Page last updated: 2024-08-16

terfenadine and chlorpheniramine

terfenadine has been researched along with chlorpheniramine in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (36.36)	18.7374
1990's	18 (27.27)	18.2507
2000's	15 (22.73)	29.6817
2010's	8 (12.12)	24.3611
2020's	1 (1.52)	2.80

Authors

Authors	Studies
Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Patel, U; Webb, M	1
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S	1
Strassburg, CP; Tukey, RH	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Keserü, GM	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Caron, G; Ermondi, G	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Jia, L; Sun, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Sen, S; Sinha, N	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Wood, SF	1
McMillan, JL; Simons, FE; Simons, KJ	1
Kaiser, HB	1
Martin, TJ; Simons, FE; Simons, KJ; Watson, WT	1
Loring, DW; Meador, KJ; Thompson, EE; Thompson, WO	1
Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM	1
Rafferty, P	1
Loring, DW; Meador, KJ	1
Nicholson, AN	1
Bjerrum, P; Illum, P; Johansen, LV	1
Fleisch, JH; Haisch, KD; Rinkema, LE; Whitesitt, CA	1
Codecasa, LR; Fugazza, A; Gerosa, S; Ortolani, C; Pastorello, EA; Pravettoni, V; Zanussi, C	1
Chung, M; Simons, FE; Simons, KJ; Yeh, J	1
Meltzer, EO	1
Backhouse, CI; Rosenberg, R	1
Chumsawat, P; Limsuwan, A; Sriwatanakul, K; Unchern, S	1
Bernstein, DI; Buckley, CE; Chu, T; Fox, RW; Grant, JA; Rocklin, RE; Schoenwetter, WF; Spector, SL; Stafford, CT; Stroh, JE	1
Del Carpio, J; Gelinas, B; Gutkowski, A; Schulz, J; Turenne, Y	1
Buckley, CE; Klemawesch, SJ; Lucas, SK	1
Brandon, ML; Weiner, M	1
Dabrowicki, E; Huddlestone, L; Kagan, G; Kapur, TR; Wolstencroft, P	1
Backhouse, CI; Brewster, BS; Lockhart, JD; Maneksha, S; Purvis, CR; Vallé-Jones, JC	1
Brostoff, J; Lockhart, JD	1
Cheng, HC; Woodward, JK	1
D'Amato, G; Del Giacco, GS; Di Tucci, A; Lenzini, L; Locci, F; Loy, M; Melillo, G; Ortolani, C; Pastorello, E; Rottoli, P; Sestini, P; Zanussi, C	1
Birnbaum, J; Charpin, J; Dugue, P; Poisson, A	1
Brewster, BS	1
Duncan, JS; Kennedy, HJ; Triger, DR	1
Elsayed, S; Holen, E; Nyfors, A	1
Canestrari, DA; Miller, RD; Riker, DK; Witek, TJ; Yang, JY	1
Guinosso, PJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Stupienski, RF; Wallace, AA	1
André, C; Hassoun, S; Le Sellin, J; Sabbah, A; Sicard, H	1
Reggin, JD; Roberts, JR; Simons, FE; Simons, KJ	1
Biegalski, CS; Brooker, AE; Philpot, EE	1
Gebhard, JS; Johnston-Jones, K; Kabo, JM; Kody, MH; Meals, RA	1
André, C; Hassoun, S; Lesellin, J; Sabbah, A; Sicard, H	1
Ido, T; Ito, K; Itoh, M; Iwata, R; Ryu, JH; Sawai, Y; Watanabe, T; Yanai, K	1
Comer, C; Harvey, RP; Marsh, W; Sanders, B; Shapiro, H; Westley, R; Wiener, M	1
Crawford, WW; Klaustermeyer, WB; Lee, PH; Placik, IM	1
Yasuda, RP; Yasuda, SU	1
Díaz-Trelles, R; Fernández-Sánchez, MT; Marini, A; Novelli, A; Vega, JA	1
Gu, X; Silver, NA; Simons, FE; Simons, KJ	1
Hasegawa, Y; Hindmarch, I; Ishikawa, K; Kamei, H; Muraoka, I; Nabeshima, T; Noda, Y; Senzaki, K	1
Boyle, J; Eriksson, M; Fujita, T; Kumagi, Y; Stanley, N	1
Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Rahman, A; Takechi, K	1
Ahn, JH; Kim, JE; Kim, MJ; Kim, SD; Lee, HW; Moon, SO; Park, DJ; Yoon, YR	1
Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H	1
Asano, K; Furuta, A; Hirano, K; Shoji, N; Suzaki, H	1
Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y	1
Abe, R; Arinami, H; Hama, N; Maruyama, R; Shimomura, Y	1
Akatsu, C; Fukui, H; Hishinuma, S; Kosaka, K; Shoji, M; Uesawa, Y	1
Hassan, K	1

Reviews

3 review(s) available for terfenadine and chlorpheniramine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis. Rhinology. Supplement, 1992, Volume: 13 Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; Conjunctivitis, Allergic; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine	1992
H1-receptor antagonist treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Ketotifen; Loratadine; Rhinitis, Allergic, Seasonal; Terfenadine	1990

Trials

28 trial(s) available for terfenadine and chlorpheniramine

Article	Year
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadine; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Placebos; Skin Tests; Terfenadine; Time Factors; Urticaria	1990
Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly. The Journal of allergy and clinical immunology, 1990, Volume: 85, Issue:3 Topics: Aged; Aging; Benzhydryl Compounds; Chlorpheniramine; Chromatography, High Pressure Liquid; Double-Blind Method; Female; Half-Life; Humans; Randomized Controlled Trials as Topic; Skin Tests; Terfenadine; Time Factors	1990
Differential cognitive effects of terfenadine and chlorpheniramine. The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:3 Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Cognition; Double-Blind Method; Evoked Potentials, Somatosensory; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Random Allocation; Reaction Time; Terfenadine	1989
Treatment of seasonal allergic rhinitis--a double blind, group comparative study of terfenadine and dexchlorpheniramine. Rhinology, 1987, Volume: 25, Issue:1 Topics: Adolescent; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1987
Antihistaminic treatment of allergic rhinitis: a double-blind study with terfenadine versus dexchlorpheniramine. Pharmatherapeutica, 1987, Volume: 5, Issue:2 Topics: Adolescent; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Pollen; Random Allocation; Rhinitis, Allergic, Seasonal; Skin Tests; Terfenadine	1987
Prophylaxis of whole season hay fever symptomatology: a comparison of terfenadine with chlorpheniramine. The British journal of clinical practice, 1987, Volume: 41, Issue:11 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Random Allocation; Rhinitis, Allergic, Seasonal; Terfenadine	1987
Double-blind comparison of terfenadine, chlorpheniramine, and placebo in the treatment of chronic idiopathic urticaria. The Journal of allergy and clinical immunology, 1988, Volume: 81, Issue:3 Topics: Adolescent; Adult; Benzhydryl Compounds; Chlorpheniramine; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Placebos; Terfenadine; Urticaria	1988
Comparative study of the efficacy, tolerance and side-effects of dexchlorpheniramine maleate 6 mg b.i.d. with terfenadine 60 mg b.i.d. The Journal of international medical research, 1985, Volume: 13, Issue:5 Topics: Adolescent; Adult; Benzhydryl Compounds; Child; Chlorpheniramine; Clinical Trials as Topic; Drug Tolerance; Humans; Middle Aged; Random Allocation; Rhinitis, Allergic, Seasonal; Sleep Stages; Terfenadine	1985
Treatment of allergic rhinitis with a new selective H1 antihistamine: terfenadine. New England and regional allergy proceedings, 1985,Winter, Volume: 6, Issue:1 Topics: Administration, Oral; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Random Allocation; Rhinitis, Allergic, Seasonal; Sleep; Terfenadine	1985
Clinical investigation of terfenadine, a non-sedating antihistamine. Annals of allergy, 1980, Volume: 44, Issue:2 Topics: Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperidines; Placebos; Pollen; Terfenadine	1980
A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders. The Journal of international medical research, 1980, Volume: 8, Issue:6 Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Placebos; Rhinitis, Allergic, Seasonal; Terfenadine	1980
Terfenadine in allergic rhinitis. A comparative trial of a new antihistamine versus chlorpheniramine and placebo. The Practitioner, 1982, Volume: 226, Issue:1364 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis; Terfenadine	1982
Controlled trial of terfenadine and chlorpheniramine maleate in perennial rhinitis. Postgraduate medical journal, 1982, Volume: 58, Issue:681 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Middle Aged; Rhinitis, Allergic, Perennial; Terfenadine	1982
A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Adolescent; Adult; Aging; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Respiratory Hypersensitivity; Rhinitis; Sex Factors; Terfenadine	1982
Clinical studies with terfenadine in seasonal allergic rhinitis in France. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Chlorpheniramine; Circadian Rhythm; Female; France; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1982
Summary of four UK clinical trials with terfenadine. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Benzhydryl Compounds; Chlorpheniramine; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; United Kingdom	1982
Treatment of pruritus due to chronic obstructive liver disease. British medical journal (Clinical research ed.), 1984, Jul-07, Volume: 289, Issue:6436 Topics: Benzhydryl Compounds; Chlorpheniramine; Cholangitis; Cholestyramine Resin; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Liver Cirrhosis, Biliary; Pruritus; Random Allocation; Terfenadine	1984
Characterization of daytime sleepiness and psychomotor performance following H1 receptor antagonists. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1995, Volume: 74, Issue:5 Topics: Adolescent; Adult; Chlorpheniramine; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Psychomotor Performance; Sleep; Terfenadine; Time Factors	1995
A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy, 1994, Volume: 49, Issue:5 Topics: Administration, Sublingual; Adolescent; Adult; Aerosols; Betamethasone; Chlorpheniramine; Combined Modality Therapy; Conjunctivitis, Allergic; Cromolyn Sodium; Desensitization, Immunologic; Double-Blind Method; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Plant Extracts; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Stereoisomerism; Tablets; Terfenadine; Time Factors; Treatment Outcome	1994
Benefit/risk ratio of the antihistamines (H1-receptor antagonists) terfenadine and chlorpheniramine in children. The Journal of pediatrics, 1994, Volume: 124, Issue:6 Topics: Action Potentials; Central Nervous System; Child; Chlorpheniramine; Cognition; Double-Blind Method; Female; Humans; Male; Odds Ratio; Rhinitis, Allergic, Perennial; Terfenadine	1994
Effects of sedating and nonsedating antihistamines on flying performance. Military medicine, 1993, Volume: 158, Issue:10 Topics: Aerospace Medicine; Analysis of Variance; Chlorpheniramine; Diphenhydramine; Double-Blind Method; Humans; Military Personnel; Neuropsychological Tests; Psychological Tests; Psychomotor Performance; Task Performance and Analysis; Terfenadine; United States	1993
[Sublingual specific immunotherapy for rhinoconjunctivitis caused by grass pollens]. Allergie et immunologie, 1993, Volume: 25, Issue:6 Topics: Administration, Sublingual; Adolescent; Adult; Allergens; Betamethasone; Chlorpheniramine; Combined Modality Therapy; Conjunctivitis, Allergic; Cromolyn Sodium; Desensitization, Immunologic; Double-Blind Method; Female; Humans; Male; Middle Aged; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome	1993
Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1996, Volume: 97, Issue:6 Topics: Adolescent; Adult; Cetirizine; Chlorpheniramine; Decision Making; Female; Formularies as Topic; Histamine H1 Antagonists; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Quality of Life; Rhinitis, Allergic, Seasonal; Terfenadine	1996
Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1998, Volume: 118, Issue:5 Topics: Adrenergic Agents; Allergens; Ambulatory Care; Analysis of Variance; Anti-Allergic Agents; Astemizole; Bronchodilator Agents; Chlorpheniramine; Confidence Intervals; Cross-Over Studies; Ephedrine; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Nasal Mucosa; Nose; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome	1998
Clinical pharmacology of H1-antihistamines in the skin. The Journal of allergy and clinical immunology, 2002, Volume: 110, Issue:5 Topics: Adult; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Skin; Skin Tests; Terfenadine	2002
Comparative study of acute effects of single doses of fexofenadine, olopatadine, d-chlorpheniramine and placebo on psychomotor function in healthy volunteers. Human psychopharmacology, 2003, Volume: 18, Issue:8 Topics: Adult; Chlorpheniramine; Choice Behavior; Cognition; Cross-Over Studies; Dibenzoxepins; Double-Blind Method; Female; Flicker Fusion; Histamine H1 Antagonists; Humans; Male; Olopatadine Hydrochloride; Psychomotor Performance; Reaction Time; Terfenadine; Time Factors	2003
Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects. Current medical research and opinion, 2006, Volume: 22, Issue:7 Topics: Adult; Anti-Allergic Agents; Asian People; Chlorpheniramine; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Japan; Male; Middle Aged; Psychomotor Performance; Sleep; Sleep, REM; Terfenadine	2006
The effects of fexofenadine at steady-state on sleep architecture: a study using polysomnography in healthy Korean volunteers. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:10 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorpheniramine; Cross-Over Studies; Double-Blind Method; Genotype; Half-Life; Histamine H1 Antagonists; Humans; Korea; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic; Sleep; Sleep, REM; Terfenadine	2008

Other Studies

35 other study(ies) available for terfenadine and chlorpheniramine

Article	Year
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20 Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Motor Activity; Piperazines; Piperidines; Rats; Structure-Activity Relationship	1995
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water	1998
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine. Agents and actions, 1989, Volume: 28, Issue:1-2 Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine	1989
The European experience with antihistamines in asthma. Annals of allergy, 1989, Volume: 63, Issue:5 Topics: Asthma; Benzhydryl Compounds; Chlorpheniramine; Europe; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Terfenadine	1989
Central nervous system effects of antihistamines on evoked potentials. Annals of allergy, 1989, Volume: 63, Issue:6 Pt 2 Topics: Adult; Alzheimer Disease; Benzhydryl Compounds; Central Nervous System; Chlorpheniramine; Evoked Potentials; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Placebos; Terfenadine	1989
Central effects of H1 and H2 antihistamines. Aviation, space, and environmental medicine, 1985, Volume: 56, Issue:4 Topics: Aerospace Medicine; Benzhydryl Compounds; Central Nervous System; Chlorpheniramine; Cimetidine; Clemastine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Phenothiazines; Promethazine; Psychomotor Performance; Ranitidine; Sleep Stages; Structure-Activity Relationship; Terfenadine; Visual Acuity; Visual Perception	1985
Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist. Agents and actions, 1987, Volume: 20, Issue:1-2 Topics: Animals; Benzhydryl Compounds; Benzimidazoles; Bronchial Provocation Tests; Chlorpheniramine; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists; Lung; Male; Muscle, Smooth; Promethazine; Pyrilamine; Terfenadine; Triprolidine	1987
The comparative pharmacokinetics of H1-receptor antagonists. Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2 Topics: Adult; Age Factors; Astemizole; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cetirizine; Child; Chlorpheniramine; Dose-Response Relationship, Drug; Half-Life; Histamine H1 Antagonists; Humans; Hydroxyzine; Terfenadine	1987
The use of antihistamines for the treatment of airway disease. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Child; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1988
Psychomotor performances and subjective feeling studies with antihistamine. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1986, Volume: 69, Issue:4 Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Cognition; Diphenhydramine; Female; Humans; Male; Nausea; Psychomotor Performance; Terfenadine	1986
A kinetic study of the antihistaminic effect of terfenadine. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Animals; Benzhydryl Compounds; Chlorpheniramine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Terfenadine; Time Factors; Trachea	1982
The effect of H1 receptor antagonists on peripheral blood mononuclear cells, adenoid cells and primary cell lines. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1995, Volume: 103, Issue:2 Topics: Adenoids; Adult; Cell Division; Cell Line; Chlorpheniramine; Dermatitis, Atopic; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Leukocytes, Mononuclear; Loratadine; Male; Middle Aged; Terfenadine	1995
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circulation research, 1995, Volume: 76, Issue:1 Topics: Action Potentials; Animals; Astemizole; Chlorpheniramine; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Potassium Channels; Pyrilamine; Refractory Period, Electrophysiological; Terfenadine	1995
Effects of antihistamines on joint stiffness and bone healing after periarticular fracture. The Journal of hand surgery, 1993, Volume: 18, Issue:6 Topics: Animals; Chlorpheniramine; Female; Fracture Healing; Fractures, Bone; Knee Injuries; Knee Joint; Rabbits; Range of Motion, Articular; Terfenadine	1993
Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography. British journal of pharmacology, 1995, Volume: 116, Issue:1 Topics: Administration, Oral; Adult; Animals; Brain; Carbon Radioisotopes; Chlorpheniramine; Doxepin; Guinea Pigs; Histamine H1 Antagonists; Humans; Male; Receptors, Histamine H1; Terfenadine; Tomography, Emission-Computed	1995
Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy, 1999, Volume: 19, Issue:4 Topics: Animals; Atropine; Brompheniramine; Chlorpheniramine; CHO Cells; Cricetinae; Histamine H1 Antagonists; Humans; Kinetics; Receptors, Muscarinic; Substrate Specificity; Terfenadine; Transfection	1999
Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death. Brain research, 2000, Oct-13, Volume: 880, Issue:1-2 Topics: Animals; Biological Transport; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chlorpheniramine; Cyclic GMP; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Histamine; Histamine H1 Antagonists; N-Methylaspartate; Neurons; Piperazines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Terfenadine; Triprolidine	2000
Newer antihistamines. The Medical letter on drugs and therapeutics, 2001, Apr-30, Volume: 43, Issue:1103 Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Somnambulism; Terfenadine	2001
Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3 Topics: Administration, Oral; Animals; Animals, Suckling; Chlorpheniramine; Cyproheptadine; Dibenzazepines; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Rats; Rats, Wistar; Seizures; Terfenadine; Time Factors	2007
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria	2008
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. International archives of allergy and immunology, 2011, Volume: 155, Issue:1 Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extracellular Signal-Regulated MAP Kinases; GATA1 Transcription Factor; Gene Expression; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Male; Middle Aged; NF-kappa B; Phosphorylation; Phthalazines; Piperazines; Plant Proteins; Rhinitis, Allergic, Seasonal; Signal Transduction; Terfenadine; Tuberculin; Young Adult	2011
Pharmacophore modeling for hERG channel facilitation. Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1 Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis	2012
Localized heat urticaria: Positive reaction of preheated autologous serum skin test. The Journal of dermatology, 2016, Volume: 43, Issue:9 Topics: Anaphylaxis; Chlorpheniramine; Desensitization, Immunologic; Drug Therapy, Combination; Histamine H1 Antagonists, Non-Sedating; Hot Temperature; Humans; Influenza, Human; Intradermal Tests; Male; Middle Aged; Serum; Skin; Terfenadine; Urticaria	2016
Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H Biochemical pharmacology, 2017, Mar-15, Volume: 128 Topics: Animals; Aspartic Acid; Cations, Monovalent; Chlorpheniramine; CHO Cells; Cricetulus; Histamine; Histamine Agonists; Histamine H1 Antagonists; Humans; Ligands; Mutation; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Histamine H1; Sodium Chloride; Terfenadine	2017
Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection. BMJ case reports, 2020, Jul-07, Volume: 13, Issue:7 Topics: Angioedema; Anti-Allergic Agents; Betacoronavirus; Chlorpheniramine; Coronavirus Infections; COVID-19; Diagnosis, Differential; Female; Humans; Middle Aged; Pandemics; Pneumonia, Viral; Prednisone; Prodromal Symptoms; SARS-CoV-2; Terfenadine; Treatment Outcome; Urticaria	2020