technetium-tc-99m-exametazime and technetium-tc-99m-tetrofosmin

Quick methods are functional in clinical practice to ensure the fastest availability of radiopharmaceuticals. For this purpose, we investigated the radiochemical purity of the widely used

Topics: Chromatography, Liquid; Drug Contamination; Drug Evaluation, Preclinical; Miniaturization; Organophosphorus Compounds; Organotechnetium Compounds; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Technetium Tc 99m Exametazime; Technetium Tc 99m Medronate

We have developed an iterative method to correct axial and tangential patient motion occurring during tomographic acquisition. The method uses axial images reconstructed from the uncorrected projection images, which are then forward projected to form a basis for registering the original planar images and, in the process, directly seeks to establish a consistent data set. Our method can be applied to all SPECT scans including myocardial and brain SPECT. We demonstrate that the method is capable of detecting and quantitatively correcting for complex motion in both axial and tangential directions. Results from phantom experiments show excellent resolution and contrast recovery after simulated movement in both the axial and tangential directions and initial results with clinical data sets are encouraging.

Topics: Biophysical Phenomena; Biophysics; Brain; Heart; Humans; Image Processing, Computer-Assisted; Models, Theoretical; Movement; Organophosphorus Compounds; Organotechnetium Compounds; Phantoms, Imaging; Radiopharmaceuticals; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon