tenocyclidine has been researched along with phencyclidine in 255 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (30.20) | 18.7374 |
| 1990's | 156 (61.18) | 18.2507 |
| 2000's | 20 (7.84) | 29.6817 |
| 2010's | 2 (0.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Cheng, BK; Contreras, PC; Gray, NM; Lair, CM; Mick, SJ | 1 |
| Annala, AJ; Baudry, M; Thompson, RF; Tocco, G | 1 |
| Akunne, HC; de Costa, BR; Johannessen, JN; Rice, KC; Rothman, RB | 1 |
| Allaoua, H; Boksa, P; Chaudieu, I; Krieger, C; Privat, A; Quirion, R | 1 |
| Lemaire, S; Rogers, C | 1 |
| Cler, JA; Garland, DJ; Hood, WF; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Sun, ET; Vazquez, ML | 1 |
| Britt, M; Paschetto, KA; Powel, RJ; Pullan, LM; Stumpo, RJ | 1 |
| Matsuda, Y; Nonaka, H; Nozawa, M; Toki, S; Tsukuda, E; Yoshida, M | 1 |
| Baudry, M; Maren, S; Shors, TJ; Thompson, RF; Tocco, G | 1 |
| Bonhaus, DW; McNamara, JO | 3 |
| Ando, K; Kawamoto, I; Matsuda, Y; Sano, H; Toki, S; Yoshida, M | 2 |
| Johnson, KM; Wang, J | 1 |
| Hatta, K; Hori, T; Moroji, T; Okuwa, M; Yamamoto, T | 1 |
| Calvet, MC; Kamenka, JM; Levallois, C; Petite, D; Privat, A | 1 |
| Casalotti, SO; Fauq, A; Kozikowski, AP; Krueger, KE; Tückmantel, W | 1 |
| Mattson, MV; Rice, KC; Schweri, MM; Thurkauf, A | 1 |
| deCosta, BR; Hardwick, WC; McMillan, DE; Rice, KC | 1 |
| Contreras, PC; Farah, JM; Jacobson, AE; Rice, KC | 1 |
| Katki, AG; Munson, PJ; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| Friedl, A; Georg, A | 1 |
| Haring, R; Pellegrini-Giampietro, DE; Scheideler, MA; Zukin, RS; Zukin, SR | 1 |
| Baudry, M; Shors, TJ; Thompson, RF; Tocco, G | 1 |
| Baudry, M; Devgan, KK; Hauge, SA; Thompson, RF; Tocco, G; Weiss, C | 1 |
| Cordi, AA; Hood, WF; Lanthorn, TH; Marinozzi, M; Monahan, JB; Natalini, B; Pellicciari, R; Sadeghpour, BM | 1 |
| Bowen, DM; Cross, AJ; Green, AR; Robinson, TN; Steele, JE | 1 |
| Johnson, KM; Sacaan, AI | 3 |
| Maurice, T; Vignon, J | 2 |
| Angst, C; Brundish, DE; Fagg, G; Hurt, SD; Pozza, M; Sills, MA; Williams, M; Wilusz, EJ | 1 |
| Nishikawa, T; Ohi, K; Takahashi, K; Takashima, M | 1 |
| Hatta, K; Hori, T; Moroji, T; Yamamoto, T | 2 |
| Bowen, WD; Reid, AA; Rothman, RB; Setterlund, C | 1 |
| Dragunow, M; Faull, RL; Jansen, KL; Leslie, RA | 1 |
| Ogita, K; Yoneda, Y | 1 |
| Deakin, JF; Royston, MC; Simpson, MD; Slater, P | 1 |
| Kloog, Y; Lamdani-Itkin, H; Sokolovsky, M | 2 |
| Barbour, G; Hallberg, PL; Jaffe, H; Kingan, T; Kwart, LD; Lawson, M; O'Neill, JB; Pert, CB; Rao, KR; Ruff, MR | 1 |
| Bonhaus, DW; Hosford, DA; McNamara, JO | 2 |
| Bonhaus, DW; McNamara, JO; Yeh, GC | 1 |
| Hatta, K; Hori, T; Moroji, T; Okuwa, M; Yamamato, T | 1 |
| Alesiani, M; Carlà, V; Cherici, G; Galli, A; Mori, F; Moroni, F; Pecorari, R; Pellicciari, R | 1 |
| Allaoua, H; Bellaidi, MH; Chaudieu, I; Chicheportiche, R; Kamenka, JM; Rondouin, G | 1 |
| Dai, JL; Xu, SF | 1 |
| Bao, WL; Sun, FY; Zhang, AZ; Zheng, FC | 1 |
| Haring, R; Moskal, JR; Scheideler, MA; Stanton, PK | 1 |
| McCulloch, J | 1 |
| Akunne, HC; de Costa, BR; Heyes, MP; Jacobson, AE; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Hashimoto, A; Katayama, S; Maeda, M; Nishikawa, T; Tobe, A; Tsukiyama, S | 1 |
| Besson, MJ; Caboche, J; Carré, JB; Maurin, Y; Mitrovic, N | 1 |
| Bonhaus, DW; Cao, Z; Crain, BJ; Friedman, AH; Hosford, DA; McNamara, JO; Nadler, JV; Okazaki, MM | 1 |
| Drian, MJ; Kamenka, JM; Pirat, JL; Privat, A | 1 |
| de Costa, BR; Jacobson, AE; Mattson, MV; Monn, JA; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Klepstad, P; Maurset, A; Moberg, ER; Oye, I | 1 |
| Ben-Ari, Y; Roisin-Lallemand, MP; Tremblay, E | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 3 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauché, D | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Foucaud, B; Gombos, G | 1 |
| Baldy-Moulinier, M; Belaidi, M; Kamenka, JM; Lerner-Natoli, M; Rondouin, G | 1 |
| London, ED; Vu, TH; Weissman, AD | 1 |
| Baudry, M; Kessler, M; Lynch, G; Massicotte, G | 1 |
| Su, TP; Wu, XZ | 1 |
| Lemaire, S; Rogers, CA | 1 |
| Compton, RP; Hood, WF; Monahan, JB; Thomas, JW | 1 |
| Jacobson, AE; Mattson, MV; Monn, JA; Rice, KC; Thurkauf, A | 1 |
| Byrd, JC; Paleos, GA; Yang, ZW | 1 |
| Besson, MJ; Maurin, Y; Mitrovic, N | 1 |
| Ikin, AF; Kloog, Y; Sokolovsky, M | 1 |
| Barbour, G; Buzy, JM; Hallberg, PL; Jaffe, H; Kingan, T; Kwart, LD; Lawson, M; O'Neill, JB; Pert, CB; Ruff, MR | 1 |
| Haring, R; Zukin, RS; Zukin, SR | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Jacobson, AE; Monn, JA; Reid, AA; Rice, KC; Rothman, RB | 3 |
| Byrd, JC; DePietro, FR | 1 |
| Enomoto, R; Katagawa, J; Meguri, H; Ogita, K; Ohgaki, T; Suzuki, T; Uchida, S; Yoneda, Y | 1 |
| Massey, BW; Wessinger, WD | 1 |
| Cruz, LJ; Gullak, MF; Mena, EE; Olivera, BM; Pagnozzi, MJ; Richter, KE; Rivier, J | 1 |
| Bonhaus, DW; McNamara, JO; Perry, WB | 1 |
| Nabeshima, T; Ogita, K; Yoneda, Y | 1 |
| Chicheportiche, R; Kamenka, JM; Rondouin, G; Torres, JH | 1 |
| de Costa, B; France, CP; Jacobson, AE; Mattson, MV; Olney, JW; Price, MT; Rice, KC; Thurkauf, A; Woods, JH | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Kimura, J; Ninomiya, H; Saitoh, T; Shimohama, S; Taniguchi, T; Terry, RD | 1 |
| Chiodo, LA; Freeman, AS; Rouillard, C | 1 |
| Bartschat, DK; Blaustein, MP | 1 |
| Haring, R; Harshak-Felixbrodt, NA; Kloog, Y; Sokolovsky, M | 1 |
| Fagg, GE | 1 |
| Bonhaus, DW; Burge, BC; McNamara, JO | 1 |
| Braunwalder, AF; Jarvis, MF; Loo, PA; Murphy, DE; Sills, MA; Williams, M | 1 |
| ffrench-Mullen, JM; Pieniek, M; Rogawski, MA; Suzuki, S | 1 |
| Johnson, KM; Morter, RS; Snell, LD | 2 |
| Bonhaus, DW; McNamara, JO; Skaryak, L; Yeh, GC | 1 |
| Bonhaus, DW; McNamara, JO; Nadler, JV; Yeh, GC | 1 |
| Belaidi, M; Kamenka, JM; Lerner-Natoli, M; N'Gouemo, P; Rondouin, G | 1 |
| Culp, SG; De Souza, EB; Wolfe, SA | 1 |
| Baudry, M; Kessler, M; Lynch, G; Terramani, T | 1 |
| Cross, AJ; Green, AR; Stirling, JM | 1 |
| Cross, AJ; Deakin, JF; Mann, DM; Reynolds, GP; Royston, MC; Simpson, MD; Slater, P | 1 |
| Beart, PM; Cincotta, M; Lodge, D; Summers, RJ | 1 |
| Compton, RP; Hood, WF; Monahan, JB; Sun, ET | 1 |
| Compton, RP; Corpus, VM; Hood, WF; Monahan, JB; Thomas, JW | 1 |
| Aanonsen, LM; Seybold, VS | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Nielsen, M; Olverman, HJ; Watkins, JC | 1 |
| Denavit-Saubié, M; Foutz, AS | 1 |
| Dragunow, M; Faull, RL; Jansen, KL | 1 |
| Allikmets, LKh; Kharro, IaE; Lang, AE; Vasar, EE | 1 |
| Pullan, LM; Salama, AI; Stumpo, RJ | 1 |
| Ishii, S; Nishikawa, T; Shinohara, K; Takahashi, K; Yamazaki, K | 1 |
| Duffy, O; Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauche, D | 1 |
| Loo, PS; Sills, MA | 1 |
| Johnson, KM; Jones, SM | 1 |
| Nishikawa, T; Takahashi, K; Tanii, Y; Yoshida, Y | 1 |
| Agid, Y; Allaoua, H; Chaudieu, I; Chicheportiche, R; Javoy-Agid, F; Journod, L; Vignon, J | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Jarvis, MF; Murphy, DE; Williams, M | 1 |
| Ludvig, N; Moshé, SL; Sircar, R; Zukin, SR | 1 |
| Knight, AR; Wong, EH; Woodruff, GN | 1 |
| Maragos, WF; Penney, JB; Young, AB | 1 |
| Albin, RL; Penney, JB; Young, AB | 1 |
| Johnson, KM; Snell, LD | 1 |
| Cross, AJ; Deakin, JF; Mann, DM; Royston, MC; Simpson, MD; Slater, P | 1 |
| Kushner, L; Zukin, RS; Zukin, SR | 1 |
| Battaglia, G; De Souza, EB; Jaffe, JH; Kulsakdinun, C; Wolfe, SA | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Braunwalder, A; Lehmann, J; Loo, P; Williams, M | 1 |
| Johnson, KM; Nichtenhauser, R; Rivier, J; Snell, LD; Vale, W; Zukin, RS; Zukin, SR | 1 |
| Javitt, DC; Jotkowitz, A; Sircar, R; Zukin, SR | 1 |
| Braunwalder, AF; Lehmann, J; Loo, PS; Sills, MA; Williams, M | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Chicheportiche, R; Drian, MJ; Kamenka, JM; Privat, A; Rondouin, G | 1 |
| Sircar, R; Zukin, SR | 1 |
| Gundlach, AL; Largent, BL; Snyder, SH | 2 |
| Chu, DC; Greenamyre, JT; Maragos, WF; Penney, JB; Young, AB | 1 |
| Contreras, PC; Freedman, R; Hoffer, B; Jacobson, AE; Johnson, S; Lessor, RA; O'Donohue, TL; Olsen, K; Rafferty, MF; Rice, KC | 1 |
| Chung, C; Cotman, CW; Geddes, JW; Monaghan, DT; Yao, D | 1 |
| Chu, DC; D'Amato, CJ; Maragos, WF; Penney, JB; Young, AB | 1 |
| Braunwalder, AF; Loo, PA; Sills, MA; Williams, M | 1 |
| Drejer, J; Honoré, T; Nielsen, M; Olverman, HJ; Watkins, JC | 1 |
| Bobker, DH; Campbell, BG; Leslie, FM; Mefford, IN; Weber, E | 1 |
| Johnson, KM; Sacaan, AI; Snell, LD | 1 |
| Johnson, KM; Snell, LD; Yi, SJ | 1 |
| Drejer, J; Honoré, T | 1 |
| Aguayo, LG; Albuquerque, EX | 1 |
| Marquis, KL; Moreton, JE | 1 |
| Jacobson, AE; Koek, W; Mattson, MV; Mudar, PJ; Woods, JH | 1 |
| Chaudieu, I; Chicheportiche, R; Kamenka, JM; Privat, A; Thierry, A; Vignon, J | 1 |
| Chicheportiche, M; Chicheportiche, R; Geneste, P; Kamenka, JM; Lazdunski, M; Vignon, J | 1 |
| Balster, RL; Brady, KT; Meltzer, LT; Schwertz, D | 1 |
| Legault, D | 1 |
| Ahmad, M; Babcock, KK; Chen, X; Johnson, PS; Kumar, KN; Michaelis, EK | 1 |
| Ault, B; DeHaven-Hudkins, DL; Dority, JA; Dung, JS; Earley, WG; Herrmann, JL; Kumar, V; Mallamo, JP; Miller, MS; Subramanyam, C | 1 |
| Baba, A; Goji, K; Kawai, N; Klenerová, V; Moroji, T; Sagi, N; Takamori, E; Yamamoto, H; Yamamoto, T | 1 |
| Greenamyre, JT; Porter, RH | 1 |
| Layer, RT; Popik, P; Skolnick, P | 1 |
| Behr, JP; Foucaud, B; Gambs, S; Goeldner, M; Schmid, N | 1 |
| Bowe, MA; Nadler, JV | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Ferkany, JW; Karbon, EW; Price, CH; Saab, OH; Sweetnam, PM; Wroblewski, JT | 1 |
| Katsuta, K; Kuno, A; Nakanishi, H; Ogita, K; Ohkubo, M; Shirakawa, K; Takasugi, H; Ueda, Y; Yoneda, Y; Yoshida, K | 1 |
| Baba, A; Kawai, N; Moroji, T; Okuyama, S; Sagi, N; Yamamoto, H; Yamamoto, T | 1 |
| Baubichon, D; Blanchet, G; Burckhart, MF; Carpentier, P; Lallement, G; Pernot-Marino, I | 1 |
| Baba, A; Moroji, T; Suzuki, T; Yamamoto, H; Yamamoto, T | 1 |
| Arckens, L; Orban, GA; Rosier, AM; Vandesande, F | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Kovács, KJ; Larson, AA | 1 |
| Hasegawa, T; Hayashi, T; Ishihara, S; Kameyama, T; Kaneyuki, T; Morimasa, T; Nabeshima, T; Shohmori, T; Yamada, K | 2 |
| Bonhaus, DW; Kraus, JE; McNamara, JO; Nadler, JV; Yeh, GC | 1 |
| Akunne, HC; Jacobson, AE; Jiang, Q; Linders, JT; Monn, JA; Porreca, F; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Foquin-Tarricone, A; Lallement, G; Pernot-Marino, I; Piras, A | 1 |
| Blanchet, G; Carpentier, P; Lallement, G; Sentenac-Roumanou, H | 1 |
| Barson, AJ; D'Souza, SW; McConnell, SE; Slater, P | 1 |
| Lillrank, SM; Oja, SS; Saransaari, P | 1 |
| Dingledine, R; Kawajiri, S | 1 |
| Mechoulam, R; Nadler, V; Sokolovsky, M | 1 |
| Blough, BE; Cadet, JL; Carroll, FI; Emilien, B; Goodman, CB; Mascarella, SW; Pert, A; Rogawski, MA; Subramaniam, S; Thomas, DN | 1 |
| Denavit-Saubié, M; Ghilini, G; Salès, N | 1 |
| Hashimoto, A; Maeda, M; Nishikawa, T; Orita, K; Sasaki, S; Umezu, K; Yugami, T | 1 |
| Casalotti, SO; Fauq, A; Kozikowski, AP; Krueger, KE; Tückemantel, W | 1 |
| Jacobsen, P; Klockgether, T; Löschmann, PA; Turski, L | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Delamanche, IS; Denoyer, M; Lallement, G; Pernot-Marino, I | 1 |
| Colpaert, FC; Koek, W; Vignon, J | 1 |
| French, ED; Mura, A; Wang, T | 1 |
| Kamenka, JM; Ohanna, F; Pencalet, P; Poulat, P; Privat, A | 1 |
| Peeling, J; Sutherland, G; Tyson, R | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| al-Deeb, OA | 1 |
| Blanchard, JC; Boireau, A; Bordier, F; Burgevin, MC; Chevet, T; Daniel, M; Doble, A; Durand, G; Jimonet, P; Malgouris, C; Meunier, M; Mignani, S; Miquet, JM; Pény, C | 1 |
| Mukherjee, J; Ouyang, X; Yang, ZY | 1 |
| Ault, B; Earley, WG; Hildebrand, LM; Kelly, MD; Luttinger, D; Mallamo, JP; Miller, MS; Ward, SJ | 1 |
| Baba, A; Goji, K; Kawai, N; Moroji, T; Yamamoto, H; Yamamoto, T; Yang, X | 1 |
| Cordon, JJ; Coughenour, LL | 1 |
| Larsen, H; Monaghan, DT | 1 |
| Nishikawa, T; Takahashi, K; Umino, A; Yoshida, Y | 1 |
| Boireau, A; Bordier, F; Doble, A; Durand, G | 1 |
| Baldet, P; Levallois, C; Privat, A; Valence, C | 1 |
| Baron, BM; Fadayel, GM; Harrison, BL; Kehne, JH; McCloskey, TC; Murawsky, MK; Nyce, P; Salituro, FG; Schmidt, CJ; Senyah, Y; Siegel, BW; Taylor, VL; van Giersbergen, PL; White, HS | 1 |
| Fukunaga, R; Kimura, H; Kitamura, Y; Matsuoka, Y; Nabeshima, T; Shimohama, S; Taniguchi, T; Tooyama, I | 1 |
| Frandsen, A; Hansen, HS; Lauritzen, L; Schousboe, A; Strand, AM; Vinggaard, AM | 1 |
| Brinton, RD; Luu, R; Proffitt, P; Tran, J | 1 |
| Cortes, VI; Eldefrawi, AT; Eldefrawi, ME; Katz, EJ | 1 |
| d'Arbigny, P; Gourdier, B; Hoizey, G; Lamiable, D; Millart, H; Vistelle, R | 1 |
| Mateu, G; Privat, A; Thibault, J; Vignon, J | 2 |
| Hardin, JS; Owens, SM; Proksch, JW; Wessinger, WD | 1 |
| Ali, SF; Itzhak, Y | 1 |
| Crow, TJ; Deakin, JF; Gottfries, CG; Grenfeldt, B; Karlsson, I; Simpson, MD; Slater, P | 1 |
| Camarasa, J; Camins, A; Canudas, AM; Escubedo, E; Pallas, M; Pubill, D; Sureda, FX | 1 |
| Eldefrawi, ME; Eterović, VA; Hann, RM; Hess, GP; Ippolito, JE; Lis, JT; Pagán, OR; Shi, H; Ulrich, H | 1 |
| Darius, J; Grecksch, G; Sabel, BA; Schroeder, H; Schroeder, U | 1 |
| Ellison, G; Keys, A; Noguchi, K | 1 |
| Copolov, DL; Dean, B; Hayes, W; Hill, C; Hussain, T; Kitsoulis, S; Opeskin, K; Scarr, E | 1 |
| Chaudieu, I; Privat, A | 1 |
| Mase, T; Nagai, T; Tamura, T; Tatsuta, K; Yamazaki, T | 1 |
| Baubichon, D; Burckhart, MF; Carpentier, P; Filliat, P; Foquin, A; Lallement, G; Masqueliez, C; Pernot-Marino, I; Perrichon, C | 1 |
| Blanton, MP; Fryer, JD; Liu, M; Lukas, RJ; McCardy, EA | 1 |
| Espaze, F; Hamon, J; Hirbec, H; Kamenka, JM; Vignon, J | 1 |
| Boireau, A; Bordier, F; Imperato, A; Meunier, M; Monterrat, C | 1 |
| Assmann, S; Foley, EC; Kinney, HC; Panigrahy, A; Rosenberg, PA | 1 |
| Carpentier, P; de Groot, DM; Foquin, A; Kamenka, JM; Lallement, G; Lerner-Natoli, M; Rondouin, G | 1 |
| Chen, JC; Hsu, PC; Lin, CY; Peng, YC; Tsai, HC; Wu, HH; Yeh, GC | 1 |
| Bierman, EP; Bruijnzeel, PL; Carpentier, P; de Groot, DM; Kulig, BM; Lallement, G; Melchers, BP; Philippens, IH; van Huygevoort, AH | 1 |
| Hirbec, H; Kamenka, JM; Mausset, AL; Privat, A; Vignon, J | 1 |
| Dean, B; Parkin, FM; Pavey, G; Scarr, E | 1 |
| Arias, HR; Bouzat, C; Gumilar, F; Spitzmaul, G | 1 |
| Sun, W; Wessinger, WD | 1 |
| Bresee, CJ; Pechnick, RN; Poland, RE | 1 |
| Arias, HR; Bhumireddy, P; Bouzat, C; Spitzmaul, G; Trudell, JR | 1 |
| Kopjar, N; Petek, MJ; Radić, B; Vrdoljak, AL; Zeljezić, D | 1 |
| Bloomquist, JR; Geldenhuys, WJ; Malan, SF; Van der Schyf, CJ | 1 |
| Oswald, RE; Pagán, OR; Sivaprakasam, K | 1 |
| Berend, S; Kopjar, N; Mladinić, M; Petek, MJ; Radić, B; Vrdoljak, AL; Zeljezić, D | 1 |
| Filer, CN; Hainley, C; Hurt, S; True, D | 1 |
| Kristie, TM; Liang, Y; Narayanan, A; Peng, H; Vogel, JL | 1 |
| Mrsić, G; Petek, MJ; Vrdoljak, AL | 1 |
| Bac, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Stanicki, D; Vamecq, J; Vanden Eynde, JJ | 1 |
1 review(s) available for tenocyclidine and phencyclidine
| Article | Year |
|---|---|
TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
Topics: Animals; Aspartic Acid; Brain; Glycine; Kindling, Neurologic; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
254 other study(ies) available for tenocyclidine and phencyclidine
| Article | Year |
|---|---|
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.
Topics: Animals; Ataxia; Behavior, Animal; Chemical Phenomena; Chemistry; Isoquinolines; Male; Molecular Structure; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereotyped Behavior; Structure-Activity Relationship; Tetrahydroisoquinolines | 1989 |
Learning of a hippocampal-dependent conditioning task changes the binding properties of AMPA receptors in rabbit hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Mapping; Conditioning, Classical; Conditioning, Eyelid; Hippocampus; Ibotenic Acid; Male; Phencyclidine; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1992 |
MPTP lesions of the nigrostriatal dopaminergic projection decrease [3H]1-[1-(2-thienyl)cyclohexyl]piperidine binding to PCP site 2: further evidence that PCP site 2 is associated with the biogenic amine reuptake complex.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Amines; Corpus Striatum; Dogs; Dopamine; Female; Neural Pathways; Phencyclidine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Reserpine; Substantia Nigra | 1992 |
Alterations in spinal cord excitatory amino acid receptors in amyotrophic lateral sclerosis patients.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Autoradiography; Humans; Middle Aged; Phencyclidine; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1992 |
Characterization of [3H]desmethylimipramine binding in bovine adrenal medulla: interactions with sigma- and (or) phencyclidine-receptor ligands.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Desipramine; Dextromethorphan; Dizocilpine Maleate; Phenazocine; Phencyclidine; Piperidines; Potassium Chloride; Receptors, Opioid, delta; Receptors, Phencyclidine; Tranquilizing Agents | 1992 |
Characterization of 3-carboxy-5-phosphono-1,2,3,4-tetrahydroisoquinoline (SC-48981), a potent competitive N-methy-D-aspartate (NMDA) receptor antagonist, in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1992 |
Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Biguanides; Magnesium; Male; Neomycin; Phencyclidine; Piperazines; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes; Tritium | 1992 |
The ES-242s, novel N-methyl-D-aspartate antagonists of microbial origin, interact with both the neurotransmitter recognition site and the ion channel domain.
Topics: Animals; Binding, Competitive; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Hippocampus; Ion Channels; Kinetics; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phencyclidine; Pipecolic Acids; Pyrans; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Autoradiography; Electric Stimulation; Evoked Potentials; Hippocampus; Ibotenic Acid; In Vitro Techniques; Ketamine; Male; Multivariate Analysis; Phencyclidine; Rats; Receptors, AMPA; Receptors, Neurotransmitter; Synapses; Tritium | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
ES-242-2, -3, -4, -5, -6, -7, and -8, novel bioxanthracenes produced by Verticillium sp., which act on the N-methyl-D-aspartate receptor.
Topics: Animals; Brain; In Vitro Techniques; Kainic Acid; Mitosporic Fungi; Phencyclidine; Piperidines; Pyrans; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1992 |
Arcaine and magnesium inhibition of the NMDA receptor ionophore complex: evidence for distinct voltage-dependent sites.
Topics: Animals; Biguanides; In Vitro Techniques; Magnesium; Male; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Effects of glycine antagonists on Mg(2+)- and glycine-induced [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine binding.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glycine; Kinetics; Magnesium; Male; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, Phencyclidine; Synaptic Membranes; Tritium | 1992 |
TCP enhances the survival of human fetal spinal cord cells in culture.
Topics: Biomarkers; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Embryo, Mammalian; Fetus; gamma-Aminobutyric Acid; Humans; Neuroglia; Neurons; Phencyclidine; Phosphopyruvate Hydratase; Spinal Cord | 1992 |
Design of an irreversible affinity ligand for the phencyclidine recognition site on N-methyl-D-aspartate-type glutamate receptors.
Topics: Affinity Labels; Alkylation; Animals; Binding Sites; Binding, Competitive; Cattle; Dizocilpine Maleate; Female; Kinetics; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiocyanates; Thiophenes | 1992 |
ES-242-1, a novel compound from Verticillium sp., binds to a site on N-methyl-D-aspartate receptor that is coupled to the channel domain.
Topics: Animals; Bacteria; Binding, Competitive; Centrifugation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Culture Techniques; Dizocilpine Maleate; Dose-Response Relationship, Drug; Fermentation; Kainic Acid; Ketamine; Mitosporic Fungi; Molecular Structure; Phencyclidine; Pyrans; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Soil Microbiology; Solubility; Synaptic Membranes | 1992 |
Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter.
Topics: Animals; Binding Sites; Brain; Female; Male; Methylphenidate; Phencyclidine; Rats; Rats, Inbred Strains | 1992 |
Effects of drugs that bind to PCP and sigma receptors on punished responding.
Topics: Animals; Buspirone; Dizocilpine Maleate; Haloperidol; Learning; Male; Pentobarbital; Phenazocine; Phencyclidine; Punishment; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
Phencyclidine increased release of beta-endorphin from anterior lobe of the pituitary.
Topics: alpha-MSH; Animals; Ataxia; Behavior, Animal; beta-Endorphin; Dexamethasone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Phencyclidine; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Sympathomimetics | 1991 |
Quantitative characterization of multiple binding sites for phencyclidine and N-allylnormetazocine in membranes from rat and guinea pig brain.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Guinea Pigs; Male; Phenazocine; Phencyclidine; Psychotropic Drugs; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1991 |
Identification and characterization of two sigma-like binding sites in the mouse neuroblastoma x rat glioma hybrid cell line NG108-15.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Glioma; Guanidines; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium; Tumor Cells, Cultured | 1991 |
High efficiency reconstitution of a phencyclidine/MK-801 receptor binding site solubilized from rat forebrain membranes.
Topics: Affinity Labels; Animals; Binding Sites; Binding, Competitive; Cholic Acids; Dizocilpine Maleate; In Vitro Techniques; Male; Membranes; Molecular Weight; Phencyclidine; Photolysis; Prosencephalon; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility | 1991 |
Selective increase of AMPA binding to the AMPA/quisqualate receptor in the hippocampus in response to acute stress.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Electroshock; Hippocampus; Ibotenic Acid; Phencyclidine; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Restraint, Physical; Stress, Psychological; Synaptic Transmission | 1991 |
Classical conditioning selectively increases AMPA receptor binding in rabbit hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Conditioning, Classical; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kinetics; Ligands; Male; Nictitating Membrane; Phencyclidine; Rabbits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Synthesis, absolute configuration and activity at N-methyl-D-aspartic acid (NMDA) receptor of the four D-2-amino-4,5-methano-adipate diastereoisomers.
Topics: 2-Aminoadipic Acid; Animals; Binding, Competitive; In Vitro Techniques; Molecular Conformation; Phencyclidine; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptic Membranes | 1991 |
A comparison of [3H]MK-801 and N-[1-(2-thienyl)cyclohexyl]-3,4-[3H]piperidine binding to the N-methyl-D-aspartate receptor complex in human brain.
Topics: Aged; Brain; Corpus Striatum; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Regulation of polyamine and magnesium inhibition of the N-methyl-D-aspartate (NMDA) receptor ionophore complex.
Topics: Animals; Biogenic Polyamines; Dizocilpine Maleate; Erythrocyte Membrane; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Structure-Activity Relationship | 1991 |
Desipramine and the phencyclidine derivative BTCP differently inhibit [3H]TCP binding to high- and low-affinity sites.
Topics: Animals; Binding, Competitive; Brain Stem; Cerebellum; Desipramine; Dopamine Agents; In Vitro Techniques; Kinetics; Male; Mice; Phencyclidine; Rats | 1991 |
[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate receptor participates in neuronal transmission of photic information through the retinohypothalamic tract.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arylamine N-Acetyltransferase; Hypothalamus; Light; Male; Melatonin; N-Methylaspartate; Neurons; Phencyclidine; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Retina; Suprachiasmatic Nucleus; Synaptic Transmission | 1991 |
Modulation of Mg(2+)-dependent [3H]TCP binding by L-glutamate, glycine, and guanine nucleotides in rat cerebral cortex.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guanylyl Imidodiphosphate; Illicit Drugs; Kinetics; Magnesium; Male; Phencyclidine; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Membranes; Tritium | 1991 |
The competitive NMDA receptor antagonist, CPP, allosterically modulates NMDA receptor associated PCP binding sites in the absence of steric hinderance.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Kinetics; Membranes; Molecular Conformation; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Autoradiographic visualisation of [3H]DTG binding to sigma receptors, [3H]TCP binding sites, and L-[3H]glutamate binding to NMDA receptors in human cerebellum.
Topics: Autoradiography; Female; Glutamates; Glutamic Acid; Guanidines; Humans; Male; Middle Aged; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium | 1991 |
Inhibitory modulation by sodium ions of the N-methyl-D-aspartate recognition site in brain synaptic membranes.
Topics: Animals; Binding, Competitive; Brain; Detergents; Glutamates; Glutamic Acid; Ions; Kinetics; Male; Octoxynol; Phencyclidine; Polyethylene Glycols; Rats; Receptors, N-Methyl-D-Aspartate; Sodium; Synaptic Membranes | 1991 |
Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication.
Topics: Antipsychotic Agents; Brain; Brain Mapping; Female; Humans; Illicit Drugs; Male; Middle Aged; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Schizophrenic Psychology | 1991 |
The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid.
Topics: Animals; Binding Sites; Glycine; Ion Channels; Kynurenic Acid; Phencyclidine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Isolation and identification of a peptide from rat brain which inhibits [3H]TCP binding.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Molecular Sequence Data; Phencyclidine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Reference Standards; Substance P | 1990 |
A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.
Topics: Animals; Aspartic Acid; Brain; Glycine; Ion Channels; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding.
Topics: Animals; Binding Sites; Glutamates; Glutamic Acid; Glycine; Ion Channels; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1990 |
3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) more potently antagonizes the high-affinity Mg2+ binding site on the N-methyl-D-aspartate/phencyclidine receptor ion channel complex than the L-glutamate recognition site.
Topics: Animals; In Vitro Techniques; Ion Channels; Magnesium; Male; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1991 |
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Chlorine; Fluorine; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; Ion Channels; Kynurenic Acid; Mice; Muscle Contraction; Myenteric Plexus; Phencyclidine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1991 |
Effect of amygdaloid kindling on the high- and low-affinity [3H]TCP binding sites of the rat CNS.
Topics: Amygdala; Animals; Binding Sites; Brain; Electric Stimulation; Kindling, Neurologic; Kinetics; Male; Phencyclidine; Rats; Stereotaxic Techniques | 1991 |
Effects of phencyclidine on contractile forces of isolated rabbit papillary muscles.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Dextrorphan; Female; Haloperidol; Male; Myocardial Contraction; Papillary Muscles; Phencyclidine; Rabbits; Stimulation, Chemical; Sulpiride | 1991 |
[Antagonistic effects of dextromethorphan on vasoconstriction of phencyclidine in vitro].
Topics: Animals; Biological Assay; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Norepinephrine; Phencyclidine; Rabbits; Vasoconstriction | 1991 |
Glycine-like modulation of N-methyl-D-aspartate receptors by a monoclonal antibody that enhances long-term potentiation.
Topics: Animals; Antibodies, Monoclonal; Brain; Glycine; Kinetics; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1991 |
Ischaemic brain damage--prevention with competitive and non-competitive antagonists of N-methyl-D-aspartate receptors.
Topics: Animals; Cats; Cerebral Arteries; Dextrorphan; Dizocilpine Maleate; Hematoma, Subdural; Ischemic Attack, Transient; Kynurenic Acid; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
[3H]1-[2-(2-thienyl)cyclohexyl]piperidine labels two high-affinity binding sites in human cortex: further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex.
Topics: Animals; Binding Sites; Binding, Competitive; Biogenic Amines; Cerebral Cortex; Fluoxetine; Guinea Pigs; Humans; Mice; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Rabbits; Sheep; Sodium Chloride; Structure-Activity Relationship; Swine; Tritium | 1991 |
Fluoromethylated and hydroxymethylated derivatives of N-methyl-D-aspartate receptor antagonist 1-[1-(2-thienyl)cyclohexyl]piperidine.
Topics: Animals; Electrophysiology; Hydrocarbons, Fluorinated; Hydroxylation; In Vitro Techniques; Male; Methylation; Phencyclidine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
The quaking mouse: an epileptic mutant with alterations affecting the modulatory mechanisms of the NMDA receptor complex.
Topics: Animals; Brain; Cell Membrane; Epilepsy; Glutamates; Glycine; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Quaking; Phencyclidine; Receptors, N-Methyl-D-Aspartate | 1991 |
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding Sites; Cell Survival; Epilepsy; Female; Hippocampus; Humans; Ibotenic Acid; Male; Neurons; Phencyclidine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values | 1991 |
Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Embryo, Mammalian; Female; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.
Topics: Analgesics; Animals; Benzomorphans; Brain; Dioxolanes; Dizocilpine Maleate; Guinea Pigs; In Vitro Techniques; Kinetics; Ligands; Narcotics; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Structure-Activity Relationship | 1990 |
Evidence of a role for NMDA receptors in pain perception.
Topics: Humans; Ketamine; Pain; Phencyclidine; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine; Stereoisomerism | 1990 |
Developmental study of [3H]TCP and [3H]glycine binding sites in the rat hippocampus.
Topics: Aging; Animals; Autoradiography; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; N-Methylaspartate; Nerve Tissue Proteins; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Competitive inhibition of magnesium-induced [3H]N-(1-[thienyl] cyclohexyl)piperidine binding by arcaine: evidence for a shared spermidine-magnesium binding site.
Topics: Animals; Biguanides; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Strychnine | 1990 |
JO 1784, a potent and selective ligand for rat and mouse brain sigma-sites.
Topics: Animals; Brain Chemistry; Cinnamates; Cyclopropanes; In Vitro Techniques; Male; Mice; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
Identification and characterization of a high-affinity glutamate-controlled TCP binding site in rat brain postsynaptic densities.
Topics: Animals; Brain; Cell Membrane; Dizocilpine Maleate; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Subcellular Fractions; Synapses; Synaptosomes | 1990 |
Biphasic effects of magnesium on the [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine binding in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Magnesium; Male; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
N-[1-(2-thienyl)cyclohexyl]-piperidine (TCP) does not block kainic acid-induced status epilepticus but reduces secondary hippocampal damage.
Topics: Animals; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Pharmacological characteristics and distributions of sigma- and phencyclidine receptors in the animal kingdom.
Topics: Animals; Binding Sites; Chickens; Fishes; Guinea Pigs; Haloperidol; Male; Phencyclidine; Phylogeny; Ranidae; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Saimiri; Sea Anemones; Turtles | 1990 |
N-Methyl-D-aspartate and quisqualate/DL-alpha-amino-3-hydroxy-5- methylisoxazole-4-propionic acid receptors: differential regulation by phospholipase C treatment.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Male; Oxazoles; Phencyclidine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Type C Phospholipases | 1990 |
Guinea pig vas deferens contains sigma but not phencyclidine receptors.
Topics: Animals; Binding, Competitive; Guinea Pigs; Male; Phenazocine; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Vas Deferens | 1990 |
Characterization of (+)-[3H]3-PPP and [3H]TCP binding sites in membrane preparations of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Binding, Competitive; Cattle; In Vitro Techniques; Membranes; Phencyclidine; Piperidines; Receptors, Opioid; Receptors, sigma | 1990 |
Guanine nucleotide modulation of [3H]TCP binding to the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Edetic Acid; Guanine Nucleotides; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Magnesium; Male; Phencyclidine; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes | 1990 |
Evidence for a functional coupling of the NMDA and glycine recognition sites in synaptic plasma membranes.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Cell Membrane; Glutamates; Glycine; In Vitro Techniques; Kinetics; Male; Phencyclidine; Piperazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Synaptic Membranes | 1990 |
Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site.
Topics: Animals; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ligands; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Regression Analysis; Structure-Activity Relationship | 1990 |
Ontogeny of PCP and sigma receptors in rat brain.
Topics: Aging; Animals; Brain; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Characterization of the stimulatory and inhibitory effects of polyamines on [3H]N-(1-[thienyl]cyclohexyl) piperidine binding to the N-methyl-D-aspartate receptor ionophore complex.
Topics: Animals; Cerebral Cortex; Ionophores; Kinetics; Phencyclidine; Polyamines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine | 1990 |
Anticonvulsant effects of antagonists of the N-methyl-D-aspartate receptor complex in a genetic model of epilepsy: the quaking mouse.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Injections, Intravenous; Male; Mice; Mice, Quaking; Phencyclidine; Physical Stimulation; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-methyl-D-aspartate/phencyclidine receptor complex of rat forebrain: purification and biochemical characterization.
Topics: Animals; Aspartic Acid; Brain; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamates; Glycine; Male; Molecular Weight; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Solubility | 1990 |
Identification of a domain in cytochrome C that displaces [3H]TCP binding from rat brain membrane receptors: synthesis of beta-neuroprotectin.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Brain; Cytochrome c Group; In Vitro Techniques; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Fragments; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Modulation of glutamate-induced uncompetitive blocker binding to the NMDA receptor by temperature and by glycine.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glycine; Kinetics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temperature | 1990 |
Photoaffinity labeling and binding studies reveal the existence of two types of phencyclidine receptors in the NCB-20 cell line.
Topics: Animals; Azides; Binding, Competitive; Cell Line; Cricetinae; Dibenzocycloheptenes; Dizocilpine Maleate; Mice; Molecular Weight; Neuroblastoma; Phencyclidine; Photochemistry; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
In vivo labeling of phencyclidine (PCP) receptors with 3H-TCP in the mouse brain.
Topics: Animals; Brain; Male; Mice; Mice, Inbred Strains; Phencyclidine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tissue Distribution; Tritium | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Pseudoallosteric modulation by (+)-MK801 of NMDA-coupled phencyclidine binding sites.
Topics: Allosteric Regulation; Allosteric Site; Animals; Binding, Competitive; Brain; Cell Membrane; Dizocilpine Maleate; Guinea Pigs; Kinetics; Ligands; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Effects of membrane fluidity on [3H]TCP binding to PCP receptors.
Topics: Animals; Membrane Fluidity; Phencyclidine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stearates; Temperature; Tritium | 1990 |
Profiles of [3H]N-[1-(2-thienyl)cyclohexyl]piperidine binding in brain synaptic membranes treated with Triton X-100.
Topics: Animals; Binding, Competitive; Brain; Detergents; Dizocilpine Maleate; Kinetics; Octoxynol; Phencyclidine; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1990 |
Alterations in rat brain [3H]-TCP binding following chronic phencyclidine administration.
Topics: Animals; Brain; Half-Life; Infusion Pumps, Implantable; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor.
Topics: Amino Acid Sequence; Animals; Conotoxins; Cyclic GMP; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1990 |
Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats.
Topics: Aging; Animals; Glycine; Hippocampus; Male; Neuronal Plasticity; Organophosphorus Compounds; Phencyclidine; Piperazines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Transmission | 1990 |
[3H]thienylcyclohexylpiperidine binding activity in brain synaptic membranes treated with Triton X-100.
Topics: Animals; Brain; Detergents; Drug Synergism; Glutamates; Male; N-Methylaspartate; Octoxynol; Phencyclidine; Polyethylene Glycols; Rats; Rats, Inbred Strains; Synaptic Membranes; Tritium | 1990 |
TCP shortens the latency of onset of isoelectricity in hypoglycaemia and fails to protect striatal neurones and dentate gyrus granule cells from hypoglycaemic injury in rats.
Topics: Animals; Corpus Striatum; Electroencephalography; Electrophysiology; Hippocampus; Hypoglycemia; Illicit Drugs; Insulin; Male; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Reference Values; Time Factors | 1990 |
Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Chemical Phenomena; Chemistry; Discrimination, Psychological; Hypoxia; Ischemia; Ketamine; Macaca mulatta; Molecular Structure; Phencyclidine; Pyridines; Rats; Structure-Activity Relationship | 1990 |
Changes in signal transduction in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Humans; Isoenzymes; Phencyclidine; Protein Kinase C; Signal Transduction | 1990 |
The effects of the phencyclidine analogs BTCP and TCP on nigrostriatal dopamine neuronal activity.
Topics: Action Potentials; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Electrophysiology; Injections, Intravenous; Iontophoresis; Male; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1990 |
Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.
Topics: Animals; Brain; Calcium; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ion Channels; Phencyclidine; Potassium; Radioisotopes; Rats; Rubidium; Synaptosomes | 1986 |
Multiple mode of binding of phencyclidines: high affinity association between phencyclidine receptors in rat brain and a monovalent ion-sensitive polypeptide.
Topics: Animals; Binding Sites; Brain Chemistry; Frontal Lobe; Hippocampus; In Vitro Techniques; Ion Channels; Molecular Weight; Peptides; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sodium Chloride; Tritium | 1987 |
Phencyclidine and related drugs bind to the activated N-methyl-D-aspartate receptor-channel complex in rat brain membranes.
Topics: Amino Acids; Anesthetics, Dissociative; Animals; Aspartic Acid; Brain; Ion Channels; Male; N-Methylaspartate; Narcotics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions | 1987 |
Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel.
Topics: Animals; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
The N-methyl-D-aspartate receptor complex.
Topics: Anesthetics, Dissociative; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Ion Channels; Magnesium; Models, Biological; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Phencyclidine selectively blocks the sustained voltage-dependent potassium conductance in PC12 cells.
Topics: Anesthetics; Animals; Dioxolanes; Electric Stimulation; Ion Channels; Membrane Potentials; Phencyclidine; Pheochromocytoma; Piperidines; Potassium; Rats; Tumor Cells, Cultured | 1988 |
Structural requirements for activation of the glycine receptor that modulates the N-methyl-D-aspartate operated ion channel.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Glycine; Ion Channels; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter | 1988 |
Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus.
Topics: Animals; Glycine; Hippocampus; Histocytochemistry; In Vitro Techniques; Ion Channels; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
Topics: Allosteric Regulation; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
Topics: Animals; Convulsants; Electric Stimulation; Glycine; Hippocampus; Illicit Drugs; Ion Channels; Kindling, Neurologic; Male; Neuronal Plasticity; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
[Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
Topics: Animals; Aspartic Acid; Hippocampus; Illicit Drugs; Kainic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary.
Topics: Adrenal Glands; Animals; Autoradiography; Brain Chemistry; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Haloperidol; Hypophysectomy; Male; Ovary; Phencyclidine; Piperidines; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Testis; Tissue Distribution | 1989 |
A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Glycine; Kynurenic Acid; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex.
Topics: Amino Acids; Animals; Glutamates; Glycine; Illicit Drugs; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine | 1989 |
D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics.
Topics: Animals; Binding, Competitive; Brain; Cycloserine; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1989 |
Reduced D-[3H]aspartate binding in Down's syndrome brains.
Topics: Aged; Aspartic Acid; Brain; Child; Down Syndrome; Humans; Middle Aged; Phencyclidine; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Bidirectional transport of NMDA receptor and ionophore in the vagus nerve.
Topics: Animals; Anticonvulsants; Autoradiography; Ionophores; Male; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vagus Nerve | 1989 |
1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Cycloleucine; In Vitro Techniques; Phencyclidine; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Characterization of a [3H]glycine recognition site as a modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry, Physical; Glycine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Membranes; Tritium | 1989 |
Phencyclidine and sigma receptors in rat spinal cord: binding characterization and quantitative autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Ganglia, Spinal; Male; Narcotic Antagonists; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Molecular target size analyses of the NMDA-receptor complex in rat cortex.
Topics: Animals; Cerebral Cortex; Freezing; Glutamates; Glycine; In Vitro Techniques; Membranes; Molecular Weight; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Differentiation of phencyclidine and sigma receptor types affecting the central inspiratory termination mechanism in cat.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Phencyclidine; Phrenic Nerve; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Respiration | 1989 |
The psychotomimetic drug phencyclidine labels two high affinity binding sites in guinea pig brain: evidence for N-methyl-D-aspartate-coupled and dopamine reuptake carrier-associated phencyclidine binding sites.
Topics: Acetylcholine; Animals; Binding Sites; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Guinea Pigs; In Vitro Techniques; Kinetics; Magnesium; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Excitatory amino acid receptors in the human cerebral cortex: a quantitative autoradiographic study comparing the distributions of [3H]TCP, [3H]glycine, L-[3H]glutamate, [3H]AMPA and [3H]kainic acid binding sites.
Topics: Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Female; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Oxazoles; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
[Adaptive changes in sigma and phencyclidine receptors during the long-term use of haloperidol and raclopride in rats].
Topics: Adaptation, Physiological; Animals; Apomorphine; Behavior, Animal; Drug Interactions; Haloperidol; Ketamine; Phenazocine; Phencyclidine; Raclopride; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Salicylamides; Time Factors; Tritium | 1989 |
Glutamine mimics glycine to enhance [3H]TCP binding at the NMDA receptor complex.
Topics: Animals; Glutamine; Glycine; In Vitro Techniques; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stimulation, Chemical; Synaptic Membranes | 1989 |
Embryonic and postnatal development of N-(1-[2-thienyl]cyclohexyl)[3H]piperidine binding sites in rat forebrain homogenates and slices.
Topics: Aging; Animals; Embryo, Mammalian; Frontal Lobe; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Neuropeptide Y and peptide YY interact with rat brain sigma and PCP binding sites.
Topics: Animals; Brain Chemistry; Haloperidol; In Vitro Techniques; Male; Neuropeptide Y; Pentazocine; Peptide YY; Peptides; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
Characterization of NMDA-coupled and dopamine reuptake carrier coupled [3H]-TCP binding sites in guinea pig brain.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Culture Techniques; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dopamine Plasma Membrane Transport Proteins; Guinea Pigs; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate.
Topics: Animals; Antidepressive Agents, Tricyclic; Dextromethorphan; Glutamates; Glutamic Acid; In Vitro Techniques; Levorphanol; Magnesium; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Frontal decortication decreases the affinity of N-(1-[2-thienyl]cyclohexyl)[3H]piperidine binding to rat striatum.
Topics: Animals; Cerebral Decortication; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Male; Neural Pathways; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Comparison of [3H] phencyclidine ([3H] PCP) and [3H] N-[1-(2-thienyl) cyclohexyl] piperidine ([3H] TCP) binding properties to rat and human brain membranes.
Topics: Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Humans; In Vitro Techniques; Male; Membranes; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
Neuroprotective effects of MK-801, TCP, PCP and CPP against N-methyl-D-aspartate induced neurotoxicity in an in vivo perinatal rat model.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Female; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Quantitative autoradiographic localization of NMDA receptors in rat brain using [3H]CPP: comparison with [3H]TCP binding sites.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Down-regulation of hippocampal phencyclidine (PCP) receptors following amygdala kindling.
Topics: Amygdala; Animals; Hippocampus; Kindling, Neurologic; Kinetics; Ligands; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
[3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes.
Topics: Animals; Anticonvulsants; Brain; Cations, Divalent; Cell Membrane; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Kinetics; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution; Tritium | 1988 |
Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain.
Topics: Animals; Binding Sites; Brain; Glutamates; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Tetrahydro-9-aminoacridine (THA) interacts with the phencyclidine (PCP) receptor site.
Topics: Acridines; Aminoacridines; Aminopyridines; Animals; Binding, Competitive; Cholinesterase Inhibitors; Frontal Lobe; Kinetics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tacrine | 1988 |
Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cycloleucine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1988 |
N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis.
Topics: Animals; Aspartic Acid; Brain; Glycine; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Regional changes in [3H]D-aspartate and [3H]TCP binding sites in Alzheimer's disease brains.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Female; Humans; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20.
Topics: Animals; Brain Chemistry; Cell Line; Cricetinae; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phenazocine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.
Topics: Animals; Guanidines; Haloperidol; Leukocytes; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists.
Topics: Animals; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Phencyclidine; Radioligand Assay; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Membranes | 1986 |
An endogenous ligand of the brain sigma/PCP receptor antagonizes NMDA-induced neurotransmitter release.
Topics: Acetylcholine; Animals; Aspartic Acid; Cattle; Corpus Striatum; Dopamine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tissue Extracts | 1987 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Valine | 1987 |
Interaction of L-glutamate and magnesium with phencyclidine recognition sites in rat brain: evidence for multiple affinity states of the phencyclidine/N-methyl-D-aspartate receptor complex.
Topics: Animals; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Magnesium; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Neurotoxins; Phencyclidine; Prodrugs; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Quantitative localization of [3H]TCP binding in rat brain by light microscopy autoradiography.
Topics: Animals; Autoradiography; Brain; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Phencyclidine and sigma opiate receptors in brain: biochemical and autoradiographical differentiation.
Topics: Autoradiography; Brain; Humans; In Vitro Techniques; Membranes; Phenazocine; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine | 1985 |
High correlation between the localization of [3H]TCP binding and NMDA receptors.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Kinetics; Male; Phenazocine; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism | 1986 |
Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat.
Topics: Acylation; Amphetamine; Animals; Ataxia; Caudate Nucleus; Dose-Response Relationship, Drug; Injections, Intraventricular; Ligands; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereotyped Behavior | 1986 |
[3H]TCP binding sites in Alzheimer's disease.
Topics: Alzheimer Disease; Autoradiography; Binding Sites; Hippocampus; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Loss of hippocampal [3H]TCP binding in Alzheimer's disease.
Topics: Alzheimer Disease; Autoradiography; Binding Sites; Hippocampus; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain.
Topics: Animals; Brain Chemistry; Convulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Molecular target size of NMDA antagonist binding sites.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Ligands; Molecular Weight; N-Methylaspartate; Phencyclidine; Pyrazines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Both the sigma receptor-specific ligand (+)3-PPP and the PCP receptor-specific ligand TCP act in the mouse vas deferens via augmentation of electrically evoked norepinephrine release.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Norepinephrine; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Vas Deferens | 1987 |
Equilibrium analysis of [3H]TCP binding: effects of glycine, magnesium and N-methyl-D-aspartate agonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Dialysis; Glycine; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
Topics: Animals; Aspartic Acid; Catecholamines; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats | 1988 |
Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1987 |
Glycine potentiates N-methyl-D-aspartate-induced [3H]TCP binding to rat cortical membranes.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Synergism; Electric Stimulation; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1987 |
Blockade and recovery of the acetylcholine receptor produced by a thienyl analog of phencyclidine: influence of voltage, temperature, frequency of stimulation and conditioning pulse duration.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Evoked Potentials; Kinetics; Membrane Potentials; Motor Endplate; Phencyclidine; Rana pipiens; Receptors, Cholinergic; Temperature | 1986 |
Animal models of intravenous phencyclinoid self-administration.
Topics: Animals; Cocaine; Conditioning, Operant; Disease Models, Animal; Female; Infusions, Intravenous; Ketamine; Phencyclidine; Phencyclidine Abuse; Rats; Reinforcement Schedule; Self Administration; Substance-Related Disorders | 1987 |
Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: structure-activity studies.
Topics: Amino Acids; Animals; Binding, Competitive; Catalepsy; Columbidae; Phencyclidine; Structure-Activity Relationship | 1987 |
[3H]thienyl-phencyclidine ([3H]TCP) binds to two different sites in rat brain. Localization by autoradiographic and biochemical techniques.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebellum; Frontal Lobe; Phencyclidine; Rats | 1986 |
[3H]TCP: a new tool with high affinity for the PCP receptor in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Illicit Drugs; Kinetics; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tritium | 1983 |
Comparison of phencyclidine and three analogues on fixed-interval performance in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cyclohexylamines; Dose-Response Relationship, Drug; Haplorhini; Ketamine; Macaca mulatta; Male; Phencyclidine | 1980 |
Investigation of the gas-liquid chromatographic separation of phencyclidine and some heterocyclic analogues by combined gas-liquid chromatography-mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Phencyclidine | 1980 |
Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Brain; Cloning, Molecular; Cysteine; DNA, Complementary; Gene Library; Glutamic Acid; Glycine; Hippocampus; Illicit Drugs; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Synaptic Membranes | 1995 |
Identification, synthesis, and characterization of a unique class of N-methyl-D-aspartate antagonists. The 6,11-ethanobenzo[b]quinolizinium cation.
Topics: Animals; Binding Sites; Ion Channels; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Ion Channels; Ligands; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential.
Topics: Acetamides; Animals; Antiparkinson Agents; Autoradiography; Binding, Competitive; Brain; Dizocilpine Maleate; Ion Channels; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution | 1995 |
The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Dizocilpine Maleate; Ibogaine; In Vitro Techniques; Ion Channels; Ligands; Phencyclidine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
A photoaffinity probe for the polyamine site regulating the NMDA receptor.
Topics: Affinity Labels; Animals; Azides; Biogenic Polyamines; In Vitro Techniques; Phencyclidine; Photochemistry; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Synaptic Membranes; Synaptosomes | 1995 |
Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.
Topics: Action Potentials; Analysis of Variance; Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Diamines; Drug Interactions; Eflornithine; Female; Hippocampus; Magnesium; Male; N-Methylaspartate; Phencyclidine; Polyamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Spermine | 1995 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
The envelope glycoprotein of HIV-1 alters NMDA receptor function.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; HIV Envelope Protein gp120; N-Methylaspartate; Oocytes; Phencyclidine; Pipecolic Acids; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 1993 |
Behavioral studies on FR115427, a novel selective N-methyl-D-aspartate antagonist.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoquinolines; Male; Membranes; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motor Activity; Phencyclidine; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1995 |
NE-100, a novel sigma ligand: effects on [3H]TCP binding to intact primary cultured neuronal cells.
Topics: Animals; Anisoles; Carbachol; Cells, Cultured; Illicit Drugs; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Neurons; Phencyclidine; Propylamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Telencephalon; Tritium | 1995 |
Modulation of soman-induced neuropathology with an anticonvulsant regimen.
Topics: Animals; Anticonvulsants; Atropine; Hippocampus; Male; Olfactory Pathways; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol, on [3H]N-(1-[2-thienyl] cyclohexyl)-3,4-piperidine ([3H]TCP) binding and [3H]dopamine uptake in the rat brain.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine Antagonists; Male; Phencyclidine; Rats; Rats, Wistar; Stereoisomerism; Synaptosomes; Tritium | 1994 |
Laminar distribution of NMDA receptors in cat and monkey visual cortex visualized by [3H]-MK-801 binding.
Topics: Animals; Autoradiography; Binding, Competitive; Cats; Dizocilpine Maleate; Female; Freeze Drying; Glutamates; Glutamic Acid; Macaca fascicularis; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Vision, Ocular; Visual Cortex | 1993 |
Potentiation by polyamines of an interaction of noncompetitive antagonists at the N-methyl-D-aspartate receptor ionophore complex with phosphatidylserine.
Topics: Animals; Brain; Calmodulin; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Illicit Drugs; Kinetics; Phencyclidine; Phosphatidylserines; Phospholipids; Polyamines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes; Tritium | 1993 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats.
Topics: Aging; Animals; Autoradiography; Benzazepines; Brain; Flunitrazepam; Male; Phencyclidine; Quinuclidinyl Benzilate; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Dopamine D1; Receptors, GABA; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Phencyclidine; Receptors, Serotonin | 1994 |
Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
Topics: Animals; Base Sequence; Glycine; Hippocampus; Kindling, Neurologic; Male; Molecular Probes; Molecular Sequence Data; Phencyclidine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reference Values; Seizures | 1994 |
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (1): Changes in the [3H]QNB binding.
Topics: Aging; Animals; Autoradiography; Brain; Drugs, Chinese Herbal; Male; Phencyclidine; Quinuclidinyl Benzilate; Rats; Rats, Inbred F344; Receptors, Neurotransmitter | 1994 |
An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2.
Topics: Affinity Labels; Animals; Brain; Cell Membrane; Cerebral Ventricles; Dizocilpine Maleate; Illicit Drugs; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Phencyclidine; Receptors, Phencyclidine | 1994 |
Coadministration of atropine, NBQX and TCP against soman-induced seizures.
Topics: Animals; Atropine; Drug Synergism; Electroencephalography; Male; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
[Prevention and treatment of status epilepticus induced by soman].
Topics: Animals; Diazepam; Guinea Pigs; Male; Phencyclidine; Rats; Rats, Wistar; Soman; Status Epilepticus | 1994 |
Postnatal changes in N-methyl-D-aspartate receptor binding and stimulation by glutamate and glycine of [3H]-MK-801 binding in human temporal cortex.
Topics: Adult; Aging; Cerebral Cortex; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Humans; In Vitro Techniques; Infant; Infant, Newborn; Male; Phencyclidine; Proteins; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Sudden Infant Death; Temporal Lobe | 1993 |
Phencyclidine treatment in mice: effects on phencyclidine binding sites and glutamate uptake in cerebral cortex preparations.
Topics: Animals; Binding Sites; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Male; Mice; Phencyclidine; Stimulation, Chemical; Synaptosomes | 1993 |
Multiple structural determinants of voltage-dependent magnesium block in recombinant NMDA receptors.
Topics: Amino Acid Sequence; Animals; Barium; DNA, Complementary; Electrophysiology; Energy Metabolism; In Vitro Techniques; Magnesium; Molecular Sequence Data; Mutagenesis; Oocytes; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Recombination, Genetic; Xenopus; Zinc | 1993 |
The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain.
Topics: Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dronabinol; L-Lactate Dehydrogenase; Neurons; Phencyclidine; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain.
Topics: Animals; Biogenic Monoamines; Brain; Dizocilpine Maleate; Electrophysiology; Guinea Pigs; In Vitro Techniques; Indenes; Ligands; Male; Microdialysis; Phencyclidine; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Phencyclidine; Synaptosomes | 1994 |
Autoradiographic localisation of NMDA binding sites in brainstem cardiorespiratory areas of adult and newborn cats.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding Sites; Brain Mapping; Brain Stem; Cats; Illicit Drugs; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Pons; Receptors, N-Methyl-D-Aspartate; Tritium | 1993 |
Synthesis and evaluation of 1-(1-[5-(2'-[18F]fluoroethyl)-2-thienyl]-cyclohexyl)piperidine as a potential in vivo radioligand for the NMDA receptor-channel complex.
Topics: Animals; Fluorine Radioisotopes; Male; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiophenes; Tissue Distribution; Tomography, Emission-Computed | 1993 |
Monoclonal antibodies against a phencyclidine derivative are used to investigate protein-ligand interactions.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclohexylamines; Drug Design; Enzyme-Linked Immunosorbent Assay; Isothiocyanates; Ligands; Mice; Mice, Inbred BALB C; Phencyclidine; Proteins; Receptors, N-Methyl-D-Aspartate | 1993 |
The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Anesthesia; Animals; Antiparkinson Agents; Binding, Competitive; Brain Chemistry; H-Reflex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Seizures; Spinal Cord | 1993 |
Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an omega 3 site ligand.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Diseases; Excitatory Amino Acid Antagonists; Hippocampus; Isoquinolines; Ligands; Male; Oxazines; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Soman | 1993 |
Effects of phencyclidine-type drugs in rats discriminating fentanyl from saline: pharmacological and behavioral characterization of intermediate levels of drug lever selection.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dizocilpine Maleate; Fentanyl; Ketamine; Male; Phencyclidine; Rats; Rats, Wistar; Reinforcement, Psychology | 1993 |
MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Illicit Drugs; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tegmentum Mesencephali; Vibrissae | 1993 |
Thienylphencyclidine protection for the spinal cord of adult rats against extension of lesions secondary to a photochemical injury.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Somatosensory; Male; Motor Activity; Phencyclidine; Photochemistry; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1993 |
Metabolic changes associated with altering blood glucose levels in short duration forebrain ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Hydrogen-Ion Concentration; Ischemic Attack, Transient; Magnetic Resonance Spectroscopy; Male; Phencyclidine; Phosphates; Phosphocreatine; Prosencephalon; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1993 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
New analgesics derived from the phencyclidine analogue thienylcyclidine.
Topics: Analgesics; Analgesics, Opioid; Animals; Male; Meperidine; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Phencyclidine; Reaction Time | 1996 |
Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro.
Topics: Aminoquinolines; Animals; Benzothiadiazines; Binding, Competitive; Cerebral Cortex; Cyclic GMP; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kynurenic Acid; Nerve Degeneration; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore.
Topics: Animals; Brain; Calcium Channels; Dizocilpine Maleate; Fluorine Radioisotopes; Indicators and Reagents; Isotope Labeling; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Phencyclidine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed | 1996 |
WIN 63480, a hydrophilic TCP-site ligand, has reduced agonist-independent NMDA ion channel access compared to MK-801 and phencyclidine.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Membrane Potentials; Mice; Phencyclidine; Quinolizines; Receptors, N-Methyl-D-Aspartate; Transfection; Xenopus laevis | 1995 |
Non-aminergic effects of amphetamine on the NMDA receptor in primary cultured cortical cells.
Topics: Amphetamines; Animals; Calcium; Cell Membrane; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Haloperidol; Phencyclidine; Protein Kinases; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1996 |
Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Female; Haloperidol; Illicit Drugs; Kinetics; Oocytes; Phencyclidine; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Trifluperidol; Xenopus | 1997 |
NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology.
Topics: Acetamides; Alternative Splicing; Animals; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Illicit Drugs; Ion Channels; Kinetics; Membrane Potentials; Oocytes; Phencyclidine; Protein Biosynthesis; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis | 1997 |
Evidence for N-methyl-D-aspartate receptor-mediated increase in norepinephrine utilization in the prefrontal cortex of unanesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic Agents; Animals; Binding, Competitive; Consciousness; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Norepinephrine; Oxidopamine; Phencyclidine; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sympathomimetics; Tritium | 1997 |
The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Binding, Competitive; Cell Membrane; Cerebral Cortex; Cyclic GMP; Dibenzazepines; Dizocilpine Maleate; Glycine; In Vitro Techniques; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1996 |
Morphological and morphometric analysis of serotonin-containing neurons in primary dissociated cultures of human rhombencephalon: a study of development.
Topics: Cell Differentiation; Cell Size; Cells, Cultured; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Fetus; Humans; Illicit Drugs; Neurons; Neuroprotective Agents; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin | 1997 |
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic GMP; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Ligands; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1997 |
In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801.
Topics: Animals; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; Immunohistochemistry; Male; Neurons; Phencyclidine; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Death; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Endocannabinoids; Ethanolamine; Ethanolamines; Glutamic Acid; Ionophores; Mice; Neurons; Phencyclidine; Phosphatidylethanolamines; Polyunsaturated Alkamides; Receptors, N-Methyl-D-Aspartate; Time Factors | 1997 |
Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Culture Media, Serum-Free; Dizocilpine Maleate; Equilin; Estradiol; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Excitatory Amino Acid Antagonists; Growth Substances; Microscopy, Video; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities.
Topics: Animals; Binding, Competitive; Bungarotoxins; Carbachol; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Insecticides; Iodine Radioisotopes; Lethal Dose 50; Nicotinic Agonists; Paraoxon; Parathion; Phencyclidine; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo; Tritium | 1997 |
Determination of gacyclidine enantiomers in human plasma by gas chromatography-mass spectrometry using selected-ion monitoring.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Male; Microchemistry; N-Methylaspartate; Phencyclidine; Quality Control; Sensitivity and Specificity; Solvents; Stereoisomerism | 1997 |
Comparison of glutamate and N-methyl-D-aspartate toxicities on rat mesencephalic primary cell cultures.
Topics: Animals; Cells, Cultured; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Neurons; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs.
Topics: Adrenergic Agents; Animals; Cyclohexylamines; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Immunoglobulin Fab Fragments; Immunoglobulin G; Male; Methamphetamine; Motor Activity; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley | 1998 |
Effect of ibogaine on the various sites of the NMDA receptor complex and sigma binding sites in rat brain.
Topics: Animals; Binding Sites; Brain; Dizocilpine Maleate; Ibogaine; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1998 |
Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains.
Topics: Aged; Amino Acid Transport System X-AG; Analysis of Variance; Aspartic Acid; ATP-Binding Cassette Transporters; Basal Ganglia; Binding Sites; Carrier Proteins; Case-Control Studies; GABA Plasma Membrane Transport Proteins; Humans; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Nipecotic Acids; Organic Anion Transporters; Phencyclidine; Proline; Radioligand Assay; Schizophrenia; Tritium | 1998 |
Effect of PCP and sigma ligands on both noradrenaline- and electrically-induced contractions and on [3H]-noradrenaline uptake in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Dextromethorphan; Dizocilpine Maleate; Dopamine Agonists; Electric Stimulation; Excitatory Amino Acid Antagonists; Ligands; Male; Muscle Contraction; Neuroprotective Agents; Norepinephrine; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Phencyclidine; Receptors, sigma; Tritium; Vas Deferens | 1998 |
In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.
Topics: Animals; Base Sequence; Binding Sites; Binding, Competitive; Cell Membrane; Cocaine; Consensus Sequence; Electric Organ; Illicit Drugs; Kinetics; Ligands; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phencyclidine; Receptors, Nicotinic; RNA; Sequence Alignment; Torpedo | 1998 |
Simulation of psychosis by continuous delivery of phencyclidine from controlled-release polymer implants.
Topics: Animals; Brain; Delayed-Action Preparations; Drug Implants; Emotions; Hallucinogens; Male; Motor Activity; Phencyclidine; Polyvinyls; Psychoses, Substance-Induced; Rats | 1998 |
Long-term changes in brain following continuous phencyclidine administration: an autoradiographic study using flunitrazepam, ketanserin, mazindol, quinuclidinyl benzilate, piperidyl-3,4-3H(N)-TCP, and AMPA receptor ligands.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Female; Flunitrazepam; Ketanserin; Ligands; Mazindol; Phencyclidine; Protein Binding; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex.
Topics: Adult; Aged; Aged, 80 and over; Binding, Competitive; Female; Humans; Ketanserin; Male; Middle Aged; Neurons; Neurotransmitter Agents; Nitric Oxide Synthase; Phencyclidine; Prefrontal Cortex; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine; Receptors, GABA-A; Receptors, Serotonin; Schizophrenia; Serotonin Antagonists; Tritium | 1999 |
Neuroprotection of cultured foetal rat hippocampal cells against glucose deprivation: are GABAergic neurons less vulnerable or more sensitive to TCP protection?
Topics: Animals; Cell Survival; Cells, Cultured; Drug Resistance; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Phencyclidine; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Synthesis of an N-methyl-D-aspartate receptor antagonist, ES-242-5, and its analogs.
Topics: Anthracenes; Excitatory Amino Acid Antagonists; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Optical Rotation; Phencyclidine; Pyrans; Receptors, N-Methyl-D-Aspartate; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism | 1999 |
Memory impairment after soman intoxication in rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics.
Topics: Animals; Antidotes; Atropine; Behavior, Animal; Cholinergic Antagonists; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Soman; Spatial Behavior; Survival Rate; Time Factors | 1999 |
5-hydroxytryptamine interaction with the nicotinic acetylcholine receptor.
Topics: Animals; Binding Sites; Bungarotoxins; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Phencyclidine; Photoaffinity Labels; Receptors, Nicotinic; Serotonin; Torpedo | 2000 |
The low affinity PCP sites in the rat cerebellum not only bind TCP-like but also BTCP-like structures.
Topics: Animals; Binding, Competitive; Cerebellum; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Kinetics; Male; Membranes; Neostriatum; Phencyclidine; Prosencephalon; Rats; Rats, Wistar; Receptors, Phencyclidine; Structure-Activity Relationship | 2000 |
Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells.
Topics: Animals; Cell Count; Cells, Cultured; Cerebellum; Chlorine; Coculture Techniques; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Iodine; Lethal Dose 50; Mesencephalon; Neurons; Neuroprotective Agents; Phencyclidine; Phenols; Phosphopyruvate Hydratase; Rats; Salicylates; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Effects of RPR 118723, a novel antagonist at the glycine site of the NMDA receptor, in vitro.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membranes; Mice; N-Methylaspartate; Phencyclidine; Pyrazines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Tritium | 2000 |
Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Stem; Child, Preschool; Excitatory Amino Acid Antagonists; Female; Glycine; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Middle Aged; Neuroprotective Agents; Phencyclidine; Pregnancy; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Sudden Infant Death | 2000 |
Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity.
Topics: Animals; Brain; Convulsants; Electroencephalography; Guinea Pigs; Male; Motor Activity; Neuroprotective Agents; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures; Soman; Time Factors | 2001 |
Amphetamine inhibits the N-methyl-D-aspartate receptor-mediated responses by directly interacting with the receptor/channel complex.
Topics: Amphetamines; Animals; Binding, Competitive; Brain; Calcium; Cell Death; Cell Membrane; Cells, Cultured; Cerebral Cortex; Dopamine Antagonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Kinetics; L-Lactate Dehydrogenase; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour.
Topics: Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Discrimination Learning; Electroencephalography; Guinea Pigs; Male; Muscarinic Antagonists; Neuroprotective Agents; Phencyclidine; Pyridostigmine Bromide; Receptors, N-Methyl-D-Aspartate; Seizures; Soman | 2001 |
Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Brain Injuries; Cerebellum; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neurons; Neuroprotective Agents; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Subcellular Fractions; Synapses; Synaptic Transmission; Tritium | 2002 |
Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Haloperidol; Ion Channels; Male; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants.
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cell Membrane; Doxepin; Excitatory Amino Acid Antagonists; Humans; Imipramine; In Vitro Techniques; Kidney; Kinetics; Membrane Potentials; Mice; Nicotinic Antagonists; Patch-Clamp Techniques; Phencyclidine; Receptors, Nicotinic; Torpedo | 2003 |
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium | 2004 |
The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of the dopamine reuptake in the neuroendocrine effects of phencyclidine.
Topics: Adrenocorticotropic Hormone; Animals; Binding Sites; Binding, Competitive; Cocaine; Corticosterone; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Neuroprotective Agents; Phencyclidine; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2006 |
Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors.
Topics: Allosteric Regulation; Amobarbital; Animals; Binding Sites; Fluorescent Dyes; Gentian Violet; Ion Channels; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Pentobarbital; Phencyclidine; Protein Binding; Protein Conformation; Quaternary Ammonium Compounds; Receptors, Nicotinic; Temperature; Tetracaine; Thiophenes; Torpedo; Tritium | 2006 |
In vitro biological efficiency of tenocyclidine-TCP and its adamantane derivative TAMORF.
Topics: Adamantane; Cell Survival; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromosome Aberrations; Comet Assay; Erythrocytes; Gamma Rays; Humans; In Vitro Techniques; Lethal Dose 50; Leukocytes; Lymphocytes; Morpholines; Mutagens; Phencyclidine; Piperidines; Radiation-Protective Agents; Soman; Structure-Activity Relationship; Thiophenes; Trypan Blue | 2006 |
Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.
Topics: Amines; Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ion Channels; Male; Mice; Mice, Inbred ICR; Models, Molecular; Phencyclidine; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptosomes; Thiophenes | 2007 |
Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors.
Topics: Anesthetics, Local; Animals; Binding, Competitive; Bungarotoxins; Cell Membrane; Electric Organ; Neuroprotective Agents; Phencyclidine; Predictive Value of Tests; Protein Conformation; Receptors, Nicotinic; Torpedo; Tritium | 2007 |
Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Comet Assay; Leukocytes; Male; Models, Chemical; Mutagens; Phencyclidine; Piperidines; Rats; Rats, Wistar; Soman; Thiophenes | 2008 |
High specific activity tritiation of TCP and BTCP.
Topics: Isotope Labeling; Phencyclidine; Tritium | 2009 |
Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.
Topics: Animals; Cell Line, Transformed; Chromatin Immunoprecipitation; DNA Replication; Enzyme Activation; Ganglia; Gene Expression Regulation, Viral; Green Fluorescent Proteins; Herpesvirus 1, Human; Herpesvirus 3, Human; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Host Cell Factor C1; Humans; Lysine; Mice; Monoamine Oxidase Inhibitors; Mutation; Neurons; Pargyline; Phencyclidine; Piperidines; Promoter Regions, Genetic; Reaction Time; RNA, Small Interfering; Simplexvirus; Thiophenes; Time Factors; Transfection; Virus Replication | 2009 |
Qualitative GC-MS assessment of TCP and TAMORF elimination in rats.
Topics: Adamantane; Animals; Gas Chromatography-Mass Spectrometry; Male; Morpholines; Organophosphate Poisoning; Phencyclidine; Piperidines; Rats; Rats, Wistar; Thiophenes | 2010 |
1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.
Topics: Animals; Anticonvulsants; Antioxidants; Benzamidines; Binding Sites; Body Temperature; Brain; Mice; Models, Molecular; Molecular Conformation; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |