tbc-11251 has been researched along with macitentan in 4 studies
| Studies (tbc-11251) | Trials (tbc-11251) | Recent Studies (post-2010) (tbc-11251) | Studies (macitentan) | Trials (macitentan) | Recent Studies (post-2010) (macitentan) |
|---|---|---|---|---|---|
| 167 | 32 | 58 | 233 | 34 | 214 |
| Protein | Taxonomy | tbc-11251 (IC50) | macitentan (IC50) |
|---|---|---|---|
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | 0.391 | |
| Endothelin receptor type B | Homo sapiens (human) | 0.5897 | |
| Endothelin-1 receptor | Homo sapiens (human) | 0.0015 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bolli, MH; Boss, C; Gatfield, J | 1 |
| Brouwer, KR; Gillies, H; Hao, J; Hubert, C; Lepist, EI; Ray, AS; Smith, W; St Claire, RL | 1 |
| Baelde, HJ; Danser, AHJ; de Vries, R; Garrelds, IM; Mirabito Colafella, KM; Montezano, AC; Neves, KB; Touyz, RM; Uijl, E; van den Meiracker, AH; van Veghel, R; Versmissen, J | 1 |
| Bahmany, S; Danser, AHJ; Hitzerd, E; Koch, BCP; van de Velde, D; van Domburg, B; Versmissen, J | 1 |
1 review(s) available for tbc-11251 and macitentan
| Article | Year |
|---|---|
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.
Topics: Bosentan; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pyrimidines; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides | 2016 |
3 other study(ies) available for tbc-11251 and macitentan
| Article | Year |
|---|---|
Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Bosentan; Endothelin Receptor Antagonists; Female; Hepatocytes; Humans; Isoxazoles; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Phenylpropionates; Pyridazines; Pyrimidines; Receptors, Endothelin; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes | 2014 |
Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats.
Topics: Albuminuria; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Epoprostenol; Hypertension; Isoxazoles; Kidney; Male; Oxidative Stress; Pyrimidines; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sulfonamides; Sunitinib; Thiophenes | 2020 |
Simultaneous quantification of ambrisentan, macitentan and sitaxentan in human plasma using UPLC-MS/MS.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Linear Models; Phenylpropionates; Pyridazines; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry; Thiophenes | 2020 |