tc 81 has been researched along with nicardipine in 2 studies
*Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [MeSH]
*Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [MeSH]
| Studies (tc 81) | Trials (tc 81) | Recent Studies (post-2010) (tc 81) | Studies (nicardipine) | Trials (nicardipine) | Recent Studies (post-2010) (nicardipine) |
|---|---|---|---|---|---|
| 10 | 0 | 0 | 2,646 | 444 | 312 |
| Protein | Taxonomy | tc 81 (IC50) | nicardipine (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 8.314 | |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 8 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 4.2992 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.42 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 1.69 | |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 2.5 | |
| Cytochrome P450 2J2 | Homo sapiens (human) | 1.69 | |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | 4.925 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 4.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, K; Kishimoto, T; Naruchi, T; Okamiya, Y; Sunakawa, K; Takeshita, T; Tanabe, H | 1 |
| Aoki, K; Kishimoto, T; Naruchi, T; Okamiya, Y; Takeshita, T; Tanabe, H | 1 |
2 other study(ies) available for tc 81 and nicardipine
| Article | Year |
|---|---|
Antihypertensive effect of the new dihydropyridine calcium antagonist (+-)-3-(benzylmethylamino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica rbo xylate hydrochloride in dogs.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; Femoral Artery; Heart Rate; Hypertension, Renal; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Norepinephrine; Potassium Chloride | 1992 |
Effect of TC-81, a new dihydropyridine derivative, on K(+)-induced contraction in rat aorta.
Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Dihydropyridines; Diltiazem; In Vitro Techniques; Isometric Contraction; Male; Nicardipine; Nifedipine; Papaverine; Potassium; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1991 |