Page last updated: 2024-08-24

telmisartan and metoprolol

telmisartan has been researched along with metoprolol in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (27.27)29.6817
2010's15 (68.18)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dahlöf, B; Dietz, R; Friedrich, MG; Knecht, M; Sechtem, U; Unger, T1
Basso, V; Licitra, R; Pannarale, G1
Böhm, M; Hohl, M; Müller, P; Reil, JC; Rosenkranz, S; Schäffer, A; Seeland, U; Selejan, S1
Böhm, M; Caglayan, E; Ghanem, A; Gross, ML; Huntgeburth, M; Mödersheim, S; Müller-Ehmsen, J; Rosenkranz, S; Schlüter, KD; Schreckenberg, R; Shahverdyan, R; Tiemann, K; Vantler, M; Zimmermann, WH1
Chatterjee, N; Das, AK; Ghosh, B; Karmakar, S; Nandi, U; Padman, A; Pal, TK1
Bentzen, BH; Grunnet, M; Hansen, HH; Hyveled-Nielsen, L; Lassen, JB; Sundgreen, C1
Huang, ZJ; Li, XH; Li, Y; Liu, JJ; Tang, XH; Yuan, H1
Chen, Z; Gongol, B; Lei, T; Li, Z; Marin, TL; Shang, F; Shyy, JY; Wang, Y; Xiao, H; Yin, Y; Zhang, J; Zhang, YY1
Agrawal, S; Anand, J; Bachani, D; Doshi, M; Gaikwad, VB; Halder, SK; Kinholkar, B; Kumar, DA; Kumbhar, A; Mathur, R; Mehta, S; Sarkar, G; Sharma, A1

Reviews

1 review(s) available for telmisartan and metoprolol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for telmisartan and metoprolol

ArticleYear
Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2003, Volume: 4, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Male; Metoprolol; Middle Aged; Research Design; Telmisartan; Treatment Outcome

2003
Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study.
    Advances in therapy, 2022, Volume: 39, Issue:2

    Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Coronary Artery Disease; Drug Therapy, Combination; Essential Hypertension; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Metoprolol; Telmisartan; Tetrazoles

2022

Other Studies

19 other study(ies) available for telmisartan and metoprolol

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
A physician with pounding headaches.
    Blood pressure monitoring, 2008, Volume: 13, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Blood Pressure Monitoring, Ambulatory; Drug Resistance; Headache Disorders; Humans; Hypertension; Male; Metoprolol; Telmisartan

2008
Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice.
    European journal of clinical investigation, 2009, Volume: 39, Issue:10

    Topics: Animals; Benzimidazoles; Benzoates; Cardiomyopathies; Collagen; Metoprolol; Mice; Mice, Transgenic; Myocytes, Cardiac; Phenotype; Renin-Angiotensin System; Telmisartan; Transforming Growth Factor beta1

2009
Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Cardiomegaly; Cells, Cultured; Echocardiography, Stress; Gene Expression Regulation; Heart; Humans; Ion Channels; Isoproterenol; Metoprolol; Mice; Mice, Transgenic; Mitochondrial Proteins; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; Telmisartan; Transforming Growth Factor beta1; Uncoupling Protein 3

2011
Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: safety profiling.
    Regulatory toxicology and pharmacology : RTP, 2013, Volume: 65, Issue:1

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Male; Metoprolol; Rats; Rats, Wistar; Tandem Mass Spectrometry; Telmisartan

2013
Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Obesity Agents; Antihypertensive Agents; Appetite; Appetite Depressants; Benzimidazoles; Benzoates; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Dose-Response Relationship, Drug; Energy Intake; Feeding Behavior; Heart Rate; Male; Metoprolol; Obesity; Rats, Sprague-Dawley; Sympathomimetics; Telmisartan

2013
Metoprolol restores expression and vasodilatation function of AT2R in spontaneously hypertensive rats.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:3

    Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Hypertension; Imidazoles; Male; Metoprolol; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Telmisartan; Vasodilation

2014
Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Benzimidazoles; Benzoates; Blotting, Western; Cardiotonic Agents; Cells, Cultured; Endothelium, Vascular; Glipizide; Humans; Male; MAP Kinase Signaling System; Metformin; Metoprolol; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats, Inbred SHR; Rats, Inbred WKY; Real-Time Polymerase Chain Reaction; Telmisartan

2016