tellurium and chromic-phosphate

An investigation of the efficacy of astatine-211--tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with alpha-emission. These results have important implications for the development and use of alpha-emitters as radiocolloid therapy for the treatment of human tumors.

Topics: Alpha Particles; Animals; Ascites; Astatine; Cell Survival; Chromium; Chromium Compounds; Colloids; Female; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Ovarian Neoplasms; Phosphates; Phosphorus Radioisotopes; Radioisotopes; Tellurium; Transplantation, Homologous