technetium-tc-99m-medronate has been researched along with sodium-borohydride* in 2 studies
2 other study(ies) available for technetium-tc-99m-medronate and sodium-borohydride
| Article | Year |
|---|---|
Effect of pH on the formation of Tc(NaBH4)-MDP radiopharmaceutical analogues.
Anion exchange high performance liquid chromatography has been employed to separate components of 99mTc(NaBH4)-MDP formulations prepared as a function of pH, the presence or absence of 99Tc carrier, and the presence or absence of air. The formulation pH is an effective variable for controlling the generation and interconversion of 99mTc-MDP components, and for allowing the preparation of large quantities of specific 99mTc-MDP complexes for biological evaluation. Topics: Air; Bone and Bones; Borohydrides; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Diphosphonates; Humans; Hydrogen-Ion Concentration; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate | 1983 |
The biological distributions of some technetium-MDP components isolated by anion exchange high performance liquid chromatography.
Individual components of 99mTc(NaBH4)-MDP mixtures, separated by anion exchange HPLC, have been evaluated as skeletal imaging agents in rats. Biodistribution data show that the evaluated components exhibit markedly different bone uptakes and soft tissue localizations. The component with the highest bone uptake and the highest bone/muscle and bone/blood ratios, is the major component of carrier-added 99mTc(NaBH4)-MDP formulations prepared at pH 8.2. Comparative scintiphotos illustrate the enhanced imaging performance of this component vs unseparated reaction mixtures. Topics: Animals; Bone and Bones; Borohydrides; Chromatography, High Pressure Liquid; Diphosphonates; Female; Radionuclide Imaging; Rats; Rats, Inbred Strains; Technetium; Technetium Tc 99m Medronate; Tissue Distribution | 1983 |