Compounds > tazobactam
Page last updated: 2024-09-03

tazobactam and serine

tazobactam has been researched along with serine in 12 studies

Compound Research Comparison

Studies
(tazobactam)		Trials
(tazobactam)		Recent Studies (post-2010)
(tazobactam)		Studies
(serine)		Trials
(serine)		Recent Studies (post-2010) (serine)
1,32715369423,9141156,084

Protein Interaction Comparison

ProteinTaxonomytazobactam (IC50)serine (IC50)
AcetylcholinesteraseElectrophorus electricus (electric eel)0.015
CholinesteraseEquus caballus (horse)0.016

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (58.33)29.6817
2010's1 (8.33)24.3611
2020's4 (33.33)2.80

Authors

AuthorsStudies
Amicosante, G; Bianchi, C; Bonfiglio, G; Franceschini, N; Nicoletti, G; Perez, MM; Perilli, M; Segatore, B; Stefani, S; Zollo, A1
Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM1
Anderson, VE; Bethel, CR; Bonomo, RA; Guo, B; Helfand, MS; Hujer, AM; Jin, Z; Ng, LM; Pagan-Rodriguez, D; Simmons, R; Zhou, X1
Bethel, CR; Bonomo, RA; Knox, JR; Sun, T1
Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Padayatti, PS; Totir, MA; van den Akker, F1
Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F1
Bonomo, RA; Buynak, JD; Carey, MP; Carey, PR; Helfand, MS; Sheri, A; Totir, MA1
Blok, A; Pannu, NS; Tassoni, R; Ubbink, M1
Abdelraouf, K; Gill, CM; Nicolau, DP1
Arthur, C; Bethel, CR; Bonomo, RA; Heesom, KJ; Hinchliffe, P; Papp-Wallace, KM; Schlatzer, DM; Shapiro, S; Spencer, J; Tooke, CL; Wang, B1
Bachta, KER; Bertucci, HK; Brunzelle, JS; Gatesy, SWM; Hauser, AR; Lebrun-Corbin, M; Minasov, G; Ozer, EA; Pincus, NB; Rosas-Lemus, M; Satchell, KJF; Shuvalova, LA1
Balasubramanium, G; Elangovan, R; Gupta, SS; Lodha, T; Muthulakshmi, T; Perumal, V; Sivaraman, GK; Visnuvinayagam, S; Yadav, A1

Other Studies

12 other study(ies) available for tazobactam and serine

ArticleYear
A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases.
    Journal of enzyme inhibition, 2000, Volume: 15, Issue:1

    Topics: Acinetobacter; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Citrobacter; Enzyme Inhibitors; Escherichia coli; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Morganella; Mycobacterium fortuitum; Penicillanic Acid; Providencia; Pseudomonas aeruginosa; Serine; Serratia marcescens; Tazobactam

2000
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors

2003
Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition.
    The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19

    Topics: beta-Lactamases; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Kinetics; Mass Spectrometry; Models, Chemical; Penicillanic Acid; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tazobactam; Trypsin

2004
Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.
    Biochemistry, 2004, Nov-09, Volume: 43, Issue:44

    Topics: Alanine; Amino Acid Substitution; Apoenzymes; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli Proteins; Genetic Variation; Glutamic Acid; Glycine; Hydrolysis; Models, Molecular; Mutagenesis, Site-Directed; Penicillanic Acid; Serine; Tazobactam

2004
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.
    The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Binding Sites; Clavulanic Acid; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Klebsiella pneumoniae; Models, Chemical; Models, Molecular; Mutation; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Time Factors; X-Rays

2005
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
    Biochemistry, 2007, Jul-24, Volume: 46, Issue:29

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam

2007
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.
    Biochemistry, 2007, Aug-07, Volume: 46, Issue:31

    Topics: Acrylates; Amino Acid Substitution; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallization; Enzyme Inhibitors; Imines; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam

2007
New Conformations of Acylation Adducts of Inhibitors of β-Lactamase from Mycobacterium tuberculosis.
    Biochemistry, 2019, 02-19, Volume: 58, Issue:7

    Topics: Acylation; Aldehydes; Amino Acid Substitution; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallography, X-Ray; Mycobacterium tuberculosis; Protein Conformation; Serine; Sulbactam; Tazobactam

2019
In vivo activity of WCK 4282 (high-dose cefepime/tazobactam) against serine β-lactamase-producing Enterobacterales and Pseudomonas aeruginosa in the neutropenic murine thigh infection model.
    The Journal of antimicrobial chemotherapy, 2021, 03-12, Volume: 76, Issue:4

    Topics: Animals; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Escherichia coli; Mice; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Serine; Tazobactam; Thigh

2021
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition.
    mBio, 2022, 06-28, Volume: 13, Issue:3

    Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Lysine; Microbial Sensitivity Tests; Serine; Sulbactam; Tazobactam

2022
Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family β-Lactamase from Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2022, 10-18, Volume: 66, Issue:10

    Topics: Anti-Bacterial Agents; Aspartic Acid; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Ceftazidime; Cephalosporinase; Cephalosporins; Glycine; Humans; Microbial Sensitivity Tests; Phenylalanine; Pseudomonas aeruginosa; Pseudomonas Infections; Serine; Tazobactam

2022
Prevalence of S. aureus and/or MRSA from seafood products from Indian seafood products.
    BMC microbiology, 2022, 10-01, Volume: 22, Issue:1

    Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cefoxitin; Gentamicins; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Multilocus Sequence Typing; Ofloxacin; Piperacillin; Prevalence; Rifampin; Seafood; Serine; Staphylococcal Infections; Staphylococcus aureus; Sulbactam; Tazobactam; Trimethoprim, Sulfamethoxazole Drug Combination; Virulence Factors

2022