tempo and ethylene-urea

tempo has been researched along with ethylene-urea* in 1 studies

Other Studies

1 other study(ies) available for tempo and ethylene-urea

ArticleYear
Catalytic Enantioselective α,β,γ-Trioxygenation.
    Organic letters, 2015, Dec-18, Volume: 17, Issue:24

    Applying a catalytic enantioselective aldehyde α-oxygenation condition to an enal substrate led to the discovery of the first α,β,γ-trifunctionalization cascade of enals. Under optimal conditions, a tryptophan-derived imidazolidinone catalyst in fluorinated aromatic solvents provided α,β,γ-trioxyaldehydes in up to 51% isolated yield (average of 80% yield per oxygenation step) and 85:15 er. Substitution at the δ position was tolerated, but not at the α, β, or γ positions. The reaction proceeded through initial TEMPO incorporation at the γ position, and rapid racemization of this intermediate, reversible conjugate addition of water, followed by TEMPO incorporation at the α position to set all three stereocenters with double dynamic kinetic resolution.

    Topics: Aldehydes; Catalysis; Cyclic N-Oxides; Imidazolidines; Kinetics; Molecular Structure; Stereoisomerism; Tryptophan

2015