temazepam has been researched along with diazepam in 105 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (42.86) | 18.7374 |
| 1990's | 25 (23.81) | 18.2507 |
| 2000's | 17 (16.19) | 29.6817 |
| 2010's | 16 (15.24) | 24.3611 |
| 2020's | 2 (1.90) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, RJ; Gall, M; Kamdar, BV | 1 |
| Babbini, M; Barbaro, AM; Bartoletti, M; Biagi, GL; Borea, PA; Gaiardi, M; Guerra, MC | 1 |
| Johnston, GA; Maddalena, DJ | 1 |
| Karplus, M; So, SS | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Du-Cuny, L; Huwyler, J; Kansy, M; Wiese, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Carmona, AV; Kumari, S; Tiwari, AK; Trippier, PC | 1 |
| Nicholson, AN; Stone, BM | 2 |
| Nicholson, AN | 2 |
| Baars, AM; Hekster, YA; O'Reilly, WJ; van der Kleijn, E; Vree, TB | 1 |
| Stone, BM | 1 |
| Allen, MD; Greenblatt, DJ; Orsulak, PJ; Shader, RI; Woo, E | 1 |
| Clarke, CH; Nicholson, AN | 1 |
| Kanto, J; Mäenpää, M; Mäntylä, R; Sellman, R; Valovirta, E | 1 |
| Loeffler, PM | 1 |
| Beischlag, TV; Inaba, T; Kalow, W; Mahon, WA | 1 |
| Cobbs, LW | 1 |
| Lewis, DC; Sullivan, JT; Swift, RM | 1 |
| Fisher, PB; Fryer, RI; Pestka, S; Solowey, WE; Spector, S | 1 |
| Guentert, TW; Stebler, T | 1 |
| Hooper, WD; Mason, SR; Reilly, PE; Thompson, DA | 1 |
| Dollar, NS; Matthews, NS; Shawley, RV | 1 |
| Dusci, LJ; Good, SM; Hall, RW; Ilett, KF | 1 |
| Chenery, RJ; Lockwood, GF; Seddon, T | 1 |
| Barry, H; Cullen, JH; Harris, D; O'Boyte, CA | 1 |
| Barry, H; Harris, D; O'Boyle, CA | 1 |
| Castleden, M; Fancourt, G | 1 |
| Brook, IM; Hoise, HE; Holmes, A | 1 |
| Barry, H; Harris, D; O'Boyle, C | 1 |
| Brook, IM; Hosie, HE; Nimmo, WS | 1 |
| Klockowski, PM; Levy, G | 2 |
| Brase, DA; Dewey, WL; Glennon, RA; Young, R | 1 |
| Dolan, S; Lau, CE; Tang, M | 1 |
| Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K | 1 |
| Herschman, HR; Kujubu, DA; Lim, RW; Varnum, BC | 1 |
| Moroji, T; Motomura, H; Noguchi, T; Sekiguchi, R; Tada, K | 1 |
| Martin, WR; McNicholas, LF; Pruitt, TA | 1 |
| Aranko, K | 1 |
| Meeles, MT; Thys, CP; Tjaden, UR; van der Kaay, M | 1 |
| Bianchi, MC; Bruni, G; Ghirardi, P; Loreti, P; Ravaccia, F; Tallone, G | 1 |
| Douglas, JG; Finlayson, ND; Heading, RC; Jarvie, DR; Nimmo, WS; Wanlesss, R | 1 |
| Amarasekera, K | 1 |
| El-Hazmi, MA | 1 |
| Bardhan, KD | 1 |
| Burt, D; Clark, G; Erwin, D; Major, E; Yate, P | 1 |
| Löscher, W | 1 |
| MacKinnon, GL; Parker, WA | 1 |
| Bittencourt, PR; Richens, A; Smith, AT; Wade, P | 2 |
| Berlin, RM; Conell, LJ | 1 |
| Swift, CG | 1 |
| Arunasalam, K; Cundy, JM | 1 |
| Booij, LH; Crul, JF; Driessen, JJ; van Egmond, J; Vree, TB | 1 |
| Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL | 1 |
| Chiba, K; Chiba, T; Hirano, T; Horii, H; Ishizaki, T; Kato, Y | 1 |
| Holden, JD; Hughes, IM; Tree, A | 1 |
| Andersson, T; Birkett, DJ; Miners, JO; Veronese, ME | 1 |
| Robertson, JR | 1 |
| Pang, KS; St-Pierre, MV | 1 |
| Garretty, DJ; Hay, AW; Raistrick, D; Wolff, K | 1 |
| Gunaratna, C; Kissinger, PT | 1 |
| Gelboin, HV; Gonzalez, FJ; Korzekwa, KR; Shou, M; Yang, SK; Yang, TJ | 1 |
| Ali, HM; Azzam, RM; Notarianni, LJ | 1 |
| Ackermann, I; Angermaier, L; Deinl, I; Franzelius, C; Machbert, G | 1 |
| Carlin, JB; Holm-Knudsen, RJ; McKenzie, IM | 1 |
| Baillie, TA; Dai, R; Ettore, MW; Mei, Q; Rushmore, TH; Shou, M | 1 |
| Augustijns, P; Kinget, R; Van den Mooter, G | 1 |
| Bond, CM; Hickey, F; Matheson, C | 1 |
| Abou-Mandour, AA; Beckmann, H; Czygan, FC; Kavvadias, D; Riederer, P; Sand, P; Schreier, P | 1 |
| Mørland, J; Olsen, KM; Skuterud, B; Smith-Kielland, A | 1 |
| Contel, N; Grossman, S; Liu, Z; Ren, S; Rose, A; Short, J; Unger, S | 1 |
| Black, M; Oliver, JS; Seymour, A | 1 |
| Blaton, N; Kinget, R; Van den Mooter, G; Verheyen, S | 1 |
| Abd-Ellah, MF; Andrews, J; Carlile, DJ; Friedberg, T; Houston, JB; Kenworthy, KE; Randolph, NL | 1 |
| Djeridane, Y; Touitou, Y | 1 |
| Fujita, S; Ishizuka, M; Kazusaka, A; Kim, HS; Saito, K; Sakai, N | 1 |
| Fidecka, S; Listos, J; Malec, D | 1 |
| Dickson, SJ; Irving, RC | 1 |
| Acikgöz, A; Bader, A; Giri, S; Karim, N; Schmidt-Heck, W | 1 |
| Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS | 1 |
| Iannello, C; Mandrioli, R; Matrisciano, F; Mercolini, L; Nicoletti, F; Raggi, MA | 1 |
| Abe, K; Kobayashi, N; Nakamura, K; Nishiya, Y; Okazaki, O; Okudaira, N | 1 |
| Acikgöz, A; Bader, A; Giri, S; Maringka, M; Nieber, K | 1 |
| Bowron, P; Fu, S; Lewis, J; Molnar, A; Wang, H | 1 |
| Darwish, WS; Hayami, A; Ikenaka, Y; Ishizuka, M; Nakayama, SM | 1 |
| Liang, C; Ni, C; Rao, Y; Wang, R; Wang, X; Xiong, L; Zhang, Y | 1 |
| Atayee, RS; Best, BM; Luk, S; Ma, JD | 1 |
| Bertol, E; Boscolo Berto, R; Favretto, D; Mannaioni, G; Mari, F; Vaiano, F | 1 |
| Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W | 1 |
| Li, J; Liu, H; Wu, L; Zhang, J | 1 |
| Darwish, WS; Hayami, A; Ikenaka, Y; Ishizuka, M; Kawai, YK; Mizukawa, H; Nakayama, SM; Watanabe, KP | 1 |
| Jia, J; Jiang, F; Johansen, SS; Linnet, K; Rao, Y; Wang, X; Zhang, Y | 1 |
| Mangelings, D; Muscat Galea, C; Vander Heyden, Y | 1 |
| Castro, A; Costa, P; Franco, JM; Melo, P; Quintas, MJ; Tarelho, S; Teixeira, HM | 1 |
| Downes, MA; Lovett, CJ; Sadler, CW; Vidler, S | 1 |
| Adhikari, S; Barron, LP; Bhatnagar, A; Bowes, DA; Coronado-Apodaca, KG; Driver, EM; Halden, RU; Kumar, R; Martínez-Ruiz, M; McCall, KL; Melchor-Martínez, EM; Ng, KT; Oyervides-Muñoz, MA; Parra-Saldivar, R; Piper, BJ; Smith, T; Sosa-Hernandez, JE | 1 |
6 review(s) available for temazepam and diazepam
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.
Topics: Amides; Carbamates; Click Chemistry; Drug Design; Pyridines; Structure-Activity Relationship; Triazoles; Urea | 2020 |
Oral benzodiazepines and conscious sedation: a review.
Topics: Administration, Oral; Alprazolam; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Conscious Sedation; Diazepam; Flurazepam; Humans; Lorazepam; Midazolam; Oxazepam; Premedication; Receptors, GABA-A; Temazepam; Triazolam | 1992 |
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam; Nitrazepam; Oxazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Temazepam; Time Factors | 1982 |
Postural instability as a measure of sedative drug response.
Topics: Adult; Aged; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlormethiazole; Diazepam; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives; Nitrazepam; Posture; Temazepam; Time Factors; Triazolam | 1984 |
16 trial(s) available for temazepam and diazepam
| Article | Year |
|---|---|
Diazepam and 3-hydroxydiazepam (temazepam) and sleep of middle age.
Topics: Anti-Anxiety Agents; Diazepam; Humans; Male; Middle Aged; Placebos; Sleep; Sleep Stages; Temazepam; Time Factors | 1979 |
Immediate and residual effects in man of the metabolites of diazepam.
Topics: Adult; Choice Behavior; Diazepam; Humans; Male; Motor Skills; Nordazepam; Oxazepam; Placebos; Reaction Time; Temazepam; Time Factors | 1978 |
Differential effect of benzodiazepine sedation in high and low anxious patients in a "real life" stress setting.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Diazepam; Double-Blind Method; Female; Humans; Male; Models, Neurological; Personality Inventory; Random Allocation; Stress, Psychological; Temazepam; Tooth, Impacted | 1986 |
Sedation in outpatient oral surgery. Comparison of temazepam by mouth and diazepam i.v.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Diazepam; Double-Blind Method; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Patient Acceptance of Health Care; Psychomotor Performance; Temazepam; Tooth Extraction; Tooth, Impacted | 1986 |
Oral sedation with temazepam: controlled comparison of a soft gelatin capsule formulation with intravenous diazepam.
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Dental; Anti-Anxiety Agents; Anxiety; Capsules; Diazepam; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Preanesthetic Medication; Temazepam; Tooth, Impacted | 1987 |
Comparison of sedation with temazepam by mouth and diazemuls i.v. for dental surgery. Variability in absorption may influence clinical effect.
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Dental; Anti-Anxiety Agents; Anxiety; Diazepam; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Intestinal Absorption; Male; Middle Aged; Surgery, Oral; Temazepam | 1988 |
Task-dependent development of cross-tolerance to psychomotor effects of lorazepam in man.
Topics: Adult; Alprazolam; Benzodiazepines; Diazepam; Drug Tolerance; Female; Humans; Lorazepam; Male; Nitrazepam; Psychomotor Performance; Temazepam | 1985 |
Sedation for upper gastro-intestinal endoscopy. A comparison of oral temazepam and i.v. diazepam.
Topics: Administration, Oral; Anti-Anxiety Agents; Diazepam; Digestive System; Endoscopy; Female; Humans; Injections, Intravenous; Male; Middle Aged; Premedication; Temazepam | 1980 |
Temazepam as a premedicant in minor surgery.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Blood Pressure; Diazepam; Female; Heart Rate; Humans; Minor Surgical Procedures; Patient Acceptance of Health Care; Preanesthetic Medication; Temazepam | 1980 |
Temazepam as premedication in elderly patients.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Male; Middle Aged; Preanesthetic Medication; Random Allocation; Temazepam; Time Factors | 1982 |
Benzodiazepines impair smooth pursuit eye movements.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Eye Movements; Humans; Male; Random Allocation; Temazepam | 1983 |
Profile of recovery after general anaesthesia.
Topics: Anesthesia, General; Anesthesia, Obstetrical; Diazepam; Female; Humans; Pregnancy; Reaction Time; Temazepam; Time Factors | 1983 |
The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
Topics: Adult; Benzodiazepines; Diazepam; Double-Blind Method; Eye Movements; Flurazepam; Humans; Male; Nitrazepam; Nordazepam; Reticular Formation; Saccades; Temazepam | 1981 |
Distress at induction of anaesthesia in children. A survey of incidence, associated factors and recovery characteristics.
Topics: Adjuvants, Anesthesia; Adolescent; Age Factors; Anesthesia; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiety; Arousal; Child; Child, Preschool; Diazepam; Female; Humans; Hypnotics and Sedatives; Infant; Male; Midazolam; Preanesthetic Medication; Temazepam | 1998 |
Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
Topics: Adult; Anti-Anxiety Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Creatinine; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Substance Abuse Detection; Substance-Related Disorders; Temazepam | 2001 |
Effect of a metabolite of diazepam, 3-hydroxydiazepam (temazepam), on sleep in man.
Topics: Adult; Diazepam; Electroencephalography; Humans; Hypnotics and Sedatives; Male; Sleep; Sleep Stages; Temazepam; Time Factors; Young Adult | 1976 |
83 other study(ies) available for temazepam and diazepam
| Article | Year |
|---|---|
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Hydroxylation; Male; Methods; Mice; Oxidation-Reduction; Triazolam; Triazoles | 1978 |
Rm values and structure-activity relationship of benzodiazepines.
Topics: Animals; Benzodiazepines; Chromatography, Thin Layer; Conflict, Psychological; Exploratory Behavior; Models, Biological; Rats; Solubility; Structure-Activity Relationship | 1980 |
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks.
Topics: Binding Sites; Ligands; Neural Networks, Computer; Predictive Value of Tests; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.
Topics: Algorithms; Benzodiazepines; Models, Genetic; Nerve Net; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Computational aqueous solubility prediction for drug-like compounds in congeneric series.
Topics: Benzodiazepines; Computer Simulation; Crystallography, X-Ray; Databases, Factual; Least-Squares Analysis; Models, Chemical; Organic Chemicals; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Sulfonamides; Water | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Hypnotics today.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Electroencephalography; Humans; Sleep; Sleep Initiation and Maintenance Disorders; Temazepam; Triazolam | 1979 |
Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Humans; Nordazepam; Oxazepam; Species Specificity; Temazepam | 1979 |
Diazepam and its hydroxylated metabolites: studies on sleep in healthy man.
Topics: Adult; Aging; Diazepam; Humans; Hydroxylation; Male; Middle Aged; Oxazepam; Sleep; Sleep, REM; Temazepam | 1979 |
Rapid recovery from massive diazepam overdose.
Topics: Adult; Biotransformation; Diazepam; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Remission, Spontaneous; Suicide, Attempted; Temazepam; Time Factors | 1978 |
Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.
Topics: Adult; Age Factors; Aged; Anesthesia, Spinal; Body Water; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Temazepam | 1979 |
Performance studies with diazepam and its hydroxylated metabolites.
Topics: Barbiturates; Diazepam; Flurazepam; Humans; Hydroxylation; Motor Skills; Oxazepam; Temazepam; Time Factors | 1979 |
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
Topics: Animals; Chromatography, Gas; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Mephenytoin; Methylation; Nordazepam; Polymorphism, Genetic; Rats; Temazepam | 1992 |
Paranoia in a polypharmacy setting.
Topics: Carisoprodol; Diazepam; Drug Therapy, Combination; Ephedrine; Haloperidol; Humans; Ibuprofen; Male; Meprobamate; Middle Aged; Phenylpropanolamine; Psychoses, Substance-Induced; Temazepam | 1992 |
Benzodiazepine requirements during alcohol withdrawal syndrome: clinical implications of using a standardized withdrawal scale.
