Page last updated: 2024-09-05

tbc-11251 and bq 123

tbc-11251 has been researched along with bq 123 in 3 studies

Compound Research Comparison

Studies (tbc-11251)	Trials (tbc-11251)	Recent Studies (post-2010) (tbc-11251)	Studies (bq 123)	Trials (bq 123)	Recent Studies (post-2010) (bq 123)
167	32	58	1,391	63	152

Protein Interaction Comparison

Protein	Taxonomy	tbc-11251 (IC50)	bq 123 (IC50)
Endothelin-1 receptor	Homo sapiens (human)		0.017
Endothelin-1 receptor	Rattus norvegicus (Norway rat)		0.014

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ	1
Lüscher, TF; Spieker, LE	1
Caballero-George, C; Digman, MA; Gratton, E; Planes, N; Vanderheyden, PPML	1

Reviews

1 review(s) available for tbc-11251 and bq 123

Article	Year
Will endothelin receptor antagonists have a role in heart failure? The Medical clinics of North America, 2003, Volume: 87, Issue:2 Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome	2003

Article

Year

Will endothelin receptor antagonists have a role in heart failure?

The Medical clinics of North America, 2003, Volume: 87, Issue:2

Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome

2003

Trials

1 trial(s) available for tbc-11251 and bq 123

Article	Year
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8 Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones	2004

Article

Year

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.

Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004

Other Studies

1 other study(ies) available for tbc-11251 and bq 123

Article	Year
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT Biochimica et biophysica acta. General subjects, 2019, Volume: 1863, Issue:5 Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes	2019

Article

Year

Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT

Biochimica et biophysica acta. General subjects, 2019, Volume: 1863, Issue:5

Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes

2019