Page last updated: 2024-09-05

tbc-11251 and isoxazoles

tbc-11251 has been researched along with isoxazoles in 146 studies

Compound Research Comparison

Studies (tbc-11251)	Trials (tbc-11251)	Recent Studies (post-2010) (tbc-11251)	Studies (isoxazoles)	Trials (isoxazoles)	Recent Studies (post-2010) (isoxazoles)
167	32	58	8,633	900	3,337

Research

Studies (146)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (2.74)	18.2507
2000's	79 (54.11)	29.6817
2010's	61 (41.78)	24.3611
2020's	2 (1.37)	2.80

Authors

Authors	Studies
Brock, T; Chan, MF; Dixon, RA; Keller, KM; Kogan, TP; Mong, S; Okun, I; Raju, B; Stavros, F; Wu, C	1
Gidday, JM; Zhu, Y	1
Arthur, AS; Helm, GA; Kassell, NF; Lee, KS; Louis, HG; Wanebo, JE; West, K	1
Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C	1
Benamou, AE; Lekeux, P; Marlin, DJ	2
Almany, DK; Crawford, FA; Davis, JN; Fary, DJ; Goldberg, AT; Hendrick, JW; Joffs, C; Spinale, FG; Walker, CA	1
Apostolova, MD; Chakrabarti, S; Chen, S; Cherian, MG	1
Wu-Wong, JR	1
Kim, NH; Rubin, LJ	1
Barst, RJ; Horn, EM; McFarlin, J; McLaughlin, V; Rich, S; Widlitz, A	1
Colucci, WS; Givertz, MM; Ooi, H	1
Lüscher, TF; Spieker, LE	1
Apostolopoulou, SC; Rammos, S	1
Carpenter, T; Colvin, K; Ivy, DD; Ozimek, J; Schomberg, S; Stenmark, K; Steudel, W	1
McLaughlin, VV; Rich, S	1
Barst, RJ; Dixon, RA; Duncan, B; Frost, A; Frumkin, LR; Hill, N; Horn, EM; Langleben, D; McLaughlin, V; Oudiz, R; Robbins, IM; Shapiro, S; Tapson, VF; Zwicke, D	1
Branzi, A; Galié, N; Manes, A	1
Wilkins, MR	1
Barst, RJ; Hirsch, AM; Langleben, D; Lesenko, L; Shalit, E	1
Barst, RJ; Horn, EM; Widlitz, AC	2
Cheng, J; Liu, C	1
Barst, R; Brock, T; Dixon, R; Langleben, D	1
Barst, RJ; DeMarco, T; Frost, AE; Hill, N; Horn, E; Langleben, D; McLaughlin, V; Oudiz, R; Robbins, IM; Rubenfire, M; Schilz, R; Shapiro, S; Tapson, VF; Zwicke, D	1
Channick, RN; Lee, SH	1
Clark, AL; Cleland, JG; Coletta, AP; Lammiman, M; Loh, H; Nasir, M; Witte, KK	1
Barst, RJ; Garofano, R; Hansen, JE; Oudiz, RJ; Sun, XG; Wasserman, K; Wu, X	1
Gaine, SP; O'Callaghan, DS	1
Badesch, D; Barst, RJ; Frost, A; Galie, N; Langleben, D; Lawrence, EC; Naeije, R; Shapiro, S	1
Archer, SL; Michelakis, ED	1
Abman, SH	1
Coyne, TC	1
Ewert, R; Opitz, CF	1
Humbert, M; Simonneau, G	1
Rubinstein, I	1
Hoeper, MM	2
Barst, RJ	1
Abubakar, A; Wittbrodt, ET	1
Cortopassi, F; Fernandes, CJ; Jardim, C; Martins, BC; Pulido, T; Sandoval, J; Souza, R	1
Barst, RJ; Benza, RL; Keogh, A; Lawrence, EC; Mehta, S; Oudiz, RJ	1
Benedict, NJ	1
Brimiouille, S; Fesler, P; Hubloue, I; Huez, S; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B; Salmon, I; Vivian, GF	1
Langleben, D	1
Scott, LJ	1
Baloira, A	1
Barst, RJ; Frost, AE; Girgis, RE; Hill, NS; Horn, EM; Langleben, D; McLaughlin, VV; Oudiz, RJ; Robbins, IM; Seibold, JR; Shapiro, S; Tapson, VF	1
Clark, L; Crawford, FA; Finklea, L; Harrell, A; Hilton, EJ; Ikonomidis, JS; Leonardi, A; Payne, K; Reeves, S; Spinale, FG; Stroud, RE	1
Waxman, AB	1
Coyne, T; Dhaun, N; Goddard, J; Kramer, W; Melville, V; Stavros, F; Swan, S; Webb, DJ	1
Dhaun, N; Goddard, J; Pollock, DM; Webb, DJ	1
Dinh-Xuan, AT; Hoeper, MM	1
Dupuis, J; Hoeper, MM	1
Amoura, Z; Cacoub, P; Langleben, D	1
Batyraliev, TA; Ekinsi, E; Makhmutkhodzhaev, SA; Pataraia, SA; Pershukov, IV; Preobrazhenskiĭ, DV; Sidorenko, BA	1
Bekri, S; Lévesque, H; Marie, I	1
Park, MH	1
Howard, LS; Price, LC	1
Ewert, R; Kirch, W; Opitz, CF; Pittrow, D	1
Badesch, DB; Barst, RJ; Benza, RL; Black, CM; Fleming, TR; Frost, A; Galie, N; Girgis, RE; Highland, KB; Naeije, R; Rubin, L; Strange, C	1
Coghlan, G; Kabunga, P	1
Badesch, DB; Despain, DJ; Dufton, C; Frost, AE; Galie, N; Gerber, MJ; McGoon, MD; McLaughlin, VV; Olschewski, H; Oudiz, RJ; Rubin, LJ	1
Stähler, G	1
Dhaun, N; Goddard, J; MacIntyre, IM; Webb, DJ	1
Book, WM; Lee, EK; Lyle, TA; McConnell, ME; Mehta, PK; Simpson, L	1
Crawford, FA; Ford, RL; Hilton, EJ; Ikonomidis, JS; Mains, IM; Reeves, ST; Spinale, FG; Stroud, RE	1
Becker, H; Domschke, W; Gaubitz, M; Mohr, M; Sunderkoetter, C; Willeke, P	1
Faruqi, S; Fathi, H; Morice, AH	1
Champion, HC; Girgis, RE; Hassoun, PM; Hummers, LK; Mathai, SC; Wigley, FM; Zaiman, A	1
Preston, IR; Steiner, MK	1
Beghetti, M; Galiè, N	1
Danesi, R; Dei Cas, L; Lombardi, C; Metra, M; Verzura, G; Zacà, V	1
Gutiérrez, R; Lupi, E; Miranda, MT; Peña, H; Pulido, T; Roquet, I; Rueda, T; Sandoval, J; Santos, E	1
Cacoub, P; Langleben, D	1
Bellamy, CO; Dhaun, N; Kluth, DC; MacIntyre, IM	1
Argyropoulou, P; Boutou, AK; Chavouzis, N; Nakou, C; Pitsiou, GG; Stanopoulos, I	1
Golpon, H; Hoeper, MM; Olsson, KM; Schneider, A	1
Mucke, HA	1
Dranitsaris, G; Mehta, S	1
Ghofrani, HA	1
Gaine, SP; Kelleher, B; Lavelle, A; Lawler, G; Mulligan, N; Murphy, DM; Sugrue, R	1
Barton, P; Chen, YF; Fry-Smith, A; Gibbs, JS; Hyde, C; Jowett, S; Malottki, K; Moore, D; Pepke-Zaba, J; Roberts, J	1
Deardorff, RL; Ikonomidis, JS; Mulcahy, J; Spinale, FG; Szeto, WY; Toole, JM; Zellner, JL	1
Kramer, WG; Stavros, F; Wilkins, MR	1
Corris, PA; Langleben, D	1
Dalton, B; Gabbay, E; Keogh, A; Steele, P; Stewart, S; Strange, G; Wlodarczyk, J	1
Gaine, SP; Murphy, DM; O'Callaghan, DS	1
Humbert, M; Montani, D	1
Hunsche, E; Lefebvre, MC	1
Abramowicz, D; Faoro, V; Huez, S; Lamotte, M; Naeije, R; Neupane, S; Retailleau, K	1
Dhaun, N; Goddard, J; Lilitkarntakul, P; MacIntyre, IM; Melville, V; Webb, DJ	1
Brouwer, K; Gorczynski, R; Hartman, JC; Mandagere, A; Melvin, L	1
Coghlan, JG; Denton, CP; Handler, CE; Kabunga, P; Smith, CJ; Valerio, CJ	1
Brimioulle, S; Dewachter, C; Dewachter, L; Fesler, P; Franck, S; Hubloue, I; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B	1
Krause, G; Lättig, J	1
Derk, CT; Shetty, N	1
Angelini, GD; George, SJ; Jones, C; Lin, H; Murphy, GJ; Patel, NN; Ray, P; Satchell, SC; Sleeman, P; Toth, T; Welsh, G	1
Fisher, AJ; Johnson, MK; Kirkham, N; Lee, WT; Lordan, JL; Peacock, AJ	1
Galiè, N; Gibbs, JS; Hoeper, MM; Simonneau, G	1
Dhaun, N; Goddard, J; Haughie, S; Johnston, NR; Kerr, D; MacIntyre, IM; Melville, V; Webb, DJ	1
Galiè, N; Gibbs, R; Hoeper, MM; Simon, J; Simonneau, G	1
Cima, K; Desole, S; Graziadei, I; Kähler, CM; Vogel, W; Vogelsinger, H	1
Safdar, Z	1
Bauleo, C; Catapano, G; Formichi, B; Genovesi, D; Giuntini, C; Mannucci, F; Marini, C; Michelassi, C; Monti, S; Prediletto, R	1
Stafford-Smith, M	1
Dhaun, N; Goddard, J; Johnston, NR; Webb, DJ	1
Barton, M	1
French, B; Gabler, NB; Halpern, SD; Kawut, SM; Liu, Z; Palevsky, HI; Strom, BL; Taichman, DB	1
de Bisschop, C; Faoro, V; Guénard, H; Leurquin-Sterk, G; Martinot, JB; Naeije, R	1
Hwang, LJ; Jardim, C; Jerjes-Sánchez Díaz, C; Kurzyna, M; Pulido, T; Ramírez, A; Sandoval, J; Souza, R; Teal, SA; Torbicki, A	1
Alexander, GJ; Davenport, AP; Davie, NJ; Gibbs, P; Kuc, RE; Ling, L; Maguire, JJ; Webb, DJ	1
Dhaun, N; Goddard, J; MacDougall, M; Melville, V; Towler, JD; Webb, DJ	1
Cross, DM; Derzi, M; Horsley, E; Owen, K; Stavros, FL	3
Hintz, E; Klein, R; Staehler, G	1
Arnaud, C; Blaise, S; Boutonnat, J; Cracowski, JL; Dufournet, B; Godin-Ribuot, D; Hellmann, M; Millet, C; Ribuot, C; Roustit, M	1
Guzik, T; Kopeć, G; Mikołajczyk, T; Miszalski-Jamka, T; Podolec, P; Tyrka, A; Waligóra, M	1
Blenkhorn, F; Eisenberg, MJ; Fox, B; Hirsch, AM; Joyal, D; Langleben, D; Lesenko, L; Schlesinger, RD	1
Biswal, S	1
Boico, A; Hamilton, K; Hanna, G; Irwin, D; Palmer, G; Piantadosi, CA; Radiloff, DR; Schroeder, T; Shan, S; Wu, C; Zhao, Y	1
Luo, N; Ryan, JJ	1
Kohan, DE; Pollock, DM	1
Blackwell, S; Dhaun, N; Goddard, J; Johnston, NR; Melville, V; Talwar, DK; Webb, DJ	1
Celermajer, DS; Corte, TJ; Don, GW; Joseph, F	1
Brizzolara, R; Cutolo, M; Ferrone, C; Montagna, P; Parodio, A; Seriolo, B; Soldano, S; Sulli, A; Villaggio, B	1
Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero Corominas, D	1
Erve, JC; Gauby, S; Maynard, JW; Quinn, KP; Svensson, MA; Tonn, G	1
Barbaro Foschino, MP; Brunetti, ND; Correale, M; Di Biase, M; Lacedonia, D; Montrone, D; Totaro, A	1
Cantatore, FP; Corrado, A; Costantino, E; Foschino Barbaro, MP; Neve, A; Palladino, GP	1
Brouwer, KR; Gillies, H; Hao, J; Hubert, C; Lepist, EI; Ray, AS; Smith, W; St Claire, RL	1
Benza, RL; Dhaun, N; Hwang, LJ; Liu, X; Naeije, R; Teal, S; Vachiery, JL; Webb, DJ	1
Baicu, CF; Bourge, RC; Little, WC; Redfield, MM; Zhou, D; Zile, MR	1
Brown, KE; Dhaun, N; Goddard, J; Kennedy, ED; Kimmitt, RA; MacIntyre, IM; Melville, V; Moorhouse, R; Oosthuyzen, W; Webb, DJ	1
Andersson, LC; Bergare, J; Billger, M; Eakins, JA; Elebring, M; Elmore, CS; Foster, AJ; Kenna, JG; Stahl, SH; Thompson, RA	1
Duthie, KM; Hadoke, PW; Ivy, JR; Kirkby, NS; Lim, WG; McShane, JF; Miller, E; Webb, DJ	1
Chariyavilaskul, P; Corder, R; Dhaun, N; Goddard, J; Kimmitt, RA; MacIntyre, IM; Webb, DJ; Wood, EG; Yuzugulen, J	1
Cheung, L; Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Liu, S; Meehan, DT; Phillips, G; Song, W	1
Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Meehan, DT; Phillips, G; Zallocchi, M	1
Eräranta, A; Lakkisto, P; Mustonen, J; Niemelä, O; Paavonen, T; Pörsti, I; Tikkanen, I; Törmänen, S	1
Caballero-George, C; Digman, MA; Gratton, E; Planes, N; Vanderheyden, PPML	1
Baginski, M; Gethings, LA; King, A; Morikawa, Y; Plumb, RS; Rainville, PD; Wilson, ID	1
Baelde, HJ; Danser, AHJ; de Vries, R; Garrelds, IM; Mirabito Colafella, KM; Montezano, AC; Neves, KB; Touyz, RM; Uijl, E; van den Meiracker, AH; van Veghel, R; Versmissen, J	1
Bahmany, S; Danser, AHJ; Hitzerd, E; Koch, BCP; van de Velde, D; van Domburg, B; Versmissen, J	1

Reviews

43 review(s) available for tbc-11251 and isoxazoles

Article	Year
Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: dose study and review of endothelin-based therapies in the literature on cerebral vasospasm. Neurosurgery, 1998, Volume: 43, Issue:6 Topics: Animals; Basilar Artery; Calcium Signaling; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Ischemic Attack, Transient; Isoxazoles; Male; Rabbits; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes	1998
Sitaxsentan (ICOS-Texas Biotechnology). Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:4 Topics: Animals; Clinical Trials as Topic; Endothelin Receptor Antagonists; Heart Failure; Humans; Isoxazoles; Lung Diseases, Obstructive; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes	2001
Endothelin in health and disease: endothelin receptor antagonists in the management of pulmonary artery hypertension. Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:1 Topics: Antihypertensive Agents; Bosentan; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; Sulfonamides; Thiophenes	2002
Will endothelin receptor antagonists have a role in heart failure? The Medical clinics of North America, 2003, Volume: 87, Issue:2 Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome	2003
Endothelin receptor blockers in cardiovascular disease. Circulation, 2003, Nov-04, Volume: 108, Issue:18 Topics: Animals; Antihypertensive Agents; Bosentan; Cardiovascular Diseases; Endothelin Receptor Antagonists; Exercise Tolerance; Hemodynamics; Humans; Isoxazoles; Sulfonamides; Thiophenes	2003
The endothelin system in pulmonary arterial hypertension. Cardiovascular research, 2004, Feb-01, Volume: 61, Issue:2 Topics: Animals; Bosentan; Endothelial Cells; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Infant, Newborn; Isoxazoles; Models, Animal; Muscle, Smooth, Vascular; Pulmonary Circulation; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Thiophenes	2004
Endothelin receptor antagonists for pulmonary arterial hypertension. The Cochrane database of systematic reviews, 2005, Jan-25, Issue:1 Topics: Adult; Antihypertensive Agents; Bosentan; Child; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2005
Endothelin antagonism in pulmonary arterial hypertension. Seminars in respiratory and critical care medicine, 2005, Volume: 26, Issue:4 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Piperazines; Pulmonary Artery; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2005
Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE. European journal of heart failure, 2005, Volume: 7, Issue:6 Topics: Cardiac Pacing, Artificial; Cardiology; Congresses as Topic; Defibrillators, Implantable; Enalapril; Enoximone; Europe; Female; Follow-Up Studies; Heart Failure; Humans; Isoxazoles; Male; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Societies, Medical; Survival Analysis; Thiophenes; Treatment Outcome	2005
Sitaxsentan: a novel endothelin-A receptor antagonist for pulmonary arterial hypertension. Expert review of cardiovascular therapy, 2005, Volume: 3, Issue:6 Topics: Clinical Trials as Topic; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Thiophenes	2005
An evidence-based approach to the management of pulmonary arterial hypertension. Current opinion in cardiology, 2006, Volume: 21, Issue:4 Topics: Antihypertensive Agents; Benzamides; Bosentan; Calcium Channel Blockers; Comorbidity; Dichloroacetic Acid; Drug Therapy, Combination; Epoprostenol; Evidence-Based Medicine; Fluoxetine; Humans; Hypertension, Pulmonary; Iloprost; Imatinib Mesylate; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins, Synthetic; Pulmonary Artery; Purines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Simvastatin; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents	2006
Pulmonary hypertension in older children: new approaches and therapies. Paediatric respiratory reviews, 2006, Volume: 7 Suppl 1 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antihypertensive Agents; Bosentan; Calcium Channel Blockers; Cardiac Catheterization; Child; Cyclic Nucleotide Phosphodiesterases, Type 5; Echocardiography; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase Inhibitors; Pulmonary Wedge Pressure; Sulfonamides; Thiophenes; Treatment Outcome	2006
Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension. European journal of clinical investigation, 2006, Volume: 36 Suppl 3 Topics: Antihypertensive Agents; Bosentan; Cell Division; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Lung; Pulmonary Fibrosis; Sulfonamides; Thiophenes; Vasoconstriction; Vasodilation	2006
Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases. Nature clinical practice. Rheumatology, 2005, Volume: 1, Issue:2 Topics: Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Rheumatic Diseases; Thiophenes; Treatment Outcome	2005
[Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. Deutsche medizinische Wochenschrift (1946), 2006, Dec-08, Volume: 131, Issue:49 Suppl 9 Topics: Algorithms; Antihypertensive Agents; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Survival Rate; Thiophenes	2006
Sitaxsentan: a selective endothelin-A receptor antagonist, for the treatment of pulmonary arterial hypertension. Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:1 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Thiophenes	2007
Sitaxsentan for treatment of pulmonary hypertension. The Annals of pharmacotherapy, 2007, Volume: 41, Issue:1 Topics: Animals; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Receptors, Endothelin; Thiophenes; Treatment Outcome	2007
Sitaxsentan in the management of pulmonary arterial hypertension. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2007, Feb-15, Volume: 64, Issue:4 Topics: Antihypertensive Agents; Clinical Trials as Topic; Drug Interactions; Humans; Hypertension; Isoxazoles; Thiophenes	2007
Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. Clinics in chest medicine, 2007, Volume: 28, Issue:1 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2007
Sitaxentan: in pulmonary arterial hypertension. Drugs, 2007, Volume: 67, Issue:5 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Thiophenes; Treatment Outcome	2007
A review of sitaxsentan sodium in patients with pulmonary arterial hypertension. Vascular health and risk management, 2007, Volume: 3, Issue:1 Topics: Clinical Trials as Topic; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Pulmonary Wedge Pressure; Thiophenes; Treatment Outcome	2007
Selective and mixed endothelin receptor antagonism in cardiovascular disease. Trends in pharmacological sciences, 2007, Volume: 28, Issue:11 Topics: Animals; Bosentan; Clinical Trials as Topic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Models, Biological; Sulfonamides; Thiophenes	2007
Endothelin receptor antagonists in pulmonary arterial hypertension. The European respiratory journal, 2008, Volume: 31, Issue:2 Topics: Animals; Bosentan; Clinical Trials, Phase III as Topic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Prognosis; Pyridazines; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Severity of Illness Index; Sulfonamides; Survival Rate; Thiophenes; Treatment Outcome	2008
[Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. La Revue de medecine interne, 2008, Volume: 29, Issue:4 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
[Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. Kardiologiia, 2007, Volume: 47, Issue:7 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Ventricular Dysfunction, Right	2007
[Endothelin 1 and selectivity of endothelin receptor antagonists: To B or not to B?]. La Revue de medecine interne, 2008, Volume: 29, Issue:4 Topics: Endothelin Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Thiophenes	2008
Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2008, Feb-01, Volume: 71, Issue:2 Topics: Antihypertensive Agents; Bosentan; Cardiac Catheterization; Disease Progression; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Platelet Aggregation Inhibitors; Prognosis; Pulmonary Artery; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasoconstriction	2008
Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2008, Volume: 8, Issue:3 Topics: Antihypertensive Agents; Bosentan; Clinical Trials, Phase III as Topic; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? European heart journal, 2008, Volume: 29, Issue:16 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Phenylpropionates; Pulmonary Artery; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance; Walking	2008
Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. Drugs, 2008, Volume: 68, Issue:12 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2008
[Specific drugs for the treatment of pulmonary arterial hypertension - current status]. Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133 Suppl 6 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Vasodilator Agents	2008
Sitaxsentan sodium for pulmonary hypertension. Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:8 Topics: Animals; Clinical Trials as Topic; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Receptors, Endothelin; Thiophenes	2008
Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. Vascular health and risk management, 2008, Volume: 4, Issue:5 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Patient Compliance; Patient Satisfaction; Phenylpropionates; Pyridazines; Quality of Life; Receptors, Endothelin; Sulfonamides; Thiophenes; Treatment Outcome	2008
Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. Journal of the American College of Cardiology, 2009, Mar-03, Volume: 53, Issue:9 Topics: Antihypertensive Agents; Bosentan; Eisenmenger Complex; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Circulation; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2009
Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. IDrugs : the investigational drugs journal, 2009, Volume: 12, Issue:6 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Design; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Patents as Topic; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2009
Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. Health technology assessment (Winchester, England), 2009, Volume: 13, Issue:49 Topics: Antihypertensive Agents; Bosentan; Cost-Benefit Analysis; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; United States; Vasodilator Agents	2009
Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy? BMC cardiovascular disorders, 2010, Feb-22, Volume: 10 Topics: Adult; Aged; Antihypertensive Agents; Bosentan; Cohort Studies; Epoprostenol; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Time Factors; Treatment Outcome	2010
[Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition]. Pharmazie in unserer Zeit, 2010, Volume: 39, Issue:6 Topics: Amino Acid Sequence; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Isoxazoles; Ligands; Models, Molecular; Molecular Sequence Data; Receptors, Endothelin; Sulfonamides; Thiophenes	2010
Endothelin receptor antagonists as disease modifiers in systemic sclerosis. Inflammation & allergy drug targets, 2011, Volume: 10, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Familial Primary Pulmonary Hypertension; Fibrosis; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2011
Endothelin antagonism and reversal of proteinuric renal disease in humans. Contributions to nephrology, 2011, Volume: 172 Topics: Endothelins; Humans; Isoxazoles; Kidney Diseases; Phenylpropionates; Proteinuria; Pyridines; Pyrimidines; Receptor, Endothelin A; Thiophenes	2011
Endothelin antagonists for diabetic and non-diabetic chronic kidney disease. British journal of clinical pharmacology, 2013, Volume: 76, Issue:4 Topics: Animals; Clinical Trials as Topic; Diabetic Nephropathies; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Kidney Failure, Chronic; Pyridines; Pyrimidines; Renal Dialysis; Renal Insufficiency, Chronic; Thiophenes; Treatment Outcome	2013
[Hepatotoxicity in patients treated with endothelin receptor antagonists: systematic review and meta-analysis of randomized clinical trials]. Medicina clinica, 2014, Apr-22, Volume: 142, Issue:8 Topics: Antihypertensive Agents; Biomarkers; Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Thiophenes; Transaminases	2014
Novelty in treatment of pulmonary fibrosis: pulmonary hypertension drugs and others. Cardiovascular & hematological agents in medicinal chemistry, 2013, Volume: 11, Issue:3 Topics: Antihypertensive Agents; Bosentan; Humans; Isoxazoles; Phenylpropionates; Phosphodiesterase Inhibitors; Pulmonary Fibrosis; Pyridazines; Sulfonamides; Thiophenes	2013

Trials

31 trial(s) available for tbc-11251 and isoxazoles

Article	Year
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:2 Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left	2001
Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest, 2002, Volume: 121, Issue:6 Topics: Adolescent; Adult; Aged; Child; Endothelin Receptor Antagonists; Exercise Tolerance; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Pilot Projects; Receptor, Endothelin A; Thiophenes	2002
Endothelin mediates increased pulmonary vascular tone in patients with heart failure: demonstration by direct intrapulmonary infusion of sitaxsentan. Circulation, 2002, Sep-24, Volume: 106, Issue:13 Topics: Blood Flow Velocity; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Female; Heart Failure; Humans; Hypertension, Pulmonary; Infusions, Intra-Arterial; Isoxazoles; Male; Middle Aged; Pulmonary Artery; Pulmonary Circulation; Receptor, Endothelin A; Reference Values; Thiophenes; Vascular Resistance; Vasomotor System; Ventricular Function, Left	2002
Sitaxsentan therapy for pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4 Topics: Adolescent; Adult; Aged; Anaerobic Threshold; Double-Blind Method; Endothelin Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Thiophenes	2004
STRIDE 1: effects of the selective ET(A) receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Canada; Double-Blind Method; Endothelin A Receptor Antagonists; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Patient Selection; Severity of Illness Index; Thiophenes; Treatment Outcome; United States; Vascular Resistance; Walking	2004
The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect. Vascular pharmacology, 2005, Volume: 43, Issue:1 Topics: Double-Blind Method; Endothelin Receptor Antagonists; Endpoint Determination; Exercise Test; Heart Diseases; Humans; Hypertension, Pulmonary; Isoxazoles; Research Design; Thiophenes; Walking	2005
Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension. The American journal of cardiology, 2006, Jan-01, Volume: 97, Issue:1 Topics: Adolescent; Adult; Aged; Clinical Competence; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Thiophenes; Walking	2006
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. Journal of the American College of Cardiology, 2006, May-16, Volume: 47, Issue:10 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Endothelin A Receptor Antagonists; Exercise Test; Exercise Tolerance; Female; Health Status Indicators; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Risk Assessment; Sulfonamides; Thiophenes; Treatment Outcome	2006
Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Child; Double-Blind Method; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Sulfonamides; Thiophenes; Treatment Outcome	2007
Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:11 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Cardiac Output; Connective Tissue Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Quality of Life; Thiophenes; Treatment Outcome; Vascular Resistance; Walking	2007
Selective endothelin-A receptor inhibition after cardiac surgery: a safety and feasibility study. The Annals of thoracic surgery, 2007, Volume: 83, Issue:6 Topics: Aged; Blood Pressure; Cardiopulmonary Bypass; Cardiovascular Agents; Coronary Artery Bypass; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Feasibility Studies; Humans; Isoxazoles; Male; Middle Aged; Postoperative Period; Pulmonary Artery; Thiophenes; Treatment Outcome; Vascular Resistance	2007
Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival. Chest, 2008, Volume: 134, Issue:4 Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Prospective Studies; Survival Rate; Thiophenes; Time Factors; Treatment Outcome	2008
Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest, 2009, Volume: 135, Issue:1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Child; Disease-Free Survival; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Transaminases; Treatment Outcome; Young Adult	2009
Endothelin-A receptor inhibition after cardiopulmonary bypass: cytokines and receptor activation. The Annals of thoracic surgery, 2008, Volume: 86, Issue:5 Topics: Cardiopulmonary Bypass; Cytokines; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelins; Humans; Isoxazoles; Male; Middle Aged; Thiophenes; Tumor Necrosis Factor-alpha	2008
Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. European journal of clinical investigation, 2009, Volume: 39 Suppl 2 Topics: Acenocoumarol; Adolescent; Adult; Anticoagulants; Antihypertensive Agents; Drug Administration Schedule; Drug Interactions; Endothelin Receptor Antagonists; Female; Hemorrhage; Humans; Hypertension, Pulmonary; International Normalized Ratio; Isoxazoles; Male; Prospective Studies; Survival Analysis; Thiophenes; Young Adult	2009
Selective endothelin-1 receptor type A inhibition in subjects undergoing cardiac surgery with preexisting left ventricular dysfunction: Influence on early postoperative hemodynamics. The Journal of thoracic and cardiovascular surgery, 2010, Volume: 139, Issue:3 Topics: Aged; Cardiopulmonary Bypass; Endothelin A Receptor Antagonists; Female; Hemodynamics; Humans; Isoxazoles; Male; Middle Aged; Postoperative Complications; Postoperative Period; Prospective Studies; Risk Factors; Single-Blind Method; Thiophenes; Time Factors; Ventricular Dysfunction, Left	2010
The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects. British journal of clinical pharmacology, 2010, Volume: 69, Issue:1 Topics: Adult; Area Under Curve; Blood Pressure; Drug Interactions; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult	2010
Pulmonary artery pressure limits exercise capacity at high altitude. The European respiratory journal, 2010, Volume: 36, Issue:5 Topics: Acute Disease; Adult; Altitude; Blood Pressure; Chronic Disease; Endothelin A Receptor Antagonists; Exercise; Female; Humans; Hypertension, Pulmonary; Hypoxia; Isoxazoles; Kidney; Male; Middle Aged; Oxygen Consumption; Pulmonary Artery; Pulmonary Gas Exchange; Thiophenes; Vascular Resistance; Young Adult	2010
Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:6 Topics: Administration, Oral; Adult; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Bosentan; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Endothelin A Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Male; Middle Aged; Plethysmography; Probability; Receptor, Endothelin A; Reference Values; Sulfonamides; Thiophenes; Young Adult	2010
Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Adult; Antihypertensive Agents; Arteries; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Female; Glomerular Filtration Rate; Humans; Hypertension; Isoxazoles; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Proteinuria; Radioimmunoassay; Thiophenes; Treatment Outcome; Vascular Resistance; Vasodilator Agents	2011
Chronic selective endothelin A receptor antagonism reduces serum uric acid in hypertensive chronic kidney disease. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 58, Issue:2 Topics: Cross-Over Studies; Double-Blind Method; Endothelin A Receptor Antagonists; Hypertension; Hyperuricemia; Isoxazoles; Kidney Failure, Chronic; Thiophenes; Treatment Outcome; Uric Acid	2011
Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest, 2012, Volume: 141, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bosentan; Child; Double-Blind Method; Endothelin Receptor Antagonists; Ethnicity; Exercise Test; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Phenylpropionates; Prevalence; Prospective Studies; Pulmonary Wedge Pressure; Pyridazines; Sex Factors; Sulfonamides; Thiophenes; Treatment Outcome; United States; Walking; Young Adult	2012
Improvement in lung diffusion by endothelin A receptor blockade at high altitude. Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:1 Topics: Adult; Altitude; Double-Blind Method; Endothelin A Receptor Antagonists; Exercise Tolerance; Female; Humans; Isoxazoles; Male; Middle Aged; Prospective Studies; Pulmonary Diffusing Capacity; Receptor, Endothelin A; Thiophenes; Young Adult	2012
Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:1 Topics: Adolescent; Adult; Aged; Blood Pressure; Child; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Endothelin Receptor Antagonists; Endpoint Determination; Female; Humans; Hypertension, Pulmonary; Intention to Treat Analysis; Isoxazoles; Kaplan-Meier Estimate; Liver Function Tests; Male; Middle Aged; Pulmonary Wedge Pressure; Sample Size; Thiophenes; Treatment Outcome; Vascular Resistance; Young Adult	2012
What is the best method of proteinuria measurement in clinical trials of endothelin receptor antagonists? Life sciences, 2012, Oct-15, Volume: 91, Issue:13-14 Topics: Albuminuria; Analysis of Variance; Creatinine; Double-Blind Method; Drug Monitoring; Endothelin Receptor Antagonists; Humans; Isoxazoles; Proteinuria; Renal Insufficiency, Chronic; Reproducibility of Results; Thiophenes	2012
Iontophoresis of endothelin receptor antagonists in rats and men. PloS one, 2012, Volume: 7, Issue:7 Topics: Adolescent; Adult; Aged; Animals; Blood Pressure; Bosentan; Electrodes; Endothelin Receptor Antagonists; Endothelins; Humans; Iontophoresis; Isoxazoles; Male; Middle Aged; Rats; Rats, Wistar; Receptors, Endothelin; Regional Blood Flow; Skin; Sulfonamides; Thiophenes; Young Adult	2012
Changes in exercise capacity and cardiac performance in a series of patients with Eisenmenger's syndrome transitioned from selective to dual endothelin receptor antagonist. Heart, lung & circulation, 2012, Volume: 21, Issue:11 Topics: Adult; Antihypertensive Agents; Bosentan; Eisenmenger Complex; Endothelin Receptor Antagonists; Endothelin-1; Exercise; Female; Follow-Up Studies; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Stroke Volume; Sulfonamides; Thiophenes	2012
Endothelin-A receptor antagonism modifies cardiovascular risk factors in CKD. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:1 Topics: Adult; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Nifedipine; Proteinuria; Pulse Wave Analysis; Renal Insufficiency, Chronic; Thiophenes; Vascular Stiffness; Vasodilator Agents	2013
Endothelin antagonism and uric acid levels in pulmonary arterial hypertension: clinical associations. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2014, Volume: 33, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Bosentan; Child; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Prospective Studies; Sulfonamides; Survival Rate; Thiophenes; Time Factors; Treatment Outcome; United States; Uric Acid; Young Adult	2014
Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction. JACC. Heart failure, 2014, Volume: 2, Issue:2 Topics: Aged; Analysis of Variance; Double-Blind Method; Echocardiography; Endothelin Receptor Antagonists; Exercise Tolerance; Female; Heart Failure; Humans; Isoxazoles; Male; Stroke Volume; Thiophenes; Treatment Outcome; Ventricular Function, Left	2014
Plasma pro-endothelin-1 peptide concentrations rise in chronic kidney disease and following selective endothelin A receptor antagonism. Journal of the American Heart Association, 2015, Mar-23, Volume: 4, Issue:3 Topics: Adult; Biomarkers; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Endothelin A Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Nifedipine; Protein Precursors; Proteinuria; Receptor, Endothelin A; Renal Insufficiency, Chronic; Scotland; Thiophenes; Time Factors; Treatment Outcome; Up-Regulation; Vascular Stiffness	2015

Other Studies

72 other study(ies) available for tbc-11251 and isoxazoles

Article	Year
Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11 Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Cell Line; COS Cells; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Half-Life; Humans; Isoxazoles; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship; Thiophenes	1997
Endothelium-dependent changes in retinal blood flow following ischemia. Current eye research, 1998, Volume: 17, Issue:8 Topics: Acetylcholine; Adenosine; Animals; Animals, Newborn; Blood Flow Velocity; Endothelin Receptor Antagonists; Endothelium, Vascular; Enzyme Inhibitors; Fluorescein Angiography; Hyperoxia; Hypoxia; Ischemia; Isoxazoles; Nitric Oxide Synthase; omega-N-Methylarginine; Reperfusion; Retinal Vessels; Swine; Thioinosine; Thiophenes	1998
TBC 11251. IPI 1040. Drugs in R&D, 1999, Volume: 2, Issue:1 Topics: Animals; Clinical Trials, Phase I as Topic; Drugs, Investigational; Endothelin Receptor Antagonists; Heart Failure; Humans; Isoxazoles; Receptor, Endothelin A; Thiophenes	1999
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist. Pulmonary pharmacology & therapeutics, 2000, Volume: 13, Issue:2 Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain	2000
Equine pulmonary and systemic haemodynamic responses to endothelin-1 and a selective ET(A) receptor antagonist. Equine veterinary journal, 2001, Volume: 33, Issue:4 Topics: Animals; Carotid Arteries; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Horses; Injections, Intravenous; Isoxazoles; Pulmonary Artery; Pulmonary Circulation; Receptor, Endothelin A; Thiophenes; Vascular Resistance; Vasoconstrictor Agents	2001
Endothelin in the equine hypoxic pulmonary vasoconstrictive response to acute hypoxia. Equine veterinary journal, 2001, Volume: 33, Issue:4 Topics: Animals; Carotid Arteries; Endothelin Receptor Antagonists; Hemodynamics; Horse Diseases; Horses; Hypoxia; Isoxazoles; Pulmonary Artery; Pulmonary Circulation; Random Allocation; Receptor, Endothelin A; Respiration; Thiophenes; Vasoconstrictor Agents	2001
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism. American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:3 Topics: Actins; Cells, Cultured; Cytoskeleton; Deoxyglucose; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Glucose; Humans; Isoxazoles; Kinetics; Metallothionein; Oligopeptides; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Thiophenes; Transcription, Genetic; Umbilical Veins	2001
Sitaxsentan in pulmonary arterial hypertension. Chest, 2003, Volume: 123, Issue:5 Topics: Endothelin Receptor Antagonists; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Receptor, Endothelin A; Thiophenes	2003
Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression. Circulation research, 2003, Sep-05, Volume: 93, Issue:5 Topics: Animals; Animals, Genetically Modified; Blotting, Western; Capillary Permeability; Disease Susceptibility; Endothelial Growth Factors; Endothelin Receptor Antagonists; Endothelins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lung; Lymphokines; Pulmonary Edema; Rats; Rats, Mutant Strains; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Thiophenes; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Exercise Test; Humans; Hypertension, Pulmonary; Isoxazoles; Sulfonamides; Thiophenes	2004
Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study. Chest, 2004, Volume: 126, Issue:4 Topics: Adult; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes	2004
Sitaxsentan, a selective endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. Expert opinion on investigational drugs, 2004, Volume: 13, Issue:11 Topics: Adult; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Receptor, Endothelin A; Receptor, Endothelin B; Substrate Specificity; Thiophenes	2004
Sitaxsentan: an endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. International journal of clinical practice, 2006, Volume: 60, Issue:4 Topics: Endothelin A Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Thiophenes; Treatment Outcome	2006
An evidence-based approach to the management of pulmonary arterial hypertension. Current opinion in cardiology, 2006, Volume: 21, Issue:5 Topics: Antihypertensive Agents; Bosentan; Disease Management; Drug Interactions; Endothelin Receptor Antagonists; Evidence-Based Medicine; Humans; Hypertension, Pulmonary; Isoxazoles; Piperazines; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents; Walking	2006
Prolonged anti-hypertensive effects of oral sitaxsentan, a selective ET(A) endothelin receptor antagonist, in spontaneoulsy hypertensive hamsters. Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:5 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cricetinae; Endothelin A Receptor Antagonists; Hypertension; Isoxazoles; Male; Thiophenes	2006
Effect of sitaxsentan treatment on quality of life in pulmonary arterial hypertension. International journal of clinical practice, 2007, Volume: 61, Issue:1 Topics: Administration, Oral; Adult; Antihypertensive Agents; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Quality of Life; Thiophenes	2007
Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension. Pediatric research, 2007, Volume: 61, Issue:3 Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes	2007
[Pulmonary hypertension treatment: future prospects]. Archivos de bronconeumologia, 2007, Volume: 43, Issue:3 Topics: Administration, Intranasal; Administration, Oral; Animals; Bosentan; Drug Evaluation, Preclinical; Endothelin A Receptor Antagonists; Epoprostenol; Forecasting; Humans; Hypertension, Pulmonary; Iloprost; Infusions, Intravenous; Isoxazoles; Life Expectancy; Lung Transplantation; Monocrotaline; Piperazines; Platelet-Derived Growth Factor; Purines; Randomized Controlled Trials as Topic; Rats; Sheep; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents	2007
The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment. British journal of clinical pharmacology, 2007, Volume: 64, Issue:6 Topics: Adolescent; Adult; Aged; Endothelin A Receptor Antagonists; Female; Humans; Isoxazoles; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Receptor, Endothelin A; Thiophenes	2007
Pulmonary hypertension: basic concepts and practical management. The European respiratory journal, 2008, Volume: 31, Issue:2 Topics: Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Receptors, Endothelin; Sensitivity and Specificity; Sulfonamides; Survival Analysis; Thiophenes; Treatment Outcome	2008
Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. Texas Heart Institute journal, 2008, Volume: 35, Issue:3 Topics: Administration, Oral; Adult; Antihypertensive Agents; Bosentan; Dose-Response Relationship, Drug; Drug Administration Schedule; Eisenmenger Complex; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Exercise Test; Female; Heart Defects, Congenital; Humans; Isoxazoles; Male; Middle Aged; Oxygen; Retrospective Studies; Sulfonamides; Thiophenes	2008
[Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy]. Zeitschrift fur Rheumatologie, 2009, Volume: 68, Issue:2 Topics: Adult; Antihypertensive Agents; Female; Humans; Isoxazoles; Leg Ulcer; Raynaud Disease; Scleroderma, Systemic; Thiophenes; Treatment Outcome	2009
Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan. International journal of cardiology, 2010, Oct-29, Volume: 144, Issue:3 Topics: Adult; Antihypertensive Agents; Bosentan; Carbolines; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Sulfonamides; Tadalafil; Thiophenes; Treatment Outcome; Vasodilator Agents	2010
Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis and rheumatism, 2009, Volume: 60, Issue:2 Topics: Bosentan; Cohort Studies; Comorbidity; Endothelin Receptor Antagonists; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Lung Diseases, Interstitial; Male; Maryland; Middle Aged; Piperazines; Prognosis; Proportional Hazards Models; Purines; Receptors, Endothelin; Scleroderma, Diffuse; Scleroderma, Systemic; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Vasodilator Agents	2009
Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade. Therapeutic advances in respiratory disease, 2009, Volume: 3, Issue:1 Topics: Endothelin Receptor Antagonists; Follow-Up Studies; HIV; HIV Infections; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Pulmonary Wedge Pressure; Receptors, Endothelin; Thiophenes	2009
A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade. European journal of clinical investigation, 2009, Volume: 39 Suppl 2 Topics: Adult; Aged; Antihypertensive Agents; Bosentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Male; Middle Aged; Randomized Controlled Trials as Topic; Sulfonamides; Survival Analysis; Thiophenes; Transaminases; Treatment Outcome	2009
Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 54, Issue:4 Topics: Amides; Antihypertensive Agents; Atrophy; Biomarkers; Biopsy; Endothelin Receptor Antagonists; Female; Fibrosis; Fumarates; Humans; Hypertension, Renal; Isoxazoles; Kidney; Middle Aged; Proteinuria; Pulmonary Fibrosis; Renal Insufficiency, Chronic; Renin; Scleroderma, Systemic; Thiophenes; Treatment Outcome	2009
Successful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy? The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2009, Volume: 28, Issue:6 Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Epoprostenol; Female; Foramen Ovale, Patent; Humans; Hypertension, Pulmonary; Iloprost; Isoxazoles; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Treatment Outcome; Vasodilator Agents	2009
Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy. The European respiratory journal, 2009, Volume: 33, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Eisenmenger Complex; Endothelin Receptor Antagonists; Female; Glucocorticoids; Humans; Isoxazoles; Liver Function Tests; Thiophenes; Young Adult	2009
Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2009, Volume: 7, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Costs and Cost Analysis; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Placebos; Purines; Pyridazines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Treatment Outcome	2009
[Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension]. Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134 Suppl 5 Topics: Antihypertensive Agents; Bosentan; Cell Proliferation; Endothelial Cells; Endothelin Receptor Antagonists; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Isoxazoles; Sulfonamides; Thiophenes; Vasoconstriction; Vasodilation	2009
Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy? The European respiratory journal, 2009, Volume: 34, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Isoxazoles; Thiophenes	2009
Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension. The European respiratory journal, 2009, Volume: 34, Issue:3 Topics: Aged; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes	2009
The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. The European respiratory journal, 2010, Volume: 35, Issue:2 Topics: Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Phenotype; Receptors, Endothelin; Sulfonamides; Thiophenes	2010
Relief of chronic neuropathic pain through endothelin antagonism. The American journal of medicine, 2010, Volume: 123, Issue:3 Topics: Chronic Disease; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Sciatic Neuropathy; Thiophenes	2010
[Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. Revue des maladies respiratoires, 2010, Volume: 27, Issue:2 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Europe; Evidence-Based Medicine; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Practice Guidelines as Topic; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2010, Volume: 8, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Cost Control; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:6 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Bosentan; Cell Culture Techniques; Cells, Cultured; Endothelin Receptor Antagonists; Enkephalin, D-Penicillamine (2,5)-; Estradiol; Female; Hepatocytes; Humans; Isoxazoles; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenylpropionates; Pyridazines; Pyrimidines; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes; Young Adult	2010
Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:11 Topics: Aged; Antihypertensive Agents; Bosentan; Clinical Trials as Topic; Connective Tissue Diseases; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Statistics as Topic; Sulfonamides; Thiophenes; Treatment Outcome	2010
Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:4 Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome	2010
Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade. Critical care medicine, 2011, Volume: 39, Issue:4 Topics: Acute Kidney Injury; Animals; Cardiopulmonary Bypass; Creatinine; Endothelin A Receptor Antagonists; Endothelium, Vascular; Female; Interleukin-18; Isoxazoles; Proteinuria; Renal Circulation; Swine; Thiophenes	2011
Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Jaundice; Liver Failure, Acute; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult	2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension. The European respiratory journal, 2011, Volume: 37, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Failure; Practice Guidelines as Topic; Thiophenes	2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension. European heart journal, 2011, Volume: 32, Issue:4 Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Early Termination of Clinical Trials; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes	2011
Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wiener klinische Wochenschrift, 2011, Volume: 123, Issue:7-8 Topics: Endothelin Receptor Antagonists; Humans; Hypertension, Portal; Hypertension, Pulmonary; Isoxazoles; Male; Pilot Projects; Syndrome; Thiophenes; Treatment Outcome; Young Adult	2011
Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension. Vascular health and risk management, 2011, Volume: 7 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Substitution; Dyspnea; Edema; Endothelin A Receptor Antagonists; Exercise Test; Exercise Tolerance; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain; Oxygen; Phenylpropionates; Pyridazines; Retrospective Studies; Texas; Thiophenes; Time Factors; Treatment Outcome; Walking	2011
Improved survival in patients with inoperable chronic thromboembolic pulmonary hypertension. Internal and emergency medicine, 2013, Volume: 8, Issue:4 Topics: Acid-Base Equilibrium; Aged; Antihypertensive Agents; Blood Gas Analysis; Bosentan; Cardiac Output; Chronic Disease; Drug Therapy, Combination; Exercise Test; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Oxygen Consumption; Oxygen Inhalation Therapy; Piperazines; Purines; Severity of Illness Index; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Thromboembolism; Treatment Outcome; Vascular Resistance; Vasodilator Agents	2013
Pharmacologic renoprotection: are the stars finally moving into alignment? Critical care medicine, 2011, Volume: 39, Issue:4 Topics: Acute Kidney Injury; Animals; Endothelin A Receptor Antagonists; Isoxazoles; Swine; Thiophenes	2011
Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice. Life sciences, 2012, Oct-15, Volume: 91, Issue:13-14 Topics: Animals; Autoradiography; Binding, Competitive; Hepatic Artery; Humans; Isoxazoles; Liver; Liver Cirrhosis; Mice; Mice, Knockout; Microscopy, Fluorescence; Phenylpropionates; Portal Vein; Pyridazines; Receptor, Endothelin A; Receptor, Endothelin B; Thiophenes; Up-Regulation	2012
Evaluation of sitaxentan (Thelin®) toxicity in juvenile rats and regulatory interactions during the development of a European Medicines Agency pediatric investigation plan. Regulatory toxicology and pharmacology : RTP, 2012, Volume: 64, Issue:1 Topics: Animals; Antihypertensive Agents; Behavior, Animal; Child; Dose-Response Relationship, Drug; Drug and Narcotic Control; Endothelin Receptor Antagonists; Europe; Female; Government Agencies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; No-Observed-Adverse-Effect Level; Pediatrics; Rats; Reproduction; Thiophenes; Toxicity Tests	2012
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension. Regulatory toxicology and pharmacology : RTP, 2012, Volume: 64, Issue:1 Topics: Alkaline Phosphatase; Animals; Antihypertensive Agents; Blood Coagulation; Carcinogenicity Tests; Carcinogens; Chemical and Drug Induced Liver Injury, Chronic; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Erythrocyte Indices; Female; Hypertension, Pulmonary; Hypertrophy; Isoxazoles; Liver; Liver Function Tests; Male; Mice; Mice, Inbred Strains; Organ Size; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Thiophenes	2012
Exacerbation of AIH in a patient with an AIH/systemic sclerosis overlap syndrome and pulmonary arterial hypertension treated with the endothelin-1 receptor antagonist sitaxentan. BMJ case reports, 2012, Jul-13, Volume: 2012 Topics: Autoantibodies; Autoantigens; Disease Progression; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Hepatitis, Autoimmune; Humans; Hypertension, Pulmonary; Isoxazoles; Middle Aged; Scleroderma, Systemic; Thiophenes; Treatment Outcome	2012
Hemodynamic stability after transitioning between endothelin receptor antagonists in patients with pulmonary arterial hypertension. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Administration, Oral; Aged; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Middle Aged; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Retrospective Studies; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance	2013
Novel cardiovascular drugs in clinical trials. Indian journal of medical sciences, 2010, Volume: 64, Issue:6 Topics: Anticholesteremic Agents; Benzaldehydes; Cardiovascular Agents; Cardiovascular Diseases; Clinical Trials as Topic; Endothelin Receptor Antagonists; Fibrinolytic Agents; Humans; Immunologic Factors; Isoxazoles; Lipoxygenase Inhibitors; Metalloendopeptidases; Oxazolidinones; Oximes; Phospholipase A2 Inhibitors; Probucol; Pyrimidines; Quinolines; Thiophenes	2010
An evaluation of reproductive and developmental toxicity of sitaxentan (thelin) in rats. Birth defects research. Part B, Developmental and reproductive toxicology, 2012, Volume: 95, Issue:5 Topics: Animals; Animals, Newborn; Crosses, Genetic; Embryonic Development; Evaluation Studies as Topic; Female; Fertility; Fetus; Isoxazoles; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reproduction; Thiophenes; Toxicity Tests; Weaning	2012
The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude. Journal of applied physiology (Bethesda, Md. : 1985), 2012, Oct-15, Volume: 113, Issue:8 Topics: Altitude; Animals; Arterial Pressure; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Endothelin Receptor Antagonists; Female; Heart Rate; Hemodynamics; Hemoglobins; Hypoxia; Isoxazoles; Oxygen; Phenylpropionates; Physical Conditioning, Animal; Piperazines; Pulmonary Artery; Purines; Pyridazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Renal Circulation; Respiration; Sildenafil Citrate; Sulfones; Task Performance and Analysis; Theophylline; Thiophenes; Vasoconstriction	2012
Transitioning between endothelin receptor blockers: monitoring to ensure a smooth transition. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Sulfonamides; Thiophenes; Vascular Resistance	2013
Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan. Internal medicine journal, 2012, Volume: 42, Issue:12 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Liver Function Tests; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Safety-Based Drug Withdrawals; Scleroderma, Systemic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2012
Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients. Reumatismo, 2012, Dec-11, Volume: 64, Issue:5 Topics: Aged; Bosentan; Cells, Cultured; Collagen Type I; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Extracellular Matrix Proteins; Female; Fibrillin-1; Fibrillins; Fibroblasts; Fibronectins; Fibrosis; Humans; Isoxazoles; Microfilament Proteins; Middle Aged; Primary Cell Culture; Scleroderma, Systemic; Sulfonamides; Thiophenes	2012
Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. Chemical research in toxicology, 2013, Jun-17, Volume: 26, Issue:6 Topics: Animals; Benzoquinones; Biotransformation; Catechols; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Glutathione; Hepatocytes; Humans; Isoxazoles; Mice; Microsomes, Liver; Quantum Theory; Rats; Tandem Mass Spectrometry; Thiophenes	2013
Effect of endothelin inhibition on lung fibroblasts on patients with systemic sclerosis. Minerva medica, 2013, Volume: 104, Issue:5 Topics: Actins; Adult; Aged; Cell Differentiation; Cell Survival; Collagen Type I; Endothelin Receptor Antagonists; Endothelins; Female; Fibroblasts; Fibronectins; Humans; Isoxazoles; Lung; Male; Middle Aged; Muscle, Smooth; Myofibroblasts; Scleroderma, Systemic; Thiophenes; Vascular Endothelial Growth Factor A	2013
Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes. PloS one, 2014, Volume: 9, Issue:1 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Bosentan; Endothelin Receptor Antagonists; Female; Hepatocytes; Humans; Isoxazoles; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Phenylpropionates; Pyridazines; Pyrimidines; Receptors, Endothelin; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes	2014
Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:2 Topics: Adult; Blood Pressure; Case-Control Studies; Circadian Rhythm; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Renal Insufficiency, Chronic; Thiophenes; Vascular Stiffness	2014
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists. The Journal of pharmacology and experimental therapeutics, 2015, Volume: 352, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Epithelial Cells; Hepatocytes; Humans; Isoxazoles; Mitochondria; Molecular Structure; Oxygen Consumption; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2015
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury. British journal of pharmacology, 2015, Volume: 172, Issue:11 Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Femoral Artery; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Neointima; Pyrrolidines; Thiophenes	2015
Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease. Kidney international, 2016, Volume: 90, Issue:2 Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glomerular Basement Membrane; Hypertension; Isoxazoles; Laminin; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; Podocytes; Proteinuria; Pseudopodia; Receptor, Endothelin A; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes; Up-Regulation	2016
Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. Hearing research, 2016, Volume: 341 Topics: Animals; Basement Membrane; Body Temperature; Capillaries; Cell Line; Collagen Type IV; Disease Models, Animal; Endothelin-1; Extracellular Matrix; Gene Expression Regulation; Hypoxia; Isoxazoles; Laminin; Mice; Nephritis, Hereditary; Oxidative Stress; Phenotype; Stria Vascularis; Thiophenes	2016
Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency. BMC nephrology, 2017, Oct-27, Volume: 18, Issue:1 Topics: Adenine; Animals; Calcimimetic Agents; Cinacalcet; Disease Models, Animal; Endothelin A Receptor Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thiophenes	2017
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT Biochimica et biophysica acta. General subjects, 2019, Volume: 1863, Issue:5 Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes	2019
Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-Treated Liver-Humanized PXB Mice. Journal of proteome research, 2019, 11-01, Volume: 18, Issue:11 Topics: Animals; Chromatography, Liquid; Endothelin Receptor Antagonists; Ions; Isoxazoles; Lipidomics; Lipids; Liver; Liver Extracts; Male; Mass Spectrometry; Mice, SCID; Reproducibility of Results; Thiophenes	2019
Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats. Cardiovascular research, 2020, 08-01, Volume: 116, Issue:10 Topics: Albuminuria; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Epoprostenol; Hypertension; Isoxazoles; Kidney; Male; Oxidative Stress; Pyrimidines; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sulfonamides; Sunitinib; Thiophenes	2020
Simultaneous quantification of ambrisentan, macitentan and sitaxentan in human plasma using UPLC-MS/MS. Biomedical chromatography : BMC, 2020, Volume: 34, Issue:3 Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Linear Models; Phenylpropionates; Pyridazines; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry; Thiophenes	2020