Page last updated: 2024-09-03

tazobactam and clavulanic acid

tazobactam has been researched along with clavulanic acid in 145 studies

Compound Research Comparison

Studies (tazobactam)	Trials (tazobactam)	Recent Studies (post-2010) (tazobactam)	Studies (clavulanic acid)	Trials (clavulanic acid)	Recent Studies (post-2010) (clavulanic acid)
1,327	153	694	1,801	212	424

Protein Interaction Comparison

Protein	Taxonomy	clavulanic acid (IC50)
Beta-lactamase	Klebsiella pneumoniae	1.72
Beta-lactamase	Escherichia coli	0.07
Beta-lactamase	Citrobacter gillenii	0.009
Beta-lactamase	Shouchella clausii	0.085
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Staphylococcus aureus	0.08
Beta-lactamase	Escherichia coli K-12	0.015
Beta-lactamase SHV-1	Escherichia coli	0.028
Beta-lactamase SHV-1	Klebsiella pneumoniae	0.17
Beta-lactamase OXA-1	Escherichia coli	3.2
Cytochrome P450 2B6	Homo sapiens (human)	0.17
Beta-lactamase	Pseudomonas aeruginosa PAO1	0.8
Beta-lactamase TEM	Escherichia coli	0.0933
Beta-lactamase	Salmonella enterica subsp. enterica serovar Westhampton	0.01
Beta-lactamase	Pseudomonas aeruginosa	0.1
Beta-lactamase	Klebsiella pneumoniae	0.02
Class D beta-lactamase	Brachyspira pilosicoli	2
Beta-lactamase	Pseudomonas luteola	0.036
Beta-lactamase	Escherichia coli	8.6
Beta-lactamase	Escherichia coli	0.009

Research

Studies (145)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (6.90)	18.7374
1990's	53 (36.55)	18.2507
2000's	45 (31.03)	29.6817
2010's	29 (20.00)	24.3611
2020's	8 (5.52)	2.80

Authors

Authors	Studies
Bonnet, R; Chanal, C; Delmas, J; Lesens, O; Robin, F; Schweitzer, C; Tournilhac, O	1
Aubert, D; Naas, T; Nordmann, P; Ozcan, A	1
Arlet, G; Loli, A; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Cattoir, V; Corvec, S; Drugeon, H; Faccone, D; Galas, M; Mugnier, P; Nordmann, P; Pasteran, F; Petroni, A; Poirel, L; Rapoport, M	1
Bush, K; Kania, M; Page, MG; Queenan, AM; Shang, W	1
Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Anderluh, PS; Andrejasic, M; Copar, A; Hesse, L; Kocijan, A; Kocjan, D; Mesar, T; Oblak, M; Plantan, I; Prevec, T; Prezelj, A; Selic, L; Solmajer, T; Turk, D; Urleb, U; Vilar, M; Vilfan, G	1
Bonnet, R; Brebion, A; Constantin, JM; Delmas, J; Dubois, D; Robin, F	1
Girlich, D; Leclercq, R; Naas, T; Nordmann, P	1
Correia, A; Domingues, MR; Domingues, P; Fonseca, F; Henriques, I; Saavedra, MJ; Samyn, B; Sarmento, AC; van Beeumen, J	1
Bonnet, R; Neuwirth, C; Robin, F; Siebor, E	1
Courvalin, P; Decré, D; Høiby, EA; Meziane-Cherif, D; Périchon, B	1
Courvalin, P; Dupêchez, M; Galimand, M; Lambert, T; Meziane-Cherif, D	1
Bonnet, R; Caniça, M; Ferreira, E; Manageiro, V; Mendonça, N; Robin, F; Salgado, MJ	1
Castanheira, M; Samuelsen, Ø; Spencer, J; Walsh, TR	1
Hesse, L; Paukner, S; Prezelj, A; Solmajer, T; Urleb, U	1
Bonnet, R; Brisabois, A; Cloeckaert, A; Doublet, B; Fabre, L; Granier, SA; Robin, F; Weill, FX	1
Chanteperdrix, V; Croizé, J; Nordmann, P; Poirel, L; Potron, A	1
Ghori, S; Griggs, DJ; Johnson, MM; Mott, A; Peake, L; Piddock, LJ	1
Bonnet, R; Casin, I; Doublet, B; Fabre, L; Le Fleche, A; Robin, F; Weill, FX	1
De Luca, F; Docquier, JD; Ide, L; Nordmann, P; Poirel, L; Rossolini, GM; Verlinde, A	1
Girlich, D; Nordmann, P; Poirel, L	1
Bethel, CR; Bonomo, RA; Distler, AM; Kasuboski, C; Papp-Wallace, KM; Taracila, M	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Kotsakis, SD; Legakis, NJ; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Anderson, VE; Bethel, CR; Bonomo, RA; Buynak, JD; Chen, SG; Doppalapudi, VR; Drawz, SM; Hujer, AM; Pagadala, SR; Sheri, A; Skalweit, MJ	1
Bonomo, RA; Distler, AM; Endimiani, A; Hornick, JM; Hujer, AM; Hujer, KM; Papp-Wallace, KM; Taracila, M	1
Kotsakis, SD; Miriagou, V; Tzelepi, E; Tzouvelekis, LS	1
Black, MT; Bruneau, JM; Claudon, M; Coleman, K; Frère, JM; Miossec, C; Péchereau, MC; Stachyra, T	1
Bethel, CR; Bonomo, RA; Caselli, E; Drawz, SM; Dwulit-Smith, JR; Papp-Wallace, KM; Prati, F; Rodkey, EA; Romagnoli, C; Smith, KM; Taracila, MA; van den Akker, F; Winkler, ML; Xu, Y	1
Bethel, CR; Bonomo, RA; Buynak, JD; Carey, PR; Chai, W; Che, T; Ding, Z; Nottingham, M; Pusztai-Carey, M; Rodkey, EA; Shanmugam, S; van den Akker, F	1
Abendroth, J; Atkins, K; Boyer, SH; Clifton, MC; Dudley, MN; Durso, S; Griffith, DC; Hecker, SJ; Hirst, GC; King, P; Lomovskaya, O; Loutit, JS; Morgan, EE; Potts, KT; Raymond, A; Reddy, KR; Sabet, M; Sun, D; Tarazi, Z; Totrov, M; Tsivkovski, R	1
Benvenuti, M; Burns, CJ; Chu, GH; Cusick, SM; Daigle, DM; De Luca, F; Docquier, JD; Hamrick, JC; Jackson, RW; Liu, B; Mangani, S; McGarry, D; Pevear, DC; Pozzi, C; Trout, REL; Weiss, WJ; Xerri, L	1
Bonomo, RA; Currie-McCumber, C; Shlaes, DM	1
Hedberg, M; Lindqvist, L; Nord, CE; Tunér, K	2
Aspinall, S; Corkill, JE; Hart, CA; McLennan, AG	1
Kunii, O; Miyashita, T; Ono, Y	1
Cullmann, W	2
Akova, M; Livermore, DM; Yang, Y	1
Kempers, J; MacLaren, DM	1
Acar, JF; Coutrot, A; Ferré, B; Gutmann, L; Kitzis, MD	1
Jacobus, NV; Kuck, NA; Petersen, PJ; Testa, RT; Weiss, WJ	1
Adachi, K; Ueda, S; Watanabe, M; Yamabe, S	1
Moosdeen, F; Williams, J; Yamabe, S	1
Aronoff, SC; Jacobs, MR; Johenning, S; Shlaes, DM; Yamabe, S	1
Aronoff, SC; Jacobs, MR; Labrozzi, PH; Yamabe, S	1
Appelbaum, PC; Jacobs, MR; Spangler, SK; Yamabe, S	1
Hall, TW; Ishida, N; Maiti, SN; Micetich, RG; Nakai, A; Ogawa, K; Spevak, P; Tanaka, M; Yamabe, S; Yamazaki, T	1
Aronoff, SC; Jacobs, MR; Johenning, S; Yamabe, S	1
Arakawa, Y; Horii, T; Ito, H; Ohsuka, S; Ohta, M	1
File, TM; Tan, JS	1
Duval, J; Leclercq, R	1
Jones, R; Satishchandran, V; Shapiro, T; Suh, B; Truant, AL	1
Chang, SC; Hsieh, WC; Luh, KT	1
Amyes, SG; London, N; Stobberingh, E; Thomson, CJ	1
Harris, EB; Hastings, RC; Prabhakaran, K; Randhawa, B	1
Cramp, R; Knowles, DJ; Payne, DJ; Winstanley, DJ	1
Aldridge, KE	1
Alós, JI; Gómez-Garcés, JL; Mateos, MV	1
Baquero, F; Reig, M	1
Edelstein, MA; Edelstein, PH	1
Duchateau, V; Husson, M; Kinzig, M; Lambert, C; Sörgel, F; Van der Auwera, P	1
Alos, I; Baquero, F; Baquero, MR; Blazquez, J; Canton, R	1
Inoue, E; Mitsuhashi, S; Muratani, T; Nakane, T; Yokota, E	1
Jin, YF; Piddock, LJ; Turner, HL	1
Bush, K; Lee, VJ; Macalintal, C; Rasmussen, BA; Yang, Y	1
Barry, A; Fuchs, P; Gerlach, E; Hardy, D; McLaughlin, J; Pfaller, M	1
Gaudreau, C; Lachance, N; Lamothe, F; Turgeon, F	1
Amyes, SG; Thomson, CJ	1
Amicosante, G; Franceschini, N; Oratore, A; Perilli, M; Segatore, B; Setacci, D	1
Labia, R; Mariotte-Boyer, S; Nicolas-Chanoine, MH	1
Alonso, JM; Fournier, JL; Jacolot, AC; Petitjean, OJ; Ramisse, F; Scavizzi, MR; Szatanik, M	1
Alós, JI; Balas, D; Cogollos, R; Gomez-Graces, JL; Tajada, P	1
Greenwood, D	1
Livermore, DM; Yuan, M	1
Knapp, CC; Ludwig, MD; Pohlman, JK; Washington, JA	1
Klepser, ME; Marangos, MN; Nicolau, DP; Nightingale, CH; Quintiliani, R; Zhu, Z	1
Blumer, JL; Bonafede, ME	1
Bonomo, RA; Rudin, SA; Shlaes, DM	1
Hanaki, H; Nagayama, A; Nomura, S	1
Constantoulaki, S; Paniara, O; Platsouka, E; Zissis, NP	1
Barthélémy, M; Chaibi, EB; Farzaneh, S; Labia, R; Péduzzi, J; Sirot, D	1
Calcagno, ML; Danelon, G; Gutkind, G; Mascaretti, O; Mata, EG; Power, P; Radice, M	1
Amicosante, G; Cornaglia, G; Franceschini, N; Mazzariol, A; Perilli, M; Segatore, B; Setacci, D	1
Anderson, V; Bonomo, RA; Knox, JR; Lin, S; Rudin, SD; Shlaes, DM; Thomas, M	1
Jarlier, V	1
de Seny, D; Frere, JM; Galleni, M; Laraki, N; Llabres, G; Prosperi-Meys, C; Soto, RP; Valladares, MH	1
de la Pena, A; Derendorf, H	1
Gardner, VM; Lister, PD; Sanders, CC	1
Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS	1
Betriu, C; Gómez, M; Palau, ML; Picazo, JJ; Sánchez, A	1
Degnan, BA; Farmer, TH; Payne, DJ	1
Kotra, LP; Levesque, RC; Mobashery, S; Sanschagrin, F; Therrien, C	1
Miranda, E; Sader, HS; Sejas, L; Tosin, I	1
Levesque, RC; Palzkill, T; Sanschagrin, F; Savoie, A; Voyer, N	1
Lister, PD	1
Bonnaure-Mallet, M; Buffet, A; Cormier, M; David, S; Dupuy, C; Jolivet-Gougeon, A; Sixou, JL	1
Amicosante, G; Belloni, R; Bianchi, C; Lombardi, G; Luzzaro, F; Perilli, M; Toniolo, A; Zollo, A	1
Chen, Y; Gao, L; Hou, F; Li, J	1
Niki, Y	1
Mealey, KL	1
Bukowski, K; Jakubczak, A; Wolska, MK	1
Nakano, R; Okamoto, R	1
Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM	1
Fosse, T; Giraud-Morin, C; Madinier, I	1
Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Hujer, AM; Totir, MA	1
Beharry, Z; Buynak, JD; Chen, H; Gadhachanda, VR; Palzkill, T	1
Higgins, PG; Seifert, H; Stefanik, D; Wisplinghoff, H	1
Høiby, N; Walther-Rasmussen, J	1
Bonnefoy, A; Delachaume, C; Dupuis-Hamelin, C; Fairley, M; Guitton, M; Lampilas, M; Seys, C; Stachyra, T; Steier, V	1
Ashkenazi, S; Bishara, J; Lev, B; Levy, I; Livne, G; Ofir, O; Pitlik, S; Samra, Z	1
Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Padayatti, PS; Totir, MA; van den Akker, F	1
Nord, CE	1
Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F	1
Bonomo, RA; Buynak, JD; Carey, MP; Carey, PR; Helfand, MS; Sheri, A; Totir, MA	1
Anuradha, K; Lakshmi, V; Sailaja, VV; Satheesh, T; Umabala, P	1
Buynak, JD; Carey, PR; Kalp, M; Totir, MA	1
Bleeker-Rovers, CP; Koopman, M; Mannaerts, L; Punt, CJ; van Herpen, CM	1
Albertí, S; Juan, C; Mulet, X; Oliver, A; Pérez, JL; Zamorano, L	1
Bonnin, RA; Lecuyer, H; Nordmann, P; Poirel, L; Potron, A; Zahar, JR	1
Bethel, CR; Bonomo, RA; Drawz, SM; Ke, W; Ori, C; Prati, F; Sampson, JM; van den Akker, F	1
Bethel, CR; Bonnet, R; Bonomo, RA; Distler, AM; Endimiani, A; Hujer, AM; Hujer, KM; Papp-Wallace, K; Shyr, T; Taracila, M; Thomson, JM	1
Baquero, F; Cantón, R; Galán, JC; Novais, A; Ripoll, A; Rodríguez-Domínguez, MJ; Turrientes, MC	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Kasap, M; Torol, S	1
Holzgrabe, U	1
Bethel, CR; Bonomo, RA; Carey, PR; de Boer, PA; Heidari Torkabadi, H; Papp-Wallace, KM	1
Beceiro, A; Bou, G; Galleni, M; García, P; Gómez-Bertomeu, F; González-López, JJ; Kerff, F; Larrosa, N; Méndez, JA; Miró, E; Navarro, F; Oliver, A; Pérez-Llarena, FJ; Zamorano, L	1
Abbas, S; Dortet, L; Nordmann, P; Oueslati, S; Poirel, L	1
Botes, J; Boutlis, CS; Glasgow, AL; Jones, SL; Riordan, JW	1
Boyd, D; Carpenter, M; Desruisseau, A; Janecko, N; Mangat, CS; Martz, SL; Mulvey, MR; Reid-Smith, RJ	1
Baumert, P; Feihl, S; Gastmeier, P; Gebhardt, F; Gölz, H; Hamprecht, A; Kern, WV; Knobloch, J; Kola, A; Mischnik, A; Obermann, B; Peter, S; Querbach, C; Rohde, A; Seifert, H; Tacconelli, E; Willmann, M	1
Chen, Y; Guo, P; Yu, G; Yue, C	1
Ledger, TS	1
Amicosante, G; Conte, V; Giani, T; Perilli, M; Piccirilli, A; Rossolini, GM; Tascini, C	1
Blok, A; Pannu, NS; Tassoni, R; Ubbink, M	1
Cardoso, MH; Costa, BO; Franco, OL	1
Deligios, M; Fiamma, M; Paglietti, B; Rubino, S; Sacarlal, J; Santona, A; Simbine, SE; Sumbana, JJ; Taviani, E; Zimba, T	1
Antonelli, A; Cherubini, S; D'Andrea, MM; Perilli, M; Piccirilli, A; Rossolini, GM	1
Adair, K; Ariza, A; Jaruthamsophon, K; Labella, M; Meng, X; Naisbitt, DJ; Peckham, D; Pirmohamed, M; Sukasem, C; Tailor, A; Torres, MJ; Whitaker, P	1
Arenere-Mendoza, M; Fernández-de-Gamarra-Martínez, E; Fernández-Polo, A; González-Suárez, S; Gutiérrez-Urbón, JM; Nicolás-Picó, J; Rodríguez-Mateos, ME; Sánchez-Yáñez, E	1
Caljon, B; Crombé, F; De Geyter, D; Demuyser, T; Janssen, T; Muyldermans, A; Piérard, D; Seyler, L; Vanstokstraeten, R; Wybo, I	1
Dalğıç, D; Kandemir, T; Nağıyev, T; Üçkayabaşı, A	1

Reviews

9 review(s) available for tazobactam and clavulanic acid

Article	Year
Efficacy and safety of piperacillin/tazobactam in skin and soft tissue infections. The European journal of surgery. Supplement. : = Acta chirurgica. Supplement, 1994, Issue:573 Topics: Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Necrosis; Penicillanic Acid; Piperacillin; Skin Diseases, Bacterial; Soft Tissue Infections; Tazobactam; Ticarcillin	1994
Role of newer broad-spectrum beta-lactam and fluoroquinolone antibiotics in children. Advances in pediatric infectious diseases, 1996, Volume: 12 Topics: Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Carbapenems; Cephalosporins; Child; Child, Preschool; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Enzyme Inhibitors; Fluoroquinolones; Humans; Molecular Structure; Penicillanic Acid; Penicillins; Piperacillin; Tazobactam; Ticarcillin	1996
Pharmacokinetic properties of beta-lactamase inhibitors. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:2 Topics: Absorption; Aging; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Biological Availability; Clavulanic Acid; Drug Synergism; Enzyme Inhibitors; Half-Life; Humans; Kidney Diseases; Penicillanic Acid; Sulbactam; Tazobactam	1999
Beta-lactamase inhibitor combinations with extended-spectrum penicillins: factors influencing antibacterial activity against enterobacteriaceae and Pseudomonas aeruginosa. Pharmacotherapy, 2000, Volume: 20, Issue:9 Pt 2 Topics: beta-Lactamases; Clavulanic Acid; Drug Therapy, Combination; Enterobacteriaceae; Enzyme Inhibitors; Penicillanic Acid; Penicillin Resistance; Piperacillin; Pseudomonas aeruginosa; Tazobactam; Ticarcillin	2000
[Fundamental and clinical studies on beta-lactamase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:4 Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2001
Penicillins and beta-lactamase inhibitor combinations. Journal of the American Veterinary Medical Association, 2001, Jun-15, Volume: 218, Issue:12 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Drug Resistance, Microbial; Drug Therapy, Combination; Enzyme Inhibitors; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	2001
[beta-Lactamase-inhibitor combinations]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 3 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Drug Design; Drug Resistance, Bacterial; Drug Therapy, Combination; Humans; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	2003
Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases. Canadian journal of microbiology, 2004, Volume: 50, Issue:3 Topics: beta-Lactamases; Cefotaxime; Cephalosporins; Clavulanic Acid; Drug Resistance, Bacterial; Enterobacteriaceae; Enzyme Inhibitors; Gene Transfer, Horizontal; Monobactams; Penicillanic Acid; Penicillins; Phylogeny; Sulbactam; Tazobactam	2004
Development of Peptides that Inhibit Aminoglycoside-Modifying Enzymes and β-Lactamases for Control of Resistant Bacteria. Current protein & peptide science, 2020, Volume: 21, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Infections; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Design; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Kanamycin Kinase; Nucleotidyltransferases; Sulbactam; Tazobactam	2020

Trials

2 trial(s) available for tazobactam and clavulanic acid

Article	Year
Comparison of the bactericidal activities of piperacillin-tazobactam, ticarcillin-clavulanate, and ampicillin-sulbactam against clinical isolates of Bacteroides fragilis, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2 Topics: Adult; Ampicillin; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Cross-Over Studies; Drug Therapy, Combination; Enterococcus faecalis; Escherichia coli; Female; Humans; Male; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Serum Bactericidal Test; Sulbactam; Tazobactam; Ticarcillin	1997
A randomized controlled clinical trial on piperacillin/tazobactam versus ticarcillin/clavulanic acid for the treatment of bacterial infections. Chinese medical journal, 1998, Volume: 111, Issue:11 Topics: Adolescent; Adult; Anti-Bacterial Agents; Clavulanic Acid; Drug Therapy, Combination; Enzyme Inhibitors; Escherichia coli Infections; Female; Humans; Male; Penicillanic Acid; Penicillins; Piperacillin; Pneumonia; Respiratory Tract Infections; Tazobactam; Ticarcillin; Urinary Tract Infections	1998

Article

Year

Comparison of the bactericidal activities of piperacillin-tazobactam, ticarcillin-clavulanate, and ampicillin-sulbactam against clinical isolates of Bacteroides fragilis, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2

Topics: Adult; Ampicillin; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Cross-Over Studies; Drug Therapy, Combination; Enterococcus faecalis; Escherichia coli; Female; Humans; Male; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Serum Bactericidal Test; Sulbactam; Tazobactam; Ticarcillin

1997

A randomized controlled clinical trial on piperacillin/tazobactam versus ticarcillin/clavulanic acid for the treatment of bacterial infections.

Chinese medical journal, 1998, Volume: 111, Issue:11

Topics: Adolescent; Adult; Anti-Bacterial Agents; Clavulanic Acid; Drug Therapy, Combination; Enzyme Inhibitors; Escherichia coli Infections; Female; Humans; Male; Penicillanic Acid; Penicillins; Piperacillin; Pneumonia; Respiratory Tract Infections; Tazobactam; Ticarcillin; Urinary Tract Infections

1998

Other Studies

134 other study(ies) available for tazobactam and clavulanic acid

Article	Year
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Evolution, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation	2007
Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: beta-Lactamases; Chromosomes; Chromosomes, Bacterial; Citrobacter; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genes, Bacterial; Molecular Sequence Data	2007
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Escherichia coli; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillinase; Plasmids; Sequence Analysis, DNA	2007
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Acinetobacter; Acinetobacter Infections; Amino Acid Sequence; Anti-Bacterial Agents; Argentina; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Cloning, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Hydrolysis; Kinetics; Microbial Sensitivity Tests; Spectrophotometry, Ultraviolet	2007
Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Anti-Bacterial Agents; Cephalosporinase; Culture Media; DNA Primers; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Spectrophotometry, Ultraviolet	2007
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity. Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17 Topics: Acylation; Anti-Bacterial Agents; Azetidines; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Crystallography, X-Ray; Drug Resistance, Bacterial; Enterobacter cloacae; Heterocyclic Compounds, 3-Ring; Models, Molecular; Molecular Structure; Stereoisomerism; Structure-Activity Relationship	2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Catalysis; Ceftazidime; Clavulanic Acid; Escherichia coli; Escherichia coli Proteins; Isoenzymes; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; beta-Lactamases; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Sequence Homology, Amino Acid; Substrate Specificity	2007
Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Aztreonam; beta-Lactamases; Carbapenems; Catalysis; Cephalosporins; Clavulanic Acid; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrolysis; Kinetics; Molecular Weight; Penicillanic Acid; Penicillins; Recombinant Proteins; Serratia; Sulbactam; Tazobactam	2007
First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Aeromonas; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; France; Integrons; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Sequence Analysis, DNA; Substrate Specificity	2007
Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Amino Acid Sequence; beta-Lactams; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillinase; Sequence Alignment; Sequence Analysis, DNA; Substrate Specificity	2008
Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; Brachyspira; Cloning, Molecular; Diarrhea; Feces; Gram-Negative Bacterial Infections; Humans; Kinetics; Molecular Sequence Data; Oxacillin; Penicillin Resistance; Sequence Analysis, DNA	2008
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amino Acid Substitution; Amoxicillin; Anti-Bacterial Agents; Arginine; Aztreonam; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acid; Computer Simulation; Imipenem; Isoelectric Focusing; Kinetics; Klebsiella pneumoniae; Lysine; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Penicillins; Protein Conformation; Protein Structure, Tertiary	2008
Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Acremonium; Bacterial Proteins; beta-Lactamases; Catalysis; Catalytic Domain; Cefepime; Ceftazidime; Cephalosporins; Kinetics; Models, Molecular; Mutation; Penicillinase; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity	2008
In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Drug Resistance, Bacterial; Enzyme Inhibitors; Microbial Sensitivity Tests	2009
Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cardiidae; Ceftazidime; Ceftriaxone; Cephalosporin Resistance; Electrophoresis, Gel, Pulsed-Field; France; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Salmonella enterica; Serotyping	2009
Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Acinetobacter baumannii; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Site-Directed	2009
Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Amino Acid Sequence; Amoxicillin; Ampicillin; Animals; Anti-Bacterial Agents; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Blotting, Southern; Campylobacter jejuni; Carbenicillin; Cephalosporins; Chickens; Cloxacillin; Isoelectric Focusing; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Piperacillin; Polymerase Chain Reaction; Sequence Alignment; Ticarcillin	2009
Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Catheters, Indwelling; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Genes, Bacterial; Genetic Variation; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Pseudomonas; Pseudomonas Infections; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity	2010
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Belgium; beta-Lactamases; Cephalosporinase; Cephalosporins; Cross Infection; Escherichia coli; Genes, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections	2010
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Blotting, Southern; Cloning, Molecular; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; France; Fresh Water; Gram-Negative Bacteria; Health Surveys; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Pseudomonas fluorescens; Water Microbiology	2010
Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Kinetics; Microbial Sensitivity Tests; Penicillanic Acid; Spectrometry, Mass, Electrospray Ionization; Sulbactam; Tazobactam	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamases; beta-Lactams; Cephalosporins; Genetic Variation; Humans; Integrons; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Pseudomonas Infections; Sequence Analysis, DNA	2010
Penicillin sulfone inhibitors of class D beta-lactamases. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Catalytic Domain; Cephaloridine; Cephalosporins; Enzyme Inhibitors; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Oxacillin; Penicillins; Recombinant Proteins; Substrate Specificity; Sulfones	2010
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporinase; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Molecular Structure; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulbactam; Tazobactam	2010
Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11 Topics: Ampicillin; beta-Lactamases; Computational Biology; Escherichia coli; Hydrogen Bonding; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Protein Structure, Secondary; Ticarcillin	2010
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Inhibitory Concentration 50; Molecular Structure; Spectrometry, Mass, Electrospray Ionization	2010
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Boronic Acids; Circular Dichroism; Clavulanic Acid; Crystallography, X-Ray; Drug Design; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds	2013
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone. Biochemistry, 2015, Jan-27, Volume: 54, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Hydrolysis; Imines; Kinetics; Microbial Sensitivity Tests; Normal Distribution; Solutions; Spectrum Analysis, Raman; Sulbactam	2015
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. Journal of medicinal chemistry, 2015, May-14, Volume: 58, Issue:9 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Boronic Acids; Carbapenems; Crystallography, X-Ray; Drug Resistance, Bacterial; Drug Synergism; Gram-Negative Bacteria; Heterocyclic Compounds, 1-Ring; Mice; Microbial Sensitivity Tests; Models, Molecular; Rats; Stereoisomerism; Structure-Activity Relationship	2015
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. Journal of medicinal chemistry, 2020, 03-26, Volume: 63, Issue:6 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactam Resistance; beta-Lactamase Inhibitors; Borinic Acids; Carbapenems; Carboxylic Acids; Humans; Mice; Models, Molecular	2020
OHIO-1 beta-lactamase resistant to mechanism-based inactivators. FEMS microbiology letters, 1992, Apr-01, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Molecular Sequence Data; Mutation; Penicillanic Acid; Plasmids; Sequence Homology, Nucleic Acid; Sulbactam; Tazobactam	1992
Effect of clavulanic acid, sulbactam and tazobactam on three different beta-lactamases from Bacteroides uniformis, Clostridium butyricum and Fusobacterium nucleatum. The Journal of antimicrobial chemotherapy, 1992, Volume: 30, Issue:1 Topics: Bacteroides; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Clostridium; Fusobacterium nucleatum; Penicillanic Acid; Sulbactam; Tazobactam	1992
Effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:11 Topics: Bacteria, Anaerobic; Bacteroides; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Clostridium; Fusobacterium nucleatum; Penicillanic Acid; Sulbactam; Tazobactam	1992
Characterization of a beta-lactamase produced by Pseudomonas paucimobilis. Journal of general microbiology, 1991, Volume: 137, Issue:6 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Chromosomes, Bacterial; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Molecular Weight; Penicillanic Acid; Penicillin Resistance; Penicillins; Pseudomonas; Sulbactam; Tazobactam	1991
[Chemical structure, anti-bacterial activity and pharmacokinetics of penicillins]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:10 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Humans; Penicillanic Acid; Penicillin Resistance; Penicillins; Piperacillin; Pseudomonas aeruginosa; Tazobactam; Ticarcillin	1991
Beta-lactamase inhibitors: relation between kinetic data and in-vitro synergism studies. Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1991, Volume: 275, Issue:4 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Drug Synergism; Enterobacter cloacae; Escherichia coli; Klebsiella; Penicillanic Acid; Piperacillin; Proteus vulgaris; Pseudomonas aeruginosa; Staphylococcus aureus; Sulbactam; Tazobactam	1991
Interactions of tazobactam and clavulanate with inducibly- and constitutively-expressed Class I beta-lactamases. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:2 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enzyme Induction; Half-Life; Kinetics; Penicillanic Acid; Piperacillin; Tazobactam; Ticarcillin	1990
Interaction of beta-lactamase inhibitors with various beta-lactamases. Chemotherapy, 1990, Volume: 36, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enterobacter; Escherichia coli; Humans; Klebsiella; Penicillanic Acid; Plasmids; Proteus vulgaris; Staphylococcus aureus; Sulbactam; Tazobactam	1990
Piperacillin/tazobactam and ticarcillin/clavulanic acid against resistant Enterobacteriaceae. The Journal of antimicrobial chemotherapy, 1990, Volume: 26, Issue:4 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Drug Therapy, Combination; Enterobacteriaceae; Hydrogen-Ion Concentration; Penicillanic Acid; Piperacillin; Tazobactam; Ticarcillin	1990
In vitro activity of combinations of beta-lactam antibiotics with beta-lactamase inhibitors against cephalosporinase-producing bacteria. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1989, Volume: 8, Issue:9 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefotaxime; Cephalosporinase; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Drug Interactions; Drug Resistance, Microbial; Enterobacteriaceae; Enzyme Induction; Humans; Isoelectric Focusing; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Ticarcillin	1989
Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:11 Topics: Animals; Bacteria; Bacterial Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Female; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1989
The effects of three beta-lactamase inhibitors: YTR830H, sulbactam and clavulanic acid on the growth of human cells in culture. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:5 Topics: beta-Lactamase Inhibitors; Cell Division; Cells, Cultured; Clavulanic Acid; Clavulanic Acids; Humans; Penicillanic Acid; Sulbactam; Tazobactam	1987
The activity of a sulphone beta-lactamase inhibitor, YTR 830. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Enterobacteriaceae; Microbial Sensitivity Tests; Penicillanic Acid; R Factors; Sulbactam; Tazobactam	1987
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ampicillin and broad-spectrum penicillins against defined beta-lactamase-producing aerobic gram-negative bacilli. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:6 Topics: Ampicillin; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Gram-Negative Aerobic Bacteria; Penicillanic Acid; Penicillins; Plasmids; Sulbactam; Tazobactam	1986
Synergy of amoxycillin combined with clavulanate and YTR 830 in experimental infections in mice. The Journal of antimicrobial chemotherapy, 1986, Volume: 18, Issue:2 Topics: Amoxicillin; Animals; Bacterial Infections; Citrobacter; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enterobacteriaceae Infections; Female; Mice; Penicillanic Acid; Proteus Infections; Staphylococcal Infections; Tazobactam	1986
Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes. Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:5 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1986
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry; Clavulanic Acid; Clavulanic Acids; Escherichia coli; Penicillanic Acid; Sulbactam; Tazobactam; Triazoles	1987
Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:4 Topics: Amoxicillin; Ampicillin; Bacteria; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Penicillanic Acid; Sulbactam; Tazobactam	1984
Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:8 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Sulbactam; Tazobactam	1995
[Bactericidal activity of combinations of ticarcillin-clavulanic acid or other beta-lactams (amoxicillin, piperacillin-tazobactam, ticarcillin) with gentamicin against Enterococcus faecalis and E. faecium]. Pathologie-biologie, 1995, Volume: 43, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus faecalis; Enterococcus faecium; Enzyme Inhibitors; Gentamicins; Humans; In Vitro Techniques; Penicillanic Acid; Penicillin Resistance; Piperacillin; Tazobactam; Ticarcillin	1995
In vitro activity of beta-lactamase inhibitors against clinical isolates of Acinetobacter species. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:2 Topics: Acinetobacter; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Cefotaxime; Ceftazidime; Ceftriaxone; Clavulanic Acid; Clavulanic Acids; Colony Count, Microbial; Imipenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sensitivity and Specificity; Sulbactam; Tazobactam	1995
Influence of beta-lactamase inhibitors on the activity of oxacillin against methicillin-resistant Staphylococcus aureus. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Methicillin Resistance; Microbial Sensitivity Tests; Oxacillin; Penicillanic Acid; Staphylococcus aureus; Sulbactam; Tazobactam	1995
A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer. FEMS immunology and medical microbiology, 1995, Volume: 11, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Escherichia coli; Feces; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Penicillin Resistance; Piperacillin; Plasmids; Population Surveillance; Tazobactam	1995
beta-Lactamase activity in mycobacteria including Mycobacterium avium and suppression of their growth by a beta-lactamase-stable antibiotic. Microbios, 1995, Volume: 81, Issue:328 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cell Division; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Isoniazid; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium avium; Penicillanic Acid; Streptomycin; Sulbactam; Tazobactam	1995
Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:4 Topics: Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Penicillanic Acid; Plasmids; Sulbactam; Tazobactam	1994
Cross-resistance to beta-lactam-beta-lactamase inhibitor combinations and clindamycin among cefoxitin-resistant and cefoxitin-susceptible strains of the Bacteroides fragilis group. Diagnostic microbiology and infectious disease, 1993, Volume: 17, Issue:3 Topics: Anti-Bacterial Agents; Bacteroides; Bacteroides fragilis; Bacteroides Infections; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Clindamycin; Drug Resistance, Microbial; Drug Synergism; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	1993
[Bacteremia by Escherichia coli resistant to amoxycillin/clavulanic acid, ampicillin/sulbactam and piperacillin/tazobactam]. Medicina clinica, 1994, Feb-12, Volume: 102, Issue:5 Topics: Aged; Ampicillin; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Drug Therapy, Combination; Escherichia coli; Escherichia coli Infections; Female; Humans; Penicillanic Acid; Sulbactam; Tazobactam	1994
Antibacterial activity of clavulanate and tazobactam on Peptostreptococcus spp. The Journal of antimicrobial chemotherapy, 1994, Volume: 33, Issue:2 Topics: Amoxicillin; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Peptostreptococcus; Piperacillin; Tazobactam	1994
In vitro extracellular and intracellular activities of clavulanic acid and those of piperacillin and ceftriaxone alone and in combination with tazobactam against clinical isolates of Legionella species. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:2 Topics: Animals; Ceftriaxone; Cells, Cultured; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Drug Therapy, Combination; Extracellular Space; Guinea Pigs; Intracellular Fluid; Legionella; Legionella pneumophila; Legionnaires' Disease; Macrophages, Alveolar; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Tazobactam	1994
Ex vivo pharmacodynamic study of piperacillin alone and in combination with tazobactam, compared with ticarcillin plus clavulanic acid. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:9 Topics: Adult; beta-Lactamase Inhibitors; Biological Assay; Chromatography, High Pressure Liquid; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Drug Therapy, Combination; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Serum Bactericidal Test; Tazobactam; Ticarcillin	1993
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Cloning, Molecular; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Humans; Mutation; Penicillanic Acid; Phenotype; Sulbactam; Tazobactam	1993
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Lactams; Penicillanic Acid; Sulbactam; Tazobactam	1993
Kinetic interactions of tazobactam with beta-lactamases from all major structural classes. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:4 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Hydrolysis; Isoelectric Focusing; Kinetics; Molecular Weight; Penicillanic Acid; Spectrophotometry, Ultraviolet; Tazobactam	1993
Relative efficacy of tazobactam, sulbactam and clavulanic acid in enhancing the potency of ampicillin against clinical isolates of Enterobacteriaceae. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:3 Topics: Ampicillin; beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Enterobacteriaceae; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Campylobacter coli; Clavulanic Acid; Clavulanic Acids; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Selection of variants of the TEM-1 beta-lactamase, encoded by a plasmid of clinical origin, with increased resistance to beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:5 Topics: Amoxicillin; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Isoelectric Focusing; Microbial Sensitivity Tests; Mutation; Penicillanic Acid; Plasmids; Restriction Mapping; Sulbactam; Tazobactam	1993
In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors. Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; Cefotaxime; Clavulanic Acid; Clavulanic Acids; Drug Combinations; Drug Interactions; Drug Stability; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	1993
A kinetic study of NMC-A beta-lactamase, an Ambler class A carbapenemase also hydrolyzing cephamycins. FEMS microbiology letters, 1996, Sep-15, Volume: 143, Issue:1 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Cephamycins; Clavulanic Acid; Clavulanic Acids; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Hydrolysis; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Substrate Specificity; Sulbactam; Tazobactam	1996
Assessment of two penicillins plus beta-lactamase inhibitors versus cefotaxime in treatment of murine Klebsiella pneumoniae infections. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:2 Topics: Animals; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Cefotaxime; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Colony Count, Microbial; Drug Combinations; Drug Therapy, Combination; Female; Klebsiella Infections; Klebsiella pneumoniae; Lung; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Pneumonia, Bacterial; Tazobactam; Ticarcillin	1996
Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli to 12 beta-lactam agents and combinations with beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:8 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Campylobacter coli; Campylobacter jejuni; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Sulbactam; Tazobactam	1996
Fixed or variable concentrations of beta-lactamase inhibitors in in-vitro tests? The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:1 Topics: beta-Lactamase Inhibitors; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1996
Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Ceftazidime; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Europe; Humans; Intensive Care Units; Klebsiella; Klebsiella Infections; Microbial Sensitivity Tests; Monobactams; Penicillanic Acid; Piperacillin; Tazobactam	1996
Timed killing kinetic studies of the interaction between ciprofloxacin and beta-lactams against gram-negative bacilli. Diagnostic microbiology and infectious disease, 1996, Volume: 26, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aztreonam; Ceftazidime; Cephalosporins; Ciprofloxacin; Clavulanic Acid; Clavulanic Acids; Drug Interactions; Drug Therapy, Combination; Enterobacter cloacae; Enzyme Inhibitors; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Monobactams; Penicillanic Acid; Penicillins; Piperacillin; Pseudomonas aeruginosa; Serratia marcescens; Tazobactam; Ticarcillin; Time Factors	1996
Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases. FEMS microbiology letters, 1997, Mar-01, Volume: 148, Issue:1 Topics: Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Kinetics; Penicillanic Acid; Penicillins; Piperacillin; Tazobactam	1997
Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:2 Topics: Ampicillin; beta-Lactamase Inhibitors; Cefoperazone; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Retrospective Studies; Sulbactam; Tazobactam; Ticarcillin; Urinary Tract; Urinary Tract Infections	1997
Comparative in vitro evaluation of piperacillin/tazobactam in a tertiary care hospital. Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:5 Topics: Amoxicillin; Ceftazidime; Cephalosporin Resistance; Cephalosporins; Ciprofloxacin; Clavulanic Acid; Enzyme Inhibitors; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Intensive Care Units; Microbial Sensitivity Tests; Penicillanic Acid; Penicillin Resistance; Penicillins; Piperacillin; Tazobactam	1997
Clinical inhibitor-resistant mutants of the beta-lactamase TEM-1 at amino-acid position 69. Kinetic analysis and molecular modelling. Biochimica et biophysica acta, 1998, Jan-15, Volume: 1382, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Drug Resistance, Microbial; Escherichia coli; Kinetics; Models, Molecular; Molecular Conformation; Penicillanic Acid; Protein Conformation; Sulbactam; Tazobactam	1998
Comparative in-vitro activities of GD-40 and other beta-lactamase inhibitors against TEM-1 and SHV-2 beta-lactamases. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Enzyme Inhibitors; Penicillanic Acid; Sulbactam; Tazobactam	1998
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:6 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamase Inhibitors; beta-Lactamases; Ceftazidime; Cephalosporins; Clavulanic Acid; Drug Interactions; Drug Resistance, Multiple; Enzyme Inhibitors; Isoelectric Focusing; Microbial Sensitivity Tests; Molecular Sequence Data; Monobactams; Penicillanic Acid; Providencia; Sulbactam; Tazobactam	1998
Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme. The Biochemical journal, 1998, Jul-15, Volume: 333 ( Pt 2) Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Circular Dichroism; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Isoleucine; Kinetics; Methionine; Microbial Sensitivity Tests; Penicillanic Acid; Point Mutation; Protein Conformation; Sulbactam; Tazobactam	1998
[Beta-lactamase producers and other bacteria: which ones to take into consideration and when? The concept of beta-lactamase inhibitor]. Presse medicale (Paris, France : 1983), 1998, Volume: 27 Suppl 4 Topics: Anti-Bacterial Agents; Bacteria; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Haemophilus influenzae; Humans; Klebsiella; Klebsiella pneumoniae; Moraxella catarrhalis; Penicillanic Acid; Proteus vulgaris; Staphylococcus aureus; Streptococcus pneumoniae; Sulbactam; Tazobactam	1998
Interaction between class B beta-lactamases and suicide substrates of active-site serine beta-lactamases. FEBS letters, 1999, Jan-25, Volume: 443, Issue:2 Topics: beta-Lactamases; Binding Sites; Catalysis; Clavulanic Acid; Isomerism; Penicillanic Acid; Substrate Specificity; Sulbactam; Tazobactam	1999
Clavulanate induces expression of the Pseudomonas aeruginosa AmpC cephalosporinase at physiologically relevant concentrations and antagonizes the antibacterial activity of ticarcillin. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:4 Topics: Anti-Bacterial Agents; Cephalosporinase; Clavulanic Acid; Enzyme Induction; Enzyme Inhibitors; Genes, Bacterial; Humans; Penicillanic Acid; Penicillins; Piperacillin; Pseudomonas aeruginosa; Tazobactam; Ticarcillin	1999
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1999
In-vitro susceptibilities of species of the Bacteroides fragilis group to newer beta-lactam agents. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Bacteroides fragilis; beta-Lactamase Inhibitors; Cefoxitin; Ceftizoxime; Chloramphenicol; Clavulanic Acid; Clindamycin; Drug Therapy, Combination; Enzyme Inhibitors; Imipenem; Metronidazole; Mezlocillin; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Species Specificity; Sulbactam; Tazobactam; Thienamycins; Ticarcillin	1999
Penetration of beta-lactamase inhibitors into the periplasm of gram-negative bacteria. FEMS microbiology letters, 1999, Jul-01, Volume: 176, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane Permeability; Clavulanic Acid; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Klebsiella pneumoniae; Lactams; Penicillanic Acid; Periplasm; Sulbactam; Tazobactam	1999
Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors. FEBS letters, 2000, Mar-31, Volume: 470, Issue:3 Topics: Acylation; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Carbenicillin; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Escherichia coli; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Penicillanic Acid; Penicillin Resistance; Penicillinase; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Thermodynamics	2000
Comparative evaluation of the in vitro activity of three combinations of beta-lactams with beta-lactamase inhibitors: piperacillin/tazobactam, ticarcillin/clavulanic acid and ampicillin/sulbactam. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2000, Volume: 4, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Clavulanic Acid; Cross Infection; Drug Therapy, Combination; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam; Ticarcillin	2000
Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein engineering, 2000, Volume: 13, Issue:4 Topics: beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Circular Dichroism; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Sulbactam; Tazobactam	2000
In vitro susceptibilities of Capnocytophaga isolates to beta-lactam antibiotics and beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; Capnocytophaga; Clavulanic Acid; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	2000
Properties of multidrug-resistant, ESBL-producing Proteus mirabilis isolates and possible role of beta-lactam/beta-lactamase inhibitor combinations. International journal of antimicrobial agents, 2001, Volume: 17, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acid; Drug Resistance, Microbial; Drug Resistance, Multiple; Enzyme Inhibitors; Genes, Bacterial; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Proteus Infections; Proteus mirabilis; Tazobactam	2001
[Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods]. Medycyna doswiadczalna i mikrobiologia, 2001, Volume: 53, Issue:1 Topics: Animals; beta-Lactamases; Cattle; Cefoxitin; Clavulanic Acid; Dogs; Fishes; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Pseudomonas aeruginosa; Species Specificity; Swine; Tazobactam	2001
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130. The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52 Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors	2003
[Phenotypes of beta-lactam resistance in the genus Aeromonas]. Pathologie-biologie, 2003, Volume: 51, Issue:5 Topics: Aeromonas; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Isoelectric Focusing; Isoelectric Point; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Phenotype; Tazobactam	2003
Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography. Biochemistry, 2003, Nov-25, Volume: 42, Issue:46 Topics: Amines; Amino Acid Substitution; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Crystallization; Deuterium Oxide; Enzyme Inhibitors; Kinetics; Microscopy; Models, Molecular; Penicillanic Acid; Recombinant Proteins; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Water	2003
Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochemical and biophysical research communications, 2004, Jan-16, Volume: 313, Issue:3 Topics: Anti-Bacterial Agents; Bacillus anthracis; beta-Lactamases; Chelating Agents; Clavulanic Acid; Enzyme Inhibitors; Hydrolysis; Inhibitory Concentration 50; Iron; Kinetics; Models, Chemical; Penicillanic Acid; Penicillins; Spectrophotometry; Tazobactam	2004
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2004
In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:2 Topics: Azepines; Bacteria; beta-Lactamases; Ceftazidime; Cephalosporins; Clavulanic Acid; Dealkylation; Enzyme Inhibitors; Escherichia coli; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Staphylococcus aureus; Sulfuric Acid Esters; Tazobactam	2004
Antibacterial susceptibility of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli. The Israel Medical Association journal : IMAJ, 2005, Volume: 7, Issue:5 Topics: Adult; Amikacin; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; beta-Lactamases; Child; Ciprofloxacin; Clavulanic Acid; Drug Resistance, Bacterial; Enzyme Inhibitors; Escherichia coli; Humans; In Vitro Techniques; Israel; Klebsiella pneumoniae; Microbial Sensitivity Tests; Odds Ratio; Penicillanic Acid; Piperacillin; Prevalence; Tazobactam	2005
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase. The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Binding Sites; Clavulanic Acid; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Klebsiella pneumoniae; Models, Chemical; Models, Molecular; Mutation; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Time Factors; X-Rays	2005
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanic acid and sulbactam combined with ampicillin and piperacillin against beta-lactamase producing anaerobic bacteria. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl Topics: Ampicillin; Anti-Bacterial Agents; Bacteroides fragilis; beta-Lactamase Inhibitors; Clavulanic Acid; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	1989
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry, 2007, Jul-24, Volume: 46, Issue:29 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam	2007
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase. Biochemistry, 2007, Aug-07, Volume: 46, Issue:31 Topics: Acrylates; Amino Acid Substitution; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallization; Enzyme Inhibitors; Imines; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam	2007
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian journal of medical microbiology, 2007, Volume: 25, Issue:3 Topics: Acinetobacter; Amoxicillin; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Enzyme Inhibitors; Gram-Negative Bacteria; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas; Stenotrophomonas; Tazobactam; Ticarcillin	2007
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence. Journal of the American Chemical Society, 2009, Feb-18, Volume: 131, Issue:6 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Imines; Penicillanic Acid; Quantum Theory; Spectrum Analysis, Raman; Sulbactam; Tazobactam	2009
Pylephlebitis after a duodenal ulcer in a patient with metastasised colon carcinoma treated with chemotherapy and bevacizumab: a case report. The Netherlands journal of medicine, 2009, Volume: 67, Issue:2 Topics: Aged; Amoxicillin; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bacterial Infections; Bevacizumab; Clavulanic Acid; Colorectal Neoplasms; Duodenal Ulcer; Humans; Male; Penicillanic Acid; Piperacillin; Portal Vein; Tazobactam; Thrombophlebitis	2009
Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Clavulanic Acid; Gentamicins; Humans; Imipenem; Integrons; Meropenem; Molecular Sequence Data; Penicillanic Acid; Piperacillin; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Spain; Tazobactam; Thienamycins	2009
Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Clavulanic Acid; Escherichia coli; Microbial Sensitivity Tests; Models, Genetic; Molecular Sequence Data; Penicillanic Acid; Polymerase Chain Reaction; Tazobactam	2011
Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: beta-Lactamase Inhibitors; Boronic Acids; Cefoperazone; Ceftazidime; Clavulanic Acid; Enzyme Inhibitors; Klebsiella pneumoniae; Magnetic Resonance Spectroscopy; Penicillanic Acid; Sulbactam; Tazobactam	2011
Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli Proteins; Kinetics; Meropenem; Molecular Dynamics Simulation; Molecular Structure; Penicillanic Acid; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulbactam; Tazobactam; Thienamycins	2011
In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario? Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:10 Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamases; Cefotaxime; Ceftazidime; Cephalosporin Resistance; Clavulanic Acid; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Penicillanic Acid; Piperacillin; Plasmids; Selection, Genetic; Tazobactam	2011
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Purification and characterization of OXA-23 from Acinetobacter baumannii. Journal of enzyme inhibition and medicinal chemistry, 2013, Volume: 28, Issue:4 Topics: Acinetobacter baumannii; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Escherichia coli; Kinetics; Models, Molecular; Penicillanic Acid; Structure-Activity Relationship; Substrate Specificity; Sulbactam; Surface Properties; Tazobactam	2013
[Inhibitors of the New Delhi-Metallolactamase]. Pharmazie in unserer Zeit, 2012, Volume: 41, Issue:4 Topics: Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; Cell Membrane; Clavulanic Acid; Drug Resistance, Bacterial; Drug Resistance, Microbial; Enzyme Inhibitors; Klebsiella pneumoniae; Methicillin-Resistant Staphylococcus aureus; Penicillanic Acid; Tazobactam	2012
Following drug uptake and reactions inside Escherichia coli cells by Raman microspectroscopy. Biochemistry, 2014, Jul-01, Volume: 53, Issue:25 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Escherichia coli; Escherichia coli Proteins; Freeze Drying; Penicillanic Acid; Spectrum Analysis, Raman; Tazobactam	2014
Genetic and kinetic characterization of the novel AmpC β-lactamases DHA-6 and DHA-7. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Clavulanic Acid; Enterobacter cloacae; Escherichia coli; Humans; Klebsiella oxytoca; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2014
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Clavulanic Acid; Cloning, Molecular; Drug Resistance, Multiple, Bacterial; Enterobacter cloacae; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillanic Acid; Plasmids; Sequence Homology, Amino Acid; Tazobactam	2015
Two cases of spondylodiscitis caused by Parvimonas micra. Internal medicine journal, 2015, Volume: 45, Issue:10 Topics: Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; C-Reactive Protein; Clavulanic Acid; Clindamycin; Discitis; Female; Gram-Positive Bacterial Infections; Humans; Magnetic Resonance Imaging; Male; Penicillanic Acid; Peptostreptococcus; Tazobactam	2015
Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada. Antimicrobial agents and chemotherapy, 2016, Jan-11, Volume: 60, Issue:3 Topics: Amino Acid Sequence; Animals; Aztreonam; Bacterial Proteins; Base Sequence; beta-Lactamases; Canada; Carbapenems; Cephalosporins; Clavulanic Acid; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Penaeidae; Penicillanic Acid; Penicillins; Seafood; Sequence Alignment; Sequence Analysis, DNA; Tazobactam; Vibrio cholerae	2016
Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. International journal of antimicrobial agents, 2017, Volume: 49, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamase Inhibitors; Cephalosporin Resistance; Cephalosporins; Clavulanic Acid; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Germany; Hospitals; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Tazobactam; Young Adult	2017
Simultaneous determination of clavulanic acid and tazobactam in bovine milk by HPLC. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2017, Volume: 34, Issue:4 Topics: Animals; Anti-Bacterial Agents; Calibration; Cattle; Chromatography, High Pressure Liquid; Clavulanic Acid; Female; Food Contamination; Humans; Lactation; Limit of Detection; Milk; Penicillanic Acid; Tazobactam	2017
BMJ case reports, 2018, Mar-27, Volume: 2018 Topics: Amoxicillin; Anti-Bacterial Agents; Clavulanic Acid; Clindamycin; Diagnosis, Differential; Female; Humans; Middle Aged; Penicillanic Acid; Penicillin G; Peritonitis; Piperacillin; Streptococcal Infections; Streptococcus pyogenes; Tazobactam; Treatment Outcome	2018
TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:9 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Escherichia coli; Humans; Kinetics; Microbial Sensitivity Tests; Sequence Alignment; Tazobactam	2018
New Conformations of Acylation Adducts of Inhibitors of β-Lactamase from Mycobacterium tuberculosis. Biochemistry, 2019, 02-19, Volume: 58, Issue:7 Topics: Acylation; Aldehydes; Amino Acid Substitution; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallography, X-Ray; Mycobacterium tuberculosis; Protein Conformation; Serine; Sulbactam; Tazobactam	2019
High-risk lineages among extended-spectrum β-lactamase-producing Escherichia coli from extraintestinal infections in Maputo Central Hospital, Mozambique. International journal of antimicrobial agents, 2022, Volume: 60, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cefotaxime; Ceftazidime; Ciprofloxacin; Clavulanic Acid; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Extraintestinal Pathogenic Escherichia coli; Gentamicins; Hospitals; Humans; Iron; Mozambique; Piperacillin; Tazobactam; Trimethoprim, Sulfamethoxazole Drug Combination	2022
Molecular and Kinetic Characterization of MOX-9, a Plasmid-Mediated Enzyme Representative of a Novel Sublineage of MOX-Type Class C β-Lactamases. Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9 Topics: Bacterial Proteins; beta-Lactamases; Cephalosporins; Clavulanic Acid; Kinetics; Plasmids; Sulbactam; Tazobactam	2022
Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients. Chemical research in toxicology, 2022, 11-21, Volume: 35, Issue:11 Topics: Aldehydes; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clavulanic Acid; Epitopes; Humans; T-Lymphocytes; Tazobactam	2022
PAUSATE Study: Prevalence and appropriateness of the use of antimicrobials in Spanish hospitals. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2022, 08-02, Volume: 46, Issue:5 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Clavulanic Acid; Cross-Sectional Studies; Hospitals; Humans; Meropenem; Piperacillin; Prevalence; Tazobactam	2022
Genotypic resistance determined by whole genome sequencing versus phenotypic resistance in 234 Escherichia coli isolates. Scientific reports, 2023, 01-09, Volume: 13, Issue:1 Topics: Amikacin; Amoxicillin; Anti-Bacterial Agents; Cefepime; Cefotaxime; Ceftazidime; Ciprofloxacin; Clavulanic Acid; Escherichia coli; Escherichia coli Infections; Genotype; Gentamicins; Humans; Meropenem; Microbial Sensitivity Tests; Phenotype; Piperacillin; Retrospective Studies; Tazobactam; Tobramycin; Whole Genome Sequencing	2023
[Relationship of Hypervirulent Capsular Genotypes of Klebsiella pneumoniae with Antibiotic Susceptibility and Beta-Lactamase Genes]. Mikrobiyoloji bulteni, 2023, Volume: 57, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Clavulanic Acid; Colistin; Drug Resistance, Bacterial; Genotype; Klebsiella pneumoniae; Microbial Sensitivity Tests; Piperacillin; Tazobactam	2023