Page last updated: 2024-09-03

tazobactam and sulbactam

tazobactam has been researched along with sulbactam in 128 studies

Compound Research Comparison

Studies (tazobactam)	Trials (tazobactam)	Recent Studies (post-2010) (tazobactam)	Studies (sulbactam)	Trials (sulbactam)	Recent Studies (post-2010) (sulbactam)
1,327	153	694	1,844	297	488

Protein Interaction Comparison

Protein	Taxonomy	sulbactam (IC50)
Beta-lactamase	Escherichia coli	6.2
Beta-lactamase	Shouchella clausii	0.075
Beta-lactamase	Pseudomonas aeruginosa	0.37
Beta-lactamase	Pseudomonas aeruginosa	3
Beta-lactamase	Aeromonas allosaccharophila	4
Beta-lactamase	Staphylococcus aureus	6.5
Beta-lactamase	Enterobacter cloacae	1.4
Beta-lactamase TEM	Escherichia coli	4.3
Beta-lactamase	Acinetobacter pittii	1.12
Beta-lactamase	Acinetobacter pittii	7.758
Beta-lactamase	Pseudomonas aeruginosa	3
Beta-lactamase	Escherichia coli	2.4

Research

Studies (128)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (10.16)	18.7374
1990's	46 (35.94)	18.2507
2000's	34 (26.56)	29.6817
2010's	25 (19.53)	24.3611
2020's	10 (7.81)	2.80

Authors

Authors	Studies
Feigelson, GB; Petersen, PJ; Prashad, AS; Sandanayaka, VP; Yang, Y	1
Lin, YI; Mansour, TS; Prashad, AS; Sandanayaka, VP; Williamson, RT; Yang, Y	1
Arlet, G; Loli, A; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Amicosante, G; Caporale, B; Celenza, G; Docquier, JD; Mezzatesta, M; Pellegrini, C; Perilli, M; Rossolini, GM; Stefani, S	1
Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Girlich, D; Leclercq, R; Naas, T; Nordmann, P	1
Correia, A; Domingues, MR; Domingues, P; Fonseca, F; Henriques, I; Saavedra, MJ; Samyn, B; Sarmento, AC; van Beeumen, J	1
Courvalin, P; Decré, D; Høiby, EA; Meziane-Cherif, D; Périchon, B	1
Courvalin, P; Dupêchez, M; Galimand, M; Lambert, T; Meziane-Cherif, D	1
Castanheira, M; Samuelsen, Ø; Spencer, J; Walsh, TR	1
Hesse, L; Paukner, S; Prezelj, A; Solmajer, T; Urleb, U	1
Chanteperdrix, V; Croizé, J; Nordmann, P; Poirel, L; Potron, A	1
De Luca, F; Docquier, JD; Ide, L; Nordmann, P; Poirel, L; Rossolini, GM; Verlinde, A	1
Bethel, CR; Bonomo, RA; Distler, AM; Kasuboski, C; Papp-Wallace, KM; Taracila, M	1
Kotsakis, SD; Legakis, NJ; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Choi, JY; Ko, KS; Lee, MY; Park, YK; Peck, KR; Rhee, JY; Shin, JY; Song, JH	1
Bonomo, RA; Distler, AM; Endimiani, A; Hornick, JM; Hujer, AM; Hujer, KM; Papp-Wallace, KM; Taracila, M	1
Kotsakis, SD; Miriagou, V; Tzelepi, E; Tzouvelekis, LS	1
Black, MT; Bruneau, JM; Claudon, M; Coleman, K; Frère, JM; Miossec, C; Péchereau, MC; Stachyra, T	1
Bethel, CR; Bonomo, RA; Caselli, E; Drawz, SM; Dwulit-Smith, JR; Papp-Wallace, KM; Prati, F; Rodkey, EA; Romagnoli, C; Smith, KM; Taracila, MA; van den Akker, F; Winkler, ML; Xu, Y	1
Bethel, CR; Bonomo, RA; Buynak, JD; Carey, PR; Chai, W; Che, T; Ding, Z; Nottingham, M; Pusztai-Carey, M; Rodkey, EA; Shanmugam, S; van den Akker, F	1
Bonomo, RA; Currie-McCumber, C; Shlaes, DM	1
Hedberg, M; Lindqvist, L; Nord, CE; Tunér, K	2
Dubreuil, L; Sedallian, A	1
Aspinall, S; Corkill, JE; Hart, CA; McLennan, AG	1
Cullmann, W	2
Nishino, T; Obana, Y	1
Higashitani, F; Hyodo, A; Inoue, M; Ishida, N; Mitsuhashi, S	1
Cherubin, CE; Eng, RH; Smith, SM	1
Descamps, P; Moittie, D; Philippon, A; Simonet, M; Veron, M	1
Appelbaum, PC; Aronoff, SC; Jacobs, MR; Yamabe, S	1
Acar, JF; Coutrot, A; Ferré, B; Gutmann, L; Kitzis, MD	1
Jacobus, NV; Kuck, NA; Petersen, PJ; Testa, RT; Weiss, WJ	1
Adachi, K; Ueda, S; Watanabe, M; Yamabe, S	1
Acar, JF; Billot-Klein, D; Carlet, J; Goldstein, FW; Gutmann, L; Kitzis, MD; Tran Van Nhieu, G; Williamson, R	1
Moosdeen, F; Williams, JD; Yamabe, S	1
Moosdeen, F; Williams, J; Yamabe, S	1
Aronoff, SC; Jacobs, MR; Johenning, S; Shlaes, DM; Yamabe, S	1
Appelbaum, PC; Jacobs, MR; Spangler, SK; Yamabe, S	1
Hall, TW; Ishida, N; Maiti, SN; Micetich, RG; Nakai, A; Ogawa, K; Spevak, P; Tanaka, M; Yamabe, S; Yamazaki, T	1
Aronoff, SC; Jacobs, MR; Johenning, S; Yamabe, S	1
Arakawa, Y; Horii, T; Ito, H; Ohsuka, S; Ohta, M	1
Blahová, J; Hupková, M; Krcméry, V	1
Jones, R; Satishchandran, V; Shapiro, T; Suh, B; Truant, AL	1
Chang, SC; Hsieh, WC; Luh, KT	1
Appelbaum, PC; Jacobs, MR; Pankuch, GA	1
Harris, EB; Hastings, RC; Prabhakaran, K; Randhawa, B	1
Guillaume, Y; Guinchard, C; Peyrin, E	1
Carias, LL; Rice, LB; Shlaes, DM	1
Atchison, K; Daneshtalab, M; Im, C; Kunugita, C; Maiti, SN; Micetich, RG; Phillips, OA	1
Cramp, R; Knowles, DJ; Payne, DJ; Winstanley, DJ	1
Alós, JI; Gómez-Garcés, JL; Mateos, MV	1
Alos, I; Baquero, F; Baquero, MR; Blazquez, J; Canton, R	1
Inoue, E; Mitsuhashi, S; Muratani, T; Nakane, T; Yokota, E	1
Jin, YF; Piddock, LJ; Turner, HL	1
Barry, A; Fuchs, P; Gerlach, E; Hardy, D; McLaughlin, J; Pfaller, M	1
Gaudreau, C; Lachance, N; Lamothe, F; Turgeon, F	1
Amyes, SG; Thomson, CJ	1
Labia, R; Mariotte-Boyer, S; Nicolas-Chanoine, MH	1
Alós, JI; Balas, D; Cogollos, R; Gomez-Graces, JL; Tajada, P	1
Greenwood, D	1
Atwood, E; DiTore, V; Landman, D; Patel, K; Quale, J; Saurina, G	1
Klepser, ME; Marangos, MN; Nicolau, DP; Nightingale, CH; Quintiliani, R; Zhu, Z	1
Lister, PD; Prevan, AM; Sanders, CC	1
Palmer, SM; Rybak, MJ	1
Hanaki, H; Nagayama, A; Nomura, S	1
Barthélémy, M; Chaibi, EB; Farzaneh, S; Labia, R; Péduzzi, J; Sirot, D	1
Calcagno, ML; Danelon, G; Gutkind, G; Mascaretti, O; Mata, EG; Power, P; Radice, M	1
Amicosante, G; Cornaglia, G; Franceschini, N; Mazzariol, A; Perilli, M; Segatore, B; Setacci, D	1
Anderson, V; Bonomo, RA; Knox, JR; Lin, S; Rudin, SD; Shlaes, DM; Thomas, M	1
Levesque, RC; Palzkill, T; Sabbagh, Y; Sanschagrin, F; Thériault, E; Voyer, N	1
Jarlier, V	1
de Seny, D; Frere, JM; Galleni, M; Laraki, N; Llabres, G; Prosperi-Meys, C; Soto, RP; Valladares, MH	1
de la Pena, A; Derendorf, H	1
Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS	1
Betriu, C; Gómez, M; Palau, ML; Picazo, JJ; Sánchez, A	1
Degnan, BA; Farmer, TH; Payne, DJ	1
Kotra, LP; Levesque, RC; Mobashery, S; Sanschagrin, F; Therrien, C	1
Miranda, E; Sader, HS; Sejas, L; Tosin, I	1
Levesque, RC; Palzkill, T; Sanschagrin, F; Savoie, A; Voyer, N	1
Cuenca, FF	1
Niki, Y	1
Mealey, KL	1
Bode, U; Fleischhack, G; Hasan, C; Havers, W; Marklein, G; Schmidt-Niemann, M; Wulff, B	1
Nakano, R; Okamoto, R	1
Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Hujer, AM; Totir, MA	1
Higgins, PG; Seifert, H; Stefanik, D; Wisplinghoff, H	1
Høiby, N; Walther-Rasmussen, J	1
Georgopapadakou, NH	1
Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Padayatti, PS; Totir, MA; van den Akker, F	1
Pang, XY; Tian, BW; Yang, YJ	1
Nord, CE	1
Banic, S	1
Hashikita, G; Kawakami, S; Kobayashi, S; Maesaki, S; Nagasawa, M; Okabe, T; Sasaki, K; Shibuya, S; Suzuki, N; Takayama, S; Uchida, T; Watanabe, M; Yamaguchi, T	1
Chang, HT; Chen, IS; Chou, MY; Hsueh, PR; Huang, WK; Hung, MN; Ko, WC; Lee, WS; Lin, CF; Liu, CY; Liu, YC; Luh, KT; Shyr, JM; Teng, LJ; Wang, JH; Wu, JJ	1
Khan, HM; Malik, A; Shahid, M; Shujatullah, F; Shukla, I; Singhai, M; Tahira, F	1
Bonomo, RA; Buynak, JD; Carey, MP; Carey, PR; Helfand, MS; Sheri, A; Totir, MA	1
Anderson, VE; Buynak, J; Carey, PR; Cha, J; Ishiwata, A; Mobashery, S; Sheri, A; Totir, MA; Wang, B	1
Buynak, JD; Carey, PR; Kalp, M; Totir, MA	1
Kuo, HY; Lin, ML; Liu, CY; Wang, FD; Yen, YF	1
Bethel, CR; Bonomo, RA; Drawz, SM; Ke, W; Ori, C; Prati, F; Sampson, JM; van den Akker, F	1
Bethel, CR; Bonnet, R; Bonomo, RA; Distler, AM; Endimiani, A; Hujer, AM; Hujer, KM; Papp-Wallace, K; Shyr, T; Taracila, M; Thomson, JM	1
Blahut, L; Hricová, K; Kolár, M; Neiser, J; Urbánek, K; Uvízl, R; Vojtová, V	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Kasap, M; Torol, S	1
Celebi, S; Demirkaya, M; Hacımustafaoglu, M; Sevinir, B	1
Chen, CL; Li, R; Wang, YT	1
Chhibba, A; Nayak, U; Patankar, M; Sequeira, L; Sukumaran, S	1
Beceiro, A; Bou, G; Galleni, M; García, P; Gómez-Bertomeu, F; González-López, JJ; Kerff, F; Larrosa, N; Méndez, JA; Miró, E; Navarro, F; Oliver, A; Pérez-Llarena, FJ; Zamorano, L	1
Akiyama, M; Hasegawa, H; Hashimoto, T; Ishii, N; Kato, Y; Ozawa, H; Tomida, E	1
Alyousef, AA; Alzahrani, AJ; Krishnappa, LG; Marie, MA; Mubaraki, MA	1
Henson, KE; Rybak, MJ; Sakoulas, G; Smith, JR; Yim, J	1
Benier, L; Bodrenko, I; Ceccarelli, M; Ghai, I; Pira, A; Scorciapino, MA; Wagner, R; Winterhalter, M	1
Cai, J; Chan, EW; Chen, S; Cheng, Q; Fang, Y; Gu, D; Shen, Y	1
Ali, I; Shabbir, M	1
Blok, A; Pannu, NS; Tassoni, R; Ubbink, M	1
Dong, D; Li, J; Li, S; Liu, Y; Su, N; Sun, X; Tan, J; Wang, W; Wu, G; Wu, Y; Xiong, W; Yu, C; Zhang, R; Zong, Z; Zou, K	1
Kharat, AS; Khobragade, K; Palwe, S; Periasamy, H; Veeraraghavan, B	1
Cardoso, MH; Costa, BO; Franco, OL	1
Chen, Y; Liu, L; Xiang, Q	1
Arthur, C; Bethel, CR; Bonomo, RA; Heesom, KJ; Hinchliffe, P; Papp-Wallace, KM; Schlatzer, DM; Shapiro, S; Spencer, J; Tooke, CL; Wang, B	1
Antonelli, A; Cherubini, S; D'Andrea, MM; Perilli, M; Piccirilli, A; Rossolini, GM	1
Bellini, R; Ciapina, LP; Dardenne, LE; de Vasconcelos, ATR; Guedes, IA; Nicolás, MF	1
Balasubramanium, G; Elangovan, R; Gupta, SS; Lodha, T; Muthulakshmi, T; Perumal, V; Sivaraman, GK; Visnuvinayagam, S; Yadav, A	1
Cao, Y; Liu, C; Ren, H; Shang, Z; Wang, R; Xie, L; Yang, Y; Zhang, J	1
Haller, IE; Heisler, S; Helmke, C; Hunger, R; Kirbach, J; Kobelt, E; Lünse, S; Mantke, R; Meyer, J; Paasch, C; Schildberg, C	1

Reviews

8 review(s) available for tazobactam and sulbactam

Article	Year
Pharmacokinetic properties of beta-lactamase inhibitors. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:2 Topics: Absorption; Aging; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Biological Availability; Clavulanic Acid; Drug Synergism; Enzyme Inhibitors; Half-Life; Humans; Kidney Diseases; Penicillanic Acid; Sulbactam; Tazobactam	1999
[Activity of betalactamase inhibitors against Acinetobacter baumannii]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2000, Volume: 13, Issue:1 Topics: Acinetobacter; Acinetobacter Infections; Animals; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Humans; Penicillanic Acid; Sulbactam; Tazobactam	2000
[Fundamental and clinical studies on beta-lactamase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:4 Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2001
Penicillins and beta-lactamase inhibitor combinations. Journal of the American Veterinary Medical Association, 2001, Jun-15, Volume: 218, Issue:12 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Drug Resistance, Microbial; Drug Therapy, Combination; Enzyme Inhibitors; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	2001
[beta-Lactamase-inhibitor combinations]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 3 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Drug Design; Drug Resistance, Bacterial; Drug Therapy, Combination; Humans; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	2003
Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases. Canadian journal of microbiology, 2004, Volume: 50, Issue:3 Topics: beta-Lactamases; Cefotaxime; Cephalosporins; Clavulanic Acid; Drug Resistance, Bacterial; Enterobacteriaceae; Enzyme Inhibitors; Gene Transfer, Horizontal; Monobactams; Penicillanic Acid; Penicillins; Phylogeny; Sulbactam; Tazobactam	2004
Beta-lactamase inhibitors: evolving compounds for evolving resistance targets. Expert opinion on investigational drugs, 2004, Volume: 13, Issue:10 Topics: Animals; beta-Lactam Resistance; beta-Lactamase Inhibitors; Enzyme Inhibitors; Humans; Penicillanic Acid; Sulbactam; Tazobactam	2004
Development of Peptides that Inhibit Aminoglycoside-Modifying Enzymes and β-Lactamases for Control of Resistant Bacteria. Current protein & peptide science, 2020, Volume: 21, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Infections; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Design; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Kanamycin Kinase; Nucleotidyltransferases; Sulbactam; Tazobactam	2020

Trials

3 trial(s) available for tazobactam and sulbactam

Article	Year
Comparison of the bactericidal activities of piperacillin-tazobactam, ticarcillin-clavulanate, and ampicillin-sulbactam against clinical isolates of Bacteroides fragilis, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2 Topics: Adult; Ampicillin; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Cross-Over Studies; Drug Therapy, Combination; Enterococcus faecalis; Escherichia coli; Female; Humans; Male; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Serum Bactericidal Test; Sulbactam; Tazobactam; Ticarcillin	1997
Piperacillin, beta-lactam inhibitor plus gentamicin as empirical therapy of a sequential regimen in febrile neutropenia of pediatric cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:5 Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Child; Drug Therapy, Combination; Enzyme Inhibitors; Fever; Gentamicins; Germany; Humans; Neoplasms; Neutropenia; Penicillanic Acid; Penicillins; Piperacillin; Prospective Studies; Sulbactam; Tazobactam; Treatment Outcome	2001
Randomized comparison of piperacillin-tazobactam plus amikacin versus cefoperazone-sulbactam plus amikacin for management of febrile neutropenia in children with lymphoma and solid tumors. Pediatric hematology and oncology, 2013, Volume: 30, Issue:2 Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Cefoperazone; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Neutropenia; Penicillanic Acid; Piperacillin; Prospective Studies; Sulbactam; Tazobactam	2013

Other Studies

117 other study(ies) available for tazobactam and sulbactam

Article	Year
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors. Bioorganic & medicinal chemistry letters, 2001, Apr-23, Volume: 11, Issue:8 Topics: Alkenes; Alkynes; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Molecular Conformation; Penicillanic Acid; Sulfones; Tazobactam; Triazoles	2001
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone. Journal of medicinal chemistry, 2003, Jun-19, Volume: 46, Issue:13 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Catalysis; Crystallography, X-Ray; Cyclopropanes; Diazonium Compounds; Enzyme Inhibitors; Escherichia coli; Microbial Sensitivity Tests; Models, Molecular; Pseudomonas aeruginosa; Rhodium; Serine; Serratia marcescens; Spiro Compounds; Structure-Activity Relationship; Sulbactam	2003
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Escherichia coli; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillinase; Plasmids; Sequence Analysis, DNA	2007
Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cephalosporins; Chryseobacterium; Flavobacteriaceae Infections; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Sequence Analysis, DNA	2007
Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Anti-Bacterial Agents; Cephalosporinase; Culture Media; DNA Primers; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Spectrophotometry, Ultraviolet	2007
Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; beta-Lactamases; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Sequence Homology, Amino Acid; Substrate Specificity	2007
Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Aztreonam; beta-Lactamases; Carbapenems; Catalysis; Cephalosporins; Clavulanic Acid; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrolysis; Kinetics; Molecular Weight; Penicillanic Acid; Penicillins; Recombinant Proteins; Serratia; Sulbactam; Tazobactam	2007
Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Amino Acid Sequence; beta-Lactams; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillinase; Sequence Alignment; Sequence Analysis, DNA; Substrate Specificity	2008
Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; Brachyspira; Cloning, Molecular; Diarrhea; Feces; Gram-Negative Bacterial Infections; Humans; Kinetics; Molecular Sequence Data; Oxacillin; Penicillin Resistance; Sequence Analysis, DNA	2008
Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Acremonium; Bacterial Proteins; beta-Lactamases; Catalysis; Catalytic Domain; Cefepime; Ceftazidime; Cephalosporins; Kinetics; Models, Molecular; Mutation; Penicillinase; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity	2008
In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Drug Resistance, Bacterial; Enzyme Inhibitors; Microbial Sensitivity Tests	2009
Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Acinetobacter baumannii; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Site-Directed	2009
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Belgium; beta-Lactamases; Cephalosporinase; Cephalosporins; Cross Infection; Escherichia coli; Genes, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections	2010
Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Kinetics; Microbial Sensitivity Tests; Penicillanic Acid; Spectrometry, Mass, Electrospray Ionization; Sulbactam; Tazobactam	2010
GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamases; beta-Lactams; Cephalosporins; Genetic Variation; Humans; Integrons; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Pseudomonas Infections; Sequence Analysis, DNA	2010
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Aged; beta-Lactamases; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Klebsiella Infections; Klebsiella pneumoniae; Male; Renal Dialysis; Republic of Korea	2010
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporinase; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Molecular Structure; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulbactam; Tazobactam	2010
Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11 Topics: Ampicillin; beta-Lactamases; Computational Biology; Escherichia coli; Hydrogen Bonding; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Protein Structure, Secondary; Ticarcillin	2010
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Inhibitory Concentration 50; Molecular Structure; Spectrometry, Mass, Electrospray Ionization	2010
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Boronic Acids; Circular Dichroism; Clavulanic Acid; Crystallography, X-Ray; Drug Design; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds	2013
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone. Biochemistry, 2015, Jan-27, Volume: 54, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Hydrolysis; Imines; Kinetics; Microbial Sensitivity Tests; Normal Distribution; Solutions; Spectrum Analysis, Raman; Sulbactam	2015
OHIO-1 beta-lactamase resistant to mechanism-based inactivators. FEMS microbiology letters, 1992, Apr-01, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Molecular Sequence Data; Mutation; Penicillanic Acid; Plasmids; Sequence Homology, Nucleic Acid; Sulbactam; Tazobactam	1992
Effect of clavulanic acid, sulbactam and tazobactam on three different beta-lactamases from Bacteroides uniformis, Clostridium butyricum and Fusobacterium nucleatum. The Journal of antimicrobial chemotherapy, 1992, Volume: 30, Issue:1 Topics: Bacteroides; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Clostridium; Fusobacterium nucleatum; Penicillanic Acid; Sulbactam; Tazobactam	1992
Effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:11 Topics: Bacteria, Anaerobic; Bacteroides; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Clostridium; Fusobacterium nucleatum; Penicillanic Acid; Sulbactam; Tazobactam	1992
[Strict anaerobic bacteria: comparative study of various beta-lactam antibiotics in combination with tazobactam or sulbactam]. Pathologie-biologie, 1991, Volume: 39, Issue:5 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactamase Inhibitors; Cefotaxime; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; In Vitro Techniques; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1991
Characterization of a beta-lactamase produced by Pseudomonas paucimobilis. Journal of general microbiology, 1991, Volume: 137, Issue:6 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Chromosomes, Bacterial; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Molecular Weight; Penicillanic Acid; Penicillin Resistance; Penicillins; Pseudomonas; Sulbactam; Tazobactam	1991
Beta-lactamase inhibitors: relation between kinetic data and in-vitro synergism studies. Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1991, Volume: 275, Issue:4 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Drug Synergism; Enterobacter cloacae; Escherichia coli; Klebsiella; Penicillanic Acid; Piperacillin; Proteus vulgaris; Pseudomonas aeruginosa; Staphylococcus aureus; Sulbactam; Tazobactam	1991
In-vitro and in-vivo activities of sulbactam and YTR830H against Acinetobacter calcoaceticus. The Journal of antimicrobial chemotherapy, 1990, Volume: 26, Issue:5 Topics: Acinetobacter; Acinetobacter Infections; Animals; beta-Lactamase Inhibitors; Humans; Male; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1990
Interaction of beta-lactamase inhibitors with various beta-lactamases. Chemotherapy, 1990, Volume: 36, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enterobacter; Escherichia coli; Humans; Klebsiella; Penicillanic Acid; Plasmids; Proteus vulgaris; Staphylococcus aureus; Sulbactam; Tazobactam	1990
Inhibition of beta-lactamases by tazobactam and in-vitro antibacterial activity of tazobactam combined with piperacillin. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:4 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acids; Drug Synergism; Drug Therapy, Combination; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1990
Beta-lactamase inhibitors and Acinetobacter spp. The Journal of antimicrobial chemotherapy, 1990, Volume: 26, Issue:3 Topics: Acinetobacter; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; beta-Lactamase Inhibitors; Clavulanic Acids; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Species Specificity; Sulbactam; Tazobactam	1990
Synergy of clavulanic acid, sulbactam and tazobactam (YTR 830) with amoxycillin against fifty beta-lactamase-producing strains of Haemophilus influenzae. The Journal of antimicrobial chemotherapy, 1989, Volume: 23, Issue:5 Topics: Amoxicillin; beta-Lactamase Inhibitors; Clavulanic Acids; Drug Synergism; Haemophilus influenzae; Microbial Sensitivity Tests; Penicillanic Acid; Penicillin Resistance; Sulbactam; Tazobactam	1989
In vitro activity of YTR 830. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:3 Topics: Ampicillin; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acids; Drug Therapy, Combination; Enterobacteriaceae; Klebsiella; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Proteus vulgaris; Sulbactam; Tazobactam; Ticarcillin	1989
In vitro activity of combinations of beta-lactam antibiotics with beta-lactamase inhibitors against cephalosporinase-producing bacteria. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1989, Volume: 8, Issue:9 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefotaxime; Cephalosporinase; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Drug Interactions; Drug Resistance, Microbial; Enterobacteriaceae; Enzyme Induction; Humans; Isoelectric Focusing; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Ticarcillin	1989
Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:11 Topics: Animals; Bacteria; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Female; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1989
The effects of three beta-lactamase inhibitors: YTR830H, sulbactam and clavulanic acid on the growth of human cells in culture. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:5 Topics: beta-Lactamase Inhibitors; Cell Division; Cells, Cultured; Clavulanic Acid; Clavulanic Acids; Humans; Penicillanic Acid; Sulbactam; Tazobactam	1987
Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:1 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acids; DNA, Bacterial; Drug Resistance, Microbial; Drug Synergism; Enterobacteriaceae; Genes, Bacterial; Humans; Nucleic Acid Hybridization; Penicillanic Acid; Penicillin Resistance; Penicillins; R Factors; Sulbactam; Tazobactam	1988
Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:6 Topics: Bacteria; Bacterial Proteins; beta-Lactamase Inhibitors; Carrier Proteins; Clavulanic Acids; Hexosyltransferases; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillanic Acid; Penicillin-Binding Proteins; Peptidyl Transferases; Sulbactam; Tazobactam	1988
The activity of a sulphone beta-lactamase inhibitor, YTR 830. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Enterobacteriaceae; Microbial Sensitivity Tests; Penicillanic Acid; R Factors; Sulbactam; Tazobactam	1987
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ampicillin and broad-spectrum penicillins against defined beta-lactamase-producing aerobic gram-negative bacilli. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:6 Topics: Ampicillin; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Gram-Negative Aerobic Bacteria; Penicillanic Acid; Penicillins; Plasmids; Sulbactam; Tazobactam	1986
Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes. Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:5 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1986
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry; Clavulanic Acid; Clavulanic Acids; Escherichia coli; Penicillanic Acid; Sulbactam; Tazobactam; Triazoles	1987
Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:4 Topics: Amoxicillin; Ampicillin; Bacteria; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Penicillanic Acid; Sulbactam; Tazobactam	1984
Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:8 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Sulbactam; Tazobactam	1995
[The effectiveness of so-called potentiated penicillins (augmentin and tazobactam) in vitro]. Casopis lekaru ceskych, 1995, Sep-06, Volume: 134, Issue:17 Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Bacteria; beta-Lactamase Inhibitors; Clavulanic Acids; Drug Therapy, Combination; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1995
In vitro activity of beta-lactamase inhibitors against clinical isolates of Acinetobacter species. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:2 Topics: Acinetobacter; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Cefotaxime; Ceftazidime; Ceftriaxone; Clavulanic Acid; Clavulanic Acids; Colony Count, Microbial; Imipenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sensitivity and Specificity; Sulbactam; Tazobactam	1995
Influence of beta-lactamase inhibitors on the activity of oxacillin against methicillin-resistant Staphylococcus aureus. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Methicillin Resistance; Microbial Sensitivity Tests; Oxacillin; Penicillanic Acid; Staphylococcus aureus; Sulbactam; Tazobactam	1995
Susceptibilities of 200 penicillin-susceptible and -resistant pneumococci to piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:12 Topics: Ampicillin; Anti-Bacterial Agents; Ceftazidime; Ceftriaxone; Clavulanic Acids; Microbial Sensitivity Tests; Penicillanic Acid; Penicillin Resistance; Piperacillin; Streptococcus pneumoniae; Sulbactam; Tazobactam; Ticarcillin	1994
beta-Lactamase activity in mycobacteria including Mycobacterium avium and suppression of their growth by a beta-lactamase-stable antibiotic. Microbios, 1995, Volume: 81, Issue:328 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cell Division; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Isoniazid; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium avium; Penicillanic Acid; Streptomycin; Sulbactam; Tazobactam	1995
Rapid determination of sulbactam and tazobactam in human serum by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1995, Mar-24, Volume: 665, Issue:2 Topics: beta-Lactamase Inhibitors; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Hydrogen-Ion Concentration; Microchemistry; Penicillanic Acid; Sulbactam; Tazobactam	1995
In vivo efficacies of beta-lactam-beta-lactamase inhibitor combinations against a TEM-26-producing strain of Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:11 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Drug Therapy, Combination; Klebsiella pneumoniae; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1994
Synthesis and beta-lactamase inhibitory activity of 6-[(1-heteroarylthioethyl-1,2,3-triazol-4-yl)-methylene]penam sulfones. The Journal of antibiotics, 1994, Volume: 47, Issue:9 Topics: beta-Lactamase Inhibitors; Drug Synergism; Molecular Structure; Penicillanic Acid; Structure-Activity Relationship; Sulbactam; Tazobactam; Thiadiazoles	1994
Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:4 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Penicillanic Acid; Plasmids; Sulbactam; Tazobactam	1994
[Bacteremia by Escherichia coli resistant to amoxycillin/clavulanic acid, ampicillin/sulbactam and piperacillin/tazobactam]. Medicina clinica, 1994, Feb-12, Volume: 102, Issue:5 Topics: Aged; Ampicillin; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Drug Therapy, Combination; Escherichia coli; Escherichia coli Infections; Female; Humans; Penicillanic Acid; Sulbactam; Tazobactam	1994
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Cloning, Molecular; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Humans; Mutation; Penicillanic Acid; Phenotype; Sulbactam; Tazobactam	1993
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Lactams; Penicillanic Acid; Sulbactam; Tazobactam	1993
Relative efficacy of tazobactam, sulbactam and clavulanic acid in enhancing the potency of ampicillin against clinical isolates of Enterobacteriaceae. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:3 Topics: Ampicillin; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Enterobacteriaceae; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Campylobacter coli; Clavulanic Acid; Clavulanic Acids; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Selection of variants of the TEM-1 beta-lactamase, encoded by a plasmid of clinical origin, with increased resistance to beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:5 Topics: Amoxicillin; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Isoelectric Focusing; Microbial Sensitivity Tests; Mutation; Penicillanic Acid; Plasmids; Restriction Mapping; Sulbactam; Tazobactam	1993
A kinetic study of NMC-A beta-lactamase, an Ambler class A carbapenemase also hydrolyzing cephamycins. FEMS microbiology letters, 1996, Sep-15, Volume: 143, Issue:1 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Cephamycins; Clavulanic Acid; Clavulanic Acids; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Hydrolysis; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Substrate Specificity; Sulbactam; Tazobactam	1996
Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli to 12 beta-lactam agents and combinations with beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:8 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Campylobacter coli; Campylobacter jejuni; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	1996
Fixed or variable concentrations of beta-lactamase inhibitors in in-vitro tests? The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:1 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1996
Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23, Issue:5 Topics: Ampicillin; Disease Outbreaks; Drug Resistance, Microbial; Enterococcus; Enterococcus faecium; Gastrointestinal Diseases; Gram-Positive Bacterial Infections; Humans; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam; Vancomycin	1996
Importance of beta-lactamase inhibitor pharmacokinetics in the pharmacodynamics of inhibitor-drug combinations: studies with piperacillin-tazobactam and piperacillin-sulbactam. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:4 Topics: Bacteria; beta-Lactamase Inhibitors; Drug Therapy, Combination; Enzyme Inhibitors; Escherichia coli; Klebsiella; Microbial Sensitivity Tests; Models, Biological; Penicillanic Acid; Penicillins; Piperacillin; Sulbactam; Tazobactam	1997
An evaluation of the bactericidal activity of ampicillin/sulbactam, piperacillin/tazobactam, imipenem or nafcillin alone and in combination with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in time-kill curves with infected fibrin The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:4 Topics: Ampicillin; Anti-Bacterial Agents; Drug Synergism; Drug Therapy, Combination; Fibrin; Imipenem; Methicillin Resistance; Microbial Sensitivity Tests; Nafcillin; Penicillanic Acid; Penicillins; Piperacillin; Staphylococcus aureus; Sulbactam; Tazobactam; Vancomycin	1997
Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:2 Topics: Ampicillin; beta-Lactamase Inhibitors; Cefoperazone; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Retrospective Studies; Sulbactam; Tazobactam; Ticarcillin; Urinary Tract; Urinary Tract Infections	1997
Clinical inhibitor-resistant mutants of the beta-lactamase TEM-1 at amino-acid position 69. Kinetic analysis and molecular modelling. Biochimica et biophysica acta, 1998, Jan-15, Volume: 1382, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Drug Resistance, Microbial; Escherichia coli; Kinetics; Models, Molecular; Molecular Conformation; Penicillanic Acid; Protein Conformation; Sulbactam; Tazobactam	1998
Comparative in-vitro activities of GD-40 and other beta-lactamase inhibitors against TEM-1 and SHV-2 beta-lactamases. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Enzyme Inhibitors; Penicillanic Acid; Sulbactam; Tazobactam	1998
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:6 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamase Inhibitors; beta-Lactamases; Ceftazidime; Cephalosporins; Clavulanic Acid; Drug Interactions; Drug Resistance, Multiple; Enzyme Inhibitors; Isoelectric Focusing; Microbial Sensitivity Tests; Molecular Sequence Data; Monobactams; Penicillanic Acid; Providencia; Sulbactam; Tazobactam	1998
Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme. The Biochemical journal, 1998, Jul-15, Volume: 333 ( Pt 2) Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Circular Dichroism; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Isoleucine; Kinetics; Methionine; Microbial Sensitivity Tests; Penicillanic Acid; Point Mutation; Protein Conformation; Sulbactam; Tazobactam	1998
Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:9 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Structure-Activity Relationship; Sulbactam; Tazobactam	1998
[Beta-lactamase producers and other bacteria: which ones to take into consideration and when? The concept of beta-lactamase inhibitor]. Presse medicale (Paris, France : 1983), 1998, Volume: 27 Suppl 4 Topics: Anti-Bacterial Agents; Bacteria; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Haemophilus influenzae; Humans; Klebsiella; Klebsiella pneumoniae; Moraxella catarrhalis; Penicillanic Acid; Proteus vulgaris; Staphylococcus aureus; Streptococcus pneumoniae; Sulbactam; Tazobactam	1998
Interaction between class B beta-lactamases and suicide substrates of active-site serine beta-lactamases. FEBS letters, 1999, Jan-25, Volume: 443, Issue:2 Topics: beta-Lactamases; Binding Sites; Catalysis; Clavulanic Acid; Isomerism; Penicillanic Acid; Substrate Specificity; Sulbactam; Tazobactam	1999
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1999
In-vitro susceptibilities of species of the Bacteroides fragilis group to newer beta-lactam agents. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Bacteroides fragilis; beta-Lactamase Inhibitors; Cefoxitin; Ceftizoxime; Chloramphenicol; Clavulanic Acid; Clindamycin; Drug Therapy, Combination; Enzyme Inhibitors; Imipenem; Metronidazole; Mezlocillin; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Species Specificity; Sulbactam; Tazobactam; Thienamycins; Ticarcillin	1999
Penetration of beta-lactamase inhibitors into the periplasm of gram-negative bacteria. FEMS microbiology letters, 1999, Jul-01, Volume: 176, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane Permeability; Clavulanic Acid; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Klebsiella pneumoniae; Lactams; Penicillanic Acid; Periplasm; Sulbactam; Tazobactam	1999
Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors. FEBS letters, 2000, Mar-31, Volume: 470, Issue:3 Topics: Acylation; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Carbenicillin; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Escherichia coli; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Penicillanic Acid; Penicillin Resistance; Penicillinase; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Thermodynamics	2000
Comparative evaluation of the in vitro activity of three combinations of beta-lactams with beta-lactamase inhibitors: piperacillin/tazobactam, ticarcillin/clavulanic acid and ampicillin/sulbactam. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2000, Volume: 4, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Clavulanic Acid; Cross Infection; Drug Therapy, Combination; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam; Ticarcillin	2000
Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein engineering, 2000, Volume: 13, Issue:4 Topics: beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Circular Dichroism; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Sulbactam; Tazobactam	2000
Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography. Biochemistry, 2003, Nov-25, Volume: 42, Issue:46 Topics: Amines; Amino Acid Substitution; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Crystallization; Deuterium Oxide; Enzyme Inhibitors; Kinetics; Microscopy; Models, Molecular; Penicillanic Acid; Recombinant Proteins; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Water	2003
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2004
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase. The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Binding Sites; Clavulanic Acid; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Klebsiella pneumoniae; Models, Chemical; Models, Molecular; Mutation; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Time Factors; X-Rays	2005
[Dynamic analysis of drug resistance of Pseudomonas aeruginosa in laboratory and clinical two-drug regimen]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2005, Volume: 25, Issue:8 Topics: Amikacin; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Pseudomonas aeruginosa; Pseudomonas Infections; Sulbactam; Tazobactam	2005
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanic acid and sulbactam combined with ampicillin and piperacillin against beta-lactamase producing anaerobic bacteria. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl Topics: Ampicillin; Anti-Bacterial Agents; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1989
Detection of bacterial strains producing sulbactam- or tazobactam-sensitive beta-lactamases by the use of disks containing the inhibitors alone instead of combining them with antibiotics. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Enterobacteriaceae; Enzyme Inhibitors; Klebsiella pneumoniae; Microbial Sensitivity Tests; Morganella morganii; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2006
[The combination effects of antibacterial agents against clinical isolated multiple-drug resistant Pseudomonas aeruginosa]. The Japanese journal of antibiotics, 2006, Volume: 59, Issue:1 Topics: Amikacin; Anti-Bacterial Agents; Aztreonam; Cefepime; Cefoperazone; Cephalosporins; Ciprofloxacin; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Humans; Meropenem; Microbial Sensitivity Tests; Oxazines; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Thienamycins	2006
In vitro activities of various piperacillin and sulbactam combinations against bacterial pathogens isolated from Intensive Care Units in Taiwan: SMART 2004 programme data. International journal of antimicrobial agents, 2007, Volume: 29, Issue:2 Topics: Bacteria; Cefoperazone; Drug Combinations; Humans; Intensive Care Units; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2007
In vitro efficacy of ceftriaxone/sulbactam against Escherichia coli isolates producing CTX-M-15 extended-spectrum beta-lactamase. The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Ceftriaxone; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Escherichia coli; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2007
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase. Biochemistry, 2007, Aug-07, Volume: 46, Issue:31 Topics: Acrylates; Amino Acid Substitution; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallization; Enzyme Inhibitors; Imines; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam	2007
Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry, 2008, Apr-01, Volume: 47, Issue:13 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Crystallography; Enzyme Inhibitors; Penicillanic Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis, Raman; Sulbactam; Tazobactam	2008
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence. Journal of the American Chemical Society, 2009, Feb-18, Volume: 131, Issue:6 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Imines; Penicillanic Acid; Quantum Theory; Spectrum Analysis, Raman; Sulbactam; Tazobactam	2009
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. The new microbiologica, 2009, Volume: 32, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2009
Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: beta-Lactamase Inhibitors; Boronic Acids; Cefoperazone; Ceftazidime; Clavulanic Acid; Enzyme Inhibitors; Klebsiella pneumoniae; Magnetic Resonance Spectroscopy; Penicillanic Acid; Sulbactam; Tazobactam	2011
Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli Proteins; Kinetics; Meropenem; Molecular Dynamics Simulation; Molecular Structure; Penicillanic Acid; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulbactam; Tazobactam; Thienamycins	2011
Antibiotic utilization and Pseudomonas aeruginosa resistance in intensive care units. The new microbiologica, 2011, Volume: 34, Issue:3 Topics: Amikacin; Anti-Bacterial Agents; Cefoperazone; Ceftazidime; Ciprofloxacin; Czech Republic; Drug Resistance, Multiple, Bacterial; Gentamicins; Intensive Care Units; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sulbactam; Tazobactam	2011
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Purification and characterization of OXA-23 from Acinetobacter baumannii. Journal of enzyme inhibition and medicinal chemistry, 2013, Volume: 28, Issue:4 Topics: Acinetobacter baumannii; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Escherichia coli; Kinetics; Models, Molecular; Penicillanic Acid; Structure-Activity Relationship; Substrate Specificity; Sulbactam; Surface Properties; Tazobactam	2013
Why tazobactam and sulbactam have different intermediates population with SHV-1 β-lactamase: a molecular dynamics study. Journal of molecular modeling, 2013, Volume: 19, Issue:6 Topics: Anti-Bacterial Agents; beta-Lactamases; Catalytic Domain; Hydrogen Bonding; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Penicillanic Acid; Protein Binding; Sulbactam; Tazobactam	2013
Comparative in-vitro activity of cefoperazone-tazobactam and cefoperazone-sulbactam combinations against ESBL pathogens in respiratory and urinary infections. The Journal of the Association of Physicians of India, 2012, Volume: 60 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; Cefoperazone; Cephalosporin Resistance; Disk Diffusion Antimicrobial Tests; Drug Combinations; Humans; India; Penicillanic Acid; Respiratory Tract Infections; Sulbactam; Tazobactam; Urinary Tract Infections	2012
Genetic and kinetic characterization of the novel AmpC β-lactamases DHA-6 and DHA-7. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Clavulanic Acid; Enterobacter cloacae; Escherichia coli; Humans; Klebsiella oxytoca; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2014
Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis. The British journal of dermatology, 2016, Volume: 175, Issue:5 Topics: Aged; Ampicillin; Anti-Bacterial Agents; Drug Combinations; Drug Eruptions; Female; Humans; Linear IgA Bullous Dermatosis; Lymphocyte Activation; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2016
A prospective evaluation of synergistic effect of sulbactam and tazobactam combination with meropenem or colistin against multidrug resistant Acinetobacter baumannii. Bosnian journal of basic medical sciences, 2015, Oct-14, Volume: 15, Issue:4 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Colistin; Drug Combinations; Drug Resistance, Bacterial; Drug Synergism; Humans; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Prospective Studies; Sulbactam; Tazobactam; Thienamycins	2015
β-Lactamase Inhibitors Enhance the Synergy between β-Lactam Antibiotics and Daptomycin against Methicillin-Resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Daptomycin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2017
General Method to Determine the Flux of Charged Molecules through Nanopores Applied to β-Lactamase Inhibitors and OmpF. The journal of physical chemistry letters, 2017, Mar-16, Volume: 8, Issue:6 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; Membrane Potentials; Molecular Dynamics Simulation; Nanopores; Penicillanic Acid; Sulbactam; Tazobactam	2017
Genetic and Functional Characterization of Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Conjugation, Genetic; Kinetics; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Sulbactam; Tazobactam	2017
Antibiotics susceptibility patterns of uropathogenic E. coli with special reference to fluoroquinolones in different age and gender groups. JPMA. The Journal of the Pakistan Medical Association, 2017, Volume: 67, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; Cefoperazone; Child; Child, Preschool; Cross-Sectional Studies; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Fluoroquinolones; Humans; Imipenem; Infant; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Sulbactam; Tazobactam; Urinary Tract Infections; Young Adult	2017
New Conformations of Acylation Adducts of Inhibitors of β-Lactamase from Mycobacterium tuberculosis. Biochemistry, 2019, 02-19, Volume: 58, Issue:7 Topics: Acylation; Aldehydes; Amino Acid Substitution; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallography, X-Ray; Mycobacterium tuberculosis; Protein Conformation; Serine; Sulbactam; Tazobactam	2019
Cefoperazone-sulbactam and risk of coagulation disorders or bleeding: a retrospective cohort study. Expert opinion on drug safety, 2020, Volume: 19, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Blood Coagulation Disorders; Blood Platelets; Cefoperazone; Ceftazidime; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Prothrombin Time; Sulbactam; Tazobactam; Young Adult	2020
Unorthodox Parenteral β-Lactam and β-Lactamase Inhibitor Combinations: Flouting Antimicrobial Stewardship and Compromising Patient Care. Antimicrobial agents and chemotherapy, 2020, 04-21, Volume: 64, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Antimicrobial Stewardship; beta-Lactamase Inhibitors; Cephalosporins; China; Drug Combinations; Drug Misuse; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Inappropriate Prescribing; India; Microbial Sensitivity Tests; Patient Care; Pseudomonas aeruginosa; Pseudomonas Infections; Sulbactam; Tazobactam	2020
Comparison of antibiotic-associated diarrhea caused by cefoperazone/sulbactam or piperacillin/tazobactam in neurosurgery patients. The Journal of international medical research, 2021, Volume: 49, Issue:5 Topics: Anti-Bacterial Agents; Cefoperazone; Diarrhea; Humans; Microbial Sensitivity Tests; Neurosurgery; Penicillanic Acid; Piperacillin; Retrospective Studies; Sulbactam; Tazobactam	2021
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition. mBio, 2022, 06-28, Volume: 13, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Lysine; Microbial Sensitivity Tests; Serine; Sulbactam; Tazobactam	2022
Molecular and Kinetic Characterization of MOX-9, a Plasmid-Mediated Enzyme Representative of a Novel Sublineage of MOX-Type Class C β-Lactamases. Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9 Topics: Bacterial Proteins; beta-Lactamases; Cephalosporins; Clavulanic Acid; Kinetics; Plasmids; Sulbactam; Tazobactam	2022
Analysis of a novel class A β-lactamase OKP-B-6 of Klebsiella quasipneumoniae: structural characterisation and interaction with commercially available drugs. Memorias do Instituto Oswaldo Cruz, 2022, Volume: 117 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Klebsiella; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Docking Simulation; Sulbactam; Sulfhydryl Reagents; Tazobactam	2022
Prevalence of S. aureus and/or MRSA from seafood products from Indian seafood products. BMC microbiology, 2022, 10-01, Volume: 22, Issue:1 Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cefoxitin; Gentamicins; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Multilocus Sequence Typing; Ofloxacin; Piperacillin; Prevalence; Rifampin; Seafood; Serine; Staphylococcal Infections; Staphylococcus aureus; Sulbactam; Tazobactam; Trimethoprim, Sulfamethoxazole Drug Combination; Virulence Factors	2022
Characteristics of and antibiotic resistance in urinary tract pathogens isolated from patients with upper urinary tract stones. Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:1 Topics: Aged; Amikacin; Anti-Bacterial Agents; Cefoperazone; Drug Resistance, Bacterial; Drug Resistance, Microbial; Escherichia coli; Female; Humans; Male; Microbial Sensitivity Tests; Piperacillin; Sulbactam; Tazobactam; Urinary Calculi; Urinary Tract; Urinary Tract Infections	2023
Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients. Scientific reports, 2023, 06-09, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cefuroxime; Colorectal Neoplasms; Humans; Metronidazole; Mezlocillin; Piperacillin; Retrospective Studies; Sulbactam; Surgical Wound Infection; Tazobactam	2023