tbc-11251 has been researched along with endothelin-1 in 23 studies
| Studies (tbc-11251) | Trials (tbc-11251) | Recent Studies (post-2010) (tbc-11251) | Studies (endothelin-1) | Trials (endothelin-1) | Recent Studies (post-2010) (endothelin-1) |
|---|---|---|---|---|---|
| 167 | 32 | 58 | 12,740 | 632 | 3,394 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, T; Chan, MF; Dixon, RA; Keller, KM; Kogan, TP; Mong, S; Okun, I; Raju, B; Stavros, F; Wu, C | 1 |
| Arthur, AS; Helm, GA; Kassell, NF; Lee, KS; Louis, HG; Wanebo, JE; West, K | 1 |
| Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C | 1 |
| Benamou, AE; Lekeux, P; Marlin, DJ | 1 |
| Almany, DK; Crawford, FA; Davis, JN; Fary, DJ; Goldberg, AT; Hendrick, JW; Joffs, C; Spinale, FG; Walker, CA | 1 |
| Apostolova, MD; Chakrabarti, S; Chen, S; Cherian, MG | 1 |
| Branzi, A; Galié, N; Manes, A | 1 |
| Channick, RN; Lee, SH | 1 |
| Ewert, R; Opitz, CF | 1 |
| Hoeper, MM | 1 |
| Brimiouille, S; Fesler, P; Hubloue, I; Huez, S; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B; Salmon, I; Vivian, GF | 1 |
| Bekri, S; Lévesque, H; Marie, I | 1 |
| Ewert, R; Kirch, W; Opitz, CF; Pittrow, D | 1 |
| Dhaun, N; Goddard, J; Lilitkarntakul, P; MacIntyre, IM; Melville, V; Webb, DJ | 1 |
| Brimioulle, S; Dewachter, C; Dewachter, L; Fesler, P; Franck, S; Hubloue, I; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B | 1 |
| Guzik, T; Kopeć, G; Mikołajczyk, T; Miszalski-Jamka, T; Podolec, P; Tyrka, A; Waligóra, M | 1 |
| Kohan, DE; Pollock, DM | 1 |
| Blackwell, S; Dhaun, N; Goddard, J; Johnston, NR; Melville, V; Talwar, DK; Webb, DJ | 1 |
| Brown, KE; Dhaun, N; Goddard, J; Kennedy, ED; Kimmitt, RA; MacIntyre, IM; Melville, V; Moorhouse, R; Oosthuyzen, W; Webb, DJ | 1 |
| Chariyavilaskul, P; Corder, R; Dhaun, N; Goddard, J; Kimmitt, RA; MacIntyre, IM; Webb, DJ; Wood, EG; Yuzugulen, J | 1 |
| Cheung, L; Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Liu, S; Meehan, DT; Phillips, G; Song, W | 1 |
| Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Meehan, DT; Phillips, G; Zallocchi, M | 1 |
| Caballero-George, C; Digman, MA; Gratton, E; Planes, N; Vanderheyden, PPML | 1 |
8 review(s) available for tbc-11251 and endothelin-1
| Article | Year |
|---|---|
Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: dose study and review of endothelin-based therapies in the literature on cerebral vasospasm.
Topics: Animals; Basilar Artery; Calcium Signaling; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Ischemic Attack, Transient; Isoxazoles; Male; Rabbits; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes | 1998 |
The endothelin system in pulmonary arterial hypertension.
Topics: Animals; Bosentan; Endothelial Cells; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Infant, Newborn; Isoxazoles; Models, Animal; Muscle, Smooth, Vascular; Pulmonary Circulation; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Thiophenes | 2004 |
Endothelin antagonism in pulmonary arterial hypertension.
Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Epoprostenol; Humans; Hypertension, Pulmonary; Isoxazoles; Piperazines; Pulmonary Artery; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes | 2005 |
Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension.
Topics: Antihypertensive Agents; Bosentan; Cell Division; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Lung; Pulmonary Fibrosis; Sulfonamides; Thiophenes; Vasoconstriction; Vasodilation | 2006 |
[Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists].
Topics: Algorithms; Antihypertensive Agents; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Survival Rate; Thiophenes | 2006 |
[Endothelin 1 and selectivity of endothelin receptor antagonists: To B or not to B?].
Topics: Endothelin Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2008 |
Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?
Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Phenylpropionates; Pulmonary Artery; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance; Walking | 2008 |
Endothelin antagonists for diabetic and non-diabetic chronic kidney disease.
Topics: Animals; Clinical Trials as Topic; Diabetic Nephropathies; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Kidney Failure, Chronic; Pyridines; Pyrimidines; Renal Dialysis; Renal Insufficiency, Chronic; Thiophenes; Treatment Outcome | 2013 |
5 trial(s) available for tbc-11251 and endothelin-1
| Article | Year |
|---|---|
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass.
Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left | 2001 |
Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men.
Topics: Administration, Oral; Adult; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Bosentan; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Endothelin A Receptor Antagonists; Endothelin-1; Humans; Isoxazoles; Male; Middle Aged; Plethysmography; Probability; Receptor, Endothelin A; Reference Values; Sulfonamides; Thiophenes; Young Adult | 2010 |
Changes in exercise capacity and cardiac performance in a series of patients with Eisenmenger's syndrome transitioned from selective to dual endothelin receptor antagonist.
Topics: Adult; Antihypertensive Agents; Bosentan; Eisenmenger Complex; Endothelin Receptor Antagonists; Endothelin-1; Exercise; Female; Follow-Up Studies; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Stroke Volume; Sulfonamides; Thiophenes | 2012 |
Endothelin-A receptor antagonism modifies cardiovascular risk factors in CKD.
Topics: Adult; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Nifedipine; Proteinuria; Pulse Wave Analysis; Renal Insufficiency, Chronic; Thiophenes; Vascular Stiffness; Vasodilator Agents | 2013 |
Plasma pro-endothelin-1 peptide concentrations rise in chronic kidney disease and following selective endothelin A receptor antagonism.
Topics: Adult; Biomarkers; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Endothelin A Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Nifedipine; Protein Precursors; Proteinuria; Receptor, Endothelin A; Renal Insufficiency, Chronic; Scotland; Thiophenes; Time Factors; Treatment Outcome; Up-Regulation; Vascular Stiffness | 2015 |
10 other study(ies) available for tbc-11251 and endothelin-1
| Article | Year |
|---|---|
Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.
Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Cell Line; COS Cells; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Half-Life; Humans; Isoxazoles; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship; Thiophenes | 1997 |
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain | 2000 |
Equine pulmonary and systemic haemodynamic responses to endothelin-1 and a selective ET(A) receptor antagonist.
Topics: Animals; Carotid Arteries; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Horses; Injections, Intravenous; Isoxazoles; Pulmonary Artery; Pulmonary Circulation; Receptor, Endothelin A; Thiophenes; Vascular Resistance; Vasoconstrictor Agents | 2001 |
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism.
Topics: Actins; Cells, Cultured; Cytoskeleton; Deoxyglucose; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Glucose; Humans; Isoxazoles; Kinetics; Metallothionein; Oligopeptides; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Thiophenes; Transcription, Genetic; Umbilical Veins | 2001 |
Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension.
Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes | 2007 |
Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.
Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome | 2010 |
Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1.
Topics: Adult; Blood Pressure; Case-Control Studies; Circadian Rhythm; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Isoxazoles; Male; Middle Aged; Renal Insufficiency, Chronic; Thiophenes; Vascular Stiffness | 2014 |
Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glomerular Basement Membrane; Hypertension; Isoxazoles; Laminin; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; Podocytes; Proteinuria; Pseudopodia; Receptor, Endothelin A; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes; Up-Regulation | 2016 |
Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.
Topics: Animals; Basement Membrane; Body Temperature; Capillaries; Cell Line; Collagen Type IV; Disease Models, Animal; Endothelin-1; Extracellular Matrix; Gene Expression Regulation; Hypoxia; Isoxazoles; Laminin; Mice; Nephritis, Hereditary; Oxidative Stress; Phenotype; Stria Vascularis; Thiophenes | 2016 |
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT
Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes | 2019 |