taxifolin and apigenin

taxifolin has been researched along with apigenin in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (19.35)18.2507
2000's9 (29.03)29.6817
2010's13 (41.94)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
Chang, CJ; Geahlen, RL1
Augereau, JM; Billon, M; Gleye, J; Herbert, JM; Lale, A; Leconte, M1
Habtemariam, S1
Jacobson, KA; Moro, S; Sanders, LH; van Rhee, AM1
Karioti, A; Konstantinopoulou, M; Skaltsa, H; Skaltsas, S1
Katavic, PL; Lamb, K; Navarro, H; Prisinzano, TE1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Gestwicki, JE; Reinke, AA; Seh, HY1
Amić, D; Lucić, B1
Alcaro, S; Bolasco, A; Chimenti, F; Chimenti, P; Cirilli, R; Ferretti, R; Fioravanti, R; Orallo, F; Ortuso, F; Rossi, F; Sanna, ML; Secci, D; Yáñez, M1
Cai, S; Chu, L; Gao, F; Ji, B; Jia, G; Liu, J; Liu, Y; Wang, A; Wei, Y; Wu, W; Xie, L; Zhang, D; Zhou, F1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Chin, YW; Han, SY; Kong, JY1
Fernandes, E; Freitas, M; Porto, G; Ribeiro, D; Silva, AM; Tomé, SM1
Cabrita, EJ; Fernandes, E; Freitas, M; Marques, MM; Porto, G; Ribeiro, D; Silva, AM; Tomé, SM1
Bicknell, KA; Farrimond, JA; Putnam, SE; Swioklo, S; Watson, KA; Williamson, EM1
Cahlikova, L; Chlebek, J; Havrankova, J; Hofman, J; Hostalkova, A; Lundova, T; Musilek, K; Novotna, E; Wsol, V; Zemanova, L1
Akagi, K; Hanaki, M; Irie, K; Murakami, K1
Fernandes, E; Fernandes, PA; Freitas, M; Oliveira, A; Proença, C; Ramos, MJ; Ribeiro, D; Silva, AMS; Sousa, JLC1
Albiñana, CB; Brynda, J; Fanfrlík, J; Flieger, M; Hodek, J; Karlukova, E; Konvalinka, J; Kožíšek, M; Machara, A; Majer, P; Radilová, K; Weber, J; Zima, V1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Bito, T; Gotoh, A; Ichihashi, M; Packer, L; Roy, S; Sen, CK; Shirakawa, T; Ueda, M1
Ueda, H; Yamazaki, C; Yamazaki, M1
Almar, M; Crespo, I; García-Mediavilla, MV; González, P; González-Gallego, J; Sánchez-Campos, S; Tuñón, MJ1
Arinç, E; Çelik, H; Koşar, M1
Benet, M; García-Mediavilla, MV; González-Gallego, J; Jorquera, F; Jover, R; Majano, PL; Pisonero-Vaquero, S; Sánchez-Campos, S1
Jacobson, KA; Ji, XD; Melman, N1
Calomme, M; Cimanga, K; Cos, P; Hu, JP; Pieters, L; Van Poel, B; Vanden Berghe, D; Vlietinck, AJ; Ying, L1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Dong, JJ; Feng, YT; He, J; Lin, WQ; Lu, CL; Ouyang, H; Peng, ZY; Wang, JX; Xiang, YP; Xiao, ZP; Zhu, HL1

Reviews

1 review(s) available for taxifolin and apigenin

ArticleYear
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.
    Journal of natural products, 1992, Volume: 55, Issue:11

    Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Protein-Tyrosine Kinases

1992

Other Studies

30 other study(ies) available for taxifolin and apigenin

ArticleYear
Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes.
    Journal of natural products, 1996, Volume: 59, Issue:3

    Topics: Amino Acid Sequence; Blood Coagulation; Cell Adhesion; Endotoxins; Flavonoids; Humans; In Vitro Techniques; Interleukin-1; Molecular Sequence Data; Monocytes

1996
Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.
    Journal of natural products, 1997, Volume: 60, Issue:8

