tellurium and regorafenib

Although nanoparticles based on Group 8 elements such as Fe and Ru have been developed, not much is known about Os nanoparticles. However, Os-based nanostructures might have potential in various applications including biomedical fields. Therefore, in this study, we synthesized Os-Te nanorods (OsTeNRs) by solvothermal galvanic replacement with Te nanotemplates. We explored the nanozymatic activity of the synthesized OsTeNRs and found that they exhibited superior photothermal conversion and photocatalytic activity. Along with chemotherapy (regorafenib) and immunotherapy, the nanozymatic, photothermal, and photodynamic activities of OsTeNRs were harnessed to develop a pentamodal treatment for hepatocellular carcinoma (HCC);

Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Catalysis; Cell Line, Tumor; Drug Carriers; Liver Neoplasms; Male; Mice, Inbred C57BL; Nanotubes; Osmium; Phenylurea Compounds; Photochemotherapy; Pyridines; Tellurium; Xenograft Model Antitumor Assays