temozolomide has been researched along with valproic acid in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 27 (75.00) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dellinger, CA; Grewal, J; Yung, WK | 1 |
| Akagi, T; Aoyanagi, E; Kaneko, S; Sasai, K; Tabu, K; Tanaka, S | 1 |
| Hoorens, A; Neyns, B; Stupp, R | 1 |
| Chang, YJ; Chen, CH; Chung, KT; Ku, MS; Yang, JT | 1 |
| Belohlavek, C; Fritz, G; Jöst, E; Kaina, B; Nagel, G; Roos, WP | 1 |
| Belanger, K; Bogdahn, U; Brandes, AA; Cairncross, JG; Forsyth, P; Gorlia, T; Lacombe, D; Macdonald, DR; Mason, W; Mirimanoff, RO; Rossetti, AO; Stupp, R; van den Bent, MJ; Vecht, CJ; Weller, M | 1 |
| Lafleur, MV; Slotman, BJ; Sminia, P; Stalpers, LJ; Van den Berg, J; Van Nifterik, KA | 1 |
| Hou, Y; Jeong, CH; Jeun, SS; Kim, SM; Lim, JY; Park, KY; Ryu, CH; Woo, JS; Yoon, WS | 1 |
| Chen, FR; Chen, ZP; Li, C; Shao, CJ; Wu, MW; Xia, YF | 1 |
| Barker, CA; Beal, K; Bishop, AJ; Chan, TA; Chang, M | 1 |
| Dielemans, JC; Kerkhof, M; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H | 1 |
| Airenne, K; Alasaarela, L; Määttä, AM; Pikkarainen, J; Samaranayake, H; Stedt, H; Ylä-Herttuala, S | 1 |
| Buslei, R; Derer, A; Fietkau, R; Frey, B; Gaipl, US; Muth, C; Rubner, Y; Sieber, R; Strnad, A | 1 |
| Cosgrove, L; Day, B; Fay, M; Head, R; Hosein, AN; Lim, YC; Martin, JH; Rose, S; Sminia, P; Stringer, B | 1 |
| Annovazzi, L; Biunno, I; Cassoni, P; Cattaneo, M; De Blasio, P; Melcarne, A; Mellai, M; Schiffer, D; Storaci, AM | 1 |
| Camphausen, K; Chang, MG; Fine, HA; Holdford, DJ; Krauze, AV; Myrehaug, SD; Shih, J; Smith, S; Tofilon, PJ | 1 |
| Chinot, O; Cloughesy, T; Gilbert, MR; Gorlia, T; Happold, C; Hegi, M; Mehta, MP; Nabors, LB; Perry, JR; Pugh, SL; Reardon, DA; Roth, P; Stupp, R; Weller, M; Wick, W | 1 |
| Dietrich, J; Le, A; McDonnell, E; Nahed, BV; Redjal, N; Reinshagen, C; Walcott, BP | 1 |
| Bumes, E; Eyüpoglu, IY; Hau, P; Hutterer, M; Proske, J; Savaskan, NE; Seliger, C; Uhl, M; Vollmann-Zwerenz, A; Walter, L | 1 |
| Pellerino, A; Rudà, R; Soffietti, R | 1 |
| Baronchelli, S; Bentivegna, A; Butta, V; Cilibrasi, C; Dalprà, L; Lavitrano, M; Redaelli, S; Riva, G | 1 |
| Hau, P; Herold-Mende, C; Hoja, S; Proescholdt, M; Rehli, M; Riemenschneider, MJ; Schulze, M | 1 |
| Araki, H; Kuwabara, Y; Ohue, S; Suehiro, S; Tanaka, A; Tanaka, M; Watanabe, S; Yamashita, D | 1 |
| Cruz, R; Figg, WD; League-Pascual, JC; Lester-McCully, CM; Peer, CJ; Rodgers, L; Ronner, L; Shandilya, S; Warren, KE | 1 |
| Mielke, D; Ninkovic, M; Rohde, V; Sachkova, A; Schatlo, B; Sperling, S | 1 |
| Chen, JC; Chung, CY; Huang, C; Lee, IN; Lee, MH; Lin, MH; Wu, YP; Yang, JT | 1 |
| Gielen, G; Hüttelmaier, S; Klusmann, JH; Kramm, C; Kühnöl, CD; Pietsch, T; Pötschke, R | 1 |
| Chen, KT; Chen, PC; Cheng, CY; Huang, WC; Kuo, YJ; Lee, IY; Lee, MH; Lin, MH; Wang, TC; Yang, JT; Yang, WH; Yang, YH | 1 |
| Bronsema, A; Guerreiro, H; Kresbach, C; Rutkowski, S; Schüller, U; Winkler, B | 1 |
| Hanashima, Y; Hara, H; Katayama, Y; Ozawa, Y; Sano, E; Sumi, K; Tatsuoka, J; Yagi, C; Yamamuro, S; Yoshimura, S; Yoshino, A | 1 |
| Camphausen, K; Cooley Zgela, T; Jiang, W; Krauze, AV; Li, MC; Mackey, M; Shankavaram, U; Shih, J; Sproull, M; Tasci, E; Tofilon, P; Zhao, Y | 1 |
1 review(s) available for temozolomide and valproic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for temozolomide and valproic acid
| Article | Year |
|---|---|
Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Canada; Dacarbazine; Europe; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2011 |
A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide; Time Factors; Valproic Acid | 2015 |
33 other study(ies) available for temozolomide and valproic acid
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Fatal reactivation of hepatitis B with temozolomide.
Topics: Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Fatal Outcome; Female; Glioblastoma; Hepatitis B; Hepatitis B virus; Humans; Temozolomide; Temporal Lobe; Valproic Acid; Viral Load; Virus Activation | 2007 |
O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Astrocytes; Cell Division; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Mice; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Transfection; Transplantation, Heterologous; Tumor Suppressor Proteins; Valproic Acid | 2007 |
Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Cholestasis; Dacarbazine; Glioblastoma; Humans; Liver Failure; Male; Middle Aged; Temozolomide; Valproic Acid | 2008 |
Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioma; Humans; Oxidation-Reduction; Temozolomide; Valproic Acid | 2011 |
Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 8; Cell Line, Tumor; Dacarbazine; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Humans; Interferon-beta; Male; Melanoma; Mice; Temozolomide; Tumor Suppressor Proteins; Valproic Acid | 2011 |
Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation.
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gamma Rays; Glioma; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Valproic Acid | 2012 |
Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Temozolomide; Tumor Suppressor Proteins; Valproic Acid; Xenograft Model Antitumor Assays | 2012 |
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell lines in vitro.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Dacarbazine; Flow Cytometry; Glioma; Histone Deacetylase Inhibitors; Humans; Temozolomide; Valproic Acid | 2012 |
Valproic acid use during radiation therapy for glioblastoma associated with improved survival.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Seizures; Survival Analysis; Temozolomide; Treatment Outcome; Valproic Acid; Young Adult | 2013 |
Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Levetiracetam; Male; Middle Aged; Neoplasm Recurrence, Local; Piracetam; Prognosis; Retrospective Studies; Seizures; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2013 |
Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide.
Topics: Adenoviruses, Human; Animals; Antineoplastic Agents, Alkylating; Antiviral Agents; Combined Modality Therapy; Dacarbazine; Ganciclovir; Genes, Transgenic, Suicide; Genes, Viral; Genetic Therapy; Genetic Vectors; Glioma; Herpesvirus 1, Human; Humans; Male; Neoplasms, Experimental; Rats; Temozolomide; Thymidine Kinase; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid | 2013 |
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Dacarbazine; Dose Fractionation, Radiation; G2 Phase; Glioblastoma; HMGB1 Protein; HSP70 Heat-Shock Proteins; Humans; Mutation; Necrosis; Temozolomide; Tumor Suppressor Protein p53; Valproic Acid | 2014 |
The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Cells, Cultured; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Gene Expression Profiling; Glioblastoma; Humans; Mice, Inbred NOD; Mice, SCID; Microarray Analysis; Neoplasm Transplantation; Promoter Regions, Genetic; Radiation-Sensitizing Agents; Temozolomide; Tumor Suppressor Proteins; Valproic Acid | 2015 |
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Doxorubicin; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Paclitaxel; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proteins; Temozolomide; Valproic Acid | 2015 |
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Trials as Topic; Dacarbazine; Epilepsy; Female; Glioblastoma; Humans; Levetiracetam; Male; Middle Aged; Piracetam; Prognosis; Survival Analysis; Temozolomide; Valproic Acid | 2016 |
Valproic acid, compared to other antiepileptic drugs, is associated with improved overall and progression-free survival in glioblastoma but worse outcome in grade II/III gliomas treated with temozolomide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2016 |
Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma.
