tellurium and peroxynitric-acid

tellurium has been researched along with peroxynitric-acid* in 4 studies

Reviews

1 review(s) available for tellurium and peroxynitric-acid

ArticleYear
Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics.
    Free radical biology & medicine, 2000, May-15, Volume: 28, Issue:10

    Peroxynitrite is an oxidant generated under inflammatory conditions, acting in defense against invading microorganisms. There is a need for protection of the organism from damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a high second-order reaction rate constant (approx. 2 x 10(6) M(-1) s(-1)), which makes them candidates for efficient protection. This applies also for selenium in proteins, occurring as selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin reductase, and selenoprotein P have been shown to play a potential role in protection against peroxynitrite. Tellurium-containing compounds also react with peroxynitrite.

    Topics: Antioxidants; Azoles; Free Radicals; Glutathione Peroxidase; Humans; Isoindoles; Nitrates; Organoselenium Compounds; Oxidants; Oxidative Stress; Proteins; Selenocysteine; Selenomethionine; Selenoprotein P; Selenoproteins; Tellurium; Thioredoxin-Disulfide Reductase

2000

Other Studies

3 other study(ies) available for tellurium and peroxynitric-acid

ArticleYear
Antioxidant activity of the organotellurium compound 3-[4-(N,N-dimethylamino)benzenetellurenyl]propanesulfonic acid against oxidative stress in synaptosomal membrane systems and neuronal cultures.
    Brain research, 2001, Aug-17, Volume: 911, Issue:1

    Antioxidant activities of 3-[4-(N,N-dimethylamino) benzenetellurenyl]propanesulfonic acid sodium salt (NDBT) were evaluated in solution, red blood cells, synaptosomal membranes, and cultured hippocampal neuronal cells after exposure to peroxynitrite (ONOO(-)) and hydroxyl radicals. The organotellurium compound NDBT possesses significant activity towards hydrogen peroxide and/or the hydroxyl radical in solution, demonstrated by inhibition of hydroxylation of terephthalic acid. In addition, the compound displayed great antioxidant abilities as shown by: reduction of ONOO(-)-induced 2,7-dichlorofluorescein (DCF) fluorescence in synaptosomes; complete prevention of lipid peroxidation in synaptosomes caused by OH radicals (TBARS), and significant prevention of protein oxidation caused by ONOO(-) and OH, indexed by the levels of protein carbonyls in synaptosomes and neuronal cells. The presence of the compound abolished neuronal cell death caused by ONOO(-). Further, the compound was effective in preventing the oxidative changes in synaptosomal membrane protein conformation and crosslinking (EPR spin labeling). Finally, the organotellurium molecule attenuated peroxynitrite-induced, luminol-dependent chemiluminescence in red blood cells--an index of cellular oxidation. These findings demonstrate the great potential of the antioxidant and are consistent with the notion that NDBT may have a role to play in modulating oxidative stress in neurodegenerative disorders, including Alzheimer's disease.

    Topics: Alkanesulfonic Acids; Animals; Antioxidants; Cell Death; Cell Membrane; Cell Survival; Cells, Cultured; Free Radical Scavengers; Free Radicals; Gerbillinae; Lipid Peroxidation; Luminescent Measurements; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Nitrates; Organometallic Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Synaptosomes; Tellurium

2001
Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein.
    Chemical research in toxicology, 2000, Volume: 13, Issue:1

    The antioxidant properties of a number of water-soluble diorganyl tellurides have been investigated. These organotellurium compounds efficiently protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123, hydroxylation of benzoate, and nitration of 4-hydroxyphenyl acetate. The peroxidation of the zinc storage protein, metallothionein, by tert-butyl hydroperoxide is also catalyzed by the water-soluble organotellurium compounds. As compared to selenium-containing compounds (e.g., ebselen and selenocystamine), some of the tellurides that were tested ¿e.g., 3-[4-(N,N-dimethylamino)benzenetellurenyl]propanesulfonic acid, sodium salt¿ exhibit a significantly higher reactivity in these assays, making them some of the most effective compounds tested thus far. The catalysis of destruction of zinc-sulfur clusters by water-soluble organotellurium compounds could have implications for the bioavailability of zinc in vivo. These compounds might be lead compounds for the development of a new class of water-soluble, tellurium-based antioxidant and zinc-releasing drugs.

    Topics: Benzoates; Catalysis; Hydroxylation; Metallothionein; Nitrates; Nitrites; Organometallic Compounds; Oxidants; Oxidation-Reduction; Phenylacetates; Rhodamines; Solubility; Tellurium; tert-Butylhydroperoxide; Water; Zinc

2000
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
    Biochemical pharmacology, 1998, Mar-15, Volume: 55, Issue:6

    Diaryl tellurides effectively protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123 (DHR), hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetate (HPA). Bis(4-aminophenyl) telluride offered the most efficient protection against oxidation of DHR induced by peroxynitrite. Protection by this compound was approximately 3 times more effective than that afforded by its selenium analog, bis(4-aminophenyl) selenide, and 11 times more effective than selenomethionine. When peroxynitrite was infused to maintain a steady-state concentration, bis(4-aminophenyl) telluride in the presence of GSH, but neither bis(4-aminophenyl) telluride nor GSH alone, effectively inhibited the peroxynitrite-mediated hydroxylation of benzoate. The inhibition of nitration was most pronounced using bis(4-hydroxyphenyl) telluride, and this compound was ca. 3 times more effective than selenomethionine. Bis(4-aminophenyl) telluride also protected proteins in lysates from human skin fibroblasts from peroxynitrite-mediated nitration of tyrosine residues more effectively than selenomethionine. These data establish a potential biological or pharmacological role of organotellurium compounds in the defense against peroxynitrite.

    Topics: Antioxidants; Benzoates; Benzoic Acid; Cells, Cultured; Fibroblasts; Glutathione Peroxidase; Humans; Hydroxylation; Nitrates; Organometallic Compounds; Oxidants; Oxidation-Reduction; Phenylacetates; Rhodamines; Tellurium

1998