technetium-tc-99m-medronate and regadenoson

Regadenoson is an FDA approved adenosine receptor agonist which increases blood-brain barrier (BBB) permeability in rodents. Regadenoson is used clinically for pharmacologic cardiac stress testing using SPECT or CT imaging agents that do not cross an intact BBB. This study was conducted to determine if standard doses of regadenoson transiently disrupt the human BBB allowing higher concentrations of systemically administered imaging agents to enter the brain. Patients without known intracranial disease undergoing clinically indicated pharmacologic cardiac stress tests were eligible for this study. They received regadenoson (0.4 mg) followed by brain imaging with either

Topics: Adenosine A2 Receptor Agonists; Aged; Blood-Brain Barrier; Brain; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Contrast Media; Female; Humans; Male; Middle Aged; Neuroimaging; Pilot Projects; Purines; Pyrazoles; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed