Page last updated: 2024-08-16

terfenadine and astemizole

terfenadine has been researched along with astemizole in 149 studies

Research

Studies (149)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (26.85)	18.7374
1990's	65 (43.62)	18.2507
2000's	25 (16.78)	29.6817
2010's	16 (10.74)	24.3611
2020's	3 (2.01)	2.80

Authors

Authors	Studies
Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Patel, U; Webb, M	1
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S	1
Achterrath, U; Duflos, M; Emig, P; Fouchard, F; Günther, E; Kutscher, B; Le Baut, G; Menciu, C; Nickel, B; Schmidt, J; Szelenyi, I	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Pearlstein, R; Rampe, D; Vaz, R	1
Keserü, GM	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Caron, G; Ermondi, G	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bergström, CA; Hubatsch, I; Johansson, K; Wassvik, CM	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Caron, G; Ermondi, G; Visentin, S	1
Abu Khalaf, R; Abu Sheikha, G; Bustanji, Y; Taha, MO	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Dalvie, D; Loi, CM; Smith, DA	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Alves de Lima Franco, F; Corpas-López, V; Correa-Basurto, J; de la Cruz, M; de Pedro, N; Díaz-Gavilán, M; Domínguez-Seglar, JF; Franco-Montalbán, F; Gómez-Vidal, JA; López-Viota, J; López-Viota, M; Martín-Sánchez, J; Morillas-Márquez, F; Panadero-Fajardo, S; Pérez Del Palacio, J; Sixto-López, Y; Tabraue-Chávez, M	1
Krause, HF	1
Nightingale, SL	1
Kaliner, MA	1
Kemp, JP	1
Wood, SF	2
Berger, U; Horak, F; Jäger, S	1
Nichols, AW	1
Fletcher, MP; Ryhal, BT	1
Blehová, H; Metys, J	1
Soter, NA	1
Gillardin, JM; Gommeren, W; Janssen, PA; Janssen, PF; Leysen, JE; Sanz, G; Schotte, A	1
Barrett, D; Biskin, N; Small, P	1
Bastecký, J; Kvasnicka, J; Tauchman, M; Vortel, J; Wasylivová, V	1
McMillan, JL; Simons, FE; Simons, KJ	1
Woodward, JK	2
Kaiser, HB	1
Simons, FE	1
Beasley, R; Holgate, ST; Miszkiel, KA; Rafferty, P	1
Bechtel, WD; Fügner, A; Kuhn, FJ; Mierau, J	1
Bödeker, RH; Paul, E	2
Lantin, JP; Pécoud, A	1
Lahti, A; Työlahti, H	1
Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM	1
Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M	1
Cilli, P; Negrini, AC; Troise, C; Voltolini, S	1
Repp, V	1
Bäurle, G	1
Norman, PS	1
Freedman, BJ	1
Drouin, MA	1
Brandon, ML	1
Araujo, OE; Flowers, FP; Nieves, CH	1
Pécoud, A	1
Beasley, R; Holgate, S; Rafferty, P; Southgate, P	1
Grillage, MG; Harcup, JW; Huddlestone, L; Mayhew, SR	1
Cainelli, T; Mosca, M; Seidenari, S; Valsecchi, R	1
Zellweger, JP; Zullig, R	1
Chung, M; Simons, FE; Simons, KJ; Yeh, J	1
Bibi, H; Greif, J; Kivity, S; Schwartz, Y; Topilsky, M	1
Boland, N	1
Filderman, RB	1
Meltzer, EO	1
Shuster, S	2
Gendreau-Reid, L; Simons, FE; Simons, KJ	1
Dolovich, J; Juniper, EF; White, J	1
Fish, A	1
Bigliardi, P; Girard, JP; Henauer, SA; Sommacal-Schopf, D	1
Nicholson, AN; Stone, BM	1
Nicholson, AN	1
Krause, L; Shuster, S	1
Holgate, ST; Howarth, PH	1
Obel, AO	1
Storms, WW	1
Berul, CI; Morad, M	1
Neuvonen, P	1
Kelloway, JS; Pongowski, MA; Schoenwetter, WF	1
Hakim, A; Stahl, A	1
Katelaris, CH	1
Smith, SJ	1
Guinosso, PJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Stupienski, RF; Wallace, AA	1
Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD	1
Darrow, WR; Woosley, R	1
Dowd, PM; Goldsmith, P	1
Conti, CR	1
Cantilena, LR; Honig, PK	1
Botstein, P	1
Bakker, A; Herings, RM; Leufkens, HG; Stricker, BH; Sturmans, F; Urquhart, J	1
Holdcroft, C	1
Bernhard, JD	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W	1
Busch, AE; Lang, F; Suessbrich, H; Waldegger, S	1
Woosley, RL	1
Haxby, DG; Zechnich, AD	1
Clark, S	1
Edwards, IR; Lindquist, M	1
Himmel, MH; Honig, PK; Worobec, AS	1
Briscoe, MP; Clark, RH; Day, JH; Ellis, AK; Gervais, P	1
Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D	1
Wroblewski, BA	1
Crawford, WW; Klaustermeyer, WB; Lee, PH; Placik, IM	1
Bevill, TV	1
Estes, KS; González, MA	1
Annunziato, L; Castaldo, P; Genovese, A; Giorgio, G; January, CT; Marone, G; Pannaccione, A; Taglialatela, M; Zhou, Z	1
Abdel-Fattah, L; Bebawy, LI; Kelani, K	1
Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
DuBuske, LM	1
de Abajo, FJ; Rodríguez, LA	1
Mattila, MJ; Paakkari, I	1
Gong, Q; January, CT; Vorperian, VR; Zhang, S; Zhou, Z	1
Roberts, DJ	1
Chachin, M; Horio, Y; Katayama, Y; Kitagawa, H; Kurachi, Y; Ohmura, T; Uchida, S; Yamada, M	1
Chachin, M; Igarashi, T; Ikeda, H; Ikegami, K; Kitagawa, H; Nagakura, A; Ohmura, T; Tarui, S; Uchida, S	1
Estelle, F; Simons, R	1
Collart, P; Nicolas, JM; Roba, J; Whomsley, R	1
Tytgat, J; Ulens, C	1
Benedetto, SR; Duncan, BS; Sloan, AS	1
Annunziato, L; Cataldi, M; Di Renzo, G; Giorgio, G; Secondo, A; Taglialatela, M; Valore, M	1
Matsumoto, S; Yamazoe, Y	1
Kohl, RL	1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
Annunziato, L; Castaldo, P; Fresi, A; Giorgio, G; Pannaccione, A; Rosati, B; Secondo, A; Taglialatela, M; Wanke, E	1
Bariletto, G; Caiaffa, MF; De Michele, G; Di Paola, R; Iudice, A; Macchia, L; Tursi, A	1
Paakkari, I	1
Dabhi, J; Mehta, A	1
Brown, AM; Kuryshev, YA; Liu, Z; Smith, SS; Wible, BA	1
Moeller, ML; Nahata, MC; Phan, H	1
Komuro, S; Mizuki, Y; Nishimuta, H; Sato, K; Yabuki, M	1
Bader, M; Klingerman, CM; Lynch, CJ; Stipanovic, ME	1
Clancy, CE; Romero, L; Saiz, J; Trenor, B; Yang, PC	1
Inoue, T; Okamoto, E; Sasaki, E; Uehara, S; Uno, Y; Yamazaki, H	1
Hinoi, E; Miyawaki, I; Tsubouchi, T; Watanabe, K; Yamada, T	1
Becker, N; Brinkwirth, N; Doi, M; Fertig, N; Friis, S; Furukawa, H; Hasegawa, Y; Obergrussberger, A; Ohtsuki, A; Oka, T; Stoelzle-Feix, S; Takasuna, K	1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H	1

Reviews

22 review(s) available for terfenadine and astemizole

Article	Year
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior. Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11 Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Models, Molecular; Pharmaceutical Preparations; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG	2003
Nonsedating antihistamines: pharmacology, clinical efficacy and adverse effects. American family physician, 1992, Volume: 45, Issue:3 Topics: Astemizole; Cyproheptadine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Terfenadine	1992
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis. Rhinology. Supplement, 1992, Volume: 13 Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; Conjunctivitis, Allergic; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine	1992
Exercise-induced anaphylaxis and urticaria. Clinics in sports medicine, 1992, Volume: 11, Issue:2 Topics: Anaphylaxis; Astemizole; Clemastine; Exercise; Humans; Terfenadine; Urticaria	1992
The second-generation antihistamines. What makes them different? Postgraduate medicine, 1991, May-01, Volume: 89, Issue:6 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Cetirizine; Cyproheptadine; Education, Medical, Continuing; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity; Loratadine; Terfenadine	1991
H1-receptor antagonist treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Ketotifen; Loratadine; Rhinitis, Allergic, Seasonal; Terfenadine	1990
Recent advances in H1-receptor antagonist treatment. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Receptors, Histamine H1; Rhinitis, Allergic, Perennial; Terfenadine; Urticaria	1990
Antihistamines. International journal of dermatology, 1986, Volume: 25, Issue:4 Topics: Animals; Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Child, Preschool; Cimetidine; Drug Synergism; Guanidines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Imidazoles; Infant; Infant, Newborn; Kinetics; Pyrimidinones; Ranitidine; Terfenadine	1986
[H1-receptor blockers: review and preview]. Harefuah, 1988, Feb-01, Volume: 114, Issue:3 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Terfenadine	1988
Pharmacology and toxicology of nonclassical antihistamines. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cyproheptadine; Drug Administration Schedule; Histamine H1 Antagonists; Humans; Loratadine; Sleep Stages; Terfenadine	1988
Treatment of seasonal allergic rhinitis with fluticasone propionate aqueous nasal spray: review of comparator studies. Allergy, 1995, Volume: 50, Issue:23 Suppl Topics: Administration, Topical; Aerosols; Androstadienes; Anti-Inflammatory Agents; Astemizole; Beclomethasone; Double-Blind Method; Fluticasone; Glucocorticoids; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine	1995
[Current hazardous drug interactions]. Duodecim; laaketieteellinen aikakauskirja, 1993, Volume: 109, Issue:20 Topics: Anti-Infective Agents; Astemizole; Benzodiazepines; Calcium Channel Blockers; Cyclosporins; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fluoroquinolones; Heart Conduction System; Histamine H1 Antagonists; Humans; Monoamine Oxidase Inhibitors; Pharmaceutical Preparations; Terfenadine	1993
Cardiovascular toxicity of antihistamines. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1994, Volume: 111, Issue:3 Pt 2 Topics: Astemizole; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Terfenadine; Torsades de Pointes	1994
The new H1 antihistamines. Treatment of urticaria and other clinical problems. Dermatologic clinics, 1993, Volume: 11, Issue:1 Topics: Astemizole; Cetirizine; Dermatitis, Atopic; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine; Urticaria	1993
Cardiac actions of antihistamines. Annual review of pharmacology and toxicology, 1996, Volume: 36 Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Torsades de Pointes	1996
Pharmacokinetic overview of oral second-generation H1 antihistamines. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:5 Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure-Activity Relationship; Terfenadine; Therapeutic Equivalency; Torsades de Pointes	1998
[The effect of new H1-receptor antagonists on cardiovascular system]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1998, Volume: 5, Issue:30 Topics: Astemizole; Heart; Histamine H1 Antagonists; Humans; Terfenadine	1998
Second-generation antihistamines: the risk of ventricular arrhythmias. Clinical therapeutics, 1999, Volume: 21, Issue:2 Topics: Animals; Astemizole; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Myocardium; Potassium Channels; Risk; Tachycardia, Ventricular; Terfenadine; Torsades de Pointes	1999
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
H1-receptor antagonists: safety issues. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5 Topics: Astemizole; Cardiovascular System; Central Nervous System; Histamine H1 Antagonists; Humans; Terfenadine	1999
[The effect of second generation histamine antagonists on the heart]. Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4 Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes	2001
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002

Trials

26 trial(s) available for terfenadine and astemizole

Article	Year
Onset and duration of the effects of three antihistamines in current use--astemizole, loratadine and terfenadine forte--studied during prolonged, controlled allergen challenges in volunteers. The Journal of international medical research, 1992, Volume: 20, Issue:5 Topics: Adult; Allergens; Astemizole; Double-Blind Method; Female; Humans; Loratadine; Male; Nasal Mucosa; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Time Factors	1992
Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation. Annals of allergy, 1990, Volume: 64, Issue:2 Pt 1 Topics: Adolescent; Adult; Aged; Allergens; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cyproheptadine; Histamine H1 Antagonists; Humans; Informed Consent; Middle Aged; Nasal Provocation Tests; Randomized Controlled Trials as Topic; Skin Tests; Terfenadine	1990
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadine; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Placebos; Skin Tests; Terfenadine; Time Factors; Urticaria	1990
The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chloride in asthma. British journal of clinical pharmacology, 1988, Volume: 25, Issue:2 Topics: Adult; Astemizole; Asthma; Benzalkonium Compounds; Benzhydryl Compounds; Benzimidazoles; Bronchial Provocation Tests; Female; Histamine H1 Antagonists; Histamine Release; Humans; Male; Middle Aged; Terfenadine	1988
Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients. Annals of allergy, 1989, Volume: 62, Issue:4 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Random Allocation; Statistics as Topic; Terfenadine; Urticaria	1989
[Comparison of astemizole and terfenadine in maintenance therapy of hay fever]. Zeitschrift fur Hautkrankheiten, 1985, Volume: 60 Suppl 1 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Clinical Trials as Topic; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1985
[Hay fever therapy with 2 non-sedating antihistaminics]. Zeitschrift fur Hautkrankheiten, 1985, Volume: 60 Suppl 1 Topics: Arousal; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis; Double-Blind Method; Eczema; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1985
[Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients]. Zeitschrift fur Hautkrankheiten, 1985, Volume: 60 Suppl 1 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Terfenadine; Urticaria	1985
Astemizole and terfenadine compared in hay fever. The Practitioner, 1986, Volume: 230, Issue:1411 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Seasonal; Terfenadine	1986
The role of histamine in allergen and adenosine-induced bronchoconstriction. International archives of allergy and applied immunology, 1987, Volume: 82, Issue:3-4 Topics: Adenosine Monophosphate; Allergens; Astemizole; Benzhydryl Compounds; Benzimidazoles; Bronchial Provocation Tests; Bronchial Spasm; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Terfenadine	1987
Astemizole suspension in the maintenance treatment of paediatric hay fever: a comparison with terfenadine suspension. Pharmatherapeutica, 1986, Volume: 4, Issue:10 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Seasonal; Suspensions; Terfenadine	1986
Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. Pharmatherapeutica, 1986, Volume: 4, Issue:10 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Double-Blind Method; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Terfenadine; Urticaria	1986
[Astemizole and terfenadine: comparison of their therapeutic effect in pollen rhinitis]. Revue medicale de la Suisse romande, 1987, Volume: 107, Issue:10 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1987
A double-blind study of astemizole and terfenadine in the treatment of perennial rhinitis. Annals of allergy, 1988, Volume: 61, Issue:1 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Perennial; Terfenadine	1988
Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans. The Journal of allergy and clinical immunology, 1986, Volume: 77, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Dose-Response Relationship, Immunologic; Double-Blind Method; Female; Histamine; Humans; Hydroxyzine; Hypersensitivity, Immediate; Immunosuppressive Agents; Male; Skin Tests; Terfenadine	1986
Efficacy of continuous treatment with astemizole (Hismanal) and terfenadine (Seldane) in ragweed pollen-induced rhinoconjunctivitis. The Journal of allergy and clinical immunology, 1988, Volume: 82, Issue:4 Topics: Adult; Allergens; Astemizole; Benzhydryl Compounds; Benzimidazoles; Conjunctivitis, Allergic; Drug Tolerance; Humans; Pollen; Rhinitis, Allergic, Seasonal; Skin Tests; Terfenadine	1988
[Multicenter double-blind study comparing astemizole and terfenadine for nonseasonal rhinitis in the adult]. Allergie et immunologie, 1988, Volume: 20, Issue:9 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Rhinitis, Allergic, Perennial; Terfenadine; Time Factors	1988
Double-blind comparison of astemizole, terfenadine and placebo in hay fever with special regard to onset of action. The Journal of international medical research, 1985, Volume: 13, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Female; Humans; Male; Random Allocation; Rhinitis, Allergic, Seasonal; Terfenadine; Time Factors	1985
Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine. British journal of clinical pharmacology, 1982, Volume: 13, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cognition; Emotions; Female; Histamine H1 Antagonists; Humans; Mental Processes; Motor Skills; Piperidines; Terfenadine; Time Factors; Triprolidine	1982
Mechanism of action of antipruritic drugs. British medical journal (Clinical research ed.), 1983, Oct-22, Volume: 287, Issue:6400 Topics: Adolescent; Adult; Aged; Antipruritics; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nitrazepam; Pruritus; Terfenadine; Trimeprazine	1983
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1984, Volume: 39, Issue:9 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1984
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:2 Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental Exposure; Female; Humans; Loratadine; Male; Middle Aged; Pruritus; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sneezing; Terfenadine; Treatment Outcome	1997
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 80, Issue:4 Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug Interactions; Electrocardiography; Erythromycin; Female; Heart; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Male; Terfenadine	1998
Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1998, Volume: 118, Issue:5 Topics: Adrenergic Agents; Allergens; Ambulatory Care; Analysis of Variance; Anti-Allergic Agents; Astemizole; Bronchodilator Agents; Chlorpheniramine; Confidence Intervals; Cross-Over Studies; Ephedrine; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Nasal Mucosa; Nose; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome	1998
Is there a role for nonsedating antihistamines in motion sickness? Fallout from space research may soon benefit your patients. The Journal of respiratory diseases, 1991, Volume: 12, Issue:4 Suppl Topics: Aerospace Medicine; Astemizole; Coriolis Force; Doxepin; Drug Evaluation; Head Movements; Histamine H1 Antagonists; Humans; Male; Motion Sickness; Rotation; Space Motion Sickness; Technology Transfer; Terfenadine	1991
Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen. Pharmacological research, 2001, Volume: 44, Issue:6 Topics: Adult; Allergens; Astemizole; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome	2001

Other Studies

101 other study(ies) available for terfenadine and astemizole

Article	Year
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20 Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Motor Activity; Piperazines; Piperidines; Rats; Structure-Activity Relationship	1995
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water	1998
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents. Journal of medicinal chemistry, 1999, Feb-25, Volume: 42, Issue:4 Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbachol; Eosinophilia; Guinea Pigs; Histamine Release; Hypersensitivity; In Vitro Techniques; Indoleacetic Acids; Interleukin-4; Interleukin-5; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; Peritoneal Cavity; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rhinitis, Allergic, Perennial; Structure-Activity Relationship; Trachea	1999
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Poorly soluble marketed drugs display solvation limited solubility. Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23 Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Tandem Mass Spectrometry; Thermodynamics	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration. European journal of medicinal chemistry, 2010, Volume: 45, Issue:4 Topics: Cholesterol Ester Transfer Proteins; Drug Discovery; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; ROC Curve	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11 Topics: Animals; Antiprotozoal Agents; Binding Sites; Female; Gold; Histone Deacetylase 1; Humans; Hydroxamic Acids; Leishmania infantum; Life Cycle Stages; Meglumine Antimoniate; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Docking Simulation; Protein Structure, Tertiary; Protozoan Proteins; Spleen	2020
Antihistamines and decongestants. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1992, Volume: 107, Issue:6 Pt 2 Topics: Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Nasal Decongestants; Rhinitis, Allergic, Perennial; Terfenadine	1992
From the Food and Drug Administration. JAMA, 1992, Aug-12, Volume: 268, Issue:6 Topics: Astemizole; Contraindications; Drug Therapy, Combination; HIV Infections; Humans; Terfenadine; United States; United States Food and Drug Administration; Zalcitabine; Zidovudine	1992
Antihistamines--is there anything safe to prescribe? Annals of allergy, 1992, Volume: 69, Issue:4 Topics: Astemizole; Cardiovascular System; Electrocardiography; Humans; Potassium Channels; Terfenadine	1992
Special drug communication teleconference. August 7, 1992. Ear, nose, & throat journal, 1992, Volume: 71, Issue:9 Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Drug Interactions; Electrocardiography; Humans; Ketoconazole; Liver Diseases; Macrolides; Terfenadine; United States; United States Food and Drug Administration	1992
[Nonsedative H1 antihistaminics]. Casopis lekaru ceskych, 1991, May-24, Volume: 130, Issue:14 Topics: Animals; Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Terfenadine	1991
Treatment of urticaria and angioedema: low-sedating H1-type antihistamines. Journal of the American Academy of Dermatology, 1991, Volume: 24, Issue:6 Pt 2 Topics: Angioedema; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Urticaria	1991
[Non-sedative antihistaminics and binding to central and peripheral H1 histamine receptors]. Allergie et immunologie, 1991, Volume: 23, Issue:2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cerebellum; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Hydroxyzine; Kinetics; Loratadine; Lung; Organ Specificity; Protein Binding; Receptors, Histamine H1; Terfenadine	1991
Safety of terfenadine and astemizole. The Medical letter on drugs and therapeutics, 1992, Feb-07, Volume: 34, Issue:863 Topics: Arrhythmias, Cardiac; Astemizole; Humans; Terfenadine	1992
[Severe antihistamine poisoning complicated by ventricular tachycardia]. Vnitrni lekarstvi, 1990, Volume: 36, Issue:3 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Tachycardia; Terfenadine; Ventricular Fibrillation	1990
Pharmacology of antihistamines. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Time Factors	1990
In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Animals; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cats; Dibenzazepines; Dogs; Female; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Ketotifen; Male; Promethazine; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Sleep; Terfenadine; Wakefulness	1988
[Optimal use of antihistaminics]. Revue medicale de la Suisse romande, 1989, Volume: 109, Issue:3 Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Phenothiazines; Pregnancy; Pregnancy Complications; Terfenadine	1989
Start and end of the effects of terfenadine and astemizole on histamine-induced wheals in human skin. Acta dermato-venereologica, 1989, Volume: 69, Issue:3 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Skin; Skin Tests; Terfenadine; Time Factors	1989
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine. Agents and actions, 1989, Volume: 28, Issue:1-2 Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine	1989
Effects of nonsedating histamine H1-antagonists on EEG activity and behavior in the cat. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4 Topics: Animals; Astemizole; Behavior, Animal; Benzhydryl Compounds; Benzimidazoles; Cats; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Histamine Antagonists; Histamine H1 Antagonists; Loratadine; Male; Phenothiazines; Sleep; Terfenadine	1989
A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever. Allergie et immunologie, 1989, Volume: 21, Issue:10 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1989
Newer antihistaminic agents. The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:2 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Histamine H1 Antagonists; Humans; Receptors, Cholinergic; Terfenadine; Wakefulness	1985
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1985, Volume: 40, Issue:5 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1985
H1 antihistamines: perspective on the use of the conventional and new agents. Annals of allergy, 1985, Volume: 55, Issue:5 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Metabolic Clearance Rate; Solubility; Structure-Activity Relationship; Terfenadine	1985
Newer non-sedating antihistamines. Will they replace older agents? Drugs, 1985, Volume: 30, Issue:5 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Hypersensitivity; Hypnotics and Sedatives; Phenothiazines; Terfenadine	1985
[A new generation of H1-receptor antagonist antihistaminics]. Revue medicale de la Suisse romande, 1986, Volume: 106, Issue:10 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Hypersensitivity; Phenothiazines; Terfenadine	1986
The comparative pharmacokinetics of H1-receptor antagonists. Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2 Topics: Adult; Age Factors; Astemizole; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cetirizine; Child; Chlorpheniramine; Dose-Response Relationship, Drug; Half-Life; Histamine H1 Antagonists; Humans; Hydroxyzine; Terfenadine	1987
Inhibition of skin reactivity by antihistamines. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Histamine H1 Antagonists; Humans; Skin; Skin Tests; Terfenadine; Time Factors	1988
The use of antihistamines for the treatment of airway disease. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Child; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1988
Antihistamines in the treatment of urticarial disorders. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Histamine H1 Antagonists; Humans; Pruritus; Sleep Stages; Terfenadine; Urticaria	1988
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1986, Volume: 41, Issue:8 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Biological Availability; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1986
Antihistamines and sedation. Lancet (London, England), 1983, Jul-23, Volume: 2, Issue:8343 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Histamine H1 Antagonists; Humans; Phenothiazines; Sleep Stages; Terfenadine; Wakefulness	1983
Non-sedative antihistamines: terfenadine and astemizole. Drug and therapeutics bulletin, 1984, Mar-23, Volume: 22, Issue:6 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Brain; Histamine H1 Antagonists; Humans; Rhinitis; Terfenadine	1984
Practical therapeutics: the use of histamine receptor antagonists in contemporary times. East African medical journal, 1984, Volume: 61, Issue:7 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Cimetidine; Conjunctivitis, Allergic; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Pyrilamine; Rhinitis, Allergic, Seasonal; Terfenadine	1984
Regulation of potassium channels by nonsedating antihistamines. Circulation, 1995, Apr-15, Volume: 91, Issue:8 Topics: Animals; Arrhythmias, Cardiac; Astemizole; Cells, Cultured; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Terfenadine	1995
Additional causes of torsades de pointes. Mayo Clinic proceedings, 1995, Volume: 70, Issue:2 Topics: Astemizole; Drug Overdose; Humans; Terfenadine; Torsades de Pointes	1995
The FDA and terfenadine. The Western journal of medicine, 1994, Volume: 161, Issue:6 Topics: Astemizole; Drug Information Services; Drug Interactions; Humans; Terfenadine; United States; United States Food and Drug Administration	1994
Non sedating antihistamines. Australian family physician, 1993, Volume: 22, Issue:9 Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Psychomotor Performance; Terfenadine	1993
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circulation research, 1995, Volume: 76, Issue:1 Topics: Action Potentials; Animals; Astemizole; Chlorpheniramine; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Potassium Channels; Pyrilamine; Refractory Period, Electrophysiological; Terfenadine	1995
Possible interactions with terfenadine or astemizole. The Western journal of medicine, 1994, Volume: 160, Issue:4 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescriptions; Erythromycin; Female; Humans; Ketoconazole; Male; Middle Aged; Retrospective Studies; Terfenadine	1994
Analysis of potential adverse drug reactions--a case of mistaken identity. The American journal of cardiology, 1994, Jul-15, Volume: 74, Issue:2 Topics: Astemizole; Atrial Fibrillation; Drug Interactions; Electrocardiography; Humans; Loratadine; Quinidine; Tachycardia, Ventricular; Terfenadine	1994
The nonsedating antihistamine scare. Clinical cardiology, 1994, Volume: 17, Issue:1 Topics: Astemizole; Drug Interactions; Drug Therapy, Combination; Humans; Long QT Syndrome; Terfenadine	1994
Ketoconazole and fluconazole drug interactions. Archives of internal medicine, 1994, May-09, Volume: 154, Issue:9 Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketoconazole; Terfenadine	1994
Is QT interval prolongation harmful? A regulatory perspective. The American journal of cardiology, 1993, Aug-26, Volume: 72, Issue:6 Topics: Astemizole; Butylamines; Electrocardiography; Humans; Terfenadine; Torsades de Pointes; Urinary Incontinence	1993
Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands. Pharmacy world & science : PWS, 1993, Oct-15, Volume: 15, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astemizole; Child; Child, Preschool; Drug Synergism; Drug Utilization; Humans; Incidence; Infant; Middle Aged; Netherlands; Risk Factors; Terfenadine; Torsades de Pointes	1993
Terfenadine, astemizole and loratadine: second generation antihistamines. The Nurse practitioner, 1993, Volume: 18, Issue:11 Topics: Astemizole; Humans; Loratadine; Terfenadine	1993
Treatment of solar urticaria with terfenadine. Journal of the American Academy of Dermatology, 1993, Volume: 28, Issue:4 Topics: Astemizole; Humans; Sunlight; Terfenadine; Urticaria	1993
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5 Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine	1996
Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS letters, 1996, Apr-29, Volume: 385, Issue:1-2 Topics: Animals; Astemizole; Cation Transport Proteins; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Kv1.1 Potassium Channel; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Xenopus	1996
Drug interactions associated with terfenadine and related nonsedating antihistamines. The Western journal of medicine, 1996, Volume: 164, Issue:1 Topics: Arrhythmias, Cardiac; Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Terfenadine	1996
Dangers of non-sedating antihistamines. Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061 Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legislation, Drug; Liver Diseases; Loratadine; Terfenadine; United Kingdom	1997
Risks of non-sedating antihistamines. Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061 Topics: Adverse Drug Reaction Reporting Systems; Astemizole; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine	1997
Dangers of non-sedating antihistamines. Lancet (London, England), 1997, Jul-05, Volume: 350, Issue:9070 Topics: Adverse Drug Reaction Reporting Systems; Arrhythmias, Cardiac; Astemizole; Histamine H1 Antagonists; Humans; Risk; Terfenadine	1997
Antihistamines. The Journal of head trauma rehabilitation, 1998, Volume: 13, Issue:1 Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis; Terfenadine	1998
'Allergies' article needs updating. The Journal of the American Osteopathic Association, 1998, Volume: 98, Issue:4 Topics: Anti-Allergic Agents; Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Terfenadine	1998
Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines. Molecular pharmacology, 1998, Volume: 54, Issue:1 Topics: Animals; Astemizole; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Histamine H1 Antagonists; Humans; Loratadine; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured; Xenopus laevis	1998
Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II). Journal of pharmaceutical and biomedical analysis, 1999, Volume: 18, Issue:6 Topics: Astemizole; Calibration; Capsules; Eosine Yellowish-(YS); Flunarizine; Fluorescent Dyes; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Indicators and Reagents; Lead; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Suspensions; Tablets; Terfenadine	1999
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs. British journal of clinical pharmacology, 1999, Volume: 47, Issue:3 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; Child, Preschool; Cohort Studies; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Information Systems; Loratadine; Male; Middle Aged; Risk Factors; Tachycardia, Ventricular; Terfenadine; Triprolidine	1999
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:6 Topics: Astemizole; Benzimidazoles; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG	1999
Cardiotoxicity of second-generation antihistamines. Drugs, 1999, Volume: 57, Issue:6 Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	1999
Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel. European journal of pharmacology, 1999, Jun-25, Volume: 374, Issue:3 Topics: Animals; Astemizole; Cation Transport Proteins; Dibenzazepines; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression; Histamine H1 Antagonists; Humans; Imidazoles; Membrane Potentials; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Xenopus	1999
Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys. European journal of pharmacology, 1999, Aug-06, Volume: 378, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Astemizole; Dibenzazepines; Electrocardiography; Heart Block; Histamine H1 Antagonists; Imidazoles; Macaca fascicularis; Male; Terfenadine; Time Factors	1999
In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines. Chemico-biological interactions, 1999, Nov-15, Volume: 123, Issue:1 Topics: Astemizole; Benzimidazoles; Cetirizine; Cytochrome P-450 Enzyme Inhibitors; Dimethyl Sulfoxide; Enzyme Inhibitors; Glucuronosyltransferase; Histamine H1 Antagonists; Humans; Isoenzymes; Kinetics; Loratadine; Microsomes, Liver; Terfenadine	1999
Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS letters, 2000, May-26, Volume: 474, Issue:1 Topics: Animals; Astemizole; Cation Transport Proteins; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene Expression; Humans; Microelectrodes; Mutation; Oocytes; Oxidation-Reduction; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Xenopus	2000
Impact of interventions designed to increase market share and prescribing of fexofenadine at HMOs. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Oct-01, Volume: 57, Issue:19 Topics: Analysis of Variance; Astemizole; Cetirizine; Cost Savings; Drug Costs; Drug Utilization; Health Maintenance Organizations; Histamine H1 Antagonists; Humans; Loratadine; Marketing of Health Services; Practice Patterns, Physicians'; Retrospective Studies; Terfenadine; United States	2000
Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells. Molecular pharmacology, 2000, Volume: 58, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Astemizole; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cation Transport Proteins; Cells, Cultured; Cetirizine; Electrophysiology; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Hydroxyzine; Large-Conductance Calcium-Activated Potassium Channels; Nimodipine; Phenethylamines; Pituitary Gland; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Rats; Small-Conductance Calcium-Activated Potassium Channels; Sulfonamides; Terfenadine	2000
Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. British journal of clinical pharmacology, 2001, Volume: 51, Issue:2 Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Antibodies; Astemizole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Microsomes, Liver; Mixed Function Oxygenases; Recombinant Proteins; Statistics as Topic; Substrate Specificity; Terfenadine; Troleandomycin	2001
Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs). Biochemical pharmacology, 2001, Nov-01, Volume: 62, Issue:9 Topics: Astemizole; Calcium; Calcium Channel Blockers; Calcium Channels; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Neuroblastoma; Norepinephrine; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Tritium; Tumor Cells, Cultured	2001
QT prolongation and safety in the Indian population. Current drug safety, 2007, Volume: 2, Issue:3 Topics: Astemizole; Cisapride; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Histamine H1 Antagonists, Non-Sedating; Humans; India; Long QT Syndrome; Serotonin Receptor Agonists; Terfenadine; Torsades de Pointes	2007
An ion channel library for drug discovery and safety screening on automated platforms. Assay and drug development technologies, 2008, Volume: 6, Issue:6 Topics: Animals; Astemizole; Automation; Cell Line; CHO Cells; Cloning, Organism; Cricetinae; Cricetulus; DNA, Complementary; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Ion Channels; Pimozide; Terfenadine	2008
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs, 2009, Volume: 69, Issue:18 Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Cetirizine; Child; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Leukotriene Antagonists; Loratadine; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Sulfides; Tablets; Terfenadine; Treatment Outcome	2009
Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amodiaquine; Animals; Antibodies; Astemizole; Biocatalysis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Intestines; Isoenzymes; Lansoprazole; Macaca fascicularis; Microsomes; Microsomes, Liver; Nicardipine; Nimodipine; Paroxetine; Pharmaceutical Preparations; Species Specificity; Terfenadine	2011
Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice. Schizophrenia bulletin, 2014, Volume: 40, Issue:2 Topics: Animals; Antipsychotic Agents; Aripiprazole; Astemizole; Behavior, Animal; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Epoxy Compounds; Fatty Acids; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olanzapine; Oxygen Consumption; Piperazines; Quinolones; Receptors, Histamine H1; Respiration; Risperidone; Terfenadine; Time Factors	2014
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of molecular and cellular cardiology, 2014, Volume: 72 Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expression; Genetic Predisposition to Disease; Heart Ventricles; Humans; Ion Channel Gating; Kinetics; Long QT Syndrome; Models, Statistical; Mutation; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Conformation; Severity of Illness Index; Sotalol; Sulfonamides; Terfenadine	2014
Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine. Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:11 Topics: Animals; Astemizole; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists, Non-Sedating; Humans; Intestine, Small; Liver; Macaca fascicularis; Mice; Rats; Terfenadine	2016
Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors. The Journal of toxicological sciences, 2019, Volume: 44, Issue:7 Topics: Animals; Astemizole; Body Temperature; Calcium Channel Blockers; Callithrix; Electrocardiography; Flecainide; Male; Models, Animal; Quinidine; Risk Assessment; Sotalol; Telemetry; Terfenadine; Verapamil; Voltage-Gated Sodium Channel Blockers	2019
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment. Journal of pharmacological and toxicological methods, 2020, Volume: 105 Topics: Animals; Arrhythmias, Cardiac; Astemizole; Benchmarking; Calibration; Cardiovascular Agents; Cell Line; CHO Cells; Cricetulus; Drug Discovery; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Heart; HEK293 Cells; Humans; Patch-Clamp Techniques; Phenethylamines; Polypropylenes; Polytetrafluoroethylene; Reference Standards; Reproducibility of Results; Sulfonamides; Terfenadine	2020
Cytochrome Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11 Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine	2022