehman, JM1
Bailey, DG; Dresser, GK; Glaeser, H; Gregor, JC; Jolicoeur, E; Kim, RB; Leake, BF; Lee, W; McGrath, JS; Schwarz, UI; Tirona, RG1
Codreanu, A; de Chillou, C; Moneret-Vautrin, DA1
Bailey, DG; Dresser, GK; Kim, RB; Leake, BF1
Aragane, Y; Ashenager, MS; Grgela, T; Kawada, A1
Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Rahman, A; Takechi, K1
Oliveira, DC; Rolim, CM; Weigch, A1
Kruszewski, J; Kłos, K; Sułek, K1
Kruszewski, J; Kruszewski, R; Kłos, K; Sułek, K1
Harding, G; Leahy, MJ; Meeves, S; Shikiar, R; Spector, SL1
Abusuev, SA; Gadzhimirzaev, GA; Gamzatova, AA; Gamzatova, EG1
Marshman, G; Pellizzari, M1
Begany, P; Dyrhonova, M; Emritte, N; Mendoza, L; Svobodova, X1
Castellano, PM; Kaufman, TS; Maggio, RM; Vignaduzzo, SE1
Chen, C1
Kumagai, Y; Sugiyama, Y; Tanimoto, T; Tozuka, Z; Yamane, N; Yamazaki, A1
Nemes, P; Vertes, A1
Asano, K; Furuta, A; Furuya, A; Hisamitsu, T; Kanai, K; Suzaki, H1
Bridges, AS; Brouwer, KL; Li, J; Nezasa, K; Patel, NJ; Raub, TJ; Tian, X; Zamek-Gliszczynski, MJ1
Hampel, FC; Kittner, B; Lanier, R; Milgrom, H1
Kabashima, K; Sugita, K; Tokura, Y1
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Bershow, A; Crowson, AN; Lee, KR1
Chwała, B; Cieślińska, A; Fiedorowicz, E; Jarmołowska, B; Kordulewska, NK; Kostyra, E; Moszyńska, M1
Dresser, GK; Griffin, KE; Kim, RB; Knauer, MJ; Li, MMJ; Lin, K; Mansell, SE; Medwid, S; Schmerk, CL; Schwarz, UI; Tirona, RG; Yousif, MD; Zhu, C1
Krecisz, B; Kucharczyk, M; Slowik-Rylska, M1
Bernstein, DI; Hassoun, Y; Stevenson, MR1
Bi, Y; Chen, Y; Chen, ZS; Cui, Y; Fu, W; Hettinghouse, A; Lei, ZN; Liu, CJ; Liu, J; Liu, R; Wang, C; Wang, S; Xiao, G; Zhang, C; Zhao, X1
Aoyama, T; Suzuki, K; Taniyama, K; Watanabe, Y1
Chen, T; Fu, LX; Lu, YH; Wang, L; Zhou, PM1
Guidon, AC; Long, AA; Slawski, BR; Suh, J1
Lunardi, M; Pighi, M; Ribichini, FL1
Bester, K; Castronovo, S; Falås, P; Henning, N; Jewell, KS; Ternes, TA; Wick, A1
Alkhodair, A; Blanke, P; Fraser, R; Hensey, M; Kütting, M; Landes, U; Leipsic, J; Sathananthan, J; Sedaghat, A; Søndergaard, L; Toggweiler, S; Webb, JG; Wood, D1
Antunes, P; Dall'Agnol, B; Ferreira, CAS; Padilha, T; Reck, J; Schott, D; Souza, GD; Souza, UA; Webster, A1
Huang, CZ; Jiang, ZH; Luo, Y; Peng, H; Wang, J1
Kumar, V; Nalini, CN1
Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K1
Bednarczyk, D; Sanghvi, MV1
Cavalli, RC; Coelho, EB; Lanchote, VL; Marques, MP; Moreira, FL; Pinto, LSR; Vale, GTD1
Åsberg, A; Christensen, H; Egeland, EJ; Robertsen, I; Witczak, BJ; Zaré, HK1
da Costa César, I; de Araújo, LL; de Castro, WV; de Lima Nascimento, M; de Oliveira, FM; Derendorf, H; do Carmo Vieira, M; do Nascimento, SB; Duarte-Almeida, JM; Siqueira, JM1
Andersen, JT; Andersson, NW; Torp-Pedersen, C1
Akhter, F; Jahan, H; Nandi, AK1
Jiang, L; Jin, MM; Liu, L; Liu, M; Liu, PH; Liu, XD; Liu, XN; Wang, ZJ; Xie, QS; Zhang, JX; Zhu, L1
Cavalli, RC; Duarte, G; Lanchote, VL; Moisés, ECD; Moreira, FL; Nardotto, GHB; Pinto, L1
Cai, W; Chien, HC; Giacomini, KM; Khuri, N; Ni, Z; Pieper, LM; Pottel, J; Shoichet, BK; Spanogiannopoulos, P; Tsakalozou, E; Turnbaugh, PJ; Vora, B; Zhang, W; Zou, L1
Hassan, K1
Fér, M; Grabic, R; Grabicová, K; Klement, A; Kočárek, M; Kodešová, R; Nikodem, A; Schmidtová, Z; Švecová, H1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N1
Doi, M; Furuichi, Y; Takano, T; Tsuji, S1
El-Bedaiwy, HM; El-Masry, SM; Helmy, SA1
Melby, PC; Osorio, EY; Peniche, AG; Travi, BL1
Fukai, K; Kusutani, N; Maekawa, N; Nishida, M; Sowa-Osako, J1
Cheng, R; Huang, X; Jiang, Z; Wu, W; Zhang, L1
Bapat, P; Berger, H; de Carvalho Cavalli, R; de Lima Moreira, F; Koren, G; Lanchote, VL; Lubetsky, A; Pinto, L1
Abalenikhina, YV; Chernykh, IV; Erokhina, PD; Shchulkin, AV; Yakusheva, EN1
Baz, JA; Berenguer, A; Cantón, T; Galeote, G; Gonzálvez-García, A; Hernández, U; Jiménez-Valero, S; Jurado-Román, A; Lázaro, E; Moreno, R; Moreu, J; Moya, H1
Abe, M; Ishii, M; Kikuchi, T; Morimoto, K; Ogihara, T; Oikawa, E; Sasaki, M; Tomita, M1
Baz, JA; Iñiguez, A; Lehtola, H; Moccetti, F; Niemelä, M; Piuhola, J; Toggweiler, S; Tonino, PAL; van Nunen, LX; Wolfrum, M1
Everardo, PG; Gabriela, SC; Magdalena, GS; Maria Elena, GP; Vanessa, CM1
Fijałkowski, M; Gozdek, M; Jagielak, D; Jaguszewski, M; Kowalewski, M; Lango, R; Milan, J; Stańska, A; Targoński, R1
Chang, H; Chen, C; Du, H; Guan, C; Li, C; Qiu, L; Wang, S; Wang, T; Wu, Y; Zhang, L; Zhang, S; Zhou, H1
Chen, Y; Hettinghouse, A; Liu, C; Liu, R; Zhao, X1
Bauersachs, J; Kempf, T; Neuser, J; Widder, JD1
De, D; Handa, S; Mahajan, R; Ningombam, A; Srivastava, N1
Fromm, MF; Hoier, E; König, J; Misaka, S; Ogata, H; Ono, T; Ono, Y; Shimomura, K; Taudte, RV; Watanabe, H1
Choi, SG; Kim, DW; Kim, SI; Kwon, HH; Ngo, VTH; Park, H; Park, JB; Pham, TL; Shin, HJ; Shin, J; Shin, N; Tran, Q; Wu, J1
Ashmawy, SM; El Maghraby, GM; El Nashar, NF; Sultan, AA1
Blaquera, CL; Capparelli, EV; Ma, JD; Nikanjam, M; Nolin, TD; Paine, MF; Penzak, SR; Piscitelli, J1
Chen, Y; Liu, H; Luo, Z; Miao, Z; Ran, J; Tian, Y; Xie, Q; Yin, G; Zhang, Q1
De Fer, BB; Lheritier-Barrand, M; Lucio, L; Rauch, C1
Akiyoshi, T; Han, H; Imaoka, A; Morita, T; Nabeta, M; Ohtani, H; Tsuchitani, T; Yajima, K1

Reviews

45 review(s) available for terfenadine and fexofenadine

ArticleYear
Structural modifications that alter the P-glycoprotein efflux properties of compounds.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Central Nervous System Agents; Central Nervous System Diseases; Drug Design; Humans; Models, Molecular; Permeability; Structure-Activity Relationship

2012
CNS drug design: balancing physicochemical properties for optimal brain exposure.
    Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6

    Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Central Nervous System Agents; Drug Design; Humans; Models, Molecular; Permeability

2015
Is my antihistamine safe?
    Home care provider, 1997, Volume: 2, Issue:3

    Topics: Adverse Drug Reaction Reporting Systems; Histamine Antagonists; Histamine H1 Antagonists; Humans; Patient Selection; Terfenadine; United States; United States Food and Drug Administration

1997
Fexofenadine.
    Drugs, 1998, Volume: 55, Issue:2

    Topics: Animals; Histamine Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria

1998
Pharmacokinetic overview of oral second-generation H1 antihistamines.
    International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:5

    Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure-Activity Relationship; Terfenadine; Therapeutic Equivalency; Torsades de Pointes

1998
Cardiovascular safety of fexofenadine HCl.
    The American journal of cardiology, 1999, May-15, Volume: 83, Issue:10

    Topics: Double-Blind Method; Drug Interactions; Electrocardiography; Heart Conduction System; Histamine Antagonists; Humans; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine

1999
Variations among non-sedating antihistamines: are there real differences?
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:2

    Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine

1999
The systemic safety of fexofenadine HCl.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3

    Topics: Aged; Child; Drug Interactions; Drug Overdose; Histamine H1 Antagonists; Humans; Kidney Diseases; Liver Diseases; Psychomotor Performance; Terfenadine

1999
Fexofenadine hydrochloride--a new anti-histaminic drug.
    The Israel Medical Association journal : IMAJ, 2001, Volume: 3, Issue:3

    Topics: Chronic Disease; Clinical Trials as Topic; Drug Interactions; Histamine H1 Antagonists; Humans; Patient Selection; Rhinitis, Allergic, Seasonal; Safety; Terfenadine; Urticaria

2001
[The effect of second generation histamine antagonists on the heart].
    Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4

    Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes

2001
Are antihistamines useful in managing asthma?
    Current opinion in allergy and clinical immunology, 2002, Volume: 2, Issue:1

    Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropanes; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Loratadine; Mannitol; Quinolines; Rhinitis; Sulfides; Terfenadine

2002
Review of fexofenadine in the treatment of chronic idiopathic urticaria.
    International journal of dermatology, 2002, Volume: 41, Issue:10

    Topics: Anti-Allergic Agents; Asia; Chronic Disease; Humans; North America; Terfenadine; Urticaria

2002
[H1 histamine antagonists].
    Revue medicale de Bruxelles, 2003, Volume: 24, Issue:2

    Topics: Acetates; Anti-Allergic Agents; Cetirizine; Chemistry, Pharmaceutical; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperazines; Rhinitis; Terfenadine; Urticaria

2003
[Clinical aspects of anti-inflammatory action of antihistamines].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2003, Volume: 14, Issue:84

    Topics: Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Piperazines; Terfenadine

2003
Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4 Suppl

    Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2003
Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4 Suppl

    Topics: Anti-Allergic Agents; Cell Adhesion Molecules; Histamine H1 Antagonists; Humans; Hypersensitivity; Leukocytes; Mast Cells; Terfenadine; Treatment Outcome

2003
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
    Current medical research and opinion, 2004, Volume: 20, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine

2004
Venom immunotherapy: adverse reactions and treatment failure.
    Current opinion in allergy and clinical immunology, 2004, Volume: 4, Issue:4

    Topics: Histamine H1 Antagonists; Humans; Hypersensitivity; Immunotherapy; Risk Factors; Terfenadine; Treatment Failure; Venoms

2004
Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:4

    Topics: Absorption; Animals; Area Under Curve; Benzimidazoles; Biological Availability; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Metabolic Clearance Rate; Piperazines; Terfenadine; Tissue Distribution

2004
Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.
    Journal of the American Academy of Nurse Practitioners, 2005, Volume: 17, Issue:8

    Topics: Adolescent; Adult; Cetirizine; Child; Child, Preschool; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nurse Practitioners; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2005
Once-daily immediate-release fexofenadine and sustained-release pseudoephedrine combination: a new treatment option for allergic rhinitis.
    Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:7

    Topics: Animals; Delayed-Action Preparations; Drug Therapy, Combination; Ephedrine; Humans; Rhinitis, Allergic, Seasonal; Terfenadine

2006
Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.
    Southern medical journal, 2006, Volume: 99, Issue:6

    Topics: Central Nervous System; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Quality of Life; Rhinitis, Allergic, Seasonal; Terfenadine

2006
New antihistamines: a critical view.
    Jornal de pediatria, 2006, Volume: 82, Issue:5 Suppl

    Topics: Anti-Allergic Agents; Blood-Brain Barrier; Central Nervous System Diseases; Cetirizine; Child; Cyproheptadine; Heart Diseases; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Mast Cells; Piperazines; Receptors, Histamine H1; Terfenadine

2006
Selecting the optimal oral antihistamine for patients with allergic rhinitis.
    Drugs, 2006, Volume: 66, Issue:18

    Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Long QT Syndrome; Loratadine; Piperazines; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2006
Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans.
    Drugs in R&D, 2007, Volume: 8, Issue:5

    Topics: Animals; Anti-Allergic Agents; Biological Availability; Biotransformation; Blood Proteins; Half-Life; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine

2007
Fexofenadine in pediatrics: oral tablet and suspension formulations.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:2

    Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Child; Child, Preschool; Deglutition; Humans; Infant; Rhinitis, Allergic, Seasonal; Suspensions; Tablets; Terfenadine

2008
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.
    Clinical pharmacokinetics, 2008, Volume: 47, Issue:4

    Topics: Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria

2008
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.
    Clinical therapeutics, 2009, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Clinical Trials as Topic; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Young Adult

2009
Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders.
    Expert opinion on drug metabolism & toxicology, 2009, Volume: 5, Issue:7

    Topics: Animals; Anti-Allergic Agents; Clinical Trials as Topic; Humans; Hypersensitivity; Terfenadine

2009
Clinical pharmacokinetics of fexofenadine enantiomers.
    Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:1

    Topics: Antifungal Agents; Calcium Channel Blockers; Drug Interactions; Histamine H1 Antagonists; Humans; Itraconazole; Stereoisomerism; Terfenadine; Verapamil

2010
Psoriasis vulgaris and digestive system disorders: is there a linkage?
    Folia histochemica et cytobiologica, 2009, Volume: 47, Issue:3

    Topics: Adult; Clemastine; Digestive System Diseases; Disease Progression; Humans; Male; Psoriasis; Terfenadine

2009
Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation.
    Clinical pharmacokinetics, 2010, Volume: 49, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Drug Interactions; Genotype; Humans; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Prescription Drugs; Propanolamines; Quinidine; Reproducibility of Results; Terfenadine

2010
Fruit juice inhibition of uptake transport: a new type of food-drug interaction.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:5

    Topics: Administration, Oral; Anti-Allergic Agents; Beverages; Biological Availability; Citrus; Citrus paradisi; Food-Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Organic Anion Transporters; Terfenadine

2010
Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.
    International archives of allergy and immunology, 2011, Volume: 156, Issue:1

    Topics: Adult; Child, Preschool; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2011
Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.
    Biomedical chromatography : BMC, 2012, Volume: 26, Issue:8

    Topics: Animals; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Terfenadine

2012
H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012, Volume: 42, Issue:10

    Topics: Anti-Allergic Agents; Cetirizine; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Predictive Value of Tests; Skin Tests; Terfenadine; Urticaria

2012
[Pharmacotherapy of urticaria--an analysis of the discrepancies between guidelines of expert bodies, registration documents and evidence for the effectiveness of drugs].
    Przeglad lekarski, 2013, Volume: 70, Issue:12

    Topics: Administration, Oral; Administration, Topical; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Glucocorticoids; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Poland; Practice Guidelines as Topic; Terfenadine; Treatment Outcome; Urticaria

2013
Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin--a mini-review.
    Life sciences, 2014, Sep-15, Volume: 113, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Citrus; Cytochrome P-450 Enzyme System; Hesperidin; Humans; Learning; Memory; Signal Transduction; Terfenadine

2014
[Determinants of the stereoselective pharmacokinetics of fexofenadine].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume: 135, Issue:3

    Topics: Animals; Biological Transport; Humans; Membrane Transport Proteins; Polymorphism, Genetic; Stereoisomerism; Terfenadine

2015
[Clinical Management of Japanese Cedar Pollinosis].
    Fukuoka igaku zasshi = Hukuoka acta medica, 2016, Volume: 107, Issue:1

    Topics: Administration, Inhalation; Cedrus; Desensitization, Immunologic; Disorders of Excessive Somnolence; Drug Combinations; Environmental Exposure; Glucocorticoids; Histamine H1 Antagonists, Non-Sedating; Humans; Nasal Obstruction; Nonprescription Drugs; Patient Satisfaction; Pollen; Practice Guidelines as Topic; Pseudoephedrine; Rhinitis, Allergic, Seasonal; Seasons; Surveys and Questionnaires; Terfenadine

2016
An update on the clinical pharmacokinetics of fexofenadine enantiomers.
    Expert opinion on drug metabolism & toxicology, 2018, Volume: 14, Issue:4

    Topics: Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Interactions; Humans; Organic Anion Transporters; Stereoisomerism; Terfenadine

2018
Drug-Drug Interactions of P-gp Substrates Unrelated to CYP Metabolism.
    Current drug metabolism, 2019, Volume: 20, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Dabigatran; Digoxin; Drug Interactions; Humans; Propanolamines; Terfenadine

2019
Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.
    The Cochrane database of systematic reviews, 2019, Jan-22, Volume: 1

    Topics: Administration, Oral; Administration, Topical; Adult; Cetirizine; Chemotherapy, Adjuvant; Child; Eczema; Histamine H1 Antagonists; Humans; Loratadine; Outcome Assessment, Health Care; Pruritus; Randomized Controlled Trials as Topic; Terfenadine

2019
Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.
    BMC pharmacology & toxicology, 2019, 11-29, Volume: 20, Issue:1

    Topics: Cognition; Drug-Related Side Effects and Adverse Reactions; Histamine H1 Antagonists, Non-Sedating; Humans; Psychomotor Performance; Randomized Controlled Trials as Topic; Terfenadine

2019
A Review of Different Analytical Techniques for Fexofenadine Hydrochloride and Montelukast Sodium in Different Matrices.
    Critical reviews in analytical chemistry, 2021, Volume: 51, Issue:3

    Topics: Acetates; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Chemistry Techniques, Analytical; Cyclopropanes; Drug Monitoring; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Quinolines; Sulfides; Terfenadine

2021

Trials

206 trial(s) available for terfenadine and fexofenadine

ArticleYear
The clinical pharmacology of fexofenadine in children.
    The Journal of allergy and clinical immunology, 1996, Volume: 98, Issue:6 Pt 1

    Topics: Child; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Terfenadine

1996
Effect of food on the bioavailability of fexofenadine hydrochloride (MDL 16455A).
    Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Diet; Dietary Fats; Fasting; Food-Drug Interactions; Histamine Antagonists; Humans; Intestinal Absorption; Male; Mass Spectrometry; Terfenadine

1997
Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Drug Evaluation; Female; Histamine Antagonists; Humans; Male; Middle Aged; Placebos; Rhinitis, Allergic, Seasonal; Single-Blind Method; Terfenadine

1997
Peripheral H1-blockade effect of fexofenadine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:6

    Topics: Adult; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists; Humans; Male; Terfenadine

1997
Onset of action, efficacy, and safety of a single dose of fexofenadine hydrochloride for ragweed allergy using an environmental exposure unit.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Environmental Exposure; Female; Histamine Antagonists; Humans; Hypersensitivity; Male; Middle Aged; Pollen; Terfenadine

1997
Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance.
    The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3

    Topics: Adult; Alcohol Drinking; Anti-Allergic Agents; Automobile Driving; Clemastine; Cross-Over Studies; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Terfenadine

1998
Atorvastatin does not produce a clinically significant effect on the pharmacokinetics of terfenadine.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Aged; Atorvastatin; Drug Interactions; Female; Heart Rate; Heptanoic Acids; Histamine H1 Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Terfenadine

1998
Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers.
    Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:7

    Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists; Humans; Male; Middle Aged; Spectrometry, Fluorescence; Stereoisomerism; Terfenadine

1998
Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers.
    Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:6

    Topics: Administration, Oral; Adult; Area Under Curve; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Heart Conduction System; Histamine Antagonists; Humans; Male; Middle Aged; Reference Values; Regression Analysis; Terfenadine

1998
Link between patient preferences and treatment outcomes in seasonal allergic rhinitis: an empiric investigation.
    Clinical therapeutics, 1999, Volume: 21, Issue:1

    Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Patient Satisfaction; Rhinitis, Allergic, Perennial; Surveys and Questionnaires; Terfenadine; Treatment Outcome

1999
Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen.
    The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:6

    Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Nasal Provocation Tests; Otolaryngology; Peak Expiratory Flow Rate; Rhinitis, Allergic, Seasonal; Terfenadine

1999
The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:1

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Child; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Efficiency; Ephedrine; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Single-Blind Method; Terfenadine; Therapeutic Equivalency; Work

1999
A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:2

    Topics: Adult; Cognition; Cross-Over Studies; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Male; Middle Aged; Promethazine; Psychomotor Performance; Reaction Time; Terfenadine; Wrist

1999
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
    Allergy, 1999, Volume: 54, Issue:7

    Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria

1999
Cardiovascular safety of fexofenadine HCl.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Torsades de Pointes

1999
Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:4

    Topics: Activities of Daily Living; Adolescent; Aged; Anti-Allergic Agents; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Terfenadine; Treatment Outcome; Work Capacity Evaluation

1999
Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine; Time Factors

1999
A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria.
    The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Pruritus; Terfenadine; Treatment Outcome; Urticaria

1999
Antihistamines and aircrew: usefulness of fexofenadine.
    Aviation, space, and environmental medicine, 2000, Volume: 71, Issue:1

    Topics: Adult; Aerospace Medicine; Attention; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Promethazine; Sleep Stages; Terfenadine

2000
Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator.
    Annals of internal medicine, 2000, Mar-07, Volume: 132, Issue:5

    Topics: Adult; Automobile Driving; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Ethanol; Female; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Iowa; Male; Markov Chains; Middle Aged; Monte Carlo Method; Placebos; Rhinitis, Allergic, Seasonal; Sleep Stages; Terfenadine

2000
Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 84, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Chronic Disease; Disorders of Excessive Somnolence; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Headache; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nausea; Terfenadine; Therapeutic Equivalency; Urticaria; Xerophthalmia; Xerostomia

2000
Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial.
    Allergy, 2000, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Angioedema; Anti-Allergic Agents; Bee Venoms; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypersensitivity, Immediate; Male; Middle Aged; Pruritus; Skin Tests; Terfenadine; Urticaria

2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Terfenadine; Treatment Outcome

2000
Effect of 60 mg twice-daily fexofenadine HCl on quality of life, work and classroom productivity, and regular activity in patients with chronic idiopathic urticaria.
    Journal of the American Academy of Dermatology, 2000, Volume: 43, Issue:1 Pt 1

    Topics: Adolescent; Adult; Aged; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Quality of Life; Terfenadine; Urticaria

2000
Efficacy and tolerability of loratadine versus fexofenadine in the treatment of seasonal allergic rhinitis: a double-blind comparison with crossover treatment of nonresponders.
    Clinical therapeutics, 2000, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine

2000
The changing face of antihistamines and cardiac adverse drug reactions: a clinical perspective.
    Journal of the Indian Medical Association, 2000, Volume: 98, Issue:7

    Topics: Cardiovascular Diseases; Drug Interactions; Electrocardiography; Erythromycin; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Seasonal; Terfenadine; Torsades de Pointes

2000
Comparison of montelukast and fexofenadine for chronic idiopathic urticaria.
    Archives of dermatology, 2001, Volume: 137, Issue:1

    Topics: Acetates; Adult; Aged; Chronic Disease; Cyclopropanes; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Leukotriene Antagonists; Male; Middle Aged; Quinolines; Sulfides; Terfenadine; Treatment Outcome; Urticaria

2001
Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 86, Issue:1

    Topics: Acetates; Adult; Allergens; Cyclopropanes; Depression, Chemical; Dermatitis, Allergic Contact; Drug Therapy, Combination; Female; Histamine; Humans; Injections; Leukotriene D4; Male; Middle Aged; Quinolines; Sulfides; Terfenadine; Time Factors

2001
Skin concentrations of H1-receptor antagonists.
    The Journal of allergy and clinical immunology, 2001, Volume: 107, Issue:3

    Topics: Adult; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypersensitivity, Delayed; Male; Prospective Studies; Skin; Terfenadine

2001
The effect of rifampin administration on the disposition of fexofenadine.
    Clinical pharmacology and therapeutics, 2001, Volume: 69, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aging; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Histamine H1 Antagonists; Humans; Male; Metabolic Clearance Rate; Rifampin; Sex Characteristics; Terfenadine

2001
A non-comparative trial of the efficacy and safety of fexofenadine for treatment of perennial allergic rhinitis.
    Asian Pacific journal of allergy and immunology, 2000, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Drug Administration Schedule; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Multicenter Studies as Topic; Rhinitis, Allergic, Perennial; Terfenadine; Thailand; Time Factors

2000
Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study.
    Clinical therapeutics, 2001, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Terfenadine

2001
Multicenter study of the efficacy and safety of fexofenadine 60 mg. twice daily in 108 Thai patients with chronic idiopathic urticaria.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2001, Volume: 84, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Terfenadine; Thailand; Urticaria

2001
Twenty-four hours of activity of cetirizine and fexofenadine in the skin.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 86, Issue:4

    Topics: Adolescent; Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; Drug Evaluation; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis; Skin; Skin Tests; Terfenadine; Time Factors

2001
Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol.
    American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:6

    Topics: Acetates; Administration, Inhalation; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cyclopropanes; Double-Blind Method; Drug Interactions; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Leukotriene Antagonists; Male; Mannitol; Middle Aged; Quinolines; Recovery of Function; Sulfides; Terfenadine; Time Factors

2001
Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis.
    International archives of allergy and immunology, 2001, Volume: 125, Issue:1

    Topics: Adult; Anti-Allergic Agents; Bronchial Provocation Tests; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Humans; Kinetics; Male; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Sneezing; Terfenadine

2001
Safety of fexofenadine in children treated for seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 87, Issue:1

    Topics: Asthma; Child; Double-Blind Method; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Therapeutic Equivalency

2001
Fexofenadine reduces nasal congestion in perennial allergic rhinitis.
    Allergy, 2001, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Animals; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Mites; Nasal Mucosa; Pilot Projects; Rhinitis, Allergic, Perennial; Sneezing; Terfenadine; Treatment Outcome

2001
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:1

    Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Beverages; Biological Availability; Carrier Proteins; Citrus; Double-Blind Method; Female; Flavonoids; Food-Drug Interactions; Fruit; HeLa Cells; Histamine H1 Antagonists; Humans; Intestinal Absorption; Male; Malus; Membrane Transport Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Symporters; Terfenadine

2002
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:2

    Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria

2002
Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.
    Clinical pharmacokinetics, 2002, Volume: 41, Issue:4

    Topics: Administration, Oral; Adult; Area Under Curve; Beverages; Biological Availability; Citrus; Confidence Intervals; Cross-Over Studies; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Terfenadine

2002
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; CD56 Antigen; Female; Fluorescent Dyes; Genes, MDR; Genotype; Histamine H1 Antagonists; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Polymorphism, Genetic; Rhodamine 123; RNA, Messenger; Sex Factors; Terfenadine

2002
A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:1

    Topics: Acetates; Adult; Anti-Allergic Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Humans; Leukotriene Antagonists; Loratadine; Nasal Cavity; Poaceae; Pollen; Pulmonary Ventilation; Quinolines; Rhinitis, Allergic, Seasonal; Single-Blind Method; Skin Tests; Sulfides; Terfenadine

2002
An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:1

    Topics: Adult; Central Nervous System; Cognition; Cross-Over Studies; Differential Threshold; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Middle Aged; Placebos; Promethazine; Psychomotor Performance; Reaction Time; Reference Values; Terfenadine

2002
[Chronic idiopathic urticaria: effectiveness of fexofenadine. A double-blind, placebo controlled study with 21 patients].
    Praxis, 2002, Apr-10, Volume: 91, Issue:15

    Topics: Adult; Aged; Anti-Allergic Agents; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Terfenadine; Urticaria

2002
Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Chemokine CCL3; Chemokine CCL4; Cross-Over Studies; Cytokines; Double-Blind Method; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Interleukin-4; Macrophage Inflammatory Proteins; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; Plant Proteins; Rhinitis, Allergic, Perennial; Terfenadine; Tumor Necrosis Factor-alpha

2002
Effect of St John's wort on the pharmacokinetics of fexofenadine.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:6

    Topics: Adult; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Hypericum; Male; Reference Values; Terfenadine

2002
Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Decongestants; Rhinitis, Allergic, Seasonal; Terfenadine

2002
Comparison of the efficacy of combined fluticasone propionate and olopatadine versus combined fluticasone propionate and fexofenadine for the treatment of allergic rhinoconjunctivitis induced by conjunctival allergen challenge.
    Clinical therapeutics, 2002, Volume: 24, Issue:7

    Topics: Administration, Intranasal; Administration, Topical; Adult; Allergens; Androstadienes; Anti-Allergic Agents; Anti-Inflammatory Agents; Conjunctivitis, Allergic; Dibenzoxepins; Double-Blind Method; Drug Therapy, Combination; Female; Fluticasone; Histamine H1 Antagonists; Humans; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Rhinitis, Allergic, Perennial; Terfenadine; Treatment Outcome

2002
Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:10

    Topics: Adult; Air Pollutants; Allergens; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Lung; Male; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine

2002
The use of handheld computers in clinical trials.
    Controlled clinical trials, 2002, Volume: 23, Issue:5

    Topics: Adult; Anti-Allergic Agents; Data Collection; Databases, Factual; Double-Blind Method; Humans; Mathematical Computing; Medical Records; Microcomputers; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Software Validation; Terfenadine

2002
Clinical pharmacology of H1-antihistamines in the skin.
    The Journal of allergy and clinical immunology, 2002, Volume: 110, Issue:5

    Topics: Adult; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Skin; Skin Tests; Terfenadine

2002
Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain.
    Life sciences, 2002, Dec-20, Volume: 72, Issue:4-5

    Topics: Adult; Arousal; Brain; Brain Chemistry; Cetirizine; Cognition; Cross-Over Studies; Discrimination, Psychological; Double-Blind Method; Doxepin; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Psychomotor Performance; Radiopharmaceuticals; Reaction Time; Receptors, Histamine H1; Sleep Stages; Terfenadine; Tomography, Emission-Computed

2002
Effects of fexofenadine on the early response to nasal allergen challenge.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Allergens; Biomarkers; Capillary Permeability; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine Release; Humans; Male; Mast Cells; Middle Aged; Molecular Structure; Nasal Cavity; Nasal Provocation Tests; Pruritus; Rhinitis, Allergic, Seasonal; Serine Endopeptidases; Serum Albumin; Sneezing; Structure-Activity Relationship; Terfenadine; Therapeutic Irrigation; Tryptases

2002
Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells.
    Asian journal of andrology, 2002, Volume: 4, Issue:4

    Topics: Adult; Biopsy, Needle; Follicle Stimulating Hormone; Histamine H1 Antagonists; Humans; Infertility, Male; Male; Mast Cells; Middle Aged; Semen; Serine Endopeptidases; Sperm Count; Sperm Motility; Terfenadine; Testis; Tryptases; Turkey

2002
Effect of fexofenadine hydrochloride on cedar pollinosis.
    Auris, nasus, larynx, 2003, Volume: 30 Suppl

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cedrus; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Patient Satisfaction; Pollen; Premedication; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2003
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects.
    Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:1

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Enzyme Induction; Female; Gene Expression Regulation; Genes, MDR; Humans; Hypericum; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Plant Preparations; Reference Values; Terfenadine

2003
Failure of cetirizine and fexofenadine to prevent motion sickness.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:2

    Topics: Adult; Analysis of Variance; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Motion Sickness; Nausea; Terfenadine; Treatment Failure

2003
Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:2

    Topics: Acetates; Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Provocation Tests; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperazines; Respiratory Hypersensitivity; Terfenadine

2003
The effects of single-dose fexofenadine, diphenhydramine, and placebo on cognitive performance in flight personnel.
    Aviation, space, and environmental medicine, 2003, Volume: 74, Issue:2

    Topics: Administration, Oral; Adult; Aerospace Medicine; Attention; Cognition; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Placebos; Reaction Time; Sleep Stages; Terfenadine

2003
Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:4

    Topics: Anti-Allergic Agents; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Seasonal; Terfenadine

2003
The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:4

    Topics: Adult; Asian People; Biotransformation; Blood-Brain Barrier; Cognition; Cross-Over Studies; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Japan; Male; Middle Aged; Promethazine; Psychomotor Performance; Reaction Time; Terfenadine

2003
Herbal supplements and skin testing: the lack of effect of commonly used herbal supplements on histamine skin prick testing.
    Allergy, 2003, Volume: 58, Issue:6

    Topics: Cross-Over Studies; Double-Blind Method; Gastrointestinal Diseases; Histamine; Histamine H1 Antagonists; Humans; Plant Preparations; Skin; Skin Tests; Terfenadine; Time Factors

2003
Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA).
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Attention; Cognition; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Reaction Time; Sleep Stages; Terfenadine

2003
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
    Drugs under experimental and clinical research, 2002, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine

2002
Supplementation of fexofenadine therapy with nedocromil sodium 2% ophthalmic solution to treat ocular symptoms of seasonal allergic conjunctivitis.
    Clinical & experimental ophthalmology, 2003, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Ambrosia; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Drug Therapy, Combination; Eye Diseases; Female; Humans; Male; Middle Aged; Nedocromil; Ophthalmic Solutions; Patient Satisfaction; Pollen; Quality of Life; Salvage Therapy; Seasons; Terfenadine; Treatment Outcome

2003
H1-antihistaminic activity of cetirizine and fexofenadine in allergic children.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:3

    Topics: Anti-Allergic Agents; Cetirizine; Child; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Prospective Studies; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome

2003
Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study.
    The British journal of dermatology, 2003, Volume: 148, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Dermatitis, Atopic; Dermatologic Agents; Double-Blind Method; Drug Combinations; Female; Histamine H1 Antagonists; Humans; Hydrocortisone; Male; Middle Aged; Pruritus; Terfenadine; Treatment Outcome

2003
Relative potency of fexofenadine HCl 180 mg, loratadine 10 mg, and placebo using a skin test model of wheal-and-flare suppression.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Histamine H1 Antagonists; Histamine Release; Humans; Loratadine; Male; Middle Aged; Reference Values; Skin Tests; Terfenadine; Time Factors; Treatment Outcome

2003
A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive
    Clinical therapeutics, 2003, Volume: 25, Issue:5

    Topics: Adult; Analysis of Variance; Automobile Driving; Cognition; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Ethanol; Histamine H1 Antagonists; Humans; Hydroxyzine; Male; Psychomotor Performance; Reaction Time; Terfenadine

2003
Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Child; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Nasal Mucosa; Omalizumab; Patient Satisfaction; Quality of Life; Rhinitis, Allergic, Perennial; Terfenadine; Treatment Outcome

2003
The effects of fexofenadine on reaction time, decision-making, and driver behavior.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Automobile Driving; Cohort Studies; Decision Making; Female; Humans; Male; Middle Aged; Psychomotor Performance; Reaction Time; Terfenadine

2003
Randomized, double-masked comparison of olopatadine ophthalmic solution, mometasone furoate monohydrate nasal spray, and fexofenadine hydrochloride tablets using the conjunctival and nasal allergen challenge models.
    Clinical therapeutics, 2003, Volume: 25, Issue:8

    Topics: Administration, Intranasal; Administration, Oral; Administration, Topical; Adult; Aged; Allergens; Anti-Allergic Agents; Conjunctiva; Conjunctivitis, Allergic; Dibenzoxepins; Double-Blind Method; Female; Humans; Male; Middle Aged; Mometasone Furoate; Nasal Mucosa; Olopatadine Hydrochloride; Ophthalmic Solutions; Pregnadienediols; Rhinitis, Allergic, Perennial; Tablets; Terfenadine; Time Factors

2003
Fexofenadine hydrochloride, 180 mg, exhibits equivalent efficacy to cetirizine, 10 mg, with less drowsiness in patients with moderate-to-severe seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Double-Blind Method; Female; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Sleep Stages; Terfenadine; Treatment Outcome

2003
Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:5

    Topics: Adult; Algorithms; Anti-Allergic Agents; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Female; Humans; In Vitro Techniques; Intestinal Absorption; Intestines; Jejunum; Male; Membrane Transport Modulators; Membrane Transport Proteins; Regional Blood Flow; Spectrophotometry, Ultraviolet; Terfenadine; Verapamil

2003
A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity.
    International archives of allergy and immunology, 2003, Volume: 132, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Butyrophenones; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Terfenadine

2003
Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function.
    British journal of clinical pharmacology, 2003, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Capsaicin; Cough; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Male; Terfenadine

2003
Mite-antigen induced immediate reactions in atopic dermatitis are inhibited by daily administration of fexofenadine.
    The Journal of dermatology, 2003, Volume: 30, Issue:11

    Topics: Administration, Oral; Adult; Animals; Antigens, Dermatophagoides; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatophagoides farinae; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Skin Tests; Terfenadine; Treatment Outcome

2003
Comparative study of acute effects of single doses of fexofenadine, olopatadine, d-chlorpheniramine and placebo on psychomotor function in healthy volunteers.
    Human psychopharmacology, 2003, Volume: 18, Issue:8

    Topics: Adult; Chlorpheniramine; Choice Behavior; Cognition; Cross-Over Studies; Dibenzoxepins; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Male; Olopatadine Hydrochloride; Psychomotor Performance; Reaction Time; Terfenadine; Time Factors

2003
Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria.
    The Journal of dermatological treatment, 2004, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Terfenadine; Treatment Outcome; Urticaria

2004
Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 92, Issue:1

    Topics: Acetates; Adolescent; Adult; Ambrosia; Anti-Allergic Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Quality of Life; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides; Surveys and Questionnaires; Terfenadine; Treatment Outcome; Vasoconstrictor Agents

2004
The effects of butterbur on the histamine and allergen cutaneous response.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 92, Issue:2

    Topics: Acetates; Adult; Anti-Inflammatory Agents; Cross-Over Studies; Cyclopropanes; Dermatitis, Atopic; Double-Blind Method; Female; Histamine; Humans; Male; Petasites; Phytotherapy; Quinolines; Skin Tests; Sulfides; Terfenadine

2004
Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients.
    Chest, 2004, Volume: 125, Issue:4

    Topics: Acetates; Adenosine Monophosphate; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Quinolines; Respiratory Hypersensitivity; Sulfides; Terfenadine; Treatment Outcome

2004
A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:4

    Topics: Adult; Anti-Allergic Agents; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Provocation Tests; Petasites; Phytotherapy; Plant Extracts; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome

2004
Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:4

    Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Provocation Tests; Piperazines; Rhinitis, Allergic, Perennial; Terfenadine; Treatment Outcome

2004
Effects of single or combined histamine H1-receptor and leukotriene CysLT1-receptor antagonism on nasal adenosine monophosphate challenge in persistent allergic rhinitis.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:6

    Topics: Acetates; Adult; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Combinations; Female; Humans; Leukotriene Antagonists; Male; Nucleotidases; Quinolines; Receptors, Histamine H1; Rhinitis, Allergic, Perennial; Sulfides; Terfenadine; Treatment Outcome

2004
Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge.
    European annals of allergy and clinical immunology, 2004, Volume: 36, Issue:4

    Topics: Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis, Allergic; Cytokines; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Interleukin-1; Interleukin-6; Male; Nasal Provocation Tests; Parietaria; Pollen; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Terfenadine; Tumor Necrosis Factor-alpha

2004
Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2004, Volume: 15, Issue:3

    Topics: Anti-Allergic Agents; Child; Double-Blind Method; Female; Headache; Histamine H1 Antagonists; Humans; Male; Meta-Analysis as Topic; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2004
Comparative efficacy of wheal-and-flare suppression among various non-sedating antihistamines and the pharmacologic insights to their efficacy.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2004, Volume: 87, Issue:5

    Topics: Adolescent; Adult; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Terfenadine; Urticaria

2004
Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:8

    Topics: Adult; Brain; Carbon Radioisotopes; Cetirizine; Cross-Over Studies; Double-Blind Method; Doxepin; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Positron-Emission Tomography; Practice Guidelines as Topic; Psychomotor Performance; Receptors, Histamine H1; Sleep Stages; Terfenadine

2004
Validation of the Dermatology Life Quality Index as an outcome measure for urticaria-related quality of life.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:2

    Topics: Chronic Disease; Dermatology; Dose-Response Relationship, Drug; Double-Blind Method; Histamine H1 Antagonists; Humans; Outcome Assessment, Health Care; Predictive Value of Tests; Pruritus; Quality of Life; Reproducibility of Results; Sensitivity and Specificity; Sickness Impact Profile; Statistics as Topic; Terfenadine; Treatment Outcome; Urticaria

2004
Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Incidence; Male; Middle Aged; Phthalazines; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2004
Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance.
    Clinical and experimental dermatology, 2004, Volume: 29, Issue:5

    Topics: Adult; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Dibenzoxepins; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Male; Olopatadine Hydrochloride; Piperidines; Psychomotor Performance; Pyridines; Sleep Stages; Terfenadine

2004
Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:1

    Topics: Adult; Alfentanil; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Female; Humans; Male; Terfenadine

2005
Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:6

    Topics: Adolescent; Adult; Cetirizine; Cross-Over Studies; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Skin Tests; Terfenadine; Urticaria

2004
H1 receptor-mediated vasodilatation contributes to postexercise hypotension.
    The Journal of physiology, 2005, Mar-01, Volume: 563, Issue:Pt 2

    Topics: Adult; Exercise; Female; Histamine H1 Antagonists; Humans; Hypotension; Male; Receptors, Histamine H1; Terfenadine; Vasodilation

2005
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.
    Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:1

    Topics: Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cimetidine; Drug Interactions; Half-Life; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Probenecid; Terfenadine; Uricosuric Agents; Verapamil

2005
Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season.
    International archives of allergy and immunology, 2005, Volume: 136, Issue:2

    Topics: Adult; Allergens; Cryptomeria; Double-Blind Method; Efficiency; Female; Histamine H1 Antagonists; Humans; Japan; Male; Pollen; Quality of Life; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2005
CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:3

    Topics: Adult; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black or African American; Cytochrome P-450 CYP3A; Female; Genotype; Herb-Drug Interactions; Hispanic or Latino; Humans; Hypericum; Male; Midazolam; Middle Aged; Phenotype; Plant Preparations; Terfenadine; White People

2005
Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides.
    Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:3

    Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Citrus paradisi; Cross-Over Studies; Drinking; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Organic Anion Transporters; Peptides; Terfenadine; Water

2005
The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:4

    Topics: Adult; Cetirizine; Cryptomeria; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Japan; Loratadine; Male; Middle Aged; Pollen; Quality of Life; Rhinitis, Allergic, Seasonal; Sneezing; Surveys and Questionnaires; Terfenadine

2005
Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration.
    British journal of clinical pharmacology, 2005, Volume: 60, Issue:1

    Topics: Adult; Cetirizine; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Nose Diseases; Patient Satisfaction; Piperazines; Terfenadine

2005
Single-dose and steady-state bioequivalence of fexofenadine and pseudoephedrine combination tablets compared with individual formulations in healthy adults.
    Current medical research and opinion, 2005, Volume: 21, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Ephedrine; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Perennial; Tablets; Terfenadine; Therapeutic Equivalency

2005
Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled study.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:6

    Topics: Adolescent; Child; Chronic Disease; Double-Blind Method; Female; Humans; Male; Terfenadine; Urticaria

2005
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:2

    Topics: Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Genes, MDR; Haplotypes; Histamine H1 Antagonists; Humans; Itraconazole; Male; Polymorphism, Genetic; Terfenadine

2005
Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use.
    Human psychopharmacology, 2005, Volume: 20, Issue:7

    Topics: Adult; Arousal; Attention; Automobile Driving; Double-Blind Method; Histamine H1 Antagonists; Humans; Hydroxyzine; Male; Mental Processes; Reaction Time; Sleep Stages; Telephone; Terfenadine

2005
A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:4

    Topics: Adult; Attention; Behavior; Cross-Over Studies; Double-Blind Method; Electroencephalography; Electrooculography; Evoked Potentials; Female; Histamine H1 Antagonists; Humans; Male; Psychomotor Performance; Reaction Time; Stimulation, Chemical; Terfenadine

2006
Suppression of the histamine-induced wheal and flare response by fexofenadine HCl 60 mg twice daily, loratadine 10 mg once daily and placebo in healthy Japanese volunteers.
    Current medical research and opinion, 2005, Volume: 21, Issue:9

    Topics: Adult; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Japan; Loratadine; Male; Middle Aged; Placebos; Prospective Studies; Terfenadine; United Kingdom; Urticaria

2005
Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 95, Issue:3

    Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Albuterol; Androstadienes; Anti-Allergic Agents; Asthma; Biomarkers; Bronchial Provocation Tests; Drug Therapy, Combination; Eosinophil Cationic Protein; Eosinophils; Female; Fluticasone; Humans; Hypersensitivity, Immediate; Inflammation; Male; Nitric Oxide; Respiratory Function Tests; Salmeterol Xinafoate; Terfenadine; Treatment Outcome

2005
[Serum sICAM-1 in patients suffering from allergic rhinitis treated with fexofenadine or fluticasone].
    Pneumonologia i alergologia polska, 2004, Volume: 72, Issue:11-12

    Topics: Adolescent; Adult; Androstadienes; Anti-Allergic Agents; Female; Fluticasone; Humans; Intercellular Adhesion Molecule-1; Male; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2004
Efficacy of fexofenadine in the prophylactic control of cat allergen-induced allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 96, Issue:2

    Topics: Adolescent; Animals; Anti-Allergic Agents; Cats; Child; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; Forced Expiratory Volume; Glycoproteins; Humans; Male; Placebos; Rhinitis, Allergic, Perennial; Terfenadine; Time Factors; Treatment Outcome

2006
Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.
    International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:2

    Topics: Administration, Oral; Adult; Anti-Allergic Agents; Anti-Bacterial Agents; Area Under Curve; Biological Availability; Capsules; Colon; Drug Synergism; Erythromycin; Female; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Intubation; Jejunum; Male; Polyethylene; Reference Values; Terfenadine; Time Factors

2006
The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:3

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Female; Half-Life; Histamine H1 Antagonists; Humans; Male; Stereoisomerism; Terfenadine; Tissue Distribution; Verapamil

2006
The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis.
    Asian Pacific journal of allergy and immunology, 2005, Volume: 23, Issue:4

    Topics: Anti-Allergic Agents; Asian People; Child; Female; Histamine H1 Antagonists; Humans; Male; Multicenter Studies as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2005
Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:5

    Topics: Adult; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Diltiazem; Drug Administration Schedule; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Itraconazole; Male; Terfenadine; Time Factors

2006
Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 96, Issue:4

    Topics: Adult; Anti-Allergic Agents; Cedrus; Dermatophagoides farinae; Desensitization, Immunologic; Female; Histamine H1 Antagonists; Humans; Male; Multicenter Studies as Topic; Pollen; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine

2006
Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesis.
    Psychopharmacology, 2006, Volume: 187, Issue:1

    Topics: Adult; Cognition; Dopamine Plasma Membrane Transport Proteins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Terfenadine; Tomography, Emission-Computed, Single-Photon; Tropanes

2006
Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:3

    Topics: Adult; Antifungal Agents; Cross-Over Studies; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Japan; Male; Terfenadine

2006
Time-dependent interaction between lopinavir/ritonavir and fexofenadine.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:7

    Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Drug Combinations; Drug Interactions; Female; Genotype; Histamine H1 Antagonists; HIV Protease Inhibitors; Humans; Liver; Lopinavir; Male; Middle Aged; Organic Anion Transporters; Pyrimidinones; Ritonavir; Terfenadine; Time Factors

2006
Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects.
    Current medical research and opinion, 2006, Volume: 22, Issue:7

    Topics: Adult; Anti-Allergic Agents; Asian People; Chlorpheniramine; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Japan; Male; Middle Aged; Psychomotor Performance; Sleep; Sleep, REM; Terfenadine

2006
Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Cetirizine; Cross-Over Studies; Double-Blind Method; Face; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Nasal Provocation Tests; Nose; Piperazines; Skin Temperature; Terfenadine; Thermography

2006
Lack of dose-dependent effects of itraconazole on the pharmacokinetic interaction with fexofenadine.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Male; Middle Aged; Terfenadine

2006
Determination of fexofenadine enantiomers in human plasma with high-performance liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 2007, Jan-17, Volume: 43, Issue:2

    Topics: Acetonitriles; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Histamine H1 Antagonists, Non-Sedating; Humans; Linear Models; Molecular Structure; Phosphates; Potassium Compounds; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Solvents; Spectrophotometry, Ultraviolet; Stereoisomerism; Terfenadine

2007
Treatment of allergic rhinitis can improve blood pressure control.
    Journal of human hypertension, 2006, Volume: 20, Issue:11

    Topics: Adult; Analysis of Variance; Androstadienes; Anti-Allergic Agents; Antihypertensive Agents; Biomarkers; Blood Pressure; C-Reactive Protein; Female; Fluticasone; Humans; Hypertension; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Perennial; Severity of Illness Index; Sodium Chloride; Surveys and Questionnaires; Terfenadine; Treatment Outcome

2006
Onset of action of fexofenadine hydrochloride 60 mg/pseudoephedrine hydrochloride 120 mg in subjects aged 12 years with moderate to severe seasonal allergic rhinitis: a pooled analysis of two single-dose, randomized, double-blind, placebo-controlled aller
    Clinical therapeutics, 2006, Volume: 28, Issue:10

    Topics: Adult; Allergens; Anti-Allergic Agents; Demography; Double-Blind Method; Ephedrine; Female; Humans; Male; Placebos; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2006
Intestinal drug transporter expression and the impact of grapefruit juice in humans.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Availability; Blotting, Western; Carrier Proteins; Citrus paradisi; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Fluorescent Antibody Technique; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Middle Aged; Organic Anion Transporters; Pharmaceutical Preparations; Reverse Transcriptase Polymerase Chain Reaction; RNA; Terfenadine

2007
Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:4

    Topics: Adult; Anticoagulants; Beverages; Citrus paradisi; Cross-Over Studies; Data Interpretation, Statistical; Double-Blind Method; Drug Interactions; Female; Flavanones; Furocoumarins; HeLa Cells; Hesperidin; Histamine H1 Antagonists; Humans; Male; Middle Aged; Organic Anion Transporters; Reproducibility of Results; Terfenadine

2007
[Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006, Volume: 21, Issue:125

    Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Placebos; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria

2006
[The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006, Volume: 21, Issue:125

    Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Drug Administration Schedule; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Regional Blood Flow; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria

2006
The effect of fexofenadine hydrochloride on productivity and quality of life in patients with chronic idiopathic urticaria.
    Cutis, 2007, Volume: 79, Issue:2

    Topics: Adolescent; Chronic Disease; Double-Blind Method; Efficiency; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Quality of Life; Surveys and Questionnaires; Terfenadine; Urticaria

2007
Bioequivalence of two fexofenadine formulations in healthy human volunteers after single oral administration.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2007, Volume: 151, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Anti-Allergic Agents; Cross-Over Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Tablets; Terfenadine; Therapeutic Equivalency

2007
Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 99, Issue:4

    Topics: Age Factors; Anti-Allergic Agents; Body Temperature; Child, Preschool; Cough; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Infant; Male; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Vomiting

2007
Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects.
    Current medical research and opinion, 2008, Volume: 24, Issue:2

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Ginkgo biloba; HIV Protease Inhibitors; Humans; Lopinavir; Male; Midazolam; Phytotherapy; Plant Extracts; Protease Inhibitors; Pyrimidinones; Ritonavir; Terfenadine

2008
Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 99, Issue:6

    Topics: Administration, Oral; Blood Pressure; Body Temperature; Body Weight; Child, Preschool; Electrocardiography; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Male; Rhinitis, Allergic, Perennial; Statistics, Nonparametric; Terfenadine

2007
The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers.
    British journal of clinical pharmacology, 2008, Volume: 65, Issue:5

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Combinations; Drug Interactions; Female; Humans; Itraconazole; Male; Terfenadine

2008
Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis.
    Archives of dermatological research, 2008, Volume: 300, Issue:6

    Topics: Adult; Cetirizine; Cross-Over Studies; Dibenzoxepins; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Histamine Antagonists; Humans; Iontophoresis; Male; Olopatadine Hydrochloride; Skin; Terfenadine; Urticaria

2008
Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:8

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cystic Fibrosis; DNA; Female; Flow Cytometry; Genotype; Histamine H1 Antagonists; Humans; Iothalamic Acid; Kidney; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Probenecid; Prospective Studies; Renal Agents; T-Lymphocytes; Terfenadine

2008
Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008, Volume: 100, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Child; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity, Immediate; Injections, Intramuscular; Male; Middle Aged; Skin Tests; Terfenadine; Time Factors; Treatment Outcome

2008
The effects of fexofenadine at steady-state on sleep architecture: a study using polysomnography in healthy Korean volunteers.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:10

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorpheniramine; Cross-Over Studies; Double-Blind Method; Genotype; Half-Life; Histamine H1 Antagonists; Humans; Korea; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic; Sleep; Sleep, REM; Terfenadine

2008
Relationship between airborne pollen count and treatment outcome in Japanese cedar pollinosis patients.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2009, Volume: 266, Issue:5

    Topics: Adult; Air; Anti-Allergic Agents; Anti-Inflammatory Agents; Cryptomeria; Female; Humans; Male; Pollen; Prospective Studies; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Terfenadine

2009
Fexofenadine effects on cognitive performance in aviators at ground level and simulated altitude.
    Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:8

    Topics: Adult; Aerospace Medicine; Altitude; Anti-Allergic Agents; Attention; Cetirizine; Cognition; Double-Blind Method; Female; Humans; Male; Placebos; Reaction Time; Sleep Stages; Terfenadine

2008
Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study.
    Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:5

    Topics: Adult; Drug Resistance; Female; Histamine H1 Antagonists; Humans; Male; Pilot Projects; Prospective Studies; Pruritus; Terfenadine; Ultraviolet Therapy; Urticaria

2008
Potential benefit from an H1-receptor antagonist on postexercise syncope in the heat.
    Medicine and science in sports and exercise, 2008, Volume: 40, Issue:11

    Topics: Adolescent; Adult; Exercise; Female; Histamine H1 Antagonists, Non-Sedating; Hot Temperature; Humans; Hypotension; Male; Syncope; Terfenadine; Young Adult

2008
Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers.
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:6

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cross-Over Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Quercetin; Reference Values; Spectrometry, Fluorescence; Terfenadine

2009
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:4

    Topics: Adult; Alfentanil; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Intestines; Liver; Male; Methadone; Narcotics; Pupil; Ritonavir; Stereoisomerism; Terfenadine

2008
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
    Allergology international : official journal of the Japanese Society of Allergology, 2009, Volume: 58, Issue:2

    Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens, Plant; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chamaecyparis; Chromones; Cough; Cryptomeria; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Middle Aged; Nasal Mucosa; Phenothiazines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Young Adult

2009
Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:5

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Terfenadine; Verapamil; Young Adult

2009
Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2009, Volume: 102, Issue:6

    Topics: Adult; Allergens; Animals; Dermatophagoides pteronyssinus; Dibenzazepines; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hydroxyzine; Imidazoles; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome; Urticaria

2009
Evaluation of the efficacy and safety of olopatadine and fexofenadine compared with placebo in Japanese cedar pollinosis using an environmental exposure unit.
    Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:4

    Topics: Adult; Allergens; Cryptomeria; Dibenzoxepins; Double-Blind Method; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Motor Activity; Olopatadine Hydrochloride; Pollen; Rhinitis, Allergic, Seasonal; Sleep; Sneezing; Terfenadine; Treatment Outcome

2009
Bioequivalence of fexofenadine tablet formulations assessed in healthy Iranian volunteers.
    Arzneimittel-Forschung, 2009, Volume: 59, Issue:7

    Topics: Adult; Analysis of Variance; Anti-Allergic Agents; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Humans; Iran; Male; Single-Blind Method; Tablets; Terfenadine; Therapeutic Equivalency; Young Adult

2009
Comparing the stimulant effects of the H1-antagonist fexofenadine with 2 psychostimulants, modafinil and methylphenidate.
    Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:5

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Methylphenidate; Modafinil; Psychomotor Performance; Reaction Time; Terfenadine; Young Adult

2009
Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis--a randomized placebo-controlled study.
    Pediatric pulmonology, 2009, Volume: 44, Issue:11

    Topics: Acetates; Adolescent; Asthma; Child; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Male; Quinolines; Rhinitis, Allergic, Perennial; Rhinometry, Acoustic; Sulfides; Terfenadine

2009
Effects of the P-glycoprotein inducer carbamazepine on fexofenadine pharmacokinetics.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:6

    Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Male; Terfenadine; Young Adult

2009
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5

    Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies; Double-Blind Method; Eye Diseases; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Nasal Mucosa; Nose Diseases; Ophthalmic Solutions; Piperidines; Placebos; Rhinitis, Allergic, Seasonal; Terfenadine

2010
Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Feb-01, Volume: 878, Issue:3-4

    Topics: Administration, Oral; Anti-Allergic Agents; Biological Transport; Calibration; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Quality Control; Reference Standards; Tandem Mass Spectrometry; Terfenadine

2010
Assessment of the antiobstructive effect of fexofenadine on nasal allergy challenge in patients with seasonal allergic rhinitis.
    Asian Pacific journal of allergy and immunology, 2009, Volume: 27, Issue:4

    Topics: Administration, Oral; Antigens, Plant; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Nasal Obstruction; Nasal Provocation Tests; Pollen; Pulmonary Ventilation; Recovery of Function; Rhinitis, Allergic, Seasonal; Rhinomanometry; Terfenadine

2009
Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Interactions; Humans; Male; Metronidazole; Terfenadine

2010
Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, May-12, Volume: 40, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Humans; Male; Middle Aged; Terfenadine; Young Adult

2010
Microdose study of a P-glycoprotein substrate, fexofenadine, using a non-radioisotope-labelled drug and LC/MS/MS.
    Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:2

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Chromatography, Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine; Young Adult

2010
Efficacy of leukotriene antagonists as concomitant therapy in allergic rhinitis.
    The Laryngoscope, 2010, Volume: 120, Issue:9

    Topics: Acetates; Adult; Airway Resistance; Anti-Allergic Agents; Case-Control Studies; Cyclopropanes; Drug Therapy, Combination; Female; Humans; Leukotriene Antagonists; Male; Pain Measurement; Patient Satisfaction; Quinolines; Rhinitis, Allergic, Perennial; Rhinomanometry; Sulfides; Terfenadine; Treatment Outcome

2010
The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.
    Pharmacogenetics and genomics, 2011, Volume: 21, Issue:2

    Topics: Adult; Animals; Anti-Allergic Agents; Area Under Curve; Beverages; Biological Transport; GABA Modulators; Humans; Male; Malus; Midazolam; Organic Anion Transporters; Polymorphism, Single Nucleotide; Terfenadine; Xenopus laevis; Young Adult

2011
Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:7

    Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Adult; Area Under Curve; Atenolol; Beverages; Celiprolol; Citrus paradisi; Cross-Over Studies; Dose-Response Relationship, Drug; Food-Drug Interactions; Humans; Male; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Genetic; Terfenadine; Young Adult

2012
Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:6

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Monitoring; Drugs, Chinese Herbal; Female; Half-Life; Herb-Drug Interactions; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Midazolam; Panax; Plant Roots; Terfenadine; Young Adult

2012
Carbamazepine differentially affects the pharmacokinetics of fexofenadine enantiomers.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:3

    Topics: Adult; Anti-Allergic Agents; Anticonvulsants; Area Under Curve; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Drug Interactions; Humans; Male; Stereoisomerism; Terfenadine; Young Adult

2012
Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:5

    Topics: Adult; Amides; Antihypertensive Agents; Beverages; Biological Transport; Citrus paradisi; Cross-Over Studies; Flavanones; Food-Drug Interactions; Fruit; Fumarates; Half-Life; HEK293 Cells; Humans; Intestinal Mucosa; Male; Organic Anion Transporters; Recombinant Proteins; Renin; Terfenadine; Young Adult

2012
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers.
    Archives of dermatological research, 2012, Volume: 304, Issue:4

    Topics: Adolescent; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Olopatadine Hydrochloride; Promethazine; Pruritus; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria; Young Adult

2012
A randomized control trail of stepwise treatment with fluticasone propionate nasal spray and fexofenadine hydrochloride tablet for seasonal allergic rhinitis.
    Allergology international : official journal of the Japanese Society of Allergology, 2012, Volume: 61, Issue:1

    Topics: Adult; Androstadienes; Anti-Allergic Agents; Female; Fluticasone; Humans; Male; Middle Aged; Nasal Sprays; Pollen; Rhinitis, Allergic, Seasonal; Tablets; Terfenadine; Treatment Outcome

2012
The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms.
    The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:2

    Topics: Adult; Ambrosia; Anti-Allergic Agents; Cross-Over Studies; Cyclobutanes; Double-Blind Method; Drug Combinations; Female; Histamine H1 Antagonists, Non-Sedating; Histamine H3 Antagonists; Humans; Male; Middle Aged; Nasal Provocation Tests; Pyrrolidines; Rhinitis, Allergic, Seasonal; Skin Tests; Terfenadine; Young Adult

2012
Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Interactions; Female; Fluvoxamine; Half-Life; Humans; Intestine, Small; Liver; Male; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Terfenadine; Young Adult

2012
Sustained postexercise vasodilatation and histamine receptor activation following small muscle-mass exercise in humans.
    Experimental physiology, 2013, Volume: 98, Issue:1

    Topics: Blood Pressure; Exercise; Female; Heart Rate; Humans; Leg; Male; Muscle, Skeletal; Ranitidine; Receptors, Histamine; Terfenadine; Vasodilation; Young Adult

2013
Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Adult; Aged; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Reference Values; Rifampin; Terfenadine; Young Adult

2013
The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers.
    Acta dermato-venereologica, 2013, Volume: 93, Issue:3

    Topics: Adult; Asian People; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Germany; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Japan; Male; Pruritus; Skin; Terfenadine; Time Factors; Treatment Outcome; Urticaria; White People; Young Adult

2013
Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:6

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; HIV Protease Inhibitors; Humans; Intestines; Liver; Liver-Specific Organic Anion Transporter 1; Male; Midazolam; Organic Anion Transporters; Pravastatin; Ritonavir; Saquinavir; Tandem Mass Spectrometry; Terfenadine; Young Adult

2013
Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe.
    Journal of ethnopharmacology, 2013, Apr-19, Volume: 146, Issue:3

    Topics: Adult; Astragalus Plant; Astragalus propinquus; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Male; Polymorphism, Single Nucleotide; Substrate Specificity; Terfenadine; Therapeutic Equivalency

2013
Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations.
    The Journal of dermatological treatment, 2013, Volume: 24, Issue:6

    Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Iontophoresis; Male; Pilot Projects; Pruritus; Terfenadine; Urticaria

2013
The effects of antihistamines with varying anticholinergic properties on voluntary and involuntary movement.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013, Volume: 124, Issue:9

    Topics: Adult; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Promethazine; Reaction Time; Sleep Stages; Terfenadine; Tremor; Young Adult

2013
A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo "connect".
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:9

    Topics: Adult; Animals; Anti-Allergic Agents; Beverages; Chlorocebus aethiops; Citrus paradisi; COS Cells; Coumarins; Cross-Over Studies; Estrone; Female; Flavonoids; Food-Drug Interactions; Fruit; HEK293 Cells; Humans; Male; Middle Aged; Organic Anion Transporters; Terfenadine; Young Adult

2013
The effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial.
    International journal of pediatric otorhinolaryngology, 2013, Volume: 77, Issue:10

    Topics: Acetates; Allergens; Animals; Asthma; Chi-Square Distribution; Child; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Pyroglyphidae; Quinolines; Reference Values; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Skin Tests; Statistics, Nonparametric; Sulfides; Terfenadine; Urticaria

2013
In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.
    Pharmacotherapy, 2014, Volume: 34, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Biological Transport; Breath Tests; Case-Control Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Flurbiprofen; Glomerulonephritis; Humans; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Terfenadine; Young Adult

2014
Sensitive LC-MS/MS-ESI method for simultaneous determination of montelukast and fexofenadine in human plasma: application to a bioequivalence study.
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:8

    Topics: Acetates; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclopropanes; Drug Stability; Humans; Linear Models; Male; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Spectrometry, Mass, Electrospray Ionization; Sulfides; Tandem Mass Spectrometry; Terfenadine; Therapeutic Equivalency

2014
Population pharmacokinetic analysis of fexofenadine in Japanese pediatric patients.
    Journal of pharmacokinetics and pharmacodynamics, 2014, Volume: 41, Issue:2

    Topics: Adolescent; Asian People; Child; Child, Preschool; Female; Histamine H1 Antagonists; Humans; Infant; Japan; Male; Models, Biological; Terfenadine

2014
Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:9

    Topics: Adult; Animals; Anti-Allergic Agents; Area Under Curve; Beverages; Cross-Over Studies; Eating; Female; Food-Drug Interactions; Fruit; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Male; Malus; Oocytes; Organic Anion Transporters; RNA, Complementary; Stereoisomerism; Terfenadine; Xenopus laevis; Young Adult

2014
Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers.
    Pakistan journal of pharmaceutical sciences, 2014, Volume: 27, Issue:5

    Topics: Adult; Chromatography, Liquid; Humans; Male; Tandem Mass Spectrometry; Terfenadine

2014
Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers.
    Journal of clinical pharmacy and therapeutics, 2015, Volume: 40, Issue:1

    Topics: Anti-Allergic Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP2B6 Inducers; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Healthy Volunteers; Humans; Japan; Rifampin; Terfenadine

2015
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
    Archives of dermatological research, 2015, Volume: 307, Issue:2

    Topics: Adult; Asian People; Benzimidazoles; China; Female; Genotyping Techniques; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Loratadine; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Receptors, IgE; Terfenadine; Urticaria; Young Adult

2015
Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.
    Expert opinion on drug safety, 2015, Volume: 14, Issue:2

    Topics: Administration, Oral; Brain; Carbon Radioisotopes; Cetirizine; Cross-Over Studies; Double-Blind Method; Doxepin; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Neuroimaging; Positron-Emission Tomography; Radioligand Assay; Receptors, Histamine H1; Sleep; Terfenadine; Young Adult

2015
Comparison of the efficacy of olopatadine and fexofenadine in chronic idiopathic urticaria patients: a crossover study.
    Pharmacology, 2015, Volume: 95, Issue:1-2

    Topics: Adult; Anti-Allergic Agents; Chronic Disease; Cross-Over Studies; Dibenzoxepins; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Olopatadine Hydrochloride; Terfenadine; Treatment Outcome; Urticaria

2015
Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:3

    Topics: Absorption, Physiological; Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Excipients; Glycerol; Healthy Volunteers; Humans; Male; Saquinavir; Substrate Specificity; Terfenadine

2015
The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:5

    Topics: Adult; Anti-Allergic Agents; Area Under Curve; Beverages; Citrus paradisi; Cross-Over Studies; Female; Food-Drug Interactions; Humans; Male; Organic Anion Transporters; Stereoisomerism; Terfenadine; Young Adult

2015
Prediction of area under the curve for a p-glycoprotein, a CYP3A4 and a CYP2C9 substrate using a single time point strategy: assessment using fexofenadine, itraconazole and losartan and metabolites.
    Drug development and industrial pharmacy, 2016, Volume: 42, Issue:6

    Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Itraconazole; Losartan; Polypharmacy; Terfenadine

2016
A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers.
    Human psychopharmacology, 2016, Volume: 31, Issue:3

    Topics: Adult; Asian People; Automobile Driving; Cetirizine; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Psychomotor Performance; Reaction Time; Terfenadine; Young Adult

2016
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:3

    Topics: Adolescent; Adult; Bupropion; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Dried Blood Spot Testing; Drug Interactions; Female; Flurbiprofen; Genotyping Techniques; Humans; Male; Midazolam; Omeprazole; Phenotype; Terfenadine; Young Adult

2016
No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:7

    Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Duodenum; Female; Folic Acid; Healthy Volunteers; Humans; Intestinal Absorption; Male; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Proton-Coupled Folate Transporter; RNA, Messenger; Terfenadine; Vitamin D; Young Adult

2016
Evidence of a broad histamine footprint on the human exercise transcriptome.
    The Journal of physiology, 2016, 09-01, Volume: 594, Issue:17

    Topics: Adult; Exercise; Female; Hemodynamics; Histamine; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H2 Antagonists; Humans; Knee; Male; Muscle, Skeletal; Ranitidine; Receptors, Histamine H1; Receptors, Histamine H2; Terfenadine; Transcriptome; Young Adult

2016
Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Black People; Blood Pressure; Double-Blind Method; Exercise; Female; Heart Rate; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Leg; Male; Oxygen Consumption; Ranitidine; Regional Blood Flow; Terfenadine; Vascular Resistance; White People; Young Adult

2016
The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice.
    Clinical and translational science, 2016, Volume: 9, Issue:4

    Topics: Administration, Oral; Beverages; Female; Healthy Volunteers; Humans; Male; Malus; Terfenadine

2016
Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study.
    Allergology international : official journal of the Japanese Society of Allergology, 2017, Volume: 66, Issue:1

    Topics: Adult; Asian People; Benzimidazoles; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine

2017
Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.
    Clinical pharmacology and therapeutics, 2017, Volume: 102, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Female; Humans; Kidney Transplantation; Liver-Specific Organic Anion Transporter 1; Male; Midazolam; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Polymorphism, Single Nucleotide; Solute Carrier Organic Anion Transporter Family Member 1B3; Tacrolimus; Terfenadine; Young Adult

2017
[The effect of combined therapy on seasonal allergic rhinitis].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2016, Jul-05, Volume: 30, Issue:13

    Topics: Administration, Intranasal; Budesonide; Double-Blind Method; Glucocorticoids; Humans; Leukotriene Antagonists; Loratadine; Quality of Life; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Terfenadine

2016
Impact of ABCB1 genotype in Collies on the pharmacokinetics of R- and S-fexofenadine.
    Journal of veterinary pharmacology and therapeutics, 2018, Volume: 41, Issue:6

    Topics: Animals; Anti-Allergic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Female; Genotype; Half-Life; Male; Terfenadine

2018
Effects of a Novel Barley-Based Formulation on Allergic Rhinitis: A Randomized Controlled Trial.
    Endocrine, metabolic & immune disorders drug targets, 2019, Volume: 19, Issue:8

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Biomarkers; Child; Female; Histamine H1 Antagonists, Non-Sedating; Hordeum; Humans; Immunoglobulin E; Iran; Male; Middle Aged; Plant Extracts; Rhinitis, Allergic; Seeds; Terfenadine; Time Factors; Treatment Outcome; Young Adult

2019
Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung Cancer.
    Journal of clinical pharmacology, 2019, Volume: 59, Issue:8

    Topics: Acrylamides; Aged; Aniline Compounds; Anti-Allergic Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; Drug Interactions; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Protein Kinase Inhibitors; Terfenadine

2019
Bioavailability assessment of fexofenadine and montelukast in a fixed-dose combination tablet
    Allergologia et immunopathologia, 2021, Volume: 49, Issue:4

    Topics: Acetates; Area Under Curve; Biological Availability; Cross-Over Studies; Cyclopropanes; Humans; Quinolines; Rhinitis, Allergic; Sulfides; Tablets; Terfenadine

2021
Addition of oral fexofenadine to topical therapy leads to a significantly greater reduction in the serum interleukin-31 levels in mild to moderate paediatric atopic dermatitis.
    Clinical and experimental dermatology, 2022, Volume: 47, Issue:4

    Topics: Administration, Topical; Child; Dermatitis, Atopic; Double-Blind Method; Humans; Interleukins; Prospective Studies; Tacrolimus; Terfenadine; Treatment Outcome

2022
Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.
    Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:3

    Topics: Antioxidants; Catechin; Cross-Over Studies; Healthy Volunteers; HEK293 Cells; Humans; Pharmaceutical Preparations; Plant Extracts; Pseudoephedrine; Tea; Terfenadine

2022
Bioequivalence of 2 Pediatric Formulations of Fexofenadine Hydrochloride Oral Suspension.
    Clinical pharmacology in drug development, 2023, Volume: 12, Issue:12

    Topics: Adult; Child; Cross-Over Studies; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine; Therapeutic Equivalency

2023

Other Studies

365 other study(ies) available for terfenadine and fexofenadine

ArticleYear
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
    Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

    Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water

1998
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.
    Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

    Topics: Amino Acids, Aromatic; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structural Homology, Protein; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2003
A two-state homology model of the hERG K+ channel: application to ligand binding.
    Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Inhibitory effect of carboxylic acid group on hERG binding.
    Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21

    Topics: Benzamidines; Carboxylic Acids; Ether-A-Go-Go Potassium Channels; Factor Xa Inhibitors; Humans

2006
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cisapride; Dimerization; Ether-A-Go-Go Potassium Channels; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Piperidines; Pyridines; Sequence Homology, Amino Acid; Terfenadine

2009
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
    Bioorganic & medicinal chemistry letters, 2009, Sep-01, Volume: 19, Issue:17

    Topics: Animals; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Humans; Protein Binding; Receptors, Histamine H1; Structure-Activity Relationship; Terfenadine; Trans-Activators; Transcriptional Regulator ERG

2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption

2010
Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:4

    Topics: Cholesterol Ester Transfer Proteins; Drug Discovery; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; ROC Curve

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.
    Bioorganic & medicinal chemistry letters, 2012, Jun-01, Volume: 22, Issue:11

    Topics: Animals; Body Weight; Brain; Carbazoles; Cyclohexanecarboxylic Acids; Diet, High-Fat; Dogs; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Receptors, Pituitary Hormone; Structure-Activity Relationship

2012
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.
    Journal of medicinal chemistry, 2014, Oct-23, Volume: 57, Issue:20

    Topics: Anti-Bacterial Agents; Chemistry Techniques, Synthetic; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Staphylococcus aureus; Structure-Activity Relationship; Terfenadine; Topoisomerase II Inhibitors

2014
Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
    Journal of chromatography, 1991, Sep-18, Volume: 570, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Spectrometry, Fluorescence; Terfenadine

1991
Investigation of the stereoselective metabolism of the chiral H1-antihistaminic drug terfenadine by high-performance liquid chromatography.
    Journal of chromatography. A, 1995, Mar-03, Volume: 694, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Stereoisomerism; Terfenadine

1995
Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography.
    British journal of pharmacology, 1995, Volume: 116, Issue:1

    Topics: Administration, Oral; Adult; Animals; Brain; Carbon Radioisotopes; Chlorpheniramine; Doxepin; Guinea Pigs; Histamine H1 Antagonists; Humans; Male; Receptors, Histamine H1; Terfenadine; Tomography, Emission-Computed

1995
From the Food and Drug Administration.
    JAMA, 1997, Feb-05, Volume: 277, Issue:5

    Topics: Animal Feed; Animals; Biological Products; Histamine Antagonists; Histamine H1 Antagonists; Humans; Prion Diseases; Ruminants; Terfenadine; United States; United States Department of Agriculture; United States Food and Drug Administration

1997
[Introduction of a new antihistamine generation].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997, Volume: 48, Issue:8 Suppl

    Topics: Histamine Antagonists; Histamine H1 Antagonists; Humans; Hypersensitivity; Hypersensitivity, Immediate; Terfenadine

1997
[Drug side effects and their prevention].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997, Volume: 48, Issue:8 Suppl

    Topics: Arrhythmias, Cardiac; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Histamine H1 Antagonists; Humans; Hypersensitivity; Mixed Function Oxygenases; Terfenadine

1997
[Further development of terfenadine].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997, Volume: 48, Issue:8 Suppl

    Topics: Clinical Trials as Topic; Histamine Antagonists; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Terfenadine; Urticaria

1997
[Fexofenadine--progress in antihistamine therapy].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1997, Volume: 48, Issue:8 Suppl

    Topics: Histamine H1 Antagonists; Humans; Hypersensitivity; Hypersensitivity, Immediate; Terfenadine

1997
Effect of fexofenadine on eosinophil-induced changes in epithelial permeability and cytokine release from nasal epithelial cells of patients with seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3

    Topics: Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Chemokine CCL5; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cytokines; Endothelium, Vascular; Eosinophils; Epithelial Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine Antagonists; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Microspheres; Nasal Mucosa; Opsonin Proteins; Proteins; Rhinitis, Allergic, Seasonal; T-Lymphocytes; Terfenadine

1998
Terfenadine and fexofenadine reduce in vitro ICAM-1 expression on human continuous cell lines.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 81, Issue:6

    Topics: Cell Line; Histamine Antagonists; Humans; Integrin beta1; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-6; Procollagen; Terfenadine; Tumor Cells, Cultured

1998
Reply to Gonzalez and Estes.
    International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:4

    Topics: Adult; Aged; Aging; Histamine H1 Antagonists; Humans; Terfenadine

1999
QT lengthening and arrhythmias associated with fexofenadine.
    Lancet (London, England), 1999, Jun-12, Volume: 353, Issue:9169

    Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Histamine Antagonists; Humans; Risk Factors; Terfenadine

1999
Pharmacokinetic aspects of second-generation H1 antihistamines: a reply to Philpot.
    International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:6

    Topics: Administration, Oral; Area Under Curve; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Terfenadine

1999
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:8

    Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Genes, MDR; HeLa Cells; Histamine H1 Antagonists; Humans; LLC-PK1 Cells; Mice; Rats; Swine; Terfenadine; Tissue Distribution; Transfection; Vaccinia virus

1999
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
    Lancet (London, England), 1999, Mar-20, Volume: 353, Issue:9157

    Topics: Aged; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Syncope; Tachycardia, Ventricular; Terfenadine; Ventricular Fibrillation

1999
Causality assessment of adverse drug effects: when is rechallenge ethically acceptable?
    Lancet (London, England), 1999, Aug-21, Volume: 354, Issue:9179

    Topics: Arrhythmias, Cardiac; Ethics, Medical; Histamine H1 Antagonists; Humans; Terfenadine

1999
Fexofenadine and prolonged QT intervals.
    Nursing, 1999, Volume: 29, Issue:9

    Topics: Aged; Drug Monitoring; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Terfenadine

1999
A new synthesis of carboxyterfenadine (fexofenadine) and its bioisosteric tetrazole analogs.
    Farmaco (Societa chimica italiana : 1989), 1999, Sep-30, Volume: 54, Issue:9

    Topics: Histamine H1 Antagonists; Humans; Magnetic Resonance Spectroscopy; Terfenadine

1999
Prolonged QTc time and ventricular arrhythmia with fexofenadine.
    The American journal of cardiology, 1999, Nov-15, Volume: 84, Issue:10

    Topics: Arrhythmias, Cardiac; Heart Conduction System; Histamine H1 Antagonists; Humans; Terfenadine

1999
Nonsedating antihistamines should be preferred over sedating antihistamines in patients who drive.
    Annals of internal medicine, 2000, Mar-07, Volume: 132, Issue:5

    Topics: Automobile Driving; Diphenhydramine; Ethanol; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Terfenadine

2000
Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria.
    Drugs, 2000, Volume: 59, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Anti-Allergic Agents; Chronic Disease; Dose-Response Relationship, Drug; Headache; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria

2000
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2000, Volume: 50, Issue:451

    Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Cohort Studies; Histamine H1 Antagonists; Humans; Terfenadine

2000
Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice.
    BMJ (Clinical research ed.), 2000, Apr-29, Volume: 320, Issue:7243

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Cetirizine; Child; Child, Preschool; Consciousness Disorders; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Loratadine; Male; Middle Aged; Product Surveillance, Postmarketing; Sleep Stages; Terfenadine; Triprolidine

2000
The potential of active metabolites of antihistamines in the management of allergic disease.
    Allergy, 2000, Volume: 55, Issue:5

    Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases

2000
Fexofenadine-induced QT prolongation: a myth or fact?
    The British journal of dermatology, 2000, Volume: 142, Issue:6

    Topics: Controlled Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Long QT Syndrome; Terfenadine

2000
In vitro studies with fexofenadine, a new nonsedating histamine H1 receptor antagonist, on isolated human basophils.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49 Suppl 1

    Topics: Basophils; Dermatitis, Atopic; Enzyme Inhibitors; Histamine H1 Antagonists; Histamine Release; Humans; Immunoglobulin E; Protein Kinase C; Terfenadine

2000
Kinetics of injected histamine in cat plasma after antihistamine prophylaxis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49 Suppl 1

    Topics: Animals; Cats; Cimetidine; Ethylenediamines; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Kinetics; Male; Terfenadine

2000
Impact of interventions designed to increase market share and prescribing of fexofenadine at HMOs.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Oct-01, Volume: 57, Issue:19

    Topics: Analysis of Variance; Astemizole; Cetirizine; Cost Savings; Drug Costs; Drug Utilization; Health Maintenance Organizations; Histamine H1 Antagonists; Humans; Loratadine; Marketing of Health Services; Practice Patterns, Physicians'; Retrospective Studies; Terfenadine; United States

2000
Drug effects on driving performance.
    Annals of internal medicine, 2000, Oct-17, Volume: 133, Issue:8

    Topics: Automobile Driving; Diphenhydramine; Ethanol; Histamine H1 Antagonists; Humans; Research Design; Terfenadine

2000
Drug effects on driving performance.
    Annals of internal medicine, 2000, Oct-17, Volume: 133, Issue:8

    Topics: Automobile Driving; Diphenhydramine; Ethanol; Histamine H1 Antagonists; Humans; Research Design; Terfenadine

2000
Drug effects on driving performance.
    Annals of internal medicine, 2000, Oct-17, Volume: 133, Issue:8

    Topics: Automobile Driving; Diphenhydramine; Ethanol; Histamine H1 Antagonists; Humans; Research Design; Terfenadine

2000
Fixed solar urticaria to visible light successfully treated with fexofenadine.
    Photodermatology, photoimmunology & photomedicine, 2001, Volume: 17, Issue:1

    Topics: Anti-Allergic Agents; Female; Humans; Middle Aged; Sunlight; Terfenadine; Ultraviolet Rays; Urticaria

2001
Uptake and efflux of the peptidic delta-opioid receptor agonist.
    Neuroscience letters, 2001, Apr-06, Volume: 301, Issue:3

    Topics: Analgesics, Opioid; Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Calcium Channel Blockers; Carrier Proteins; Digoxin; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Estradiol; Histamine H1 Antagonists; Male; Mice; Mice, Knockout; Perfusion; Receptors, Opioid, delta; Terfenadine; Verapamil

2001
[Multiple prevention. On the way to an ideal antihistamine?].
    MMW Fortschritte der Medizin, 2000, Jan-13, Volume: 142, Issue:1-2

    Topics: Histamine H1 Antagonists; Humans; Mast Cells; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2000
Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein.
    Pharmaceutical research, 2000, Volume: 17, Issue:12

    Topics: Animals; Area Under Curve; Bile; Biological Transport, Active; Erythromycin; Histamine H1 Antagonists; Liver; Male; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Terfenadine

2000
Newer antihistamines.
    The Medical letter on drugs and therapeutics, 2001, Apr-30, Volume: 43, Issue:1103

    Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Somnambulism; Terfenadine

2001
Seldane approval may be withdrawn by FDA.
    AIDS patient care and STDs, 1997, Volume: 11, Issue:3

    Topics: Drug Approval; Drug Interactions; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perennial; Terfenadine; United States; United States Food and Drug Administration

1997
[Seasonal allergic rhinitis. Nasal obstruction can also beh improved].
    MMW Fortschritte der Medizin, 2001, May-03, Volume: 143, Issue:18

    Topics: Anti-Allergic Agents; Double-Blind Method; Humans; Loratadine; Multicenter Studies as Topic; Nasal Obstruction; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine

2001
A descriptive analysis of the use and cost of new-generation antihistamines in the treatment of allergic rhinitis: a retrospective database analysis.
    The American journal of managed care, 2001, Volume: 7, Issue:4 Suppl

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Databases as Topic; Drug Utilization Review; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Retrospective Studies; Rhinitis, Allergic, Perennial; Terfenadine; United States

2001
Identification of functionally variant MDR1 alleles among European Americans and African Americans.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:2

    Topics: Africa; Alleles; Anti-Allergic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black People; Cloning, Molecular; Digoxin; DNA Primers; Enzyme Inhibitors; Europe; Genes, MDR; Genetic Variation; Genotype; Haplotypes; Humans; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Terfenadine; Time Factors; White People

2001
Ugly wait at the counter. Insurer pushes to make allergy drugs nonprescription.
    Modern healthcare, 2001, Aug-06, Volume: 31, Issue:32

    Topics: Anti-Allergic Agents; Health Services Accessibility; Humans; Insurance Carriers; Legislation, Drug; Loratadine; Nonprescription Drugs; Terfenadine; United States; United States Food and Drug Administration

2001
Evaluation of the safety of fexofenadine from experience gained in general practice use in England in 1997.
    European journal of clinical pharmacology, 2001, Volume: 57, Issue:4

    Topics: Adult; Anti-Allergic Agents; England; Family Practice; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Product Surveillance, Postmarketing; Terfenadine

2001
The costs of nonsedating antihistamine therapy for allergic rhinitis in managed care: an updated analysis.
    The American journal of managed care, 2001, Volume: 7, Issue:15 Suppl

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Cetirizine; Child; Cohort Studies; Drug Costs; Economics, Pharmaceutical; Female; Health Care Costs; Histamine H1 Antagonists; Humans; Loratadine; Male; Managed Care Programs; Middle Aged; Retrospective Studies; Rhinitis, Allergic, Perennial; Terfenadine; United States

2001
Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Humans; Lymphocytes; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Terfenadine

2002
Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Jan-25, Volume: 766, Issue:2

    Topics: Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Mass Spectrometry; Terfenadine

2002
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].
    Terapevticheskii arkhiv, 2002, Volume: 74, Issue:3

    Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine

2002
[Hay fever and asthma. Many of your patients have both].
    MMW Fortschritte der Medizin, 2002, Apr-25, Volume: 144, Issue:17

    Topics: Asthma; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2002
Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block.
    Circulation, 2002, Jun-18, Volume: 105, Issue:24

    Topics: Anti-Arrhythmia Agents; Cell Line; Dose-Response Relationship, Drug; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Membrane Potentials; Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine

2002
Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:1

    Topics: Adult; Cell Count; Exercise; Female; Histamine H1 Antagonists; Humans; Hydroxyurea; Hypoxia; Inflammation Mediators; Leukotriene Antagonists; Leukotriene E4; Lung; Male; Oxygen Consumption; Pulmonary Gas Exchange; Respiratory Function Tests; Sports; Sputum; Terfenadine

2002
Are herbal products dietary supplements or drugs? An important question for public safety.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:6

    Topics: Anti-Allergic Agents; Cardiovascular System; Ephedra; Histamine H1 Antagonists; Humans; Hypericum; Pharmacokinetics; Plant Extracts; Terfenadine; United States; United States Food and Drug Administration

2002
Simultaneous determination of fexofenadine and its related compounds by HPLC.
    Journal of pharmaceutical and biomedical analysis, 2002, Jul-20, Volume: 29, Issue:4

    Topics: Capsules; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Histamine H1 Antagonists; Sensitivity and Specificity; Tablets; Terfenadine

2002
Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness.
    The Journal of allergy and clinical immunology, 2002, Volume: 110, Issue:1

    Topics: Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Inflammation; Lung; Mice; Mice, Inbred BALB C; T-Lymphocytes; Terfenadine

2002
Chronic urticaria and angioedema.
    The New England journal of medicine, 2002, Jul-18, Volume: 347, Issue:3

    Topics: Angioedema; Chronic Disease; Histamine H1 Antagonists; Humans; Terfenadine; Urticaria

2002
In vivo anti-inflammatory effects of fexofenadine in chronic idiopathic urticaria.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2002, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Biopsy, Needle; Case-Control Studies; Chronic Disease; Culture Techniques; E-Selectin; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Middle Aged; Probability; Prospective Studies; Reference Values; Severity of Illness Index; Terfenadine; Treatment Outcome; Urticaria; Vascular Cell Adhesion Molecule-1

2002
Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE.
    Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:20

    Topics: Adrenergic beta-Antagonists; Bronchodilator Agents; Chromatography, Liquid; Ephedrine; Histamine H1 Antagonists; Humans; Leprostatic Agents; Metoprolol; Pharmaceutical Preparations; Quality Control; Reproducibility of Results; Rifampin; Robotics; Solvents; Spectrometry, Mass, Electrospray Ionization; Terfenadine

2002
The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Aged; Amino Acid Sequence; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Base Sequence; Blotting, Western; Cation Transport Proteins; Cell Line; Colforsin; COS Cells; DNA; DNA Mutational Analysis; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Genotype; Histamine H1 Antagonists; Humans; Immunohistochemistry; Male; Membrane Potentials; Molecular Sequence Data; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Potassium Channels; Potassium Channels, Voltage-Gated; Pruritus; Sequence Homology, Amino Acid; Terfenadine; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Regulator ERG

2002
Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:11

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Depression, Chemical; Drug Interactions; Drug Stability; Fluorometry; Histamine H1 Antagonists; Humans; In Vitro Techniques; Kinetics; Rhodamines; Ritonavir; Terfenadine; Time Factors; Verapamil

2002
The use of antihistamines in safety-critical jobs: a meeting report.
    Current medical research and opinion, 2002, Volume: 18, Issue:6

    Topics: Aviation; Cognition; Histamine H1 Antagonists; Humans; Occupational Diseases; Occupations; Rhinitis, Allergic, Seasonal; Safety; Seasons; Sleep Stages; Terfenadine

2002
Inhibitory effects of oral prednisolone and fexofenadine on skin responses by prick tests with histamine and compound 48/80.
    Journal of dermatological science, 2002, Volume: 30, Issue:3

    Topics: Administration, Oral; Adult; Anti-Allergic Agents; Female; Glucocorticoids; Histamine; Humans; Hypersensitivity, Immediate; Male; p-Methoxy-N-methylphenethylamine; Prednisolone; Skin Tests; Terfenadine

2002
Facial swelling and eosinophilia in a 44-year-old woman.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Angioedema; Cefuroxime; Cetirizine; Diagnosis, Differential; Drug Hypersensitivity; Edema; Eosinophilia; Face; Fatigue; Female; Humans; Hypereosinophilic Syndrome; Indoles; Lansoprazole; Methylprednisolone; Methylprednisolone Acetate; Omeprazole; Penicillins; Phenylcarbamates; Prednisone; Ranitidine; Recurrence; Sulfonamides; Syndrome; Terfenadine; Tosyl Compounds

2002
Internal standard signal suppression by co-eluting analyte in isotope dilution LC-ESI-MS.
    The Analyst, 2003, Volume: 128, Issue:1

    Topics: Calibration; Chromatography, Liquid; Dapsone; Ephedrine; Isotope Labeling; Pharmaceutical Preparations; Spectrometry, Mass, Electrospray Ionization; Terfenadine

2003
The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique.
    British journal of clinical pharmacology, 2003, Volume: 55, Issue:2

    Topics: Adult; Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Intestinal Absorption; Jejunum; Ketoconazole; Male; Permeability; Terfenadine

2003
Decongestant effects of antihistamines: a class effect?
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:3

    Topics: Controlled Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Loratadine; Nasal Decongestants; Rhinitis, Allergic, Seasonal; Terfenadine

2003
Solar urticaria induced by infrared radiation.
    Clinical and experimental dermatology, 2003, Volume: 28, Issue:2

    Topics: Female; Histamine H1 Antagonists; Humans; Infrared Rays; Middle Aged; PUVA Therapy; Terfenadine; Urticaria

2003
[Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2003, Volume: 14, Issue:79

    Topics: Adult; Anti-Allergic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Receptors, Histamine H1; Terfenadine; Time Factors

2003
Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.
    BMC family practice, 2003, Aug-13, Volume: 4

    Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Patient Satisfaction; Rhinitis, Allergic, Seasonal; Sleep Wake Disorders; Terfenadine; Treatment Outcome

2003
Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4 Suppl

    Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Histamine H1 Antagonists; Immunoglobulin E; Injections, Intraperitoneal; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; T-Lymphocytes; Terfenadine; Time Factors; Treatment Outcome

2003
Is 3-mm less drowsiness important?
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4

    Topics: Anti-Allergic Agents; Automobile Driving; Cetirizine; Humans; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Sleep Stages; Terfenadine; Treatment Outcome

2003
Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro.
    International archives of allergy and immunology, 2004, Volume: 133, Issue:3

    Topics: Adult; Allergens; Antigens, Plant; Cell Division; Chemokine CCL17; Chemokines, CC; Dose-Response Relationship, Immunologic; Histamine H1 Antagonists; Humans; Interferon-gamma; Interleukin-4; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Plant Proteins; Polymerase Chain Reaction; Rhinitis, Allergic, Seasonal; RNA, Messenger; Terfenadine

2004
The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis.
    International immunopharmacology, 2004, Volume: 4, Issue:3

    Topics: Anaphylaxis; Animals; Antigens, Helminth; Chemokine CCL11; Chemokines, CC; Dose-Response Relationship, Drug; Endotoxins; Eosinophilia; Histamine H1 Antagonists; Interleukin-5; Intestine, Small; Male; Mast Cells; Mice; Species Specificity; Terfenadine; Trichinella spiralis; Trichinellosis

2004
Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.
    Managed care interface, 2004, Volume: 17, Issue:2

    Topics: Anti-Allergic Agents; Cetirizine; Choice Behavior; Data Collection; Humans; Loratadine; Managed Care Programs; Nonprescription Drugs; Patient Satisfaction; Terfenadine; United States

2004
Lack of association between fexofenadine and rhabdomyolysis.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2004, Apr-01, Volume: 61, Issue:7

    Topics: Histamine H1 Antagonists; Humans; Rhabdomyolysis; Terfenadine; United States

2004
Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:5

    Topics: Adult; Anti-Allergic Agents; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Flow Cytometry; Fluorescent Dyes; Genotype; Humans; Lymphocytes; Male; Mixed Function Oxygenases; Omeprazole; Rhodamine 123; Terfenadine

2004
Determination of fexofenadine in human plasma using 96-well solid phase extraction and HPLC with tandem mass spectrometric detection.
    Journal of pharmaceutical and biomedical analysis, 2004, Jun-29, Volume: 35, Issue:4

    Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Terfenadine

2004
Liquid chromatographic determination of fexofenadine in human plasma with fluorescence detection.
    Journal of pharmaceutical and biomedical analysis, 2004, Jun-29, Volume: 35, Issue:4

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Spectrometry, Fluorescence; Terfenadine

2004
A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine".
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2004, Volume: 20, Issue:8

    Topics: Anti-Allergic Agents; Biosensing Techniques; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Ions; Membranes, Artificial; Molecular Structure; Solutions; Terfenadine; Time Factors

2004
Transport characteristics of fexofenadine in the Caco-2 cell model.
    Pharmaceutical research, 2004, Volume: 21, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Diffusion; Humans; Inhibitory Concentration 50; Kinetics; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Permeability; Terfenadine

2004
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine

2004
Suppressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:8

    Topics: Cells, Cultured; Chemokine CCL5; Chemokines; Chemotactic Factors; Eosinophils; Fibroblasts; Histamine H1 Antagonists; Humans; Lipopolysaccharides; Nasal Mucosa; Nasal Polyps; RNA, Messenger; Terfenadine

2004
The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride.
    Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:9

    Topics: Administration, Oral; Adult; Age Factors; Analysis of Variance; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Infant; Male; Models, Biological; Rhinitis, Allergic, Seasonal; Sex Factors; Terfenadine

2004
A variant 2677A allele of the MDR1 gene affects fexofenadine disposition.
    Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:5

    Topics: Adult; Alleles; Area Under Curve; Exons; Female; Gene Frequency; Genes, MDR; Genetic Variation; Genotype; Haplotypes; Histamine H1 Antagonists; Humans; Korea; Male; Polymorphism, Genetic; Terfenadine

2004
Effect of fruit juices on the oral bioavailability of fexofenadine in rats.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Beverages; Biological Availability; Citrus; Food-Drug Interactions; Fruit; Histamine H1 Antagonists; Intestinal Absorption; Male; Malus; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Terfenadine

2005
Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:12

    Topics: Adult; Cells, Cultured; Depression, Chemical; Female; Fibroblasts; Histamine H1 Antagonists; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloproteases; Nasal Mucosa; Terfenadine; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2

2004
Preferential downmodulation of certain chemokines by fexofenadine in human keratinocytes.
    Journal of dermatological science, 2005, Volume: 38, Issue:1

    Topics: Cell Line; Chemokines; Down-Regulation; Histamine H1 Antagonists; Humans; Keratinocytes; Terfenadine

2005
P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Blood-Brain Barrier; Histamine H1 Antagonists; Intestine, Small; Male; Mice; Mice, Knockout; Rats; Rats, Mutant Strains; Terfenadine

2005
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:5

    Topics: Area Under Curve; Heterozygote; Histamine H1 Antagonists; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Polymorphism, Genetic; Terfenadine

2005
Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria.
    Health and quality of life outcomes, 2005, May-20, Volume: 3

    Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Clinical Trials, Phase III as Topic; Data Interpretation, Statistical; Dermatology; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pruritus; Quality of Life; Self Disclosure; Severity of Illness Index; Sickness Impact Profile; Surveys and Questionnaires; Terfenadine; Urticaria

2005
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:10

    Topics: Cell Line; Estradiol; Estrone; Histamine H1 Antagonists; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Organic Anion Transport Protein 1; Sincalide; Terfenadine

2005
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
    Pharmacology, 2005, Volume: 75, Issue:2

    Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Animal; Guinea Pigs; Indoles; Leukotrienes; Male; Ovalbumin; Phenylcarbamates; Pyrilamine; Rhinitis; Sulfonamides; Terfenadine; Thromboxanes; Tosyl Compounds

2005
Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2005, Volume: 26, Issue:2

    Topics: Anti-Allergic Agents; Biological Transport; Cell Membrane Permeability; Cell Polarity; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Electric Impedance; Epithelial Cells; Humans; Nasal Mucosa; Terfenadine; Time Factors

2005
The advantages of the Ussing chamber in drug absorption studies.
    Journal of biomolecular screening, 2005, Volume: 10, Issue:5

    Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Cell Membrane; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Jejunum; Ketoconazole; Kinetics; Mass Spectrometry; Permeability; Protein Binding; Rats; Terfenadine; Time Factors

2005
Assessing the therapeutic benefits of antihistamines for the treatment of chronic idiopathic urticaria--a requirement for well-designed comparative clinical studies.
    The Journal of dermatological treatment, 2005, Volume: 16, Issue:3

    Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine; Treatment Outcome; Urticaria

2005
Development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2005, Aug-11, Volume: 8, Issue:2

    Topics: Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Solubility; Tablets, Enteric-Coated; Terfenadine

2005
Determination of fexofenadine in tablets by capillary electrophoresis in free solution and in solution with cyclodextrins as analyte carriers.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:8

    Topics: Anti-Allergic Agents; beta-Cyclodextrins; Chemistry, Pharmaceutical; Drug Carriers; Electrolytes; Electrophoresis, Capillary; Histamine H1 Antagonists; Tablets; Terfenadine

2005
Differential effects of fexofenadine on arachidonic acid metabolism in cultured human monocytes.
    Pharmacology, 2006, Volume: 76, Issue:1

    Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Arachidonic Acid; Cells, Cultured; Dinoprostone; Histamine H1 Antagonists; Humans; Leukotrienes; Lipopolysaccharides; Monocytes; Terfenadine; Zymosan

2006
Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2005, Volume: 54, Issue:9

    Topics: Animals; Cetirizine; CHO Cells; Cricetinae; Cricetulus; Histamine H1 Antagonists; Humans; Loratadine; Piperazines; Predictive Value of Tests; Receptors, Histamine H1; Recombination, Genetic; Terfenadine; Urticaria

2005
Treatment of ear pain in pilots in flight.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 95, Issue:4

    Topics: Aerospace Medicine; Anti-Allergic Agents; Humans; Loratadine; Pain; Rhinitis, Allergic, Seasonal; Steroids; Terfenadine

2005
The methanol disolvate and the dihydrate of fexofenadine, an antihistamine drug.
    Acta crystallographica. Section C, Crystal structure communications, 2005, Volume: 61, Issue:Pt 12

    Topics: Crystallography, X-Ray; Histamine H1 Antagonists, Non-Sedating; Hydrogen Bonding; Methanol; Models, Molecular; Molecular Conformation; Molecular Structure; Solubility; Terfenadine

2005
The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis.
    The Journal of dermatology, 2005, Volume: 32, Issue:10

    Topics: Adult; Anti-Allergic Agents; Cetirizine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; E-Selectin; Female; Histamine H1 Antagonists; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Male; Olopatadine Hydrochloride; Substance P; Terfenadine; Vascular Cell Adhesion Molecule-1

2005
[Wheat anaphylaxis enhanced by administration of acetylsalicylic acid or by exercise].
    Arerugi = [Allergy], 2005, Volume: 54, Issue:10

    Topics: Administration, Oral; Adult; Aspirin; Cromolyn Sodium; Exercise; Female; Humans; Radioallergosorbent Test; Skin Tests; Terfenadine; Wheat Hypersensitivity

2005
Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5

    Topics: Anti-Allergic Agents; Biological Transport, Active; Chromatography, Liquid; Drug Interactions; Humans; Kidney; Kinetics; Mass Spectrometry; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Probenecid; Renal Agents; Terfenadine

2006
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Biological Transport, Active; Brain; Chromatography, Liquid; Intestinal Absorption; Kinetics; LLC-PK1 Cells; Male; Mass Spectrometry; Mice; Mice, Knockout; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Swine; Terfenadine; Verapamil

2006
Fexofenadine in horses: pharmacokinetics, pharmacodynamics and effect of ivermectin pretreatment.
    Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:2

    Topics: Animals; Antiparasitic Agents; Area Under Curve; Biological Availability; Drug Interactions; Female; Half-Life; Histamine H1 Antagonists; Horses; Ivermectin; Terfenadine

2006
Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata.
    The Journal of dermatology, 2006, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Alopecia Areata; Cohort Studies; Cyclopropanes; Dermatitis, Contact; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Male; Middle Aged; Prospective Studies; Pruritus; Risk Assessment; Severity of Illness Index; Terfenadine; Treatment Outcome

2006
First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7

    Topics: Animals; Antipyrine; Bile; Calcium Channel Blockers; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Intestinal Absorption; Liver; Models, Animal; Perfusion; Swine; Terfenadine; Verapamil

2006
Pustular exacerbation of psoriasis due to fexofenadine.
    Clinical and experimental dermatology, 2006, Volume: 31, Issue:3

    Topics: Acute Disease; Drug Eruptions; Histamine H1 Antagonists; Humans; Male; Middle Aged; Psoriasis; Terfenadine

2006
Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:2

    Topics: Animals; Bile; Biotransformation; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Hepatocytes; Histamine H1 Antagonists; Liver; Male; Mass Spectrometry; Models, Statistical; Pharmaceutical Preparations; Protein Binding; Rats; Rats, Wistar; Terfenadine

2006
In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist.
    Drugs in R&D, 2006, Volume: 7, Issue:4

    Topics: Animals; Benzimidazoles; Bradykinin; Bronchial Spasm; Capillary Permeability; Cetirizine; Dermatitis; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Antagonists; Hypersensitivity; Male; Mice; Molecular Structure; Oxazolone; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H1; Serotonin; Structure-Activity Relationship; Terfenadine; Time Factors

2006
Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A.
    Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:9

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cardiotonic Agents; Chromatography, Liquid; Digoxin; Genistein; Half-Life; Histamine H1 Antagonists; Injections, Intravenous; Male; Mass Spectrometry; Paclitaxel; Rats; Rats, Sprague-Dawley; Terfenadine

2006
Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biliary Tract; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Injections, Intraperitoneal; Kinetics; Lipopolysaccharides; Liver; Male; Metabolic Clearance Rate; Organic Anion Transporters; Perfusion; Rats; Rats, Sprague-Dawley; Terfenadine

2006
Saliva secretion in patients with allergic rhinitis.
    International archives of allergy and immunology, 2006, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Patient Satisfaction; Pilot Projects; Rhinitis; Saliva; Salivary Glands; Terfenadine; Xerostomia

2006
Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Citric Acid; Cough; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Histamine; Histamine H1 Antagonists, Non-Sedating; Male; Purinergic P2 Receptor Antagonists; Receptors, Histamine H1; Receptors, Purinergic P2; Receptors, Purinergic P2X; Reflex; Terfenadine

2006
Combination therapy using fexofenadine, disodium cromoglycate, and a hypoallergenic amino acid-based formula induced remission in a patient with steroid-dependent, chronically active ulcerative colitis.
    International journal of colorectal disease, 2007, Volume: 22, Issue:7

    Topics: Administration, Oral; Adult; Amino Acids; Anti-Asthmatic Agents; Biopsy; Colitis, Ulcerative; Colonoscopy; Cromolyn Sodium; Drug Therapy, Combination; Follow-Up Studies; Glucocorticoids; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Remission Induction; Terfenadine

2007
Marketing of a new non-sedating antihistamine (fexofenadine) puts an additional burden on healthcare system resources in Israel.
    The European journal of general practice, 2006, Volume: 12, Issue:2

    Topics: Commerce; Cost-Benefit Analysis; Cross-Sectional Studies; Delivery of Health Care; Drug Prescriptions; Histamine H1 Antagonists, Non-Sedating; Humans; Israel; Loratadine; Marketing of Health Services; Terfenadine

2006
Transporter-mediated intestinal absorption of fexofenadine in rats.
    Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:4

    Topics: Animals; Anti-Allergic Agents; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Dose-Response Relationship, Drug; Estrone; Intestinal Absorption; Ketoconazole; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Wistar; Terfenadine; Xenopus

2006
Simultaneous quantification of fexofenadine and pseudoephedrine in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: method development, validation and application to a clinical study.
    Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:20

    Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Complex Mixtures; Ephedrine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terfenadine

2006
Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer.
    International journal of pharmaceutics, 2007, Feb-07, Volume: 330, Issue:1-2

    Topics: Cell Membrane Permeability; Cell Survival; Drug Synergism; Epithelial Cells; Formazans; Histamine H1 Antagonists, Non-Sedating; Humans; Microscopy, Confocal; Nasal Mucosa; Poloxamer; Polysorbates; Sodium Cholate; Surface-Active Agents; Taurocholic Acid; Terfenadine; Tetrazolium Salts

2007
New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro.
    Pharmacology, 2006, Volume: 78, Issue:3

    Topics: Animals; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Sheep; Terfenadine

2006
QT interval prolongation and beyond.
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2006, Volume: 11, Issue:4

    Topics: Animals; Anti-Allergic Agents; Dogs; Electrocardiography; Heart Rate; Humans; Long QT Syndrome; Terfenadine

2006
The proarrhythmic antihistaminic drug terfenadine increases spontaneous calcium release in human atrial myocytes.
    European journal of pharmacology, 2006, Dec-28, Volume: 553, Issue:1-3

    Topics: Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Cyproheptadine; Electrophysiology; Histamine H1 Antagonists; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Membrane Potentials; Microscopy, Confocal; Myocytes, Cardiac; Patch-Clamp Techniques; Sarcoplasmic Reticulum; Terfenadine

2006
Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3

    Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Ketoconazole; Liver; Macaca fascicularis; Male; Microsomes; Midazolam; Terfenadine

2007
Ultrarush venom desensitization after systemic reactions during conventional venom immunotherapy.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:5

    Topics: Adult; Anti-Allergic Agents; Desensitization, Immunologic; Female; Humans; Hypersensitivity, Immediate; Prednisolone; Ranitidine; Terfenadine; Wasp Venoms

2006
Quantification of fexofenadine in human plasma by liquid chromatography coupled to electrospray tandem mass spectrometry using mosapride as internal standard.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2

    Topics: Benzamides; Chromatography, High Pressure Liquid; Drug Stability; Humans; Morpholines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine

2007
Pharmacokinetics of fexofenadine enantiomers in healthy subjects.
    Chirality, 2007, Volume: 19, Issue:3

    Topics: Adult; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Stereoisomerism; Terfenadine

2007
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.
    European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:10

    Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunctivitis, Allergic; Cromolyn Sodium; Diabetes Mellitus, Type 1; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Piperazines; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine

2006
Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines.
    Journal of investigational allergology & clinical immunology, 2007, Volume: 17, Issue:1

    Topics: Cells, Cultured; Cetirizine; Dibenzoxepins; Histamine H1 Antagonists, Non-Sedating; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Loratadine; Olopatadine Hydrochloride; RNA, Messenger; T-Lymphocytes; Terfenadine

2007
Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3

    Topics: Administration, Oral; Animals; Animals, Suckling; Chlorpheniramine; Cyproheptadine; Dibenzazepines; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Rats; Rats, Wistar; Seizures; Terfenadine; Time Factors

2007
Simple and reliable HPLC analysis of fexofenadine hydrochloride in tablets and its application to dissolution studies.
    Die Pharmazie, 2007, Volume: 62, Issue:2

    Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Reference Standards; Reproducibility of Results; Solubility; Spectrophotometry, Ultraviolet; Tablets; Terfenadine

2007
[Treatment of allergic rhinitis associated with hypothyroidism].
    Vestnik otorinolaringologii, 2006, Issue:6

    Topics: Adult; Anti-Allergic Agents; Female; Humans; Hypothyroidism; Immunoglobulins; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine

2006
Formaldehyde-induced urticarial vasculitis.
    The Australasian journal of dermatology, 2007, Volume: 48, Issue:3

    Topics: Adult; Drug Therapy, Combination; Formaldehyde; Glucocorticoids; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Occupational Exposure; Prednisolone; Serum Sickness; Students, Medical; Terfenadine; Urticaria; Vasculitis, Leukocytoclastic, Cutaneous

2007
Alternative and improved method for the simultaneous determination of fexofenadine and pseudoephedrine in their combined tablet formulation.
    Journal of pharmaceutical and biomedical analysis, 2007, Dec-21, Volume: 45, Issue:5

    Topics: Calibration; Chromatography, High Pressure Liquid; Drug Combinations; Histamine H1 Antagonists, Non-Sedating; Least-Squares Analysis; Molecular Structure; Nasal Decongestants; Pseudoephedrine; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets; Terfenadine; Time Factors

2007
Microdose clinical trial: quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2

    Topics: Anti-Allergic Agents; Calibration; Chromatography, Liquid; Humans; Molecular Structure; Randomized Controlled Trials as Topic; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine

2007
Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry.
    Analytical chemistry, 2007, Nov-01, Volume: 79, Issue:21

    Topics: Atmospheric Pressure; Humans; Molecular Weight; Particle Size; Plant Leaves; Plant Roots; Plant Stems; Proteins; Reserpine; Seedlings; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tagetes; Terfenadine; Verapamil

2007
Suppressive activity of fexofenadine hydrochloride on nitric oxide production in-vitro and in-vivo.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:10

    Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression Regulation; Histamine H1 Antagonists, Non-Sedating; Hypersensitivity; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Nasal Polyps; Nitric Oxide; Nitric Oxide Synthase Type II; RNA, Messenger; Terfenadine; Time Factors; Tumor Necrosis Factor-alpha

2007
Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:1

    Topics: Animals; Bile; Histamine H1 Antagonists, Non-Sedating; Liver; Male; Membrane Transport Proteins; Metabolic Clearance Rate; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rats; Rats, Inbred Strains; Species Specificity; Terfenadine

2008
Fexofenadine downmodulates antigen-presenting ability of murine epidermal Langerhans cells.
    Journal of dermatological science, 2008, Volume: 49, Issue:1

    Topics: Animals; Anti-Allergic Agents; Cells, Cultured; Down-Regulation; Epidermal Cells; Langerhans Cells; Mice; Mice, Inbred BALB C; Terfenadine

2008
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:2

    Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Fungal Proteins; Guinea Pigs; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Male; Methacholine Chloride; Respiratory Hypersensitivity; Terfenadine

2008
Isolation and structure elucidation of photodegradation products of fexofenadine.
    Journal of pharmaceutical and biomedical analysis, 2008, Jan-22, Volume: 46, Issue:2

    Topics: Histamine H1 Antagonists; Molecular Structure; Photochemistry; Spectrophotometry, Ultraviolet; Terfenadine

2008
Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis.
    Allergy, 2007, Volume: 62, Issue:12

    Topics: Adolescent; Anaphylaxis; Anti-Asthmatic Agents; Cold Temperature; Cromolyn Sodium; Drug Therapy, Combination; Exercise; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Pruritus; Swimming; Terfenadine; Treatment Outcome; Triticum; Urticaria; Water; Wheat Hypersensitivity

2007
[Linear dermatitis due to shiitake mushrooms].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2007, Volume: 58, Issue:12

    Topics: Administration, Oral; Administration, Topical; Adult; Androstadienes; Anti-Allergic Agents; Dermatitis, Atopic; Drug Therapy, Combination; Fluticasone; Food Hypersensitivity; Humans; Hypersensitivity, Immediate; Male; Shiitake Mushrooms; Terfenadine

2007
Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms.
    Journal of pharmaceutical and biomedical analysis, 2008, Jan-22, Volume: 46, Issue:2

    Topics: Cetirizine; Chromatography, High Pressure Liquid; Dosage Forms; Histamine H1 Antagonists; Pharmaceutical Preparations; Pseudoephedrine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Terfenadine

2008
Fexofenadine/cyclodextrin inclusion complexation: phase solubility, thermodynamic, physicochemical, and computational analysis.
    Drug development and industrial pharmacy, 2007, Volume: 33, Issue:11

    Topics: Calorimetry, Differential Scanning; Cyclodextrins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Osmolar Concentration; Solubility; Terfenadine; Thermodynamics; X-Ray Diffraction

2007
Two cases of alopecia areata responsive to fexofenadine.
    The Journal of dermatology, 2007, Volume: 34, Issue:12

    Topics: Adult; Aged; Alopecia Areata; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine

2007
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:4

    Topics: Animals; Biological Transport; Cell Line; Dogs; Drug Interactions; Humans; Liver; Pharmaceutical Preparations; Terfenadine

2008
Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cell Line; Dogs; Gene Expression Regulation; Glutathione; Humans; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Quinolines; Recombinant Proteins; Terfenadine

2008
Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5

    Topics: Animals; Bile; Histamine H1 Antagonists, Non-Sedating; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Terfenadine

2008
Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Dogs; Female; Intestinal Absorption; Loperamide; Male; Mutation; Quinidine; Terfenadine

2008
Non-interventional study comparing treatment satisfaction in patients treated with antihistamines.
    Clinical drug investigation, 2008, Volume: 28, Issue:4

    Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Child, Preschool; Data Collection; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Europe; Female; Histamine H1 Antagonists; Humans; Infant; Male; Middle Aged; Patient Satisfaction; Piperazines; Prevalence; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Urticaria

2008
Relative contribution of absorptive and secretory transporters to the intestinal absorption of fexofenadine in rats.
    International journal of pharmaceutics, 2008, Sep-01, Volume: 361, Issue:1-2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Dose-Response Relationship, Drug; Duodenum; Histamine H1 Antagonists, Non-Sedating; Ileum; Intestinal Absorption; Jejunum; Male; Organic Anion Transporters; Permeability; Rats; Rats, Wistar; Terfenadine

2008
A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma--application to preclinical pharmacokinetics.
    Talanta, 2008, Jul-15, Volume: 76, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Fluorescence; Rats; Reproducibility of Results; Terfenadine

2008
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria

2008
Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Administration, Oral; Animals; Antirheumatic Agents; Area Under Curve; Azithromycin; Biological Transport, Active; Cell Line; Clarithromycin; Dogs; Histamine H1 Antagonists, Non-Sedating; Infusions, Intravenous; Intestinal Absorption; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley; Rifamycins; Taurocholic Acid; Terfenadine; Transfection

2008
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Algorithms; Animals; Biological Transport, Active; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Diffusion; Estrone; Fatty Acids, Monounsaturated; Fluvastatin; Hepatocytes; Indoles; Kinetics; Male; Membranes, Artificial; Models, Biological; Naphthalenes; Oligopeptides; Organic Anion Transporters; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Piperidines; Quinolines; Rats; Rats, Wistar; Sincalide; Temperature; Terfenadine

2008
Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2008, Volume: 47, Issue:6

    Topics: Animals; Antipyrine; Catheterization; Cost-Benefit Analysis; Femoral Artery; Hematocrit; Jugular Veins; Male; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Surgical Procedures, Operative; Terfenadine; Time Factors; Triazoles

2008
The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:3

    Topics: Cell Line; Cimetidine; Drug Interactions; Humans; Kidney; Organic Cation Transport Proteins; Probenecid; Terfenadine

2009
Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Mice; Terfenadine

2009
IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model.
    International archives of allergy and immunology, 2009, Volume: 149, Issue:4

    Topics: Animals; Anti-Allergic Agents; Carbazoles; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Interleukin-16; Mice; Mice, Inbred BALB C; Nasal Mucosa; Ovalbumin; Platelet Aggregation Inhibitors; Rhinitis, Allergic, Perennial; Sulfonamides; Terfenadine

2009
Multiple H1-antihistamine-induced urticaria.
    The Journal of dermatology, 2009, Volume: 36, Issue:4

    Topics: Administration, Oral; Adult; Drug Eruptions; Female; Histamine; Histamine H1 Antagonists; Humans; Immunologic Tests; Leukotriene B4; Loratadine; Piperidines; Pyridines; Skin Tests; Terfenadine; Urticaria

2009
Visualization of first-pass drug metabolism of terfenadine by MALDI-imaging mass spectrometry.
    Drug metabolism letters, 2008, Volume: 2, Issue:1

    Topics: Animals; Biological Availability; Histamine H1 Antagonists, Non-Sedating; Intestinal Mucosa; Liver; Male; Mice; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Terfenadine; Tissue Distribution

2008
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:12

    Topics: Animals; Anti-Allergic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estradiol; Hypnotics and Sedatives; Intestinal Absorption; Isoquinolines; Male; Midazolam; Pharmaceutical Preparations; Prazosin; Quinazolines; Rats; Rats, Sprague-Dawley; Sympatholytics; Terfenadine

2009
Pharmacokinetic drug interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009, Jun-28, Volume: 37, Issue:3-4

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Histamine H1 Antagonists; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intestinal Absorption; Male; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Terfenadine

2009
Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function.
    Pharmaceutical research, 2009, Volume: 26, Issue:8

    Topics: Animals; Biliary Tract; Cells, Cultured; Histamine H1 Antagonists, Non-Sedating; Humans; Liver; Models, Biological; Molecular Probes; Rats; Rats, Wistar; Terfenadine

2009
Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases.
    The Journal of dermatology, 2009, Volume: 36, Issue:6

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Alopecia Areata; Child; Child, Preschool; Cyclobutanes; Cyclopropanes; Dermatologic Agents; Female; Humans; Hypersensitivity; Immunotherapy; Male; Middle Aged; Retrospective Studies; Terfenadine; Young Adult

2009
Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics.
    Urological research, 2009, Volume: 37, Issue:4

    Topics: Diagnosis, Differential; Glucocorticoids; Histamine H1 Antagonists, Non-Sedating; Histamine H2 Antagonists; Humans; Hysteroscopy; Male; Mast Cells; Mastocytosis, Systemic; Middle Aged; Physical Examination; Prednisolone; Ranitidine; Terfenadine; Tomography, X-Ray Computed; Treatment Outcome; Ureteral Calculi; Urolithiasis

2009
Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: application to a clinical pharmacokinetic study.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Chromatography, Liquid; Female; Fractional Precipitation; Histamine H1 Antagonists, Non-Sedating; Humans; Linear Models; Male; Proteins; Sensitivity and Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult

2010
Long-term effects of Panax ginseng on disposition of fexofenadine in rats in vivo.
    The American journal of Chinese medicine, 2009, Volume: 37, Issue:4

    Topics: Animals; Anti-Allergic Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Metabolic Clearance Rate; Panax; Plant Preparations; Random Allocation; Rats; Rats, Sprague-Dawley; Terfenadine; Time Factors

2009
Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.
    International archives of allergy and immunology, 2010, Volume: 151, Issue:1

    Topics: Acetates; Alcohols; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Cetirizine; Drug Interactions; Female; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Hydroxyzine; Hypersensitivity; Immunoglobulin G; Interleukin-4; Leukocytes; Loratadine; Male; Mice; Mice, Inbred BALB C; Nasal Lavage Fluid; Nasal Mucosa; Pentobarbital; Piperazines; Sneezing; Terfenadine

2010
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:10

    Topics: Adult; Aged; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Urea Nitrogen; Cytochrome P-450 CYP3A; Enterocytes; Female; Hepatocytes; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Organic Anion Transporters; Prospective Studies; Rats; Rats, Sprague-Dawley; Terfenadine

2009
Effect of St John's wort on the disposition of fexofenadine in the isolated perfused rat liver.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cyclosporine; Drug Interactions; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Hypericum; Liver; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Terfenadine

2009
Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats.
    Pharmacology, 2009, Volume: 84, Issue:5

    Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Dibenzoxepins; Disease Models, Animal; Drug Administration Schedule; Histamine H1 Antagonists, Non-Sedating; Male; Nerve Growth Factor; Olopatadine Hydrochloride; Rats; Rats, Inbred BN; Rhinitis, Allergic, Seasonal; Terfenadine; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A

2009
Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:2

    Topics: Biological Transport; Caco-2 Cells; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Membrane Permeability; Diffusion; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Esters; Humans; Intestinal Absorption; Nitrophenols; Prodrugs; Propranolol; Terfenadine

2010
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
    Drugs, 2009, Volume: 69, Issue:18

    Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Cetirizine; Child; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Leukotriene Antagonists; Loratadine; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Sulfides; Tablets; Terfenadine; Treatment Outcome

2009
[Administration of premedication with fexofenadine for paclitaxel-induced hypersensitive reactions in breast cancer patients complicated with closed-angle glaucoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:1

    Topics: Anti-Allergic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Hypersensitivity; Female; Glaucoma, Angle-Closure; Humans; Middle Aged; Paclitaxel; Premedication; Terfenadine

2010
Allergies in India: a study on medication compliance.
    Journal of the Indian Medical Association, 2009, Volume: 107, Issue:7

    Topics: Adolescent; Adult; Anti-Allergic Agents; Asthma; Bronchodilator Agents; Budesonide; Child; Ethanolamines; Female; Formoterol Fumarate; Humans; Immunoglobulin E; India; Male; Patient Compliance; Rhinitis, Allergic, Perennial; Skin Tests; Spirometry; Terfenadine; Treatment Outcome; Urticaria

2009
Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis.
    Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents; Antigens, Plant; Artemisia; Betula; Disease Progression; Eosinophil Cationic Protein; Female; Histamine; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Leukotriene D4; Male; Middle Aged; Nasal Lavage Fluid; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome

2009
Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Apr-16, Volume: 40, Issue:1

    Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Area Under Curve; Biological Availability; Cell Line; Drug Carriers; Electric Impedance; Epithelial Cells; Humans; Hyaluronic Acid; Microscopy, Electron, Scanning; Microspheres; Particle Size; Permeability; Polyethylene Glycols; Rabbits; Respiratory Mucosa; Surface Properties; Taurocholic Acid; Terfenadine

2010
Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction.
    Journal of food science, 2010, Volume: 75, Issue:3

    Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Food-Drug Interactions; Gastric Emptying; Half-Life; Histamine H1 Antagonists, Non-Sedating; Intestinal Absorption; Male; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Terfenadine

2010
Melt-in-mouth pellets of fexofenadine hydrochloride using crospovidone as an extrusion-spheronisation aid.
    AAPS PharmSciTech, 2010, Volume: 11, Issue:2

    Topics: Administration, Oral; Anti-Allergic Agents; Capsules; Drug Compounding; Drug Stability; Excipients; Mouth; Povidone; Solubility; Terfenadine

2010
Preparation and evaluation of fexofenadine microemulsions for intranasal delivery.
    International journal of pharmaceutics, 2010, Aug-16, Volume: 395, Issue:1-2

    Topics: Administration, Intranasal; Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Compounding; Emulsions; Glycerides; Glycols; Histamine H1 Antagonists, Non-Sedating; Injections, Intravenous; Male; Nasal Mucosa; Oils; Organic Chemicals; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Technology, Pharmaceutical; Terfenadine; Viscosity

2010
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:8

    Topics: Animals; Bile Acids and Salts; Bilirubin; Female; Liver; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Mice; Mice, Knockout; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Rifampin; Terfenadine

2010
Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:2

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Intranasal; Animals; beta-Cyclodextrins; Cell Membrane Permeability; Cells, Cultured; Chitosan; Gels; Histamine H1 Antagonists, Non-Sedating; Humans; Poloxamer; Rabbits; Temperature; Terfenadine; Viscosity

2011
A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Humans; Quantitative Structure-Activity Relationship; Rabbits; Terfenadine

2010
20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Digoxin; Etoposide; Ginsenosides; Herb-Drug Interactions; Humans; Ileum; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Terfenadine; Verapamil

2010
Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:11

    Topics: Adult; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Female; Humans; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Polymorphism, Genetic; Stereoisomerism; Terfenadine; Young Adult

2010
Pharmacokinetics of fexofenadine following LPS administration to rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:11

    Topics: Administration, Oral; Animals; Anti-Allergic Agents; Biological Availability; Inflammation; Injections, Intravenous; Lipopolysaccharides; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Terfenadine

2010
Regional absorption of fexofenadine in rat intestine.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Dec-23, Volume: 41, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Colon; Cyclosporins; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Wistar; RNA, Messenger; Terfenadine

2010
The relationship between the drug concentration profiles in plasma and the drug doses in the colon.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:10

    Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil

2010
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.
    International archives of allergy and immunology, 2011, Volume: 155, Issue:1

    Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extracellular Signal-Regulated MAP Kinases; GATA1 Transcription Factor; Gene Expression; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Male; Middle Aged; NF-kappa B; Phosphorylation; Phthalazines; Piperazines; Plant Proteins; Rhinitis, Allergic, Seasonal; Signal Transduction; Terfenadine; Tuberculin; Young Adult

2011
Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice.
    Archives of dermatological research, 2011, Volume: 303, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Dermatitis, Atopic; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Histamine H1 Antagonists, Non-Sedating; Immunohistochemistry; Male; Medicine, Kampo; Mice; Mice, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sex Factors; Signal Transduction; Skin; Social Isolation; Terfenadine

2011
Urticaria due to antihistamines.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:1

    Topics: Administration, Oral; Butyrophenones; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Piperidines; Terfenadine; Urticaria

2011
Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma.
    Journal of pharmaceutical and biomedical analysis, 2011, Jul-15, Volume: 55, Issue:5

    Topics: Buspirone; Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography, Liquid; Humans; Models, Chemical; Omeprazole; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine

2011
Evaluation of the genotoxicity and cytotoxicity of fexofenadine in cultured human peripheral blood lymphocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:7

    Topics: Cell Nucleus Division; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Lymphocytes; Male; Micronucleus Tests; Mitotic Index; Molecular Structure; Terfenadine; Toxicity Tests; Young Adult

2011
In brief: fexofenadine (Allegra) and fruit juice.
    The Medical letter on drugs and therapeutics, 2011, May-30, Volume: 53, Issue:1365

    Topics: Beverages; Food-Drug Interactions; Fruit; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine

2011
Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus.
    Neuroreport, 2011, Aug-03, Volume: 22, Issue:11

    Topics: Acetylcholine; Animals; Attention; Cholinesterase Inhibitors; Cimetidine; Dimaprit; Electroencephalography; Hippocampus; Histamine; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Hypoxia, Brain; In Vitro Techniques; Male; Microelectrodes; Physostigmine; Pyramidal Tracts; Rats; Rats, Wistar; Terfenadine

2011
Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2011, Aug-30, Volume: 25, Issue:16

    Topics: Cell Extracts; Cetirizine; Chromatography, Liquid; HEK293 Cells; Humans; Least-Squares Analysis; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Terfenadine

2011
Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters.
    Molecular pharmaceutics, 2011, Oct-03, Volume: 8, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Cell Polarity; Dogs; Enterocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Kidney Tubules, Distal; Membrane Transport Modulators; Models, Biological; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Prodrugs; Protein Transport; Recombinant Proteins; Terfenadine

2011
Development of a novel high-throughput analytical methodology, multiple injection method, for quantitative analysis in drug metabolism and pharmacokinetic studies using liquid chromatography with tandem mass spectrometry.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:8

    Topics: Animals; Chromatography, High Pressure Liquid; Imipramine; Male; Ondansetron; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Risperidone; Tandem Mass Spectrometry; Terfenadine; Validation Studies as Topic; Verapamil

2011
In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate.
    European journal of drug metabolism and pharmacokinetics, 2012, Volume: 37, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Dose-Response Relationship, Drug; Electric Impedance; Histamine H1 Antagonists, Non-Sedating; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Models, Biological; Permeability; Rats; Rats, Wistar; Sodium Dodecyl Sulfate; Solubility; Surface-Active Agents; Terfenadine

2012
Spectrofluorimetric determination of etodolac, moxepril HCl and fexofenadine HCl using europium sensitized fluorescence in bulk and pharmaceutical preparations.
    Journal of fluorescence, 2012, Volume: 22, Issue:1

    Topics: Buffers; Chemistry, Pharmaceutical; Etodolac; Europium; Hydrogen-Ion Concentration; Reproducibility of Results; Spectrometry, Fluorescence; Terfenadine; Tetrahydroisoquinolines; Tromethamine

2012
Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies.
    International journal of nanomedicine, 2011, Volume: 6

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Drug Delivery Systems; Drug Stability; Emulsions; Half-Life; Humans; Oleic Acid; Permeability; Rabbits; Solubility; Terfenadine; Water

2011
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Nov-20, Volume: 44, Issue:4

    Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine

2011
Assessment of fexofenadine hydrochloride permeability and dissolution with an anionic surfactant using Caco-2 cells.
    Die Pharmazie, 2011, Volume: 66, Issue:10

    Topics: Algorithms; Caco-2 Cells; Chromatography, High Pressure Liquid; Electric Impedance; Epithelium; Histamine H1 Antagonists, Non-Sedating; Humans; Permeability; Sodium Dodecyl Sulfate; Solubility; Spectrometry, Fluorescence; Surface-Active Agents; Terfenadine

2011
Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
    Rapid communications in mass spectrometry : RCM, 2011, Dec-15, Volume: 25, Issue:23

    Topics: Animals; Autoradiography; Histocytochemistry; Histocytological Preparation Techniques; Liquid-Liquid Extraction; Male; Mass Spectrometry; Mice; Reproducibility of Results; Sensitivity and Specificity; Terfenadine; Tissue Distribution

2011
The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:6

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cetirizine; Chromatography, High Pressure Liquid; Drug Interactions; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Loratadine; Mass Spectrometry; Permeability; Terfenadine

2012
Ketoconazole-associated preferential increase in dopamine D2 receptor occupancy in striatum compared to pituitary in vivo: role for drug transporters?
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:1

    Topics: Administration, Oral; Adult; Anti-Allergic Agents; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Binding, Competitive; Blood-Brain Barrier; Corpus Striatum; Drug Therapy, Combination; Humans; Injections, Intramuscular; Ketoconazole; Male; Neoplasm Proteins; Pituitary Gland; Positron-Emission Tomography; Psychotic Disorders; Receptors, Dopamine D2; Risperidone; Schizophrenia; Terfenadine

2012
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen.
    Acta oto-laryngologica, 2012, Volume: 132, Issue:4

    Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; Interleukins; Male; Middle Aged; Nasal Mucosa; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine

2012
Fluorodeoxyglucose-induced allergic reaction: a case report.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2013, Volume: 19, Issue:1

    Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Carcinoma, Squamous Cell; Diphenhydramine; Drug Hypersensitivity; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Prednisone; Pyriform Sinus; Radiopharmaceuticals; Secondary Prevention; Squamous Cell Carcinoma of Head and Neck; Terfenadine; Tomography, X-Ray Computed; Treatment Outcome

2013
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch.
    International archives of allergy and immunology, 2012, Volume: 158, Issue:2

    Topics: Adult; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Pruritus; Pyridines; Skin; Terfenadine; Urticaria

2012
Treatment of acquired perforating dermatosis with cantharidin.
    Archives of dermatology, 2012, Volume: 148, Issue:2

    Topics: Aged; Anti-Allergic Agents; Cantharidin; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Keratolytic Agents; Kidney Failure, Chronic; Nicotinic Acids; Peritoneal Dialysis; Skin Diseases; Terfenadine

2012
Structure determination of fexofenadine-α-cyclodextrin complex by quantitative 2D ROESY analysis and molecular mechanics studies.
    Magnetic resonance in chemistry : MRC, 2012, Volume: 50, Issue:4

    Topics: alpha-Cyclodextrins; Histamine Antagonists; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Molecular Structure; Solubility; Solutions; Terfenadine; Water

2012
Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome.
    International journal of pharmaceutics, 2012, Jul-01, Volume: 430, Issue:1-2

    Topics: Adhesiveness; Administration, Intranasal; Administration, Oral; Adsorption; Animals; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chitosan; Cholesterol; Delayed-Action Preparations; Dimyristoylphosphatidylcholine; Drug Compounding; Histamine H1 Antagonists, Non-Sedating; Injections, Intravenous; Lipids; Liposomes; Male; Mucins; Nanoparticles; Particle Size; Phosphatidylglycerols; Rats; Rats, Sprague-Dawley; Surface Properties; Technology, Pharmaceutical; Terfenadine

2012
Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:7

    Topics: Administration, Oral; Animals; Anti-Allergic Agents; Antifungal Agents; Cyclosporine; Gene Expression Regulation; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; RNA, Messenger; Terfenadine

2012
Case of intractable ophiasis type of alopecia areata presumably improved by fexofenadine.
    The Journal of dermatology, 2012, Volume: 39, Issue:12

    Topics: Adult; Alopecia Areata; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Terfenadine; Young Adult

2012
Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:9

    Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Chemistry, Pharmaceutical; Enterocytes; Histamine H1 Antagonists, Non-Sedating; Hydrolases; Hydrolysis; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Jejunum; Liver; Male; Prodrugs; Protein Binding; Rats; Rats, Wistar; Technology, Pharmaceutical; Terfenadine

2012
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:5

    Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibenzoxepins; Electroshock; Epilepsy; GABA Antagonists; Histamine H1 Antagonists; Ketotifen; Male; Olopatadine Hydrochloride; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Terfenadine

2012
Development of a highly sensitive methodology for quantitative determination of fexofenadine in a microdose study by multiple injection method using ultra-high performance liquid chromatography with tandem mass spectrometry.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:5

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine

2012
Enhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride.
    Asian Pacific journal of allergy and immunology, 2012, Volume: 30, Issue:2

    Topics: Adult; Cells, Cultured; Cryptomeria; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Cavity; Pollen; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Terfenadine; Tumor Necrosis Factor-alpha; Uteroglobin

2012
Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice.
    Drug metabolism and pharmacokinetics, 2013, Volume: 28, Issue:2

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Female; HIV Protease Inhibitors; Inactivation, Metabolic; Mice; Microsomes; Midazolam; Pravastatin; Ritonavir; Saquinavir; Terfenadine

2013
Exploring novel colon-targeting antihistaminic prodrug for colitis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:4

    Topics: Amides; Animals; Colitis, Ulcerative; Colon; Glucosamine; Histamine Antagonists; Liver; Male; Pancreas; Prodrugs; Rats; Rats, Wistar; Stomach; Terfenadine; Trinitrobenzenesulfonic Acid

2012
Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:1

    Topics: Adenosine Triphosphate; Anti-Allergic Agents; Binding, Competitive; Biological Transport, Active; Caco-2 Cells; Enterocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Kinetics; Membrane Transport Modulators; Organic Anion Transporters; Proton Ionophores; Stereoisomerism; Terfenadine; Uncoupling Agents

2013
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:3

    Topics: Absorption; Animals; Beverages; Binding Sites; Binding, Competitive; Biological Transport; Citrus paradisi; Citrus sinensis; Estrone; Food-Drug Interactions; Fruit; Kinetics; Malus; Oocytes; Organic Anion Transporters; Terfenadine; Xenopus laevis

2013
You're the flight surgeon: nasal congestion and Eustachian tube dysfunction.
    Aviation, space, and environmental medicine, 2013, Volume: 84, Issue:3

    Topics: Adult; Aerospace Medicine; Desensitization, Immunologic; Eustachian Tube; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Military Personnel; Rhinitis, Allergic, Perennial; Terfenadine

2013
Application of in-line near infrared spectroscopy and multivariate batch modeling for process monitoring in fluid bed granulation.
    International journal of pharmaceutics, 2013, Aug-16, Volume: 452, Issue:1-2

    Topics: Humidity; Models, Theoretical; Multivariate Analysis; Particle Size; Spectroscopy, Near-Infrared; Technology, Pharmaceutical; Temperature; Terfenadine

2013
In vivo assessment of the impact of efflux transporter on oral drug absorption using portal vein-cannulated rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:8

    Topics: Absorption; Adenosine; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Catheterization; Dibenzocycloheptenes; Diketopiperazines; Heterocyclic Compounds, 4 or More Rings; Male; Portal Vein; Quinolines; Rats; Rats, Sprague-Dawley; Sulfasalazine; Terfenadine; Topotecan

2013
Improved oral bioavailability of fexofenadine hydrochloride using lipid surfactants: ex vivo, in situ and in vivo studies.
    Drug development and industrial pharmacy, 2014, Volume: 40, Issue:8

    Topics: Administration, Oral; Animals; Biological Availability; Calorimetry, Differential Scanning; Drug Carriers; Intestinal Absorption; Lipids; Male; Permeability; Polyethylene Glycols; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Terfenadine; Vitamin E

2014
Simultaneous determination of montelukast and fexofenadine using Fourier transform convolution emission data under non- parametric linear regression method.
    Journal of fluorescence, 2013, Volume: 23, Issue:6

    Topics: Acetates; Calibration; Cyclopropanes; Linear Models; Quinolines; Spectroscopy, Fourier Transform Infrared; Sulfides; Terfenadine

2013
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Blotting, Western; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Irritable Bowel Syndrome; Mast Cells; Maternal Deprivation; Occludin; Piperidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; Terfenadine

2013
The role of multidrug resistance-1 (MDR1) variants in response to fexofenadine among Jordanians.
    International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:11

    Topics: Adult; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Humans; Jordan; Male; Multivariate Analysis; Polymorphism, Single Nucleotide; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sex Characteristics; Terfenadine

2013
Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jun-16, Volume: 57

    Topics: Animals; Bile; Biological Transport; Biotransformation; Chromatography, Liquid; Drug Interactions; Hepatobiliary Elimination; Infusions, Intravenous; Kidney; Liver; Male; Models, Biological; Swine; Tandem Mass Spectrometry; Terfenadine; Verapamil

2014
Thin layer chromatography-densitometric determination of some non-sedating antihistamines in combination with pseudoephedrine or acetaminophen in synthetic mixtures and in pharmaceutical formulations.
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:3

    Topics: Acetaminophen; Chromatography, Thin Layer; Densitometry; Histamine H1 Antagonists, Non-Sedating; Limit of Detection; Linear Models; Loratadine; Pseudoephedrine; Reproducibility of Results; Tablets; Terfenadine

2014
Flare-up reaction after creeping disease.
    The Australasian journal of dermatology, 2013, Volume: 54, Issue:4

    Topics: Aged; Anti-Allergic Agents; Antiparasitic Agents; Humans; Ivermectin; Male; Skin Diseases, Parasitic; Terfenadine

2013
Efficacy of fexofenadine in isolated rat tracheas.
    Rhinology, 2013, Volume: 51, Issue:4

    Topics: Animals; Electric Stimulation; Histamine H1 Antagonists, Non-Sedating; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Rats; Terfenadine; Tissue Culture Techniques; Trachea

2013
How should we handle decreased efficacy caused by DDI on transporters for drug absorption and target-tissue distribution, but not associated with toxicity?
    Drug metabolism and pharmacokinetics, 2013, Volume: 28, Issue:6

    Topics: Beverages; Drug Interactions; Fruit; Humans; Intestinal Absorption; Organic Anion Transporters; Terfenadine; Tissue Distribution

2013
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.
    Bioanalysis, 2014, Volume: 6, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Flurbiprofen; Half-Life; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2014
Phenylalanine-free taste-masked orodispersible tablets of fexofenadine hydrochloride: development, in vitro evaluation and in vivo estimation of the drug pharmacokinetics in healthy human volunteers.
    Pharmaceutical development and technology, 2015, Volume: 20, Issue:5

    Topics: Administration, Oral; Adult; Alginates; Anti-Allergic Agents; Chitosan; Excipients; Glucuronic Acid; Hexuronic Acids; Humans; Male; Phenylalanine; Tablets; Taste; Taste Perception; Terfenadine; Young Adult

2015
Idiopathic pure sudomotor failure responding to oral antihistamine with sweating activities.
    Acta dermato-venereologica, 2014, Volume: 94, Issue:6

    Topics: Administration, Oral; Adult; Autonomic Nervous System Diseases; Biopsy; Histamine H1 Antagonists, Non-Sedating; Humans; Hypohidrosis; Male; Sweating; Terfenadine; Treatment Outcome

2014
Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.
    Pharmaceutical research, 2014, Volume: 31, Issue:8

    Topics: Animals; Beverages; Binding Sites; Cells, Cultured; Citrus paradisi; Dose-Response Relationship, Drug; Female; Food-Drug Interactions; Oocytes; Organic Anion Transporters; Pravastatin; Substrate Specificity; Terfenadine; Xenopus laevis

2014
Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.
    Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:3

    Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Capsules; Carbonated Beverages; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Enzyme Inhibitors; Feasibility Studies; Flurbiprofen; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenotype; Pilot Projects; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult

2014
[Establishment of reverse-phase high-performance liquid chromatography with chiral reagent derivatization for separation of fexofenadine enantiomers].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2014, Volume: 43, Issue:2

    Topics: Chromatography, High Pressure Liquid; Stereoisomerism; Terfenadine

2014
H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Jul-15, Volume: 307, Issue:2

    Topics: Animals; Apolipoproteins E; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biomarkers; Cetirizine; Cholesterol Esters; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Histamine H1 Antagonists; Lipogenesis; Liver; Liver-Specific Organic Anion Transporter 1; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organic Anion Transporters, Sodium-Independent; Severity of Illness Index; Terfenadine; Triglycerides

2014
Chronic ingestion of H1-antihistamines increase progression of atherosclerosis in apolipoprotein E-/- mice.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Analysis of Variance; Animals; Apolipoproteins E; Atherosclerosis; Blood Chemical Analysis; CD36 Antigens; Cetirizine; Cholesterol, LDL; Diet, High-Fat; Disease Progression; Fluorescent Antibody Technique; Histamine H1 Antagonists; Male; Mast Cells; Mice; Mice, Knockout; Nitric Oxide Synthase; Signal Transduction; Terfenadine

2014
Application of the BCS biowaiver approach to assessing bioequivalence of orally disintegrating tablets with immediate release formulations.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Nov-20, Volume: 64

    Topics: Administration, Oral; Animals; Biopharmaceutics; Chemistry, Pharmaceutical; Dibenzoxepins; Droxidopa; Famotidine; Humans; Hydrochlorothiazide; Olopatadine Hydrochloride; Pharmaceutical Vehicles; Tablets; Terfenadine; Therapeutic Equivalency

2014
Determination of fexofenadine in Hank's balanced salt solution by high-performance liquid chromatography with ultraviolet detection: application to Caco-2 cell permeability studies.
    Biomedical chromatography : BMC, 2015, Volume: 29, Issue:4

    Topics: Caco-2 Cells; Cells; Chromatography, High Pressure Liquid; Culture Media; Humans; Membrane Transport Proteins; Permeability; Terfenadine

2015
Pruritic eruption on the chest.
    The Journal of family practice, 2014, Volume: 63, Issue:11

    Topics: Acantholysis; Acneiform Eruptions; Administration, Oral; Administration, Topical; Biopsy; Clobetasol; Dermatitis, Seborrheic; Dermatologic Agents; Diagnosis, Differential; Drug Eruptions; Folliculitis; Histamine Antagonists; Humans; Ichthyosis; Male; Middle Aged; Skin; Terfenadine; Treatment Outcome

2014
Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:3

    Topics: Administration, Intravenous; Administration, Oral; Animals; Antipyrine; Biological Availability; Blood Specimen Collection; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Monitoring; Ibuprofen; Male; Mice, Inbred C57BL; Models, Animal; Organic Anion Transporters; Pravastatin; Reproducibility of Results; Rifampin; Tail; Terfenadine; Triazoles; Veins

2015
Effect of CKD and dialysis modality on exposure to drugs cleared by nonrenal mechanisms.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015, Volume: 65, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Anti-Anxiety Agents; Cytochrome P-450 CYP3A; Female; Humans; Kidney; Male; Midazolam; Middle Aged; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency, Chronic; Severity of Illness Index; Terfenadine

2015
Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 352, Issue:3

    Topics: Acute Disease; Animals; Chronic Disease; Colitis; Endoplasmic Reticulum Stress; Female; HCT116 Cells; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Terfenadine

2015
Myocardial infarction associated with eosinophilia and plasma extravasation at multiple sites. A variant of Kounis syndrome.
    BMJ case reports, 2015, Jan-21, Volume: 2015

    Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Eosinophilia; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methylprednisolone; Myocardial Infarction; Plasma; Rhinitis, Allergic; Syndrome; Terfenadine

2015
The determination of crystal structures of active pharmaceutical ingredients from X-ray powder diffraction data: a brief, practical introduction, with fexofenadine hydrochloride as example.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:6

    Topics: Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Humans; Hydrogen Bonding; Molecular Structure; Pharmaceutical Preparations; Powder Diffraction; Powders; Reproducibility of Results; Solvents; Terfenadine; X-Rays

2015
[Sex differences of P-glycoprotein functional activity and expression in rabbits].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:8

    Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Gene Expression; Half-Life; Histamine H1 Antagonists, Non-Sedating; Intestinal Mucosa; Intestines; Liver; Male; Rabbits; Sex Factors; Terfenadine

2014
Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:2

    Topics: Administration, Oral; Animals; Biological Availability; Diosmin; Drug Interactions; Intestinal Absorption; Male; Permeability; Propranolol; Rats; Terfenadine

2015
Carbopol-incorporated thermoreversible gel for intranasal drug delivery.
    Molecules (Basel, Switzerland), 2015, Mar-04, Volume: 20, Issue:3

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acrylates; Adhesiveness; Administration, Intranasal; Animals; beta-Cyclodextrins; Biological Availability; Drug Delivery Systems; Gels; Histamine H1 Antagonists, Non-Sedating; Poloxamer; Rabbits; Rheology; Terfenadine; Tissue Distribution; Viscosity

2015
Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:3

    Topics: Animals; Antidepressive Agents, Second-Generation; Biological Transport; Caco-2 Cells; Drug Interactions; Drug Therapy, Combination; Feces; Flavanones; Glyburide; Humans; Hypoglycemic Agents; Intestinal Absorption; Male; Microsomes, Liver; Organic Anion Transporters, Sodium-Independent; Paroxetine; Rats, Sprague-Dawley; Terfenadine

2015
Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
    Molecular pharmaceutics, 2015, Jun-01, Volume: 12, Issue:6

    Topics: Budesonide; Colon; Cyclosporine; Fenofibrate; Humans; Intestinal Absorption; Intestinal Mucosa; Lisdexamfetamine Dimesylate; Metoprolol; Nifedipine; Pyrimidines; Ranitidine; Rivastigmine; Sumatriptan; Terfenadine; Theophylline

2015
Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carboxylic Ester Hydrolases; Cell Line; Cell Membrane Permeability; Esterases; HEK293 Cells; Humans; Hydrolysis; Intestinal Absorption; Intestine, Small; LLC-PK1 Cells; Prodrugs; Swine; Terfenadine

2015
Impact of fexofenadine, osthole and histamine on peripheral blood mononuclear cell proliferation and cytokine secretion.
    European journal of pharmacology, 2015, Aug-15, Volume: 761

    Topics: Adult; Cell Proliferation; Cells, Cultured; Coumarins; Cytokines; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Humans; Interleukin-10; Interleukin-6; Leukocytes, Mononuclear; Male; Terfenadine; Time Factors; Tumor Necrosis Factor-alpha

2015
Treatment of solar urticaria using antihistamine and leukotriene receptor antagonist combinations tailored to disease severity.
    Photodermatology, photoimmunology & photomedicine, 2015, Volume: 31, Issue:6

    Topics: Acetates; Adolescent; Adult; Cetirizine; Child; Child, Preschool; Cyclopropanes; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Photosensitivity Disorders; Quinolines; Remission Induction; Remission, Spontaneous; Severity of Illness Index; Sulfides; Sunlight; Terfenadine; Ultraviolet Rays; Urticaria; Young Adult

2015
Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid.
    The British journal of dermatology, 2015, Volume: 173, Issue:5

    Topics: Adolescent; Cholangitis, Sclerosing; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Humans; Lysophospholipids; Male; Pruritus; Terfenadine

2015
Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.
    PLoS neglected tropical diseases, 2015, Volume: 9, Issue:7

    Topics: Animals; Cimetidine; Cytokines; Eosinophils; Female; Filariasis; Filarioidea; Gene Expression Regulation; Histamine H1 Antagonists; Histamine H2 Antagonists; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Receptors, Histamine H1; Sex Ratio; Spleen; Terfenadine

2015
Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:2

    Topics: Administration, Cutaneous; Animals; Carboxylesterase; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Male; Organ Culture Techniques; Prodrugs; Rats; Rats, Wistar; Skin Absorption; Terfenadine

2016
The Interesting Case of Acyclovir Delivered Using Chitosan in Humans: Is it a Drug Issue or Formulation Issue?
    Pharmaceutical research, 2016, Volume: 33, Issue:3

    Topics: Acyclovir; Adhesiveness; Administration, Oral; Biological Availability; Chemistry, Pharmaceutical; Chitosan; Drug Delivery Systems; Excipients; Humans; Intestinal Absorption; Permeability; Terfenadine

2016
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Action Potentials; Berberine; Caveolin 1; Cell Membrane; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Kinetics; Mutation; Phenylalanine; Potassium Channel Blockers; Resveratrol; RNA Interference; Stilbenes; Terfenadine; Transfection; Tyrosine

2015
HPLC Determination of Fexofenadine in Human Plasma For Therapeutic Drug Monitoring and Pharmacokinetic Studies.
    Biomedical chromatography : BMC, 2016, Volume: 30, Issue:7

    Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Histamine H1 Antagonists, Non-Sedating; Humans; Quality Control; Terfenadine; Young Adult

2016
Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Dioxoles; Drug Interactions; Food-Drug Interactions; Humans; Intestinal Absorption; Lignans; Male; Plant Extracts; Rats, Wistar; Rhodamine 123; Seeds; Sesamum; Terfenadine

2015
Simultaneous quantitation of Ofloxacin, Fexofenadine HCl and Diclofenac Potassium in affixed dose combinative formulation by HPLC-UV method.
    Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:6

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Diclofenac; Drug Combinations; Histamine H1 Antagonists, Non-Sedating; Ofloxacin; Reproducibility of Results; Spectrophotometry, Ultraviolet; Terfenadine

2015
Unique case of postural cholinergic urticaria induced by a standing position.
    Clinical and experimental dermatology, 2016, Volume: 41, Issue:4

    Topics: Acetylcholine; Adolescent; Diphenhydramine; Humans; Male; Posture; Terfenadine; Urticaria

2016
Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:2

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Drug Interactions; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Rats; Rats, Wistar; Resveratrol; Stilbenes; Terfenadine; Verapamil

2016
Localized heat urticaria: Positive reaction of preheated autologous serum skin test.
    The Journal of dermatology, 2016, Volume: 43, Issue:9

    Topics: Anaphylaxis; Chlorpheniramine; Desensitization, Immunologic; Drug Therapy, Combination; Histamine H1 Antagonists, Non-Sedating; Hot Temperature; Humans; Influenza, Human; Intradermal Tests; Male; Middle Aged; Serum; Skin; Terfenadine; Urticaria

2016
Oxidation of cetirizine, fexofenadine and hydrochlorothiazide during ozonation: Kinetics and formation of transformation products.
    Water research, 2016, May-01, Volume: 94

    Topics: Cetirizine; Chromatography, Liquid; Hydrochlorothiazide; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Ozone; Tandem Mass Spectrometry; Terfenadine; Wastewater; Water Pollutants, Chemical; Water Purification

2016
Binding of fexofenadine hydrochloride to bovine serum albumin: structural considerations by spectroscopic techniques and molecular docking.
    Journal of biomolecular structure & dynamics, 2017, Volume: 35, Issue:6

    Topics: Animals; Binding Sites; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Serum Albumin, Bovine; Spectrum Analysis; Terfenadine; Thermodynamics

2017
Transcatheter aortic valve implantation with the NVT Allegra transcatheter heart valve system: first-in-human experience with a novel self-expanding transcatheter heart valve.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2016, May-17, Volume: 12, Issue:1

    Topics: Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Cardiac Catheterization; Female; Heart Valve Prosthesis; Humans; Male; Patient Selection; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2016
Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach.
    British journal of clinical pharmacology, 2016, Volume: 82, Issue:6

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Fermented Foods; Healthy Volunteers; Humans; Losartan; Male; Midazolam; Middle Aged; Omeprazole; Panax; Pharmaceutical Preparations; Terfenadine; Young Adult

2016
Cosmetic tattoo pigment reaction.
    Dermatology online journal, 2016, Jul-15, Volume: 22, Issue:7

    Topics: Adult; Anti-Allergic Agents; Coloring Agents; Cosmetic Techniques; Facial Dermatoses; Female; Glucocorticoids; Humans; Lymphocytes; Prednisone; Skin; Tattooing; Terfenadine

2016
Cytokine production by PBMC and serum from allergic and non-allergic subjects following in vitro histamine stimulation to test fexofenadine and osthole anti-allergic properties.
    European journal of pharmacology, 2016, Nov-15, Volume: 791

    Topics: Adult; Anti-Allergic Agents; Coumarins; Cytokines; Histamine; Humans; Hypersensitivity; Immunoglobulin E; Leukocytes, Mononuclear; Male; Terfenadine

2016
Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H
    Immunobiology, 2017, Volume: 222, Issue:3

    Topics: Adult; Case-Control Studies; Chemokine CCL5; Coumarins; Cyclooxygenase 2; Female; Gene Expression Regulation; Histamine; Humans; Hypersensitivity; Interleukin-1beta; Leukocytes, Mononuclear; Male; NF-kappa B; Receptors, Histamine H1; RNA, Messenger; Terfenadine

2017
Investigating Drug Repositioning Approach to Design Novel Prodrugs for Colon-specific Release of Fexofenadine for Ulcerative Colitis.
    Current drug delivery, 2017, Volume: 14, Issue:4

    Topics: Animals; Colitis, Ulcerative; Colon; Drug Liberation; Drug Repositioning; Prodrugs; Rats; Rats, Wistar; Terfenadine

2017
The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers.
    European journal of clinical pharmacology, 2017, Volume: 73, Issue:3

    Topics: Adult; Alkaloids; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Half-Life; Healthy Volunteers; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Polyunsaturated Alkamides; Terfenadine

2017
Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models'".
    Molecular pharmaceutics, 2017, 01-03, Volume: 14, Issue:1

    Topics: Biopharmaceutics; Computer Simulation; Gastrointestinal Agents; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Pharmaceutical Preparations; Terfenadine

2017
Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H
    Biochemical pharmacology, 2017, Mar-15, Volume: 128

    Topics: Animals; Aspartic Acid; Cations, Monovalent; Chlorpheniramine; CHO Cells; Cricetulus; Histamine; Histamine Agonists; Histamine H1 Antagonists; Humans; Ligands; Mutation; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Histamine H1; Sodium Chloride; Terfenadine

2017
Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers.
    The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Dogs; Fluorescence; Stereoisomerism; Terfenadine

2017
Capsaicin pretreatment enhanced the bioavailability of fexofenadine in rats by P-glycoprotein modulation: in vitro, in situ and in vivo evaluation.
    Drug development and industrial pharmacy, 2017, Volume: 43, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Capsaicin; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Intestinal Absorption; Male; Perfusion; Permeability; Propranolol; Rats; Rats, Wistar; Terfenadine

2017
Effect of Garlic, Gingko, and St. John's Wort Extracts on the Pharmacokinetics of Fexofenadine: A Mechanistic Study.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Interactions; Garlic; Ginkgo biloba; Hypericum; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Organic Anion Transporters, Sodium-Independent; Perfusion; Plant Extracts; Rats; Substrate Specificity; Terfenadine; Tissue Distribution

2017
CYP3A4 Activity is Markedly Lower in Patients with Crohn's Disease.
    Inflammatory bowel diseases, 2017, Volume: 23, Issue:5

    Topics: Adult; Aged; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Crohn Disease; Cytochrome P-450 CYP3A; Female; Follow-Up Studies; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Prognosis; Substrate Specificity; Terfenadine

2017
Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 08-01, Volume: 158, Issue:2

    Topics: Action Potentials; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Leukemia, Promyelocytic, Acute; Long QT Syndrome; Lysosomes; Myocytes, Cardiac; Oxides; Patch-Clamp Techniques; Proteolysis; Resveratrol; Stilbenes; Terfenadine

2017
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Induced by Fexofenadine.
    Journal of investigational allergology & clinical immunology, 2017, Volume: 27, Issue:3

    Topics: Anti-Allergic Agents; Drug Hypersensitivity; Female; Humans; Middle Aged; Skin Tests; Stevens-Johnson Syndrome; Terfenadine

2017
Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.
    International journal of molecular sciences, 2017, Jun-25, Volume: 18, Issue:7

    Topics: Allergens; Animals; Anti-Allergic Agents; Antigen-Presenting Cells; Biomarkers; Cytokines; Disease Models, Animal; Edema; Female; Histamine H1 Antagonists, Non-Sedating; Hypersensitivity, Delayed; Mice; Palladium; Prednisolone; Signal Transduction; T-Lymphocyte Subsets; Terfenadine

2017
A Method for Decreasing the Amount of the Drug Remaining on the Surfaces of the Mortar and Pestle after Grinding Small Amount of Tablets.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2017, Volume: 137, Issue:8

    Topics: Adsorption; Calcium Phosphates; Drug Compounding; Excipients; Lactose; Mannitol; Powders; Tablets; Terfenadine

2017
Sorption of citalopram, irbesartan and fexofenadine in soils: Estimation of sorption coefficients from soil properties.
    Chemosphere, 2018, Volume: 195

    Topics: Adsorption; Agriculture; Aluminum Silicates; Biphenyl Compounds; Citalopram; Clay; Irbesartan; Soil; Soil Pollutants; Terfenadine; Tetrazoles; Wastewater

2018
Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Curcumin; Cytochrome P-450 CYP3A; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Lapatinib; Macaca fascicularis; Male; Midazolam; Neoplasm Proteins; Pantoprazole; Quinazolines; Rosuvastatin Calcium; Sulfasalazine; Terfenadine

2018
Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition.
    Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 48

    Topics: 3-Hydroxysteroid Dehydrogenases; Autocrine Communication; Cell Line; Cell Survival; Cetirizine; Enzyme Inhibitors; Gene Expression Regulation; Histamine Antagonists; Histamine H1 Antagonists; Humans; Promethazine; Real-Time Polymerase Chain Reaction; Steroids; Terfenadine; Up-Regulation

2018
Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsa
    The Journal of toxicological sciences, 2018, Volume: 43, Issue:3

    Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Halothane; Heart Rate; Myocardial Contraction; Risk; Terfenadine

2018
IDENTIFICATION AND DETERMINATION OF RUPATADINE AND FEXOFENADINE BY DENSITOMETRIC METHOD.
    Acta poloniae pharmaceutica, 2016, Volume: 73, Issue:6

    Topics: Cyproheptadine; Densitometry; Histamine H1 Antagonists; Limit of Detection; Reproducibility of Results; Terfenadine

2016
A case of food-dependent exercise-induced angioedema.
    The journal of allergy and clinical immunology. In practice, 2019, Volume: 7, Issue:1

    Topics: Adult; Allergens; Angioedema; Animals; Asthma, Exercise-Induced; Cattle; Diet Therapy; Female; Humans; Immunoglobulin E; Milk Hypersensitivity; Milk Proteins; Skin Tests; Terfenadine

2019
Population histamine burden assessed using wastewater-based epidemiology: The association of 1,4‑methylimidazole acetic acid and fexofenadine.
    Environment international, 2018, Volume: 120

    Topics: Australia; Histamine Antagonists; Imidazoles; Terfenadine; Wastewater; Water Pollutants, Chemical

2018
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H
    European journal of pharmacology, 2018, Nov-05, Volume: 838

    Topics: Benzimidazoles; Diphenhydramine; HeLa Cells; Histamine H1 Antagonists, Non-Sedating; Humans; Piperidines; Receptors, Histamine H1; Terfenadine; Time Factors

2018
LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses.
    Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Variation, Population; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Healthy Volunteers; Humans; Isoenzymes; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine

2019
Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy - in vitro study Short communication.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2019, Volume: 22, Issue:1

    Topics: Anti-Allergic Agents; Cells, Cultured; Child; Child, Preschool; Female; Gene Expression Regulation; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Leukocytes, Mononuclear; Male; Receptors, Histamine H1; Receptors, Histamine H4; Terfenadine

2019
Transfermoral aortic valve implantation using self-expanding New Valve Technology (NVT) Allegra bioprosthesis: A pilot prospective study.
    Cardiology journal, 2021, Volume: 28, Issue:3

    Topics: Aftercare; Aged; Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Patient Discharge; Prospective Studies; Prosthesis Design; Technology; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2021
The Allegra transcatheter heart valve: European multicentre experience with a novel self-expanding transcatheter aortic valve.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2019, May-20, Volume: 15, Issue:1

    Topics: Aortic Valve; Aortic Valve Stenosis; Heart Valve Prosthesis; Humans; Prosthesis Design; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2019
Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray.
    American journal of rhinology & allergy, 2019, Volume: 33, Issue:4

    Topics: Acetates; Adult; Anti-Allergic Agents; Cetirizine; Cryptomeria; Cyclopropanes; Drug Therapy, Combination; Female; Fluticasone; Humans; Leukocyte Count; Leukotriene Antagonists; Male; Mast Cells; Middle Aged; Nasal Cavity; Nasal Sprays; Neutrophils; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides; Terfenadine; Treatment Outcome

2019
Real-life experience in the treatment of solar urticaria: retrospective cohort study.
    Clinical and experimental dermatology, 2019, Volume: 44, Issue:5

    Topics: Acetates; Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Cohort Studies; Cyclopropanes; Disease Management; Female; Histamine Antagonists; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Omalizumab; Photosensitivity Disorders; Quinolines; Retrospective Studies; Sulfides; Terfenadine; Urticaria; Young Adult

2019
Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors.
    Scientific reports, 2019, 03-07, Volume: 9, Issue:1

    Topics: Animals; Cyproheptadine; Histamine; Histamine Agonists; Histamine Antagonists; Mucous Membrane; Muscle, Smooth; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2; Swine; Terfenadine; Urinary Bladder; Urothelium

2019
Elephantiasis nostras verrucosa secondary to scleroderma.
    Cutis, 2019, Volume: 103, Issue:2

    Topics: Anti-Bacterial Agents; Bandages; Biopsy; Cephalexin; Dermatologic Agents; Doxepin; Elephantiasis; Female; Humans; Methotrexate; Middle Aged; Mupirocin; Mycophenolic Acid; PUVA Therapy; Scleroderma, Systemic; Skin; Skin Cream; Terfenadine; Treatment Outcome

2019
A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole.
    International immunopharmacology, 2019, Volume: 72

    Topics: Anti-Inflammatory Agents; Autism Spectrum Disorder; Child; Child, Preschool; Coumarins; Cyclooxygenase 2; Female; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Infant; Leukocytes, Mononuclear; Male; Terfenadine

2019
Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:8

    Topics: Administration, Intravenous; Administration, Oral; Animals; Area Under Curve; Food-Drug Interactions; Fruit and Vegetable Juices; HEK293 Cells; HeLa Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Mice; Mice, Knockout; Organic Anion Transporters; Rosuvastatin Calcium; Terfenadine

2019
Insect bites as a trigger factor of eosinophilic cellulitis.
    Annals of agricultural and environmental medicine : AAEM, 2019, Jun-17, Volume: 26, Issue:2

    Topics: Adolescent; Cellulitis; Eosinophilia; Female; Humans; Insect Bites and Stings; Terfenadine

2019
Idiopathic postprandial diarrhea responsive to antihistamines.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019, Volume: 123, Issue:4

    Topics: Adult; Angioedema; Cetirizine; Diarrhea; Famotidine; Female; Food Hypersensitivity; Histamine Antagonists; Humans; Male; Middle Aged; Postprandial Period; Ranitidine; Terfenadine; Urticaria

2019
Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.
    Annals of the rheumatic diseases, 2019, Volume: 78, Issue:11

    Topics: Animals; Arthritis, Experimental; Mice; Mice, Inbred DBA; Mice, Transgenic; Phospholipases A2, Cytosolic; Signal Transduction; Terfenadine; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha

2019
Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buspirone; Cytochrome P-450 CYP3A; Furocoumarins; Liver; Male; Rats; Terfenadine

2020
Elevated YKL-40 serum levels in patients with chronic spontaneous urticaria.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019, Volume: 123, Issue:4

    Topics: Antigens, CD; Cadherins; Cell Line; Cetirizine; Chitinase-3-Like Protein 1; Chronic Urticaria; Histamine Antagonists; Humans; Mast Cells; Terfenadine

2019
Rituximab desensitization in two patients with muscle-specific kinase myasthenia gravis.
    Muscle & nerve, 2019, Volume: 60, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Autoantibodies; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Humans; Hydrocortisone; Immunologic Factors; Infusions, Intravenous; Myasthenia Gravis; Premedication; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rituximab; Terfenadine

2019
NVT ALLEGRA transcatheter heart valve for valve-in-valve procedures in failing surgical aortic bioprostheses: let us wait and see.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2019, Oct-04, Volume: 15, Issue:9

    Topics: Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Cardiac Catheterization; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heart Valves; Humans; Prosthesis Design; Prosthesis Failure; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2019
Biological transformation of fexofenadine and sitagliptin by carrier-attached biomass and suspended sludge from a hybrid moving bed biofilm reactor.
    Water research, 2019, Dec-15, Volume: 167

    Topics: Biofilms; Biomass; Bioreactors; Chromatography, Liquid; Sewage; Sitagliptin Phosphate; Tandem Mass Spectrometry; Terfenadine

2019
Impact of implant depth on hydrodynamic function of the ALLEGRA bioprosthesis in valve-in-valve interventions.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2020, Feb-07, Volume: 15, Issue:15

    Topics: Aortic Valve; Bioprosthesis; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hemodynamics; Hydrodynamics; Prosthesis Design; Prosthesis Failure; Terfenadine; Transcatheter Aortic Valve Replacement

2020
Clinical Findings Associated with Ornithodoros brasiliensis Tick Parasitism in Travelers, Southern Brazil.
    Wilderness & environmental medicine, 2019, Volume: 30, Issue:4

    Topics: Animals; Anti-Allergic Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents; Brazil; Dermatitis; Dexamethasone; Female; Humans; Male; Middle Aged; Ornithodoros; Terfenadine; Tick Bites; Travel; Young Adult

2019
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
    European journal of pharmacology, 2020, May-15, Volume: 875

    Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Morpholines; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Piperidines; Prostaglandin D2; Pyrroles; Quality of Life; Quinolines; Rats; Rhinitis, Allergic; Sulfides; Terfenadine

2020
Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's hypothesized function?
    Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:9

    Topics: Coproporphyrins; Humans; Intestinal Absorption; Organic Anion Transporters; Terfenadine

2020
Direct chiral LC-MS/MS analysis of fexofenadine enantiomers in plasma and urine with application in a maternal-fetal pharmacokinetic study.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, May-15, Volume: 1145

    Topics: Adult; Anti-Allergic Agents; Chromatography, High Pressure Liquid; Female; Humans; Plasma; Pregnancy; Stereoisomerism; Tandem Mass Spectrometry; Terfenadine; Urine; Young Adult

2020
Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End-Stage Renal Disease.
    Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:4

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Midazolam; Middle Aged; Organic Anion Transporters; Prospective Studies; Renal Dialysis; Renal Elimination; Terfenadine; Time Factors; Treatment Outcome

2020
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein.
    Current drug metabolism, 2020, Volume: 21, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ketoconazole; Male; Maytenus; Midazolam; Plant Extracts; Quinolines; Rats; Rats, Wistar; Terfenadine

2020
Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes.
    JAMA pediatrics, 2020, 08-01, Volume: 174, Issue:8

    Topics: Adult; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Infant, Newborn; Infant, Small for Gestational Age; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Prenatal Care; Propensity Score; Retrospective Studies; Terfenadine; Young Adult

2020
Efficacy of Fexofenadine in the Treatment of Chronic Idiopathic Urticaria.
    Mymensingh medical journal : MMJ, 2020, Volume: 29, Issue:2

    Topics: Adolescent; Bangladesh; Chronic Disease; Chronic Urticaria; Double-Blind Method; Humans; Terfenadine; Treatment Outcome; Urticaria

2020
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:3

    Topics: Acetates; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Butyrates; Caco-2 Cells; Histone Deacetylase Inhibitors; Humans; Intestinal Mucosa; Male; Mice, Inbred BALB C; NF-kappa B; PPAR gamma; Propionates; Rats, Sprague-Dawley; Rosuvastatin Calcium; Signal Transduction; Terfenadine

2021
Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.
    Pharmaceutical research, 2020, Jun-17, Volume: 37, Issue:7

    Topics: Adult; Antidepressive Agents, Second-Generation; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Drug Interactions; Female; Fetal Blood; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Intestinal Mucosa; Maternal-Fetal Exchange; Parturition; Placental Circulation; Pregnancy; Terfenadine; Young Adult

2020
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 07-07, Volume: 117, Issue:27

    Topics: Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Azo Compounds; Bacteria; Excipients; Female; Food; Food Additives; Gastrointestinal Microbiome; Histamine H1 Antagonists, Non-Sedating; Humans; Intestinal Absorption; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Organic Anion Transporters; Terfenadine

2020
Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection.
    BMJ case reports, 2020, Jul-07, Volume: 13, Issue:7

    Topics: Angioedema; Anti-Allergic Agents; Betacoronavirus; Chlorpheniramine; Coronavirus Infections; COVID-19; Diagnosis, Differential; Female; Humans; Middle Aged; Pandemics; Pneumonia, Viral; Prednisone; Prodromal Symptoms; SARS-CoV-2; Terfenadine; Treatment Outcome; Urticaria

2020
Competitive and synergic sorption of carbamazepine, citalopram, clindamycin, fexofenadine, irbesartan and sulfamethoxazole in seven soils.
    Journal of contaminant hydrology, 2020, Volume: 234

    Topics: Adsorption; Carbamazepine; Citalopram; Clindamycin; Irbesartan; Soil; Soil Pollutants; Sulfamethoxazole; Terfenadine

2020
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
    Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4

    Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil

2020
Eosinophilic gastroenteritis treated with a targeted food elimination diet.
    Pediatrics international : official journal of the Japan Pediatric Society, 2020, Volume: 62, Issue:7

    Topics: Acetates; Anti-Allergic Agents; Arylsulfonates; Child; Cyclopropanes; Diarrhea; Diet; Enteritis; Eosinophilia; Food Hypersensitivity; Gastritis; Humans; Male; Quinolines; Sulfides; Sulfonium Compounds; Terfenadine; Treatment Outcome

2020
Applying Biopharmaceutical Classification System criteria to predict the potential effect of Cremophor
    Therapeutic delivery, 2020, Volume: 11, Issue:7

    Topics: Biological Availability; Biological Products; Humans; Polyethylene Glycols; Terfenadine

2020
Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous Leishmania major infection.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:8

    Topics: Animals; Histamine H1 Antagonists, Non-Sedating; Leishmania major; Leishmaniasis, Cutaneous; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Phthalazines; Terfenadine; Tissue Culture Techniques

2020
Acute generalized exanthematous pustulosis induced by pseudoephedrine in a combination tablet with fexofenadine.
    International journal of dermatology, 2021, Volume: 60, Issue:7

    Topics: Acute Generalized Exanthematous Pustulosis; Humans; Pseudoephedrine; Tablets; Terfenadine

2021
UPLC-MS/MS method for the simultaneous quantification of pravastatin, fexofenadine, rosuvastatin, and methotrexate in a hepatic uptake model and its application to the possible drug-drug interaction study of triptolide.
    Biomedical chromatography : BMC, 2021, Volume: 35, Issue:7

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Drug Interactions; Epoxy Compounds; Hepatocytes; Linear Models; Male; Methotrexate; Phenanthrenes; Pravastatin; Rats, Wistar; Reproducibility of Results; Rosuvastatin Calcium; Sensitivity and Specificity; Tandem Mass Spectrometry; Terfenadine

2021
Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model.
    Pharmaceutical research, 2021, Volume: 38, Issue:4

    Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Drug Interactions; Female; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Pregnancy Complications; Stereoisomerism; Terfenadine

2021
The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress.
    Biochemistry. Biokhimiia, 2021, Volume: 86, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Cell Membrane Permeability; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Lipid Peroxidation; NF-E2-Related Factor 2; Oxidative Stress; Terfenadine

2021
Transcatheter aortic valve implantation for degenerated aortic valves: Experience with a new supra-annular device. The Spanish Allegra valve-in-valve (SAVIV) registry.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2021, 08-01, Volume: 98, Issue:2

    Topics: Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Catheters; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Prosthesis Design; Registries; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2021
Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:5

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Administration, Oral; Animals; Caco-2 Cells; Citrus paradisi; Citrus sinensis; Diabetes Mellitus, Type 2; Food-Drug Interactions; Fruit and Vegetable Juices; Half-Life; HEK293 Cells; Humans; Intestinal Absorption; Male; Malus; Organic Anion Transporters; Piperidines; Rats; Terfenadine; Uracil

2021
The Allegra transcatheter heart valve: Short term results from a multicenter registry.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2021, 11-15, Volume: 98, Issue:6

    Topics: Aged; Aged, 80 and over; Animals; Aortic Valve; Aortic Valve Stenosis; Cattle; Female; Heart Valve Prosthesis; Humans; Male; Prosthesis Design; Registries; Risk Factors; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2021
Transfermoral transcatheter aortic valve implantation using self-expanding Allegra bioprosthesis: One-year single-center outcomes.
    Cardiology journal, 2021, Volume: 28, Issue:6

    Topics: Aged; Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Female; Heart Valve Prosthesis; Humans; Prosthesis Design; Stroke; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2021
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:5

    Topics: Animals; Antipyrine; Atenolol; Carbamazepine; Cell Membrane; Digoxin; Diltiazem; Diphenhydramine; Drug Elimination Routes; Gabapentin; Lamotrigine; Liver; Memantine; Membrane Transport Proteins; Microdialysis; Muscle, Skeletal; Ofloxacin; Pharmaceutical Preparations; Propranolol; Pyrilamine; Quinidine; Rats; Terfenadine

2021
Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice.
    International journal of molecular sciences, 2021, Oct-15, Volume: 22, Issue:20

    Topics: Animals; Biomarkers, Pharmacological; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipases A2, Cytosolic; Terfenadine

2021
Novel self-expanding ALLEGRA transcatheter aortic valve for native aortic stenosis and degenerated bioprosthesis.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2022, Volume: 99, Issue:4

    Topics: Aged; Aged, 80 and over; Animals; Aortic Valve; Aortic Valve Stenosis; Bioprosthesis; Cattle; Heart Valve Prosthesis; Humans; Prosthesis Design; Terfenadine; Transcatheter Aortic Valve Replacement; Treatment Outcome

2022
Targeting spinal microglia with fexofenadine-loaded nanoparticles prolongs pain relief in a rat model of neuropathic pain.
    Nanomedicine : nanotechnology, biology, and medicine, 2022, Volume: 44

    Topics: Animals; Microglia; Nanoparticles; Neuralgia; Rats; Spinal Cord; Spinal Nerves; Terfenadine

2022
Cubosomes for Enhancing Intestinal Absorption of Fexofenadine Hydrochloride: In situ and in vivo Investigation.
    International journal of nanomedicine, 2022, Volume: 17

    Topics: Animals; Drug Liberation; Intestinal Absorption; Particle Size; Poloxamer; Rabbits; Rats; Terfenadine

2022
Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach.
    Therapeutic drug monitoring, 2023, 08-01, Volume: 45, Issue:4

    Topics: Adult; Bayes Theorem; Citrus paradisi; Humans; Organic Anion Transporters; Pharmaceutical Preparations; Terfenadine

2023
Fexofenadine protects against lipopolysaccharide-induced acute lung injury by targeting cytosolic phospholipase A2.
    International immunopharmacology, 2023, Volume: 116

    Topics: Acute Lung Injury; Animals; Cytokines; Lipopolysaccharides; Lung; Mice; Mice, Knockout; NF-kappa B; Phospholipases A2; Signal Transduction; Terfenadine

2023
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine.
    Biological & pharmaceutical bulletin, 2023, Volume: 46, Issue:12

    Topics: Animals; Caco-2 Cells; Food; Food-Drug Interactions; Humans; Intestinal Absorption; Mice; Organic Anion Transporters; Terfenadine

2023