Compounds > temozolomide
Page last updated: 2024-08-16

temozolomide and methoxyamine

temozolomide has been researched along with methoxyamine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's6 (50.00)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chatterjee, S; Gerson, SL; Liu, L; Taverna, P; Whitacre, CM1
Gerson, SL; Hanson, AJ; Hwang, HS; Kinsella, TJ; Liu, L; Taverna, P1
Gerson, SL; Liu, L; Nakatsuru, Y1
Caldwell, D; Kelley, MR; Rinne, M1
Fishel, ML; He, Y; Kelley, MR; Smith, ML1
Bulgar, A; Donze, JR; Gerson, SL; Liu, L; Mahajan, V; Miao, Y; Yan, L1
Ogawa, M; Ueda, T; Yamauchi, T1
Banze, LA; Brown, AR; Goellner, EM; Hamilton, RL; Moore, B; Sobol, RW; Svilar, D; Tang, JB; Trivedi, RN; Wang, XH1
Brown, AR; Goellner, EM; Grimme, B; Lin, YC; Mitchell, L; Sobol, RW; Sugrue, KF; Tang, JB; Trivedi, RN; Wang, XH1
Gerson, SL; Liu, L; Savvides, P; Xu, Y; Yang, S1
Montaldi, AP; Sakamoto-Hojo, ET1
Brassesco, MS; Delsin, LE; Pezuk, JA; Scrideli, CA; Tone, LG; Valera, ET1

Other Studies

12 other study(ies) available for temozolomide and methoxyamine

ArticleYear
Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:10

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Cycle; Colonic Neoplasms; Dacarbazine; DNA Repair; Drug Synergism; Humans; Hydroxylamines; Isoquinolines; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide

1999
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
    Mutation research, 2001, May-10, Volume: 485, Issue:4

    Topics: Apoptosis; Blotting, Western; Colonic Neoplasms; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Synergism; Electrophoresis, Gel, Pulsed-Field; Humans; Hydroxylamines; In Situ Nick-End Labeling; Temozolomide; Tumor Cells, Cultured

2001
Base excision repair as a therapeutic target in colon cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Bone Marrow Diseases; Chromosome Aberrations; Colonic Neoplasms; Dacarbazine; Deoxyguanosine; DNA Adducts; DNA Repair; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Humans; Hydroxylamines; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:8

    Topics: Adenoviridae; Alkylating Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Genetic Therapy; Genetic Vectors; Humans; Hydroxylamines; Immunohistochemistry; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Oligonucleotides; Sensitivity and Specificity; Sulfuric Acid Esters; Temozolomide; Time Factors

2004
Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jan-01, Volume: 13, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Base Sequence; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Female; Humans; Hydroxylamines; Molecular Sequence Data; Ovarian Neoplasms; Temozolomide

2007
Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Mar-01, Volume: 13, Issue:5

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Bone Marrow Cells; Dacarbazine; DNA; DNA Breaks, Double-Stranded; DNA Repair; DNA Topoisomerases, Type II; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Drug Synergism; Fluorescent Antibody Technique; Humans; Hydroxylamines; Mice; Temozolomide; Tumor Cells, Cultured

2007
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadmium Chloride; Carmustine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Dacarbazine; DNA Mismatch Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Hydroxylamines; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide

2008
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
    Neuro-oncology, 2011, Volume: 13, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Polymerase beta; DNA Repair; DNA Repair Enzymes; Drug Synergism; Glioma; Guanine; Humans; Hydroxylamines; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins

2011
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.
    Cancer research, 2011, Mar-15, Volume: 71, Issue:6

    Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Hydroxylamines; Immunoblotting; Methyl Methanesulfonate; NAD; Piperidines; Poly(ADP-ribose) Polymerases; RNA Interference; Temozolomide

2011
Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jul-15, Volume: 901

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzaldehydes; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Dacarbazine; Drug Stability; Humans; Hydroxylamines; Linear Models; Liquid-Liquid Extraction; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temozolomide

2012
Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide.
    Clinical and experimental medicine, 2013, Volume: 13, Issue:4

    Topics: Alkylating Agents; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; DNA Damage; Glioblastoma; Humans; Hydroxylamines; Neuroglia; Temozolomide

2013
The Antiproliferative and Pro-apoptotic Effects of Methoxyamine on Pediatric Medulloblastoma Cell Lines Exposed to Ionizing Radiation and Chemotherapy.
    Central nervous system agents in medicinal chemistry, 2015, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Child; Cisplatin; Dacarbazine; DNA Repair; Humans; Hydroxylamines; Medulloblastoma; Radiation-Sensitizing Agents; Radiation, Ionizing; Temozolomide; Thiotepa; Tumor Stem Cell Assay

2015