    Topics: Animals; Apoptosis; Drug Synergism; Flavonoids; Mice; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1997
Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.
    Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1

    Topics: Binding Sites; Computer Simulation; Flavonoids; Kinetics; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Regression Analysis; Reproducibility of Results; Static Electricity; Structure-Activity Relationship

1998
Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity.
    Journal of natural products, 2003, Volume: 66, Issue:5

    Topics: Asteraceae; Gram-Negative Bacteria; Gram-Positive Bacteria; Greece; Helicobacter pylori; Lactones; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sesquiterpenes; Stereoisomerism

2003
Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.
    Journal of natural products, 2007, Volume: 70, Issue:8

    Topics: Flavonoids; Humans; Hypericum; Ligands; Narcotic Antagonists; Plants, Medicinal; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship

2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
    Bioorganic & medicinal chemistry letters, 2009, Sep-01, Volume: 19, Issue:17

    Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Fluorescent Dyes; Indoles; Spectrometry, Fluorescence; Thiazoles

2009
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Flavonoids; Free Radical Scavengers; Models, Biological; Quantitative Structure-Activity Relationship; Quantum Theory; Software; Thermodynamics

2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.
    Bioorganic & medicinal chemistry, 2010, Volume: 18, Issue:3

    Topics: Flavanones; Flavones; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Sulfhydryl Compounds

2010
Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:9

    Topics: Antioxidants; Cell Line; Fatty Liver; Flavonoids; Humans; In Vitro Techniques; Oleic Acid; Reactive Oxygen Species; Triglycerides

2011
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Flavonoids; fms-Like Tyrosine Kinase 3; Humans; Luteolin; Protein Kinase Inhibitors

2013
Modulation of human neutrophils' oxidative burst by flavonoids.
    European journal of medicinal chemistry, 2013, Volume: 67

    Topics: Flavonoids; Humans; Luminescent Measurements; Molecular Structure; Neutrophils; Oxidation-Reduction

2013
Inhibition of LOX by flavonoids: a structure-activity relationship study.
    European journal of medicinal chemistry, 2014, Jan-24, Volume: 72

    Topics: Dose-Response Relationship, Drug; Flavonoids; Glycine max; Humans; Leukotriene B4; Lipoxygenase; Molecular Structure; Neutrophils; Structure-Activity Relationship

2014
Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids.
    Journal of natural products, 2015, Nov-25, Volume: 78, Issue:11

    Topics: Cell Differentiation; Flavonoids; Humans; Mesenchymal Stem Cells; Molecular Structure; Osteogenesis; Signal Transduction; Structure-Activity Relationship

2015
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.
    Journal of natural products, 2015, Nov-25, Volume: 78, Issue:11

    Topics: Aldehyde Reductase; Aldo-Keto Reductases; Apigenin; Daunorubicin; Enzyme Inhibitors; Flavones; Flavonoids; HCT116 Cells; Humans; Luteolin; Molecular Conformation; Molecular Structure; Neoplasms

2015
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.
    Bioorganic & medicinal chemistry, 2016, Jan-15, Volume: 24, Issue:2

    Topics: Amyloid beta-Peptides; Dose-Response Relationship, Drug; Flavonoids; Molecular Structure; Peptide Fragments; Structure-Activity Relationship

2016
Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.
    Journal of natural products, 2020, 05-22, Volume: 83, Issue:5

    Topics: Drug Design; Enzyme Inhibitors; Flavonoids; Fructose; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Liver; Molecular Structure

2020
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
    European journal of medicinal chemistry, 2020, Dec-15, Volume: 208

    Topics: Antiviral Agents; Crystallography, X-Ray; Drug Evaluation, Preclinical; Endonucleases; Enzyme Assays; Enzyme Inhibitors; Flavonoids; Influenza A virus; Microbial Sensitivity Tests; Molecular Structure; Protein Binding; Protein Domains; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Viral Proteins

2020
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action.
    FEBS letters, 2002, Jun-05, Volume: 520, Issue:1-3

    Topics: Apigenin; Catechin; Cell Adhesion; Cell Line; Cells, Cultured; Coