terbinafine has been researched along with pramiconazole* in 2 studies
2 other study(ies) available for terbinafine and pramiconazole
| Article | Year |
|---|---|
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models.
The triazole antifungal pramiconazole (Stiefel, a GSK company) was compared with itraconazole, miconazole, and terbinafine in vitro and in vivo. Potent in vitro activities against Candida spp. (50% inhibitory concentration [IC₅₀], 0.04 to 1.83 μM) and Microsporum and Trichophyton spp. (IC₅₀, 0.15 to 1.34 μM) were obtained but not, however, against other filamentous molds and zygomycetes. In the M. canis guinea pig model and C. albicans vulvovaginitis rat model, pramiconazole was superior to the reference compounds after oral and topical administration. Topics: Administration, Topical; Animals; Antifungal Agents; Candida albicans; Dermatitis; Female; Guinea Pigs; Humans; Imidazoles; Inhibitory Concentration 50; Itraconazole; Microsporum; Naphthalenes; Terbinafine; Triazoles; Vaginitis | 2010 |
Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology.
In search for new compounds with potential for clinical use as antifungal agents in dermatology, a series of 12 azole compounds were synthesized stereospecifically and investigated specifically for their activity against dermatophyte fungal infections in animal models. This panel of azoles was studied in vitro and compared with itraconazole and terbinafine for their antifungal activity using a panel of 24 Candida spp. and 182 dermatophyte isolates. Three azoles (1c, 2c, and 4c) showed in vitro antifungal potency equivalent to itraconazole, but superior to terbinafine, against a panel of 24 Candida spp. with comparable or lower activity than that of itraconazole and terbinafine against 182 dermatophyte isolates and only rare activity against other pathogenic fungi. However, in vivo 1c and 4c, both given orally, demonstrated antifungal activity at least three times greater than itraconazole and were superior compared to terbinafine in M. canis infected guinea pigs. In a mouse model infected by T. mentagrophytes, again 4c, but not 1c, showed 5-fold superior activity over itraconazole and terbinafine. Compound 2c was effective in both models but less effective than itraconazole in these models. On the basis of these promising results, 4c is currently being clinically investigated for its potential as a novel antifungal agent against dermatophytosis. Topics: Animals; Antifungal Agents; Dermatologic Agents; Guinea Pigs; Imidazoles; Itraconazole; Mice; Mitosporic Fungi; Mycoses; Naphthalenes; Stereoisomerism; Structure-Activity Relationship; Terbinafine; Triazoles | 2005 |