tellurium has been researched along with dihydrorhodamine-123* in 2 studies
2 other study(ies) available for tellurium and dihydrorhodamine-123
Article | Year |
---|---|
Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein.
The antioxidant properties of a number of water-soluble diorganyl tellurides have been investigated. These organotellurium compounds efficiently protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123, hydroxylation of benzoate, and nitration of 4-hydroxyphenyl acetate. The peroxidation of the zinc storage protein, metallothionein, by tert-butyl hydroperoxide is also catalyzed by the water-soluble organotellurium compounds. As compared to selenium-containing compounds (e.g., ebselen and selenocystamine), some of the tellurides that were tested ¿e.g., 3-[4-(N,N-dimethylamino)benzenetellurenyl]propanesulfonic acid, sodium salt¿ exhibit a significantly higher reactivity in these assays, making them some of the most effective compounds tested thus far. The catalysis of destruction of zinc-sulfur clusters by water-soluble organotellurium compounds could have implications for the bioavailability of zinc in vivo. These compounds might be lead compounds for the development of a new class of water-soluble, tellurium-based antioxidant and zinc-releasing drugs. Topics: Benzoates; Catalysis; Hydroxylation; Metallothionein; Nitrates; Nitrites; Organometallic Compounds; Oxidants; Oxidation-Reduction; Phenylacetates; Rhodamines; Solubility; Tellurium; tert-Butylhydroperoxide; Water; Zinc | 2000 |
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
Diaryl tellurides effectively protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123 (DHR), hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetate (HPA). Bis(4-aminophenyl) telluride offered the most efficient protection against oxidation of DHR induced by peroxynitrite. Protection by this compound was approximately 3 times more effective than that afforded by its selenium analog, bis(4-aminophenyl) selenide, and 11 times more effective than selenomethionine. When peroxynitrite was infused to maintain a steady-state concentration, bis(4-aminophenyl) telluride in the presence of GSH, but neither bis(4-aminophenyl) telluride nor GSH alone, effectively inhibited the peroxynitrite-mediated hydroxylation of benzoate. The inhibition of nitration was most pronounced using bis(4-hydroxyphenyl) telluride, and this compound was ca. 3 times more effective than selenomethionine. Bis(4-aminophenyl) telluride also protected proteins in lysates from human skin fibroblasts from peroxynitrite-mediated nitration of tyrosine residues more effectively than selenomethionine. These data establish a potential biological or pharmacological role of organotellurium compounds in the defense against peroxynitrite. Topics: Antioxidants; Benzoates; Benzoic Acid; Cells, Cultured; Fibroblasts; Glutathione Peroxidase; Humans; Hydroxylation; Nitrates; Organometallic Compounds; Oxidants; Oxidation-Reduction; Phenylacetates; Rhodamines; Tellurium | 1998 |