Page last updated: 2024-08-16

terfenadine and ebastine

terfenadine has been researched along with ebastine in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (43.24)	18.2507
2000's	15 (40.54)	29.6817
2010's	5 (13.51)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Patel, U; Webb, M	1
Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Sen, S; Sinha, N	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Imano, K; Ishii, K; Karasawa, T; Nakamura, H; Seto, Y; Takeyama, K; Yakuo, I	1
O'Hanlon, JF; Ramaekers, JG	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W	2
Kalis, B	1
Llenas, J; Roberts, DJ	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J	1
Delpón, E; Franqueza, L; Gay, P; Tamargo, J; Valenzuela, C; Vicente, J	1
Roberts, DJ	2
Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y	1
Mattila, MJ; Paakkari, I	1
Danielson, L; DeVos, C; Grant, JA; Rihoux, JP	1
Hanada, E; Hirota, M; Iga, T; Kotaki, H; Nakaya, H; Ohtani, H; Sato, H; Sawada, Y; Uemura, H	1
López, M; Palacios, JM; Roberts, DJ; Ryder, H; Segarra, V	1
Chaikin, P; Gillen, MS; Miller, B; Morganroth, J	1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM	1
Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE	1
Paakkari, I	1
Malik, M	1
Boyce, M; Carey, W; Luria, X; Warrington, S	1
Antonijoan, RM; Barbanoj, MJ; Esbrí, R; Garcia, E; García-Gea, C; Gich, I; Gispert, J; Luria, X; Morte, A	1
Appajosyula, S; Gelfand, EW; Meeves, S	1
Buisson, D; Jaouen, M; Mazier, C; Sari, MA	1
Codreanu, A; de Chillou, C; Moneret-Vautrin, DA	1
Cheng, J; Jiang, H; Li, W; Liu, H; Tang, Y; Zhu, W	1
Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H	1
Laguna Martínez, JJ; Reaño Martos, M; Rojas Pérez-Ezquerra, P; Sánchez Morillas, L; Sanz, ML	1
Fukui, H; Hattori, M; Kitamura, Y; Kuroda, W; Mizuguchi, H; Ogishi, H; Takeda, N	1
Bekkali, N; Boeckxstaens, GE; de Jonge, WJ; Shi, J; Stanisor, OI; van den Wijngaard, RM; van Diest, SA; Welting, O; Yu, Z	1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H	1

Reviews

5 review(s) available for terfenadine and ebastine

Article	Year
Towards the optimal antihistamine: studies with ebastine. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Piperidines; Potassium Channels; Rats; Structure-Activity Relationship; Terfenadine	1998
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
[The effect of second generation histamine antagonists on the heart]. Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4 Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes	2001
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research. Current medical research and opinion, 2004, Volume: 20, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine	2004

Trials

7 trial(s) available for terfenadine and ebastine

Article	Year
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94. Allergy, 1995, Volume: 50, Issue:3 Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine	1995
Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs, 1996, Volume: 52 Suppl 1 Topics: Adult; Anti-Allergic Agents; Butyrophenones; Chronic Disease; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine; Urticaria	1996
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. Allergy, 1999, Volume: 54, Issue:7 Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria	1999
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. British journal of clinical pharmacology, 2001, Volume: 52, Issue:2 Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines; Terfenadine	2001
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:2 Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria	2002
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. Drugs under experimental and clinical research, 2002, Volume: 28, Issue:6 Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine	2002
A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity. International archives of allergy and immunology, 2003, Volume: 132, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Butyrophenones; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Terfenadine	2003

Other Studies

25 other study(ies) available for terfenadine and ebastine

Article	Year
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20 Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Motor Activity; Piperazines; Piperidines; Rats; Structure-Activity Relationship	1995
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR. Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:3 Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Male; Phenothiazines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Terfenadine	1994
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5 Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine	1996
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. Arzneimittel-Forschung, 1996, Volume: 46, Issue:2 Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes	1996
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines. Arzneimittel-Forschung, 1996, Volume: 46, Issue:8 Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes	1996
Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels. European journal of pharmacology, 1997, May-20, Volume: 326, Issue:2-3 Topics: Animals; Butyrophenones; Cells, Cultured; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Terfenadine	1997
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; Piperidines; Rats; Rats, Sprague-Dawley; Terfenadine	1999
Cardiotoxicity of second-generation antihistamines. Drugs, 1999, Volume: 57, Issue:6 Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	1999
Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9 Topics: Animals; Butyrophenones; Dibenzazepines; Electrophysiology; Heart Ventricles; Histamine H1 Antagonists; Imidazoles; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley; Terfenadine	1999
Computer-assisted comparison of the structural and electronic dispositions of ebastine and terfenadine. Drug safety, 1999, Volume: 21 Suppl 1 Topics: Butyrophenones; Histamine H1 Antagonists; Models, Molecular; Molecular Conformation; Piperidines; Signal Processing, Computer-Assisted; Terfenadine	1999
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations]. Terapevticheskii arkhiv, 2002, Volume: 74, Issue:3 Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine	2002
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. British journal of clinical pharmacology, 2002, Volume: 54, Issue:6 Topics: Butyrophenones; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	2002
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine. Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21 Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine	2004
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:10 Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunctivitis, Allergic; Cromolyn Sodium; Diabetes Mellitus, Type 1; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Piperazines; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine	2006
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking. Proteins, 2008, May-01, Volume: 71, Issue:2 Topics: Amino Acid Sequence; Binding Sites; Butyrophenones; Computer Simulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Oxygenases; Piperidines; Protein Interaction Domains and Motifs; Sequence Alignment; Structural Homology, Protein; Substrate Specificity; Terfenadine	2008
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria	2008
Urticaria due to antihistamines. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:1 Topics: Administration, Oral; Butyrophenones; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Piperidines; Terfenadine; Urticaria	2011
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen. Acta oto-laryngologica, 2012, Volume: 132, Issue:4 Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; Interleukins; Male; Middle Aged; Nasal Mucosa; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine	2012
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists. PloS one, 2013, Volume: 8, Issue:6 Topics: Animals; Blotting, Western; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Irritable Bowel Syndrome; Mast Cells; Maternal Deprivation; Occludin; Piperidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; Terfenadine	2013
Cytochrome Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11 Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine	2022