Topics: Administration, Oral; Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hospitalization; Humans; Length of Stay; Lorazepam; Neurologic Examination; Oxazepam; Retrospective Studies; Temazepam; Triazolam | 1991 |
Peripheral-acting benzodiazepines inhibit the growth of human melanoma cells and potentiate the antiproliferative activity of recombinant human interferons.
Topics: Antineoplastic Agents; Benzodiazepines; Cell Division; Diazepam; Drug Synergism; Humans; Interferon Type I; Interferon-gamma; Interferons; Melanoma; Recombinant Proteins; Structure-Activity Relationship; Temazepam; Tumor Cells, Cultured | 1990 |
Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam.
Topics: Chromatography, High Pressure Liquid; Diazepam; Flurazepam; Humans; Hydrogen-Ion Concentration; Milk, Human; Nordazepam; Oxazepam; Temazepam | 1991 |
Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Diazepam; Female; Hydroxylation; Kinetics; Male; Microsomes, Liver; Nordazepam; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Substrate Specificity; Temazepam | 1990 |
Halothane-sparing effect of benzodiazepines in ponies.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Blood Gas Analysis; Blood Pressure; Diazepam; Female; Halothane; Heart Rate; Horses; Male; Positive-Pressure Respiration; Pulmonary Alveoli; Respiration; Temazepam | 1990 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Temazepam | 1990 |
In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Diazepam; Liver; Macaca fascicularis; Male; Models, Biological; Nordazepam; Oxazepam; Oxygenases; Temazepam; Time Factors | 1989 |
The use of benzodiazepines with particular reference to the elderly.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Humans; Infusions, Parenteral; Kinetics; Sleep Initiation and Maintenance Disorders; Temazepam; Triazolam | 1986 |
Studies in dental sedation and anaesthesia.
Topics: Anesthesia, Dental; Anti-Anxiety Agents; Diazepam; Humans; Midazolam; Temazepam | 1986 |
Oral sedation with temazepam: a practical alternative for use in dentistry?
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Dental; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Middle Aged; Preanesthetic Medication; Random Allocation; Temazepam; Time Factors | 1987 |
Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Female; Nordazepam; Oxazepam; Rats; Rats, Inbred Lew; Reflex; Temazepam | 1988 |
Potencies of diazepam metabolites in rats trained to discriminate diazepam.
Topics: Animals; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nordazepam; Oxazepam; Rats; Rats, Inbred Strains; Temazepam | 1986 |
Microsample determination of diazepam and its three metabolites in serum by reversed-phase high-performance liquid chromatography.
Topics: Animals; Biotransformation; Chlordiazepoxide; Chromatography, High Pressure Liquid; Diazepam; Hydrogen-Ion Concentration; Indicators and Reagents; Nordazepam; Rats; Spectrophotometry, Ultraviolet; Temazepam | 1987 |
Simultaneous determination of diazepam and its active metabolites in rat serum, brain and cerebrospinal fluid by high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Female; Nordazepam; Oxazepam; Postural Balance; Rats; Rats, Inbred Strains; Temazepam | 1987 |
Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam.
Topics: Animals; Blood Proteins; Brain Chemistry; Diazepam; Drug Interactions; Imipramine; Liver; Male; Nordazepam; Oxazepam; Pentylenetetrazole; Protein Binding; Rats; Rats, Inbred Strains; Temazepam | 1987 |
Induction of transiently expressed genes in PC-12 pheochromocytoma cells.
Topics: Animals; Benzodiazepines; Cell Differentiation; Cell Division; Cell Line; Cycloheximide; Dexamethasone; Diazepam; Epidermal Growth Factor; Gene Expression Regulation; Nerve Growth Factors; Pheochromocytoma; Potassium; Rats; RNA, Messenger; Temazepam; Tetradecanoylphorbol Acetate | 1987 |
Liquid-chromatographic assay of diazepam and its major metabolites in serum, and application to pharmacokinetic study of high doses of diazepam in schizophrenics.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Diazepam; Female; Humans; Kinetics; Nordazepam; Oxazepam; Schizophrenia; Temazepam | 1985 |
N-desmethyldiazepam physical dependence in dogs.
Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazepam; Muscle Spasticity; Nordazepam; Oxazepam; Paresthesia; Substance Withdrawal Syndrome; Temazepam; Time Factors | 1985 |
Determination of some benzodiazepines and metabolites in serum, urine and saliva by high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Humans; Mathematics; Nordazepam; Oxazepam; Saliva; Temazepam | 1980 |
Reaction time to acoustic or visual stimuli after administration of camazepam and diazepam in man.
Topics: Acoustic Stimulation; Adult; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Humans; Male; Middle Aged; Photic Stimulation; Reaction Time; Temazepam | 1980 |
Aspects of the interaction of thyroxine and its binding serum proteins with 1,4-benzodiazepine tranquillizers.
Topics: Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Chlordiazepoxide; Diazepam; Electrophoresis, Polyacrylamide Gel; Humans; Male; Nordazepam; Oxazepam; Temazepam; Thyroxine; Thyroxine-Binding Proteins | 1981 |
Sedation for upper gastrointestinal endoscopy.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Gastroscopy; Humans; Temazepam | 1981 |
Rapid gas chromatographic measurement of diazepam and its metabolites desmethyldiazepam, oxazepam, and 3-hydroxydiazepam (temazepam) in small samples of plasma.
Topics: Anti-Anxiety Agents; Biotransformation; Chromatography, Gas; Diazepam; Humans; Nordazepam; Oxazepam; Temazepam | 1982 |
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine.
Topics: Anti-Anxiety Agents; Anxiety; Chronic Disease; Delayed-Action Preparations; Diazepam; Flurazepam; Half-Life; Humans; Oxazepam; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Temazepam | 1983 |
In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Muscle Contraction; Neuromuscular Junction; Nordazepam; Oxazepam; Pancuronium; Rats; Rats, Inbred Strains; Succinylcholine; Temazepam | 1984 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacaine; Mice; Nitrazepam; Nordazepam; Oxazepam; Prilocaine; Seizures; Structure-Activity Relationship; Temazepam | 1980 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; Medazepam; Nitrazepam; Oxazepam; Safety; Substance Withdrawal Syndrome; Substance-Related Disorders; Temazepam; Triazolam | 1980 |
Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.
Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Reproducibility of Results; Temazepam | 1995 |
Benzodiazepine prescribing and withdrawal for 3234 patients in 15 general practices.
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Diazepam; Drug Prescriptions; Drug Utilization; England; Family Practice; Follow-Up Studies; Humans; Lorazepam; Medical Audit; Nitrazepam; Temazepam | 1994 |
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; In Vitro Techniques; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Nordazepam; Temazepam | 1994 |
Misuse of benzodiazepines. Drug users will shift to another preparation.
Topics: Capsules; Choice Behavior; Diazepam; Humans; Substance Abuse, Intravenous; Temazepam | 1994 |
Concentration-dependent metabolism of diazepam in mouse liver.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Chromatography, High Pressure Liquid; Computer Simulation; Diazepam; Glucuronates; In Vitro Techniques; Liver; Mice; Microsomes, Liver; Oxidation-Reduction; Temazepam | 1995 |
Benzodiazepine misuse by drug addicts.
Topics: Alcoholism; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Humans; Narcotics; Nitrazepam; Nordazepam; Substance-Related Disorders; Temazepam | 1997 |
Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes.
Topics: Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diazepam; Ibuprofen; Kinetics; Microdialysis; Microsomes, Liver; Nordazepam; Rats; Salicylates; Salicylic Acid; Temazepam | 1997 |
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
Topics: Cytochrome P-450 Enzyme System; Diazepam; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Linear Models; Microsomes, Liver; Nordazepam; Temazepam | 1998 |
Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine.
Topics: Calibration; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Temazepam | 1998 |
Simultaneous extraction of selected benzodiazepines and benzodiazepine-glucuronides from urine by immunoadsorption.
Topics: Anti-Anxiety Agents; Diazepam; Glucuronates; Humans; Immunosorbent Techniques; Immunosorbents; Lorazepam; Oxazepam; Temazepam | 1998 |
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
Topics: Adult; Allosteric Regulation; Allosteric Site; Antibodies, Monoclonal; Catalysis; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Models, Chemical; Nordazepam; Oxidation-Reduction; Temazepam | 1999 |
Stability prediction of amorphous benzodiazepines by calculation of the mean relaxation time constant using the Williams-Watts decay function.
Topics: Benzodiazepines; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Crystallization; Diazepam; Drug Stability; Temazepam; Thermodynamics; Time Factors; Triazolam | 1999 |
Prescribing and dispensing for drug misusers in primary care: current practice in Scotland.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Codeine; Community Pharmacy Services; Diazepam; Drug Prescriptions; Drug Utilization; Humans; Methadone; Narcotics; Practice Patterns, Physicians'; Primary Health Care; Scotland; Substance-Related Disorders; Surveys and Questionnaires; Temazepam | 1999 |
Identification of benzodiazepines in Artemisia dracunculus and Solanum tuberosum rationalizing their endogenous formation in plant tissue.
Topics: Artemisia; Benzodiazepines; Binding, Competitive; Cerebral Cortex; Chromatography, High Pressure Liquid; Diazepam; Humans; In Vitro Techniques; Mass Spectrometry; Plants, Medicinal; Receptors, GABA-A; Solanum tuberosum; Temazepam | 2000 |
The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Mass Spectrometry; Nordazepam; Oxazepam; Reproducibility of Results; Temazepam | 2001 |
Drug related deaths in the Strathclyde region of Scotland, 1995-1998.
Topics: Adolescent; Adult; Cause of Death; Diazepam; Female; Humans; Incidence; Male; Methadone; Middle Aged; Morphine; Prisoners; Scotland; Substance-Related Disorders; Temazepam | 2001 |
Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Diazepam; Particle Size; Polyethylene Glycols; Solubility; Temazepam | 2002 |
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diazepam; Dose-Response Relationship, Drug; Escherichia coli; Excitatory Amino Acid Antagonists; Female; GABA Modulators; Humans; Kinetics; Liver; Lymphocytes; Male; Microsomes, Liver; Midazolam; Middle Aged; Protein Binding; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Temazepam | 2002 |
Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study.
Topics: Animals; Circadian Rhythm; Diazepam; Harderian Gland; In Vitro Techniques; Male; Melatonin; Nordazepam; Oxazepam; Perfusion; Pineal Gland; Rats; Rats, Wistar; Temazepam | 2003 |
Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats.
Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Diazepam; Hydroxylation; Immune Sera; Kinetics; Male; Membrane Proteins; Microsomes, Liver; NADP; Polymorphism, Genetic; Rats; Rats, Inbred BN; Rats, Inbred Strains; Rats, Mutant Strains; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Steroid 16-alpha-Hydroxylase; Temazepam | 2004 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Pentylenetetrazole; Phenethylamines; Purinergic Agonists; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Seizures; Substance Withdrawal Syndrome; Temazepam | 2005 |
The detection of sedatives in hair and nail samples using tandem LC-MS-MS.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Azabicyclo Compounds; Benzodiazepines; Chromatography, Liquid; Clobazam; Clonazepam; Diazepam; Female; Forensic Pathology; Hair; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Midazolam; Middle Aged; Nails; Oxazepam; Piperazines; Predictive Value of Tests; Rape; Temazepam; Triazolam | 2007 |
Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.
Topics: Anti-Inflammatory Agents; Antithyroid Agents; Biotransformation; Cell Separation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dexamethasone; Diazepam; Enzyme Induction; Hepatocytes; Humans; Hypnotics and Sedatives; Models, Biological; Models, Statistical; Nordazepam; Organ Culture Techniques; Oxazepam; Phenobarbital; Temazepam | 2009 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; Drug Overdose; Female; Heroin Dependence; Humans; Hydrocodone; Malpractice; Methadone; Nordazepam; Pain; Pain Measurement; Practice Guidelines as Topic; Shoulder; Shoulder Injuries; Temazepam | 2009 |
Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Nordazepam; Oxazepam; Rats; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Temazepam | 2009 |
Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.
Topics: Acetonitriles; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Dimethyl Sulfoxide; GABA Modulators; Humans; Kinetics; Methanol; Microsomes, Liver; Nordazepam; Solvents; Temazepam | 2010 |
Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.
Topics: Adult; Animals; Bioreactors; Biotransformation; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Diazepam; Female; Hepatocytes; Humans; Inactivation, Metabolic; Liver, Artificial; Male; Nordazepam; Oxazepam; Swine; Temazepam; Young Adult | 2011 |
Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis.
Topics: Benzodiazepines; Chromatography, Liquid; Diazepam; Glucuronidase; Humans; Hydrolysis; Lorazepam; Mass Spectrometry; Nordazepam; Reference Standards; Temazepam | 2011 |
In vitro diazepam metabolism in horses.
Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Diazepam; Horses; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Temazepam | 2013 |
Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Diazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Limit of Detection; Nordazepam; Oxazepam; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Temazepam | 2013 |
Urinary diazepam metabolite distribution in a chronic pain population.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chronic Pain; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Drug Interactions; Esomeprazole; Female; Fluoxetine; Humans; Male; Methadone; Nordazepam; Oxazepam; Retrospective Studies; Specimen Handling; Temazepam | 2014 |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepam; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nordazepam; Oxazepam; Psychotropic Drugs; Pyrrolidines; Substance-Related Disorders; Synthetic Cathinone; Temazepam | 2014 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water | 2014 |
A comparative study of primary secondary amino (PSA) and multi-walled carbon nanotubes (MWCNTs) as QuEChERS absorbents for the rapid determination of diazepam and its major metabolites in fish samples by high-performance liquid chromatography-electrospray
Topics: Adsorption; Animals; Chromatography, High Pressure Liquid; Diazepam; Fishes; Food Contamination; Nanotubes, Carbon; Nordazepam; Oxazepam; Seafood; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temazepam | 2016 |
Characterization of equine cytochrome P450: role of CYP3A in the metabolism of diazepam.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP3A; Diazepam; Horses; Hypnotics and Sedatives; Male; Microsomes, Liver; Nordazepam; Oxazepam; Phylogeny; Protein Isoforms; Rats; Rats, Sprague-Dawley; Species Specificity; Temazepam | 2016 |
Deposition of diazepam and its metabolites in hair following a single dose of diazepam.
Topics: Adult; Asian People; Chromatography, Liquid; Diazepam; Female; Hair; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Nordazepam; Oxazepam; Tandem Mass Spectrometry; Temazepam; Young Adult | 2017 |
Investigation of the effect of mobile phase composition on selectivity using a solvent-triangle based approach in achiral SFC.
Topics: 1-Propanol; Acetonitriles; Benzodiazepines; Chromatography, Supercritical Fluid; Diazepam; Drug Contamination; Ethanol; Furans; Hydrogen Bonding; Lorazepam; Methanol; Multivariate Analysis; Organic Chemicals; Oxazepam; Principal Component Analysis; Reproducibility of Results; Silicon Dioxide; Solvents; Temazepam | 2017 |
Pentobarbital in the context of possible suicides: Analysis of a Case.
Topics: Adult; Central Nervous System Depressants; Diazepam; Ethanol; Gastrointestinal Contents; Humans; Male; Nordazepam; Oxazepam; Pentobarbital; Suicide; Temazepam | 2017 |
Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.
Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Diazepam; Droperidol; Humans; Male; Problem Behavior; Seizures; Substance Withdrawal Syndrome; Temazepam | 2019 |
Occurrence of Z-drugs, benzodiazepines, and ketamine in wastewater in the United States and Mexico during the Covid-19 pandemic.
Topics: Alprazolam; Benzodiazepines; Clonazepam; COVID-19; Diazepam; Humans; Ketamine; Lorazepam; Mexico; Nordazepam; Pandemics; Tandem Mass Spectrometry; Temazepam; United States; Wastewater; Zolpidem | 2023 |