tellurium and formal-glycol

The increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. In the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (PTeDOX 01, PTeDOX 02, and PTeDOX 03) against Trichomonas vaginalis. Six concentrations of these compounds were analyzed for in vitro activity against ATCC 30236 isolate of T. vaginalis. PTeDOX 01 reported a cytotoxic effect against 100% of T. vaginalis trophozoites at a final concentration of 90μM with an IC

Topics: Animals; Antiparasitic Agents; Cell Line; CHO Cells; Cricetulus; Dioxolanes; Parasitic Sensitivity Tests; Tellurium; Trichomonas Infections; Trichomonas vaginalis; Trophozoites