td-5108 has been researched along with norcisapride* in 1 studies
1 other study(ies) available for td-5108 and norcisapride
Article | Year |
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mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).
Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described. Topics: Analgesics, Opioid; Cisapride; Gastrointestinal Transit; Humans; Metoclopramide; Receptors, Opioid, mu; Receptors, Serotonin, 5-HT4; Respiratory System; Serotonin 5-HT4 Receptor Agonists; Stereoisomerism; Tramadol | 2009 |