temelastine has been researched along with pyrimidinones in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (72.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atterwill, CK; Betton, GR; Poole, A; Salmon, G; Sutton, T | 1 |
| Catto, L; Jones, RB; Leonard, T; Poole, A; Pritchard, D | 1 |
| Doyle, E; Mitchell, AM; Picot, VS; Rogers, SJ | 1 |
| Atterwill, CK; Brown, C; Jones, C; Jones, R; Poole, A | 1 |
| Chenery, RJ; Cox, PJ; Oldham, HG; Rath, LC; Standring, P | 1 |
| Bach, FW; Bang, P; Knigge, U; Matzen, S; Warberg, J | 1 |
| Beattie, IG; Blake, TJ | 1 |
| Malo, PE; Muccitelli, R; Tucker, SS; Wasserman, MA | 1 |
| Alexander, F; Allison, N; Dubb, JW; Familiar, RG; Stote, RM; Tatoian, D | 1 |
| Doyle, E; Lee, RM; McCulla, BA; Rogers, SJ | 1 |
| Knigge, U; Matzen, S; Warberg, J | 2 |
| Konno, K; Mattila, M; Mattila, MJ | 1 |
| Brown, EA; Griffiths, R; Harvey, CA; Owen, DA | 1 |
| Calcutt, CR; Ganellin, CR; Jackson, B; Leigh, BK; Owen, DA; Smith, IR | 1 |
| Adam, K; Oswald, I | 1 |
| Eden, RJ; Owen, DA; Raval, P; Wright, A | 1 |
| Marks, R; Shall, L | 1 |
| Charles, BG; Norris, RL; Ravenscroft, PJ; Schneider, JJ | 1 |
| Doyle, E; Lee, RM; Pearce, JC; Picot, VS | 1 |
| Blake, TJ | 1 |
| Bristow, DR; Dupere, JR; Zamani, MR | 1 |
| Hough, LB; Mischler, SA; Nalwalk, JW; Thoburn, KK | 1 |
| Bach, FW; Kjaer, A; Knigge, U; Madsen, EL; Søe-Jensen, P; Warberg, J | 1 |
| Mitchell, RC; Salter, CJ; Tam, KY | 1 |
5 trial(s) available for temelastine and pyrimidinones
| Article | Year |
|---|---|
Temelastine, a new H1-receptor antagonist.
Topics: Adult; Chemical Phenomena; Chemistry; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Male; Pyrimidinones | 1986 |
Acute and subacute actions on human performance and interactions with diazepam of temelastine (SK&F93944) and diphenhydramine.
Topics: Adult; Analysis of Variance; Diazepam; Diphenhydramine; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Kinetics; Male; Psychomotor Performance; Pyrimidinones | 1986 |
No effects on sleep of a histamine H1-receptor antagonist: temelastine.
Topics: Aged; Double-Blind Method; Electroencephalography; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Pyrimidinones; Sleep; Sleep Stages | 1986 |
Non-invasive instrumental techniques to detect terfenadine and temelastine induced suppression of histamine weals in man.
Topics: Adolescent; Adult; Benzhydryl Compounds; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Pyrimidinones; Random Allocation; Regional Blood Flow; Skin; Skin Tests; Terfenadine | 1987 |
Temelastine does not affect theophylline pharmacokinetics in normal subjects.
Topics: Adult; Aminophylline; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Male; Pyrimidinones; Theophylline | 1987 |
20 other study(ies) available for temelastine and pyrimidinones
| Article | Year |
|---|---|
Comparative toxicology of temelastine. A novel H1 antagonist in dog, rat, and monkey.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Dogs; Female; Glutamate Dehydrogenase; Histamine H1 Antagonists; Liver; Macaca fascicularis; Male; Pyrimidinones; Rats; Rats, Inbred Strains; Species Specificity; Thyroid Gland | 1990 |
In vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine H1-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Female; Histamine H1 Antagonists; Liver; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroxine; Triazoles; Triiodothyronine | 1990 |
Determination of temelastine and a hydroxymethyl-pyridyl metabolite in biological fluid by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Humans; Pyrimidinones; Rats; Rats, Inbred Strains; Species Specificity; Spectrophotometry, Ultraviolet | 1990 |
Mechanistic investigation of species-specific thyroid lesions induced by treatment with the histamine H1 antagonist temelastine (SK&F 93944) in rats.
Topics: Animals; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Iodine Radioisotopes; Liver; Male; Metabolic Clearance Rate; Methimazole; Mice; Pyrimidinones; Rats; Rats, Inbred Strains; Sodium Iodide; Species Specificity; Staining and Labeling; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine | 1989 |
The interaction of temelastine with cytochrome P450 mixed-function oxidase enzymes in vivo and in vitro.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Female; Half-Life; Histamine H1 Antagonists; Kinetics; Male; Pyrimidinones; Rats; Rats, Inbred Strains | 1989 |
Involvement of histaminergic neurons in the stress-induced release of pro-opiomelanocortin-derived peptides in rats.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; beta-Lipotropin; Chromatography, Gel; Cimetidine; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Pyrilamine; Pyrimidinones; Rats; Rats, Inbred Strains; Stress, Physiological | 1989 |
The analysis and characterization of isomeric metabolites of temelastine by the combined use of thermospray liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Feces; Glucuronates; Humans; Hydroxylation; Isomerism; Mass Spectrometry; Pyrimidinones; Spectrophotometry, Ultraviolet | 1989 |
Effects of SK&F 93944 (Temelastine), a potent histamine H1-receptor antagonist in pharmacologic and antigen-induced bronchoconstriction.
Topics: Animals; Antigens; Bronchi; Dogs; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Ovalbumin; Pyrilamine; Pyrimidinones; Trachea | 1986 |
Measurement of concentrations of the histamine H1 receptor antagonist temelastine in biological fluids.
Topics: Bile; Body Fluids; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Kinetics; Pyrimidinones; Spectrophotometry, Ultraviolet | 1986 |
Histaminergic stimulation of prolactin secretion mediated via H1- or H2-receptors: dependence on routes of administration.
Topics: Animals; Cimetidine; Dimaprit; Histamine; Histamine H1 Antagonists; Male; Methylhistamines; Pituitary Gland, Anterior; Prolactin; Pyrilamine; Pyrimidinones; Rats; Receptors, Histamine; Thiazoles; Thiourea | 1986 |
Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system.
Topics: Animals; Autonomic Nervous System; Central Nervous System; Cerebrovascular Circulation; Female; Guinea Pigs; Hemodynamics; Histamine; Histamine H1 Antagonists; Male; Parasympatholytics; Pyrilamine; Pyrimidinones; Skin Absorption; Sympathetic Nervous System | 1986 |
Evidence for low brain penetration by the H1-receptor antagonist temelastine (SK&F 93944).
Topics: Animals; Brain; Dose-Response Relationship, Drug; Histamine H1 Antagonists; In Vitro Techniques; Male; Mice; Motor Activity; Promethazine; Pyrilamine; Pyrimidinones; Receptors, Histamine H1; Tritium | 1987 |
Histamine H1-receptor antagonist activity assessed in conscious dogs.
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Histamine H1 Antagonists; Male; Pyridines; Pyrimidinones | 1987 |
Analysis of drugs from biological fluids using disposable solid phase columns.
Topics: Antihypertensive Agents; Bile; Chromatography, High Pressure Liquid; Histamine H2 Antagonists; Humans; Pharmaceutical Preparations; Pyridazines; Pyrimidinones | 1987 |
Histaminergic mediation of the stress-induced release of prolactin in male rats.
Topics: Animals; Cimetidine; Ether; Histamine; Injections, Intravenous; Injections, Intraventricular; Male; Prolactin; Pyrilamine; Pyrimidinones; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Histamine; Restraint, Physical; Stress, Physiological | 1988 |
Structure elucidation of drug metabolites using thermospray liquid chromatography-mass spectrometry.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dogs; Glucuronates; Liver; Male; Mass Spectrometry; Pharmaceutical Preparations; Pyridazines; Pyrimidinones; Spectrophotometry, Ultraviolet | 1987 |
An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.
Topics: Animals; Carbachol; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutamic Acid; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Hypothalamus; Inositol Phosphates; Kinetics; Mice; Neurons; Neuropeptide Y; Piperidines; Pyrimidinones; Ranitidine; Receptors, Histamine H1; Serotonin; Substance P; Tritium | 1994 |
Histamine-induced modulation of nociceptive responses.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mesencephalon; Microinjections; Naloxone; Nociceptors; Pain Measurement; Periaqueductal Gray; Pyrimidinones; Raphe Nuclei; Rats; Rats, Sprague-Dawley | 1994 |
Insulin/hypoglycemia-induced adrenocorticotropin and beta-endorphin release: involvement of hypothalamic histaminergic neurons.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cetirizine; Cimetidine; Histamine; Histamine Agonists; Histamine Antagonists; Hypoglycemia; Hypothalamus; Insulin; Male; Methylhistamines; Neurons; Pyrilamine; Pyrimidinones; Rats; Rats, Wistar | 1993 |
Multiwavelength spectrophotometric determination of acid dissociation constants: Part III. Resolution of multi-protic ionization systems.
Topics: Algorithms; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Pyridines; Pyrimidinones; Solubility; Spectrophotometry, Ultraviolet | 1999 |