technetium-tc-99m-medronate and mercuric-iodide--red

A miniature solid-state mercuric iodide (HgI2) nuclear probe detector has been developed in conjunction with a computerized nuclear probe (Nuclear Stethoscope) to enable continuous non-invasive monitoring of left ventricular function using 99Tc-labelled equilibrium blood pool techniques. Left ventricular ejection fraction was measured in 54 patients undergoing radionuclide angiography with a gamma-camera and with the Nuclear Stethoscope and a good correlation was obtained between both techniques (r = 0.94, n = 54, P less than 0.001). The prototype mercuric iodide detector was compared with the sodium iodide detector of the Nuclear Stethoscope and a study in 41 consecutive patients demonstrated a good correlation for the measurement of ejection fraction, ejection rate, peak filling rate and time to peak filling rate (r = 0.94, 0.89, 0.90 and 0.78 respectively). It may be possible to adapt the mercuric iodide detector for continuous non-invasive monitoring of left ventricular performance in critically ill patients and during physiological or pharmacological interventions.

Topics: Adult; Aged; Cardiac Output; Coronary Disease; Diphosphonates; Female; Heart; Heart Function Tests; Heart Ventricles; Humans; Iodides; Male; Mercury; Mercury Compounds; Middle Aged; Monitoring, Physiologic; Radionuclide Imaging; Stroke Volume; Technetium; Technetium Tc 99m Medronate