tecoflex and methylene-iodide

tecoflex has been researched along with methylene-iodide* in 1 studies

Other Studies

1 other study(ies) available for tecoflex and methylene-iodide

ArticleYear
In vitro thrombogenicity investigation of new water-dispersible polyurethane anionomers bearing carboxylate groups.
    Journal of biomaterials science. Polymer edition, 2005, Volume: 16, Issue:3

    New segmented polyurethane (PU) anionomers based on hydroxytelechelic polybutadiene were synthesized via an aqueous dispersion process. Incorporation of carboxylic groups was achieved using thioacids of different length. Surface properties were investigated by mean of water absorption analysis and static contact-angle measurements using water, diiodomethane, formamide and ethylene glycol. Blood compatibility of the PUs was evaluated by in vitro adhesion assays using 111In-radiolabeled platelet-rich plasma and [125I]fibrinogen. Morphology of the adhered platelets was examined by scanning electron microscopy (SEM). Results were compared to two biomedical-grade PUs, namely Pellethane and Tecoflex. Insertion of carboxylic groups increased surface hydrophilicity and limited water uptake ( < 8% for an ion content of 5% by weight). Surface energy of all synthesized PUs was between 40 and 45 mJ/m2. Platelet adhesion and fibrinogen adsorption on the PU anionomer surfaces were affected as a function to the increase of graft length; thiopropionic was the most haemocompatible, followed by thiosuccinic and then thioglycolic acid. SEM analyses of all ionic PU samples exhibited low platelet adhesion to surfaces with no morphological modification. In conclusion, increased hydrophily, dynamic mobility and charge repulsion are synergistic key factors for enhanced haemocompatibility.

    Topics: Absorption; Biocompatible Materials; Blood Platelets; Carboxylic Acids; Cell Adhesion; Cell Movement; Ethylene Glycol; Fibrinogen; Formamides; Hemolysis; Humans; Hydrocarbons, Iodinated; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Materials Testing; Microscopy, Electron, Scanning; Models, Chemical; Platelet Activation; Platelet Adhesiveness; Polyurethanes; Stereoisomerism; Surface Properties; Temperature; Time Factors; Water

2005