tellurium has been researched along with 1-1-diphenyl-2-picrylhydrazyl* in 5 studies
5 other study(ies) available for tellurium and 1-1-diphenyl-2-picrylhydrazyl
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Synthesis, Antioxidant Activity and Cytotoxicity of N-Functionalized Organotellurides.
The use of antioxidants is the most effective means to protect the organism against cellular damage caused by oxidative stress. In this context, organotellurides have been described as promising antioxidant agents for decades. Herein, a series of N-functionalized organotellurium compounds has been tested as antioxidant and presented remarkable activities by three different in vitro chemical assays. They were able to reduce DPPH radical with IC Topics: Animals; Benzothiazoles; Biphenyl Compounds; Drug Design; Fibroblasts; Free Radical Scavengers; Mice; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Picrates; Structure-Activity Relationship; Sulfonic Acids; Tellurium | 2019 |
Facile One-Pot Synthesis of Tellurium Nanorods as Antioxidant and Anticancer Agents.
Nanorods have been utilized in targeted therapy, controlled release, molecular diagnosis, and molecule imaging owing to their large surface area and optical, magnetic, electronic, and structural properties. However, low stability and complex synthetic methods have substantially limited the application of tellurium nanorods for use as antioxidant and anticancer agents. Herein, a facile one-pot synthesis of functionalized tellurium nanorods (PTNRs) by using a hydrothermal synthetic system with a polysaccharide-protein complex (PTR), which was extracted from Pleurotus tuber-regium, as a capping agent is described. PTNRs remained stable in water and in phosphate-buffered saline and exhibited high hemocompatibility. Interestingly, these nanorods possessed strong antioxidant activity for scavenging 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid radical cation (ABTS(.+) ) and 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH) free radicals and demonstrated novel anticancer activities. However, these nanorods exhibited low cytotoxicity toward normal human cells. In addition, the PTNRs effectively induced a decrease in the mitochondrial membrane potential in a dose-dependent manner, which indicated that mitochondrial dysfunction might play an important role in PTNR-induced apoptosis. Therefore, this study provides a one-pot strategy for the facile synthesis of tellurium nanorods with novel antioxidant and anticancer application potentials. Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Benzothiazoles; Biphenyl Compounds; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Erythrocytes; Humans; Nanotubes; Particle Size; Picrates; Pleurotus; Polysaccharides; Proteins; Structure-Activity Relationship; Sulfonic Acids; Surface Properties; Tellurium | 2016 |
In vitro antioxidant and antimicrobial activities of Merremia emarginata using thio glycolic acid-capped cadmium telluride quantum dots.
This study was undertaken to evaluate the antioxidant potential of an aqueous extract from Merremia emarginata leaves because this plant has a very high flavonoid and phenol content. The in vitro antioxidant activity was measured by diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid (ABTS), superoxide anion scavenging assay and lipid peroxidation activity; the total reducing capability of the plant extract indicates that this plant is a source for natural antioxidants. Furthermore, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as fluorescent probes to study the antioxidant activity of the M. emarginata extract through fluorescence quenching. The antimicrobial activity was also investigated using a disc diffusion method and fluorescence microscopy. The TGA-CdTe QDs and M. emarginata complex could provide antimicrobial activity through a reactive oxygen species pathway and/or microbial endocytosis through an electrostatic attraction. Based on our findings, we suggest that the QDs act as potential probes for the in vitro antioxidant and antimicrobial activities. In addition, their cooperative effect with the plant extract indicates that QDs could be used as nanocarriers to enhance the antimicrobial capability. Further in vivo studies on the photolabelling of antioxidants with QDs will provide insights into the mechanistic pathways of secondary metabolites against various degenerative diseases. Topics: Anti-Bacterial Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Cadmium Compounds; Convolvulaceae; Diffusion; Escherichia coli; Flavonoids; Indicators and Reagents; Lipid Peroxidation; Microbial Sensitivity Tests; Nanoparticles; Phenols; Picrates; Plant Extracts; Plant Leaves; Quantum Dots; Spectrometry, Fluorescence; Sulfonic Acids; Superoxides; Tellurium; Thioglycolates | 2013 |
Interaction of CdTe quantum dots with 2,2-diphenyl-1-picrylhydrazyl free radical: a spectroscopic, fluorimetric and kinetic study.
The interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH(·) free radical with thiol-capped CdTe quantum dots (QDs) has been studied by UV-vis spectroscopy, steady state and time resolved fluorescence measurements. Addition of DPPH(·) radical to CdTe QDs resulted in fluorescence quenching. The interaction occurs through static quenching as this was confirmed by fluorescence lifetime measurements. Time course absorption studies indicates that DPPH(·) may be reduced by interaction with QDs to the substituted hydrazine form (2,2-diphenyl-1-picrylhydrazine) DPPH-H. The mechanism of fluorescence quenching of CdTe QDs by DPPH(·) is proposed. Topics: Biphenyl Compounds; Cadmium Compounds; Fluorescence; Fluorometry; Free Radicals; Kinetics; Picrates; Quantum Dots; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tellurium | 2012 |
Effect of in vitro exposure of human serum to 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on oxidative stress.
The objective of this study was to verify the effect of the organochalcogen 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on some parameters of oxidative stress in human serum. Serum of volunteers were incubated for 30 min in the presence or absence of 1, 10, or 30 microM of 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one and oxidative stress was measured. First, we tested the influence of the compound on 1,1-diphenyl-2-picrylhydrazyl (DPPH(*)) radical-scavenging and verified that the organotellurium did not have any antioxidant properties. The organochalcogen was capable to enhance TBARS but the compound was not able to alter carbonyl assay. Furthermore, the organochalcogen provoked a reduction of protein thiol groups measured by the sulfhydryl assay. Moreover, the organotellurium enhanced the activity of catalase and superoxide dismutase, inhibited the activity of glutathione peroxidase and did not modify the glutathione S-transferase activity. Furthermore, nitric oxide production and hydroxyl radical activity were not affected by the compound. Our findings showed that this organochalcogen induces oxidative stress in human serum, indicating that this compound is potentially toxic to human beings. Topics: Biphenyl Compounds; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Hydroxyl Radical; In Vitro Techniques; Indicators and Reagents; Nitric Oxide; Organometallic Compounds; Oxidative Stress; Picrates; Protein Carbonylation; Serum; Superoxide Dismutase; Tellurium; Thiobarbituric Acid Reactive Substances | 2009 |