Page last updated: 2024-09-03

tazobactam and cefepime

tazobactam has been researched along with cefepime in 100 studies

Compound Research Comparison

Studies (tazobactam)	Trials (tazobactam)	Recent Studies (post-2010) (tazobactam)	Studies (cefepime)	Trials (cefepime)	Recent Studies (post-2010) (cefepime)
1,327	153	694	1,737	186	684

Research

Studies (100)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (6.00)	18.2507
2000's	32 (32.00)	29.6817
2010's	37 (37.00)	24.3611
2020's	25 (25.00)	2.80

Authors

Authors	Studies
Bonnet, R; Chanal, C; Delmas, J; Lesens, O; Robin, F; Schweitzer, C; Tournilhac, O	1
Aubert, D; Naas, T; Nordmann, P; Ozcan, A	1
Arlet, G; Loli, A; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Cattoir, V; Corvec, S; Drugeon, H; Faccone, D; Galas, M; Mugnier, P; Nordmann, P; Pasteran, F; Petroni, A; Poirel, L; Rapoport, M	1
Ayala, JA; Casellas, JM; Di Conza, J; Ghiglione, B; Gutkind, G; Power, P; Radice, M; Rodríguez, MM	1
Amicosante, G; Caporale, B; Celenza, G; Docquier, JD; Mezzatesta, M; Pellegrini, C; Perilli, M; Rossolini, GM; Stefani, S	1
Bush, K; Kania, M; Page, MG; Queenan, AM; Shang, W	1
Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Bonnet, R; Brebion, A; Constantin, JM; Delmas, J; Dubois, D; Robin, F	1
Girlich, D; Leclercq, R; Naas, T; Nordmann, P	1
Courvalin, P; Decré, D; Høiby, EA; Meziane-Cherif, D; Périchon, B	1
Bonnet, R; Caniça, M; Ferreira, E; Manageiro, V; Mendonça, N; Robin, F; Salgado, MJ	1
Castanheira, M; Samuelsen, Ø; Spencer, J; Walsh, TR	1
Andlovic, A; Jeverica, S; Karisik, E; Koren, S; Krizan-Hergouth, V; Livermore, DM; Mesko Meglic, K; Müller-Premru, M; Palepou, MF; Pike, R; Seme, K; Woodford, N	1
Nordmann, P; Plésiat, P; Poirel, L; Rodriguez-Martinez, JM	1
Bonnet, R; Brisabois, A; Cloeckaert, A; Doublet, B; Fabre, L; Granier, SA; Robin, F; Weill, FX	1
Chanteperdrix, V; Croizé, J; Nordmann, P; Poirel, L; Potron, A	1
Kotsakis, SD; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Bonnet, R; Casin, I; Doublet, B; Fabre, L; Le Fleche, A; Robin, F; Weill, FX	1
De Luca, F; Docquier, JD; Ide, L; Nordmann, P; Poirel, L; Rossolini, GM; Verlinde, A	1
Girlich, D; Nordmann, P; Poirel, L	1
Kotsakis, SD; Legakis, NJ; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS	1
Choi, JY; Ko, KS; Lee, MY; Park, YK; Peck, KR; Rhee, JY; Shin, JY; Song, JH	1
Abendroth, J; Atkins, K; Boyer, SH; Clifton, MC; Dudley, MN; Durso, S; Griffith, DC; Hecker, SJ; Hirst, GC; King, P; Lomovskaya, O; Loutit, JS; Morgan, EE; Potts, KT; Raymond, A; Reddy, KR; Sabet, M; Sun, D; Tarazi, Z; Totrov, M; Tsivkovski, R	1
Colchón, E; González-Bello, C; Pernas, M; Rodríguez, Á; Rodríguez, D	1
Benvenuti, M; Burns, CJ; Chu, GH; Cusick, SM; Daigle, DM; De Luca, F; Docquier, JD; Hamrick, JC; Jackson, RW; Liu, B; Mangani, S; McGarry, D; Pevear, DC; Pozzi, C; Trout, REL; Weiss, WJ; Xerri, L	1
Dornbusch, K; Göransson, E; Mörtsell, E	1
Cony Makhoul, P; Darmaillac, V; Fourche, J; Maugein, J; Perrier, F	1
Harris, EB; Hastings, RC; Prabhakaran, K; Randhawa, B	1
Eliopoulos, GM; Moellering, RC; Thauvin-Eliopoulos, C; Tripodi, MF	1
Böhme, A; Hoelzer, D; Shah, PM; Stille, W	1
Kays, MB	1
Moland, ES; Thomson, KS	1
Batlle, M; Benlloch, L; Capote, FJ; Gutiérrez, M; Jarque, I; Julià, A; Lahuerta, JJ; Larrea, L; López, J; Palau, J; Pérez, C; Ramos, F; Rovira, M; Sanz, MA; Vázquez, L	1
Jones, RN; Mutnick, AH; Turner, PJ	1
Burgess, DS; Nathisuwan, S	1
Kotapati, S; Kuti, JL; Nicolau, DP; Nightingale, CH	1
Choi, MK; Fish, DN; Husain, M; Jung, R	1
Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM	1
Burgess, DS; Hall, RG	1
Fraser, A; Leibovici, L; Paul, M; Yahav, D	1
Capparelli, FJ; Del Castillo, ME; Diaz, MF; Hlavnika, A; Leiguarda, R; Wainsztein, NA	1
Hashikita, G; Kawakami, S; Kobayashi, S; Maesaki, S; Nagasawa, M; Okabe, T; Sasaki, K; Shibuya, S; Suzuki, N; Takayama, S; Uchida, T; Watanabe, M; Yamaguchi, T	1
Arora, J; Dogra, A; Rao, P; Taneja, N	1
Kulkarni, KP; Pal, P; Pal, RB; Venkatesh, V	1
Albertí, S; Juan, C; Mulet, X; Oliver, A; Pérez, JL; Zamorano, L	1
De Backer, D; Delattre, I; Dugernier, T; Jacobs, F; Laterre, PF; Layeux, B; Spapen, H; Taccone, FS; Vincent, JL; Wallemacq, P; Wittebole, X	1
Adams, CA; Cioffi, WG; Connolly, MD; Gregg, S; Heffernan, DS; Monaghan, SF; Stephen, A; Thakkar, RK	1
Chander, J; Garg, R; Gulati, N; Gupta, V; Krishnan, P; Kumarasamy, K	1
Beumier, M; Cotton, F; De Backer, D; Hites, M; Jacobs, F; Lorent, S; Roisin, S; Seyler, L; Surin, R; Taccone, FS; Vincent, JL; Wolff, F	1
Arakawa, S; Fujisawa, M; Miyake, H; Shigemura, K; Tanaka, K	1
Dharuman, JG; Vasudevan, M	1
Gautam, V; Kaur, R; Ray, P; Singhal, L	1
Frey, L; Maier, B; Suhr, A; Teupser, D; Vogeser, M; Zander, J; Zoller, M	1
Al-Attas, A; Belal, F; El-Enany, N; Nasr, JJ	1
Nicolau, DP; Sutherland, CA	1
Berrazeg, M; Broutin, I; Fournier, D; Jeannot, K; Loeffert, S; Ntsogo Enguéné, VY; Plésiat, P	1
Lavigne, JP; Meiller, E; Merens, A; Nicolas-Chanoine, MH; Pantel, A; Robert, J	1
Manian, FA	1
Kaye, KS; Navalkele, B; Pogue, JM	1
Kim, HS; Kim, HY; Kim, YK; Lee, J; Lee, JA; Lee, SS; Seo, YB; Song, W; Uh, Y	1
Mueller, BA; Shaw, AR	1
Flamm, RK; Huband, MD; Jones, RN; Riedel, S; Sader, HS	1
Goodlet, KJ; Nailor, MD; Nicolau, DP	1
Hindler, JA; Humphries, RM; Miller, SA; Wong-Beringer, A	1
Coburn, B; Daneman, N; MacFadden, DR	1
Kollef, MH; Micek, ST; Vazquez Guillamet, MC; Vazquez, R	1
Livermore, DM; Mushtaq, S; Turner, SJ; Warner, M; Woodford, N	1
Bansal, N; Gopalakrishnan, R; Kumar D, S; Nambi, PS; Ramasubramanian, V; Sukhwani, KS	1
Castanheira, M; Duncan, LR; Mendes, RE; Sader, HS; Shortridge, D	1
An, G; Bach, T; D'Cunha, R; Li, P; Nalbant, D; Winokur, P; Young, BA; Zhang, J	2
Farkas, A; Heil, EL; Nicolau, DP; Roberts, JA; Thom, KA	1
Blevins, AM; Juang, P; Kollef, M; Lashinsky, JN; McCammon, C; Micek, S	1
Beaulieu, C; Kurczewski, L; Yajnik, V	1
Banerjee, R; Esbenshade, AJ; Quach, HT; Zhao, Z	1
Albanèse, J; Bornet, C; Curti, C; Fersing, C; Guinard, B; Lamy, E; Mathias, F; Primas, N; Souab, HK; Vanelle, P	1
Aboklaish, AF; Brem, J; Jackson, DE; Langley, GW; Schofield, CJ; Tselepis, L; Tyrrell, JM; Walsh, TR; Widlake, E	1
Dorn, C; Hitzenbichler, F; Kees, F; Kees, M; Liebchen, U; Paal, M; Schiesser, S	1
Al-Shaer, MH; Alghamdi, WA; Peloquin, C	1
Abdelraouf, K; Gill, CM; Nicolau, DP	1
Garello, P; Livermore, DM; Mushtaq, S; Vickers, A; Woodford, N	1
Barreto, EF; Bjergum, MW; Jannetto, PJ; Rule, AD; Scheetz, MH	1
Burgess, DS; Clark, JA; Landmesser, KB	1
Imai, S; Itoh, T; Kadomura, S; Kashiwagi, H; Momo, K; Sato, Y; Sugawara, M; Takekuma, Y	1
Carvalhaes, CG; Castanheira, M; Mendes, RE; Sader, HS	1
Alonso-Ramos, H; Barrera-Cabeza, J; Cordero-Ramos, J; Fernández-Del-Castillo, SS; Hoxha, M; Moya-Martin, M; Murillo-Izquierdo, M; Nunez-Nunez, M; Oltra-Hostalet, F; Quesada Pérez, MT; Retamar-Gentil, P	1
Sun, J; Xie, L; Xu, R; Zhu, D	1
Carvalhaes, CG; Castanheria, M; Duncan, LR; Mendes, RE; Sader, HS	1
Alonso-García, I; Arca-Suárez, J; Beceiro, A; Bou, G; Cabot, G; Fraile-Ribot, PA; Galán-Sánchez, F; Guijarro-Sánchez, P; Lasarte-Monterrubio, C; Oliver, A; Rumbo-Feal, S; Vázquez-Ucha, JC	1
Babiak, P; Cizmarova, I; Kovac, A; Mikus, P; Parrak, V; Piestansky, J; Secnik, P	1
Al Jalali, V; Ballarini, N; Bauer, M; Bergmann, F; Jorda, A; König, F; Lackner, E; Nussbaumer-Pröll, A; Oesterreicher, Z; Reiter, B; Stimpfl, T; Wölfl-Duchek, M; Wulkersdorfer, B; Zeitlinger, M	1
Azam, N; Cherkaoui, A; Crudeli, L; Fernandez, J; Fischer, A; Renzi, G; Schorderet, D; Schrenzel, J	1
Attwood, M; Chavan, R; MacGowan, A; Muller, AE; Noel, A; Periasamy, H; Van den Berg, S	1
Gill, CM; Nicolau, DP	2
Caljon, B; Crombé, F; De Geyter, D; Demuyser, T; Janssen, T; Muyldermans, A; Piérard, D; Seyler, L; Vanstokstraeten, R; Wybo, I	1
Belley, A; Kaye, KS; Velicitat, P	1
Hsu, CK; Lai, CC; Tsai, WW	1
Deng, T; Kong, W; Li, S; Shu, Y; Wu, Y	1

Reviews

6 review(s) available for tazobactam and cefepime

Article	Year
β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs. Journal of medicinal chemistry, 2020, 03-12, Volume: 63, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; Drug Resistance, Microbial; Humans; Protein Structure, Secondary; Protein Structure, Tertiary; Treatment Outcome	2020
Role of pharmacodynamics in designing dosage regimens for beta-lactams. Connecticut medicine, 2003, Volume: 67, Issue:5 Topics: Anti-Bacterial Agents; Cefepime; Cephalosporins; Dose-Response Relationship, Drug; Humans; Meropenem; Penicillanic Acid; Piperacillin; Tazobactam; Thienamycins	2003
Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials. The Journal of antimicrobial chemotherapy, 2006, Volume: 57, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; Carbapenems; Cefepime; Cephalosporins; Enzyme Inhibitors; Fever; Humans; Neutropenia; Penicillanic Acid; Penicillins; Quality Assurance, Health Care; Randomized Controlled Trials as Topic; Tazobactam; Treatment Outcome	2006
Antibiotic Dosing in Continuous Renal Replacement Therapy. Advances in chronic kidney disease, 2017, Volume: 24, Issue:4 Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Computer Simulation; Critical Illness; Humans; Levofloxacin; Meropenem; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Renal Replacement Therapy; Sepsis; Tazobactam; Thienamycins	2017
Compatibility of prolonged infusion antibiotics during Y-site administration. Nursing in critical care, 2022, Volume: 27, Issue:6 Topics: Anti-Bacterial Agents; Cefepime; Humans; Infusions, Intravenous; Meropenem; Tazobactam	2022
Efficacy, safety, and tolerability of antimicrobial agents for complicated intra-abdominal infection: a systematic review and network meta-analysis. BMC infectious diseases, 2023, Apr-21, Volume: 23, Issue:1 Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cefepime; Humans; Intraabdominal Infections; Meropenem; Metronidazole; Network Meta-Analysis; Tazobactam; Tigecycline	2023

Trials

6 trial(s) available for tazobactam and cefepime

Article	Year
Piperacillin/tazobactam versus cefepime as initial empirical antimicrobial therapy in febrile neutropenic patients: a prospective randomized pilot study. European journal of medical research, 1998, Jul-20, Volume: 3, Issue:7 Topics: Anti-Infective Agents; Cefepime; Cephalosporins; Drug Therapy, Combination; Fever; Humans; Neutropenia; Penicillanic Acid; Pilot Projects; Piperacillin; Prognosis; Prospective Studies; Tazobactam	1998
Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trial. The Journal of antimicrobial chemotherapy, 2002, Volume: 50, Issue:1 Topics: Adult; Amikacin; Anti-Bacterial Agents; Cefepime; Cephalosporins; Drug Therapy, Combination; Female; Fever; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Male; Neutropenia; Penicillanic Acid; Piperacillin; Tazobactam; Treatment Outcome	2002
Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli. BMC infectious diseases, 2017, 06-07, Volume: 17, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cefepime; Cephalosporins; Cross Infection; Ertapenem; Escherichia coli; Escherichia coli Infections; Female; Genotype; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Republic of Korea; Tazobactam; Urinary Tract Infections	2017
Incidence of acute kidney injury among pediatric hematology/oncology patients receiving vancomycin in combination with piperacillin/tazobactam or cefepime. Pediatric blood & cancer, 2019, Volume: 66, Issue:7 Topics: Acute Kidney Injury; Adolescent; Cefepime; Child; Child, Preschool; Female; Hematologic Neoplasms; Humans; Male; Piperacillin; Retrospective Studies; Tazobactam; Vancomycin	2019
Comparison of pharmacokinetics and stability of generics of cefepime, linezolid and piperacillin/tazobactam with their respective originator drugs: an intravenous bioequivalence study in healthy volunteers. The Journal of antimicrobial chemotherapy, 2022, 10-28, Volume: 77, Issue:11 Topics: Anti-Bacterial Agents; Cefepime; Drugs, Generic; Healthy Volunteers; Humans; Linezolid; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam; Therapeutic Equivalency	2022
Fully Automated EUCAST Rapid Antimicrobial Susceptibility Testing (RAST) from Positive Blood Cultures: Diagnostic Accuracy and Implementation. Journal of clinical microbiology, 2022, 10-19, Volume: 60, Issue:10 Topics: Anti-Bacterial Agents; beta-Lactamases; Blood Culture; Cefepime; Ceftazidime; Humans; Imipenem; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Piperacillin; Prospective Studies; Tazobactam	2022

Other Studies

88 other study(ies) available for tazobactam and cefepime

Article	Year
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Evolution, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation	2007
Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: beta-Lactamases; Chromosomes; Chromosomes, Bacterial; Citrobacter; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genes, Bacterial; Molecular Sequence Data	2007
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Escherichia coli; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillinase; Plasmids; Sequence Analysis, DNA	2007
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Acinetobacter; Acinetobacter Infections; Amino Acid Sequence; Anti-Bacterial Agents; Argentina; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Cloning, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Biochemical characterization of PER-2 and genetic environment of blaPER-2. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7 Topics: Amino Acid Sequence; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Catalysis; Citrobacter freundii; Conjugation, Genetic; DNA, Bacterial; DNA, Recombinant; Enterobacteriaceae; Genes, Bacterial; Humans; Hydrolysis; Isoelectric Focusing; Kinetics; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Conformation; Protein Sorting Signals; Sequence Analysis, DNA	2007
Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cephalosporins; Chryseobacterium; Flavobacteriaceae Infections; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Sequence Analysis, DNA	2007
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Hydrolysis; Kinetics; Microbial Sensitivity Tests; Spectrophotometry, Ultraviolet	2007
Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Anti-Bacterial Agents; Cephalosporinase; Culture Media; DNA Primers; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Spectrophotometry, Ultraviolet	2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Catalysis; Ceftazidime; Clavulanic Acid; Escherichia coli; Escherichia coli Proteins; Isoenzymes; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; beta-Lactamases; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Sequence Homology, Amino Acid; Substrate Specificity	2007
Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Amino Acid Sequence; beta-Lactams; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillinase; Sequence Alignment; Sequence Analysis, DNA; Substrate Specificity	2008
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amino Acid Substitution; Amoxicillin; Anti-Bacterial Agents; Arginine; Aztreonam; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acid; Computer Simulation; Imipenem; Isoelectric Focusing; Kinetics; Klebsiella pneumoniae; Lysine; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Penicillins; Protein Conformation; Protein Structure, Tertiary	2008
Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Acremonium; Bacterial Proteins; beta-Lactamases; Catalysis; Catalytic Domain; Cefepime; Ceftazidime; Cephalosporins; Kinetics; Models, Molecular; Mutation; Penicillinase; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity	2008
Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamases; Electrophoresis, Gel, Pulsed-Field; Genes, Bacterial; Hospitals; Klebsiella pneumoniae; Microbial Sensitivity Tests; Slovenia	2009
Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; beta-Lactamases; Burkholderia cepacia complex; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Hydrolysis; Isoelectric Point; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Sequence Analysis, DNA; Sequence Homology, Amino Acid	2009
Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cardiidae; Ceftazidime; Ceftriaxone; Cephalosporin Resistance; Electrophoresis, Gel, Pulsed-Field; France; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Salmonella enterica; Serotyping	2009
Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Acinetobacter baumannii; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Site-Directed	2009
Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Aztreonam; beta-Lactamases; beta-Lactams; Ceftazidime; Cephalosporins; Escherichia coli Proteins; Protein Binding; Protein Structure, Secondary	2009
Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Catheters, Indwelling; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Genes, Bacterial; Genetic Variation; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Pseudomonas; Pseudomonas Infections; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity	2010
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Belgium; beta-Lactamases; Cephalosporinase; Cephalosporins; Cross Infection; Escherichia coli; Genes, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections	2010
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Blotting, Southern; Cloning, Molecular; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; France; Fresh Water; Gram-Negative Bacteria; Health Surveys; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Pseudomonas fluorescens; Water Microbiology	2010
GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamases; beta-Lactams; Cephalosporins; Genetic Variation; Humans; Integrons; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Pseudomonas Infections; Sequence Analysis, DNA	2010
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Aged; beta-Lactamases; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Klebsiella Infections; Klebsiella pneumoniae; Male; Renal Dialysis; Republic of Korea	2010
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. Journal of medicinal chemistry, 2015, May-14, Volume: 58, Issue:9 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Boronic Acids; Carbapenems; Crystallography, X-Ray; Drug Resistance, Bacterial; Drug Synergism; Gram-Negative Bacteria; Heterocyclic Compounds, 1-Ring; Mice; Microbial Sensitivity Tests; Models, Molecular; Rats; Stereoisomerism; Structure-Activity Relationship	2015
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. Journal of medicinal chemistry, 2020, 03-26, Volume: 63, Issue:6 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactam Resistance; beta-Lactamase Inhibitors; Borinic Acids; Carbapenems; Carboxylic Acids; Humans; Mice; Models, Molecular	2020
In vitro activity of cefepime, a new parenteral cephalosporin, against recent European blood isolates and in comparison with piperacillin/tazobactam. Chemotherapy, 1990, Volume: 36, Issue:4 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cephalosporins; Drug Resistance, Microbial; Drug Synergism; Enterobacteriaceae; Gram-Negative Bacteria; Microbial Sensitivity Tests; Penicillanic Acid; Penicillin Resistance; Piperacillin; Staphylococcus; Tazobactam	1990
[In vitro activity of six beta-lactams against 295 strains of enterobacteriaceae and P. aeruginosa isolated from neutropenic patients]. Pathologie-biologie, 1995, Volume: 43, Issue:4 Topics: Cefepime; Cefotaxime; Cefpirome; Ceftazidime; Cephalosporins; Drug Resistance, Microbial; Drug Therapy, Combination; Enterobacteriaceae; Humans; Imipenem; In Vitro Techniques; Neutropenia; Penicillanic Acid; Penicillins; Piperacillin; Pseudomonas aeruginosa; Tazobactam; Thienamycins	1995
beta-Lactamase activity in mycobacteria including Mycobacterium avium and suppression of their growth by a beta-lactamase-stable antibiotic. Microbios, 1995, Volume: 81, Issue:328 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cell Division; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Isoniazid; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium avium; Penicillanic Acid; Streptomycin; Sulbactam; Tazobactam	1995
Efficacies of piperacillin-tazobactam and cefepime in rats with experimental intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:5 Topics: Abdominal Abscess; Animals; beta-Lactamases; Cefepime; Cephalosporins; Drug Therapy, Combination; Enzyme Inhibitors; Klebsiella Infections; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Rats; Rats, Sprague-Dawley; Tazobactam	1997
Comparison of five beta-lactam antibiotics against common nosocomial pathogens using the time above MIC at different creatinine clearances. Pharmacotherapy, 1999, Volume: 19, Issue:12 Topics: Anti-Bacterial Agents; Bacteria; Cefepime; Ceftazidime; Cephalosporins; Creatinine; Humans; Imipenem; In Vitro Techniques; Microbial Sensitivity Tests; Models, Biological; Penicillanic Acid; Piperacillin; Tazobactam; Time Factors	1999
Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cephalosporins; Chromosomes, Bacterial; Drug Resistance, Microbial; Enterobacteriaceae; Enzyme Inhibitors; Escherichia coli; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Tazobactam	2001
Emerging antimicrobial resistances among Proteus mirabilis in Europe: report from the MYSTIC Program (1997-2001). Meropenem Yearly Susceptibility Test Information Collection. Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:3 Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Ciprofloxacin; Critical Care; Cystic Fibrosis; Data Collection; Drug Resistance, Bacterial; Europe; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Neutropenia; Penicillanic Acid; Piperacillin; Population Surveillance; Proteus Infections; Proteus mirabilis; Tazobactam; Thienamycins	2002
Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 2002, Volume: 44, Issue:1 Topics: Cefepime; Cephalosporins; Ciprofloxacin; Drug Resistance, Microbial; Drug Therapy, Combination; Gentamicins; Humans; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sensitivity and Specificity; Tazobactam	2002
Synergistic activities of moxifloxacin combined with piperacillin-tazobactam or cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii clinical isolates. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:3 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Infective Agents; Aza Compounds; Cefepime; Cephalosporins; Colony Count, Microbial; Drug Synergism; Enterobacter cloacae; Enterobacteriaceae Infections; Enzyme Inhibitors; Fluoroquinolones; Humans; Klebsiella Infections; Klebsiella pneumoniae; Moxifloxacin; Penicillanic Acid; Penicillins; Piperacillin; Quinolines; Tazobactam	2004
Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition. FEMS microbiology letters, 2004, May-01, Volume: 234, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Ertapenem; Escherichia coli; Escherichia coli Infections; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	2004
In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. Diagnostic microbiology and infectious disease, 2004, Volume: 49, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cefepime; Cephalosporins; Culture Media, Conditioned; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sensitivity and Specificity; Tazobactam; Thienamycins	2004
Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology, 2005, Dec-13, Volume: 65, Issue:11 Topics: Aged, 80 and over; Anti-Bacterial Agents; Brain; Cefepime; Cefixime; Cephalosporins; Confusion; Consciousness Disorders; Delirium; Epididymitis; Humans; Kidney; Male; Metabolic Clearance Rate; Neurotoxicity Syndromes; Penicillanic Acid; Piperacillin; Recovery of Function; Secondary Prevention; Systemic Inflammatory Response Syndrome; Tazobactam; Urinary Tract Infections; Withholding Treatment	2005
[The combination effects of antibacterial agents against clinical isolated multiple-drug resistant Pseudomonas aeruginosa]. The Japanese journal of antibiotics, 2006, Volume: 59, Issue:1 Topics: Amikacin; Anti-Bacterial Agents; Aztreonam; Cefepime; Cefoperazone; Cephalosporins; Ciprofloxacin; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Humans; Meropenem; Microbial Sensitivity Tests; Oxazines; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Sulbactam; Tazobactam; Thienamycins	2006
Occurrence of ESBL & Amp-C beta-lactamases & susceptibility to newer antimicrobial agents in complicated UTI. The Indian journal of medical research, 2008, Volume: 127, Issue:1 Topics: Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; beta-Lactamases; Cefepime; Cephalosporins; Drug Resistance, Bacterial; Humans; Penicillanic Acid; Piperacillin; Prospective Studies; Tazobactam; Urinary Tract Infections	2008
Evaluation of sensitivity of different organisms to cefepime and tazobactum (megapime XP) in comparison to cefepime and ceftazidime. Journal of the Indian Medical Association, 2008, Volume: 106, Issue:9 Topics: Anti-Bacterial Agents; Bacteria; Cefepime; Ceftazidime; Cephalosporins; Drug Combinations; Gram-Negative Bacteria; Gram-Positive Bacteria; Penicillanic Acid; Tazobactam	2008
Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Clavulanic Acid; Gentamicins; Humans; Imipenem; Integrons; Meropenem; Molecular Sequence Data; Penicillanic Acid; Piperacillin; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Spain; Tazobactam; Thienamycins	2009
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Critical care (London, England), 2010, Volume: 14, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Sepsis; Shock, Septic; Tazobactam; Thienamycins	2010
Empiric antibiotics pending bronchoalveolar lavage data in patients without pneumonia significantly alters the flora, but not the resistance profile, if a subsequent pneumonia develops. The Journal of surgical research, 2013, Volume: 181, Issue:2 Topics: Acetamides; Anti-Bacterial Agents; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cefepime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Penicillanic Acid; Piperacillin; Pneumonia, Ventilator-Associated; Retrospective Studies; Tazobactam; Treatment Outcome; Vancomycin; Wounds and Injuries	2013
AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India. The Indian journal of medical research, 2012, Volume: 136, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cephalosporins; Cross Infection; Drug Resistance, Bacterial; Humans; India; Klebsiella pneumoniae; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	2012
Case-control study of drug monitoring of β-lactams in obese critically ill patients. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Case-Control Studies; Cefepime; Ceftazidime; Cephalosporins; Drug Monitoring; Enzyme Inhibitors; Female; Humans; Male; Meropenem; Middle Aged; Obesity; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Sepsis; Shock, Septic; Tazobactam; Thienamycins; Young Adult	2013
Postoperative bacteriuria, pyuria and urinary tract infection in patients with an orthotopic sigmoid colon neobladder replacement. The Journal of antibiotics, 2014, Volume: 67, Issue:2 Topics: Aged; Anti-Bacterial Agents; Bacteriuria; Cefepime; Cephalosporins; Colon, Sigmoid; Cystectomy; Drug Resistance, Multiple, Bacterial; Enterococcus; Escherichia coli; Female; Humans; Klebsiella pneumoniae; Leukocyte Count; Levofloxacin; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Postoperative Complications; Prevalence; Pyuria; Staphylococcus aureus; Sulfamethoxazole; Tazobactam; Thienamycins; Trimethoprim; Urinary Diversion; Urinary Tract Infections	2014
Reliability-targeted HPLC-UV method validation--a protocol enrichment perspective. Journal of separation science, 2014, Volume: 37, Issue:3 Topics: Bayes Theorem; Cefepime; Cephalosporins; Chromatography, High Pressure Liquid; Humans; Penicillanic Acid; Reproducibility of Results; Ritonavir; Spectrophotometry, Ultraviolet; Tazobactam	2014
Antimicrobial activity of cefepime-tazobactam combination tested against clinical isolates of Enterobacteriaceae. The Journal of antibiotics, 2014, Volume: 67, Issue:8 Topics: Anti-Bacterial Agents; Cefepime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Enterobacteriaceae; Humans; India; Penicillanic Acid; Tazobactam	2014
Quantification of piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in serum using an isotope dilution UHPLC-MS/MS method with semi-automated sample preparation. Clinical chemistry and laboratory medicine, 2015, Volume: 53, Issue:5 Topics: Analytic Sample Preparation Methods; Anti-Bacterial Agents; Automation; Blood Chemical Analysis; Cefepime; Cephalosporins; Chromatography, High Pressure Liquid; Ciprofloxacin; Humans; Isotopes; Linezolid; Meropenem; Penicillanic Acid; Piperacillin; Tandem Mass Spectrometry; Tazobactam; Thienamycins; Time Factors	2015
A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma. Biomedical chromatography : BMC, 2015, Volume: 29, Issue:12 Topics: Cefepime; Cephalosporins; Dosage Forms; Electrophoresis, Capillary; Green Chemistry Technology; Humans; Linear Models; Penicillanic Acid; Piperacillin; Reproducibility of Results; Sensitivity and Specificity; Tazobactam	2015
Susceptibility Profile of Ceftolozane/Tazobactam and Other Parenteral Antimicrobials Against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa From US Hospitals. Clinical therapeutics, 2015, Jul-01, Volume: 37, Issue:7 Topics: Adult; Anti-Infective Agents; beta-Lactamases; Cefepime; Cephalosporins; Cross Infection; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Enterobacteriaceae; Escherichia coli; Hospitals; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Tazobactam; United States	2015
Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: Adaptation, Physiological; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Gene Expression; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Protein Structure, Secondary; Protein Structure, Tertiary; Pseudomonas aeruginosa; Tazobactam; Ticarcillin	2015
Development of an algorithm for phenotypic screening of carbapenemase-producing Enterobacteriaceae in the routine laboratory. BMC infectious diseases, 2017, 01-17, Volume: 17, Issue:1 Topics: Algorithms; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Cefepime; Cephalosporins; Clavulanic Acids; Drug Resistance, Bacterial; Enterobacteriaceae; Ertapenem; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Tazobactam; Thienamycins; Ticarcillin	2017
Should We Revisit the Nephrotoxic Potential of Piperacillin-Tazobactam as Well? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, 07-01, Volume: 65, Issue:1 Topics: Acute Kidney Injury; Cefepime; Humans; Piperacillin; Tazobactam; Vancomycin	2017
Reply to Manian. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, 07-01, Volume: 65, Issue:1 Topics: Acute Kidney Injury; Cefepime; Humans; Piperacillin; Tazobactam; Vancomycin	2017
Determination of Disk Diffusion and MIC Quality Control Guidelines for High-Dose Cefepime-Tazobactam (WCK 4282), a Novel Antibacterial Combination Consisting of a β-Lactamase Inhibitor and a Fourth-Generation Cephalosporin. Journal of clinical microbiology, 2017, Volume: 55, Issue:10 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cephalosporins; Disk Diffusion Antimicrobial Tests; Drug Combinations; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Guidelines as Topic; Humans; Penicillanic Acid; Quality Control; Tazobactam	2017
Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12 Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Ciprofloxacin; Drug Combinations; Drug Resistance, Multiple, Bacterial; Febrile Neutropenia; Humans; Iatrogenic Disease; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pneumonia; Practice Guidelines as Topic; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Tazobactam; Thienamycins; Tobramycin	2017
Activity of Ceftolozane-Tazobactam and Ceftazidime-Avibactam against Beta-Lactam-Resistant Pseudomonas aeruginosa Isolates. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactam Resistance; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Drug Combinations; Gene Expression; Humans; Los Angeles; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam; Thienamycins	2017
Optimizing Empiric Antibiotic Selection in Sepsis: Turning Probabilities Into Practice. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 01-18, Volume: 66, Issue:3 Topics: Anti-Bacterial Agents; Bacteremia; Cefepime; Gram-Negative Bacteria; Humans; Meropenem; Probability; Sepsis; Tazobactam	2018
Reply to MacFadden et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 01-18, Volume: 66, Issue:3 Topics: Bacteremia; Cefepime; Gram-Negative Bacteria; Humans; Meropenem; Piperacillin; Sepsis; Tazobactam	2018
Potential of high-dose cefepime/tazobactam against multiresistant Gram-negative pathogens. The Journal of antimicrobial chemotherapy, 2018, Jan-01, Volume: 73, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cefepime; Cephalosporins; Drug Combinations; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	2018
Clinical efficacy and safety of cefepime-tazobactam in hospitalized patients in South India. Infectious diseases (London, England), 2018, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Escherichia coli; Escherichia coli Infections; Female; Hospitalization; Humans; India; Klebsiella Infections; Klebsiella pneumoniae; Male; Middle Aged; Penicillanic Acid; Piperacillin; Tazobactam; Treatment Outcome; Young Adult	2018
Activity of Ceftolozane-Tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae Isolates Collected from Respiratory Tract Specimens of Hospitalized Patients in the United States during 2013 to 2015. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Gene Expression; Hospitalization; Humans; Isoenzymes; Meropenem; Microbial Sensitivity Tests; Piperacillin, Tazobactam Drug Combination; Plasmids; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory System; Retrospective Studies; Tazobactam; United States	2018
Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 2: Stability Evaluation. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:9 Topics: Anti-Bacterial Agents; Cefepime; Chromatography, Liquid; Drug Stability; Humans; Meropenem; Piperacillin; Tandem Mass Spectrometry; Tazobactam; Temperature	2018
Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 1: Assay Development and Validation. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:9 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Chromatography, Liquid; Humans; Meropenem; Piperacillin; Sensitivity and Specificity; Tandem Mass Spectrometry; Tazobactam	2018
Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:9 Topics: Anti-Bacterial Agents; Cefepime; Critical Illness; Female; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Tazobactam	2018
Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:5 Topics: Acute Kidney Injury; Aged; Cefepime; Critical Illness; Female; Humans; Incidence; Male; Meropenem; Middle Aged; Multivariate Analysis; Piperacillin; Retrospective Studies; Tazobactam; Vancomycin	2019
Cefepime challenge after piperacillin/tazobactam-induced thrombocytopenia. Journal of thrombosis and thrombolysis, 2019, Volume: 48, Issue:1 Topics: Adult; Anti-Bacterial Agents; Cefepime; Female; Humans; Immunity, Humoral; Male; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pneumonia, Aspiration; Tazobactam; Thrombocytopenia	2019
Stability Studies of Antipyocyanic Beta-Lactam Antibiotics Used in Continuous Infusion. Die Pharmazie, 2019, 06-01, Volume: 74, Issue:6 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactams; Cefepime; Ceftazidime; Cilastatin; Cilastatin, Imipenem Drug Combination; Imipenem; Meropenem; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam	2019
In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae. International journal of antimicrobial agents, 2020, Volume: 56, Issue:1 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Cefepime; Drug Combinations; Enterobacteriaceae Infections; Humans; Imipenem; Microbial Sensitivity Tests; Tazobactam; Triazoles	2020
Comment on "Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples". Therapeutic drug monitoring, 2020, Volume: 42, Issue:6 Topics: Anti-Bacterial Agents; Cefepime; Humans; Meropenem; Piperacillin; Protein Binding; Tazobactam	2020
Comment on "Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples". Therapeutic drug monitoring, 2020, Volume: 42, Issue:6 Topics: Anti-Bacterial Agents; Cefepime; Humans; Meropenem; Piperacillin; Protein Binding; Tazobactam	2020
In vivo activity of WCK 4282 (high-dose cefepime/tazobactam) against serine β-lactamase-producing Enterobacterales and Pseudomonas aeruginosa in the neutropenic murine thigh infection model. The Journal of antimicrobial chemotherapy, 2021, 03-12, Volume: 76, Issue:4 Topics: Animals; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Escherichia coli; Mice; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Serine; Tazobactam; Thigh	2021
Cefepime/tazobactam compared with other tazobactam combinations against problem Gram-negative bacteria. International journal of antimicrobial agents, 2021, Volume: 57, Issue:5 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cefepime; Cephalosporins; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Tazobactam	2021
Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum. The journal of applied laboratory medicine, 2021, 09-01, Volume: 6, Issue:5 Topics: Cefepime; Chromatography, Liquid; Humans; Meropenem; Piperacillin; Reproducibility of Results; Tandem Mass Spectrometry; Tazobactam	2021
Time Above All Else: Pharmacodynamic Analysis of β-Lactams in Critically Ill Patients. Journal of clinical pharmacology, 2022, Volume: 62, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Critical Illness; Humans; Meropenem; Microbial Sensitivity Tests; Monte Carlo Method; Piperacillin; Pseudomonas aeruginosa; Tazobactam	2022
Effects of piperacillin/tazobactam or cefepime on folinate dose in patients receiving high-dose methotrexate: A retrospective cohort study using Japanese administrative claims data. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:7 Topics: Cefepime; Drug Therapy, Combination; Humans; Japan; Leucovorin; Methotrexate; Penicillanic Acid; Piperacillin; Retrospective Studies; Tazobactam	2022
Antimicrobial activity of high-dose cefepime-tazobactam (WCK 4282) against a large collection of gram-negative organisms collected worldwide in 2018 and 2019. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022, Volume: 116 Topics: Anti-Bacterial Agents; Cefepime; Cephalosporins; Humans; Meropenem; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Tazobactam	2022
Emerging resistance to ceftriaxone treatment owing to different ampD mutations in Enterobacter roggenkampii. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2022, Volume: 102 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cefepime; Ceftriaxone; Drug Resistance, Bacterial; Enterobacter; Enterobacter cloacae; Humans; Liver Abscess; Microbial Sensitivity Tests; Mutation; Piperacillin; Tazobactam	2022
Antimicrobial activity of cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer combination, against clinical isolates of Gram-negative bacteria collected worldwide (2018-19). The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Carbapenems; Cefepime; Ceftazidime; Cephalosporins; Cyclooctanes; Enterobacteriaceae; Gram-Negative Bacteria; Hydrazines; Lactams; Microbial Sensitivity Tests; Piperidines; Pseudomonas aeruginosa; Tazobactam	2022
Activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamases; Borinic Acids; Carboxylic Acids; Cefepime; Cefiderocol; Ceftazidime; Cephalosporins; Cyclooctanes; Humans; Imipenem; Piperidines; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam	2022
An Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Determination of 4 β-Lactam Antibiotics, Tazobactam, and Linezolid in Human Plasma Samples. Therapeutic drug monitoring, 2022, 12-01, Volume: 44, Issue:6 Topics: Anti-Bacterial Agents; Cefepime; Cefotaxime; Chromatography, High Pressure Liquid; Critical Illness; Drug Monitoring; Humans; Linezolid; Meropenem; Monobactams; Piperacillin; Reproducibility of Results; Tandem Mass Spectrometry; Tazobactam	2022
Cefepime pharmacodynamic targets against Enterobacterales employing neutropenic murine lung infection and in vitro pharmacokinetic models. The Journal of antimicrobial chemotherapy, 2022, 11-28, Volume: 77, Issue:12 Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Lung; Mice; Microbial Sensitivity Tests; Tazobactam	2022
Phenotypic and genotypic profile of ceftolozane/tazobactam-non-susceptible, carbapenem-resistant Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy, 2022, 12-23, Volume: 78, Issue:1 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamases; Carbapenems; Cefepime; Ceftazidime; Cephalosporins; Drug Combinations; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam	2022
Carbapenem-resistant Pseudomonas aeruginosa: an assessment of frequency of isolation from ICU versus non-ICU, phenotypic and genotypic profiles in a multinational population of hospitalized patients. Antimicrobial resistance and infection control, 2022, 11-30, Volume: 11, Issue:1 Topics: Carbapenems; Cefepime; Ceftazidime; Phenotype; Pseudomonas aeruginosa; Tazobactam	2022
Genotypic resistance determined by whole genome sequencing versus phenotypic resistance in 234 Escherichia coli isolates. Scientific reports, 2023, 01-09, Volume: 13, Issue:1 Topics: Amikacin; Amoxicillin; Anti-Bacterial Agents; Cefepime; Cefotaxime; Ceftazidime; Ciprofloxacin; Clavulanic Acid; Escherichia coli; Escherichia coli Infections; Genotype; Gentamicins; Humans; Meropenem; Microbial Sensitivity Tests; Phenotype; Piperacillin; Retrospective Studies; Tazobactam; Tobramycin; Whole Genome Sequencing	2023
Cefepime/Enmetazobactam vs Piperacillin/Tazobactam and Complicated Urinary Tract Infection or Acute Pyelonephritis-Reply. JAMA, 2023, 02-28, Volume: 329, Issue:8 Topics: Cefepime; Humans; Piperacillin; Pyelonephritis; Tazobactam; Urinary Tract Infections	2023
Cefepime/Enmetazobactam vs Piperacillin/Tazobactam and Complicated Urinary Tract Infection or Acute Pyelonephritis. JAMA, 2023, 02-28, Volume: 329, Issue:8 Topics: Anti-Bacterial Agents; Cefepime; Drug Therapy, Combination; Humans; Piperacillin; Pyelonephritis; Tazobactam; Urinary Tract Infections	2023