Topics: Adaptive Immunity; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cancer Vaccines; Cell Line, Tumor; Dacarbazine; Glioblastoma; Mice; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Valproic Acid; Xenograft Model Antitumor Assays | 2016 |
Does valproic acid affect tumor growth and improve survival in glioblastomas?
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Seizures; Temozolomide; Valproic Acid | 2016 |
Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Shape; Cell Survival; Cell Transformation, Neoplastic; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide; Valproic Acid | 2016 |
Molecular dissection of the valproic acid effects on glioma cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin; Dacarbazine; Decision Support Systems, Clinical; DNA Repair; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioblastoma; Glioma; High-Throughput Nucleotide Sequencing; Histone Deacetylase Inhibitors; Histones; Humans; RNA; RNA, Small Interfering; Temozolomide; Transcription, Genetic; Treatment Outcome; Valproic Acid | 2016 |
Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioma; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Temozolomide; Valproic Acid; Young Adult | 2017 |
Plasma and cerebrospinal fluid pharmacokinetics of select chemotherapeutic agents following intranasal delivery in a non-human primate model.
Topics: Administration, Intranasal; Animals; Antineoplastic Agents; Blood-Brain Barrier; Dacarbazine; Disease Models, Animal; Macaca mulatta; Male; Nasal Absorption; Phosphorylcholine; Temozolomide; Valproic Acid | 2017 |
Combined Applications of Repurposed Drugs and Their Detrimental Effects on Glioblastoma Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; Humans; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Riluzole; Temozolomide; Tranylcypromine; Valproic Acid; Xenograft Model Antitumor Assays | 2019 |
Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells.
Topics: Amphiregulin; Antibodies, Blocking; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Gene Knockdown Techniques; Glioblastoma; Humans; Lentivirus; Neuroglia; Temozolomide; Valproic Acid | 2019 |
Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Infant; Male; Nerve Tissue Proteins; RNA-Binding Proteins; Signal Transduction; Temozolomide; Valproic Acid | 2020 |
Effect of valproic acid on overall survival in patients with high-grade gliomas undergoing temozolomide: A nationwide population-based cohort study in Taiwan.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Enzyme Inhibitors; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Staging; Population Surveillance; Prognosis; Retrospective Studies; Survival Rate; Taiwan; Temozolomide; Valproic Acid; Young Adult | 2020 |
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling.
Topics: Adolescent; Brain Neoplasms; Glioblastoma; Humans; Methylation; Prognosis; Temozolomide; Valproic Acid; Vinblastine | 2022 |
Anti‑tumor effects of anti‑epileptic drugs in malignant glioma cells.
Topics: Anticonvulsants; Cadherins; Carbamazepine; Glioma; Humans; Levetiracetam; Matrix Metalloproteinase 2; RNA, Messenger; Temozolomide; Valproic Acid | 2022 |
Revisiting Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients with Glioblastoma-Proteomic Alteration and Comparison Analysis with the Standard-of-Care Chemoirradiation.
Topics: Antineoplastic Agents, Alkylating; Glioblastoma; Hedgehog Proteins; Histone Deacetylase Inhibitors; Humans; Proteome; Proteomics; Retrospective Studies; Temozolomide; Valproic Acid | 2023 |