tedanolide and gephyronic-acid

Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and evaluated for potency in mammalian cancer cells. The truncated analogues were found to retain significant activity in vitro (23 μmol mL(-1) for the example shown) compared with the parent compound tedanolide (0.33 nmol mL(-1)), and represent potential leads for the development of novel anticancer agents.

Topics: Alkenes; Animals; Antineoplastic Agents; Cell Line, Tumor; Epoxy Compounds; Fatty Acids, Monounsaturated; Humans; Inhibitory Concentration 50; Macrolides; Mice; Molecular Structure; Neoplasms