tectochrysin and chrysin

To optimize the extraction of total flavonoids (TFL) from the leaves of

Topics: Alpinia; Antioxidants; Chemical Fractionation; Flavonoids; Microwaves; Plant Extracts; Plant Leaves

Two new diarylheptanoids, 1-(3',5'-dihydroxy-4'-methoxyphenyl)-7-phenyl-3-heptanone (1) and 1-(2',4'-dihydroxy-3'-methoxyphenyl)-7-(4″-methoxyphenyl)-3-heptanone (2), along with known diarylheptanoid yakuchinone A (3), and five flavanoids, tectochrysin (4), chrysin (5), izalpinin (6), kaempferol 7, 4'-dimethyl ether (7), and kaempferide (8) were isolated from the fruits of Alpinia oxyphylla Miq. Their structures were determined by means of spectroscopic methods. Antioxidant activities of all the isolated compounds were evaluated using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Compounds 1-3 and 6-8 exhibited potent antioxidant activities in the DPPH assay.

Topics: Alpinia; Antioxidants; Biphenyl Compounds; Diarylheptanoids; Drugs, Chinese Herbal; Flavonoids; Fruit; Guaiacol; Kaempferols; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Picrates

A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect.

Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Flavonoids; Hypoglycemic Agents; Kinetics; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Time Factors

The present study deals with the investigation of the naturally occurring derivatives of the benzo[b]pyran-4-one - flavonoids - chrysin, tectochrysin and galangin, and with the effect of minor changes in their chemical structure on their separation using GC/MS. In the relation to their close chemical structure, their basic polarographic parameters were also investigated. Their potential carcinogenicity index tg alpha was determined by DC polarography experiments in the presence of alpha-lipoic acid. The tg alpha values for chrysin, tectochrysin and galangin were all under 0.180. This indicates a very minor carcinogenic potential that does not prevent the use of the investigated flavonoids in human.

Topics: Carcinogens; Flavonoids; Gas Chromatography-Mass Spectrometry; Humans; Polarography; Propolis; Thioctic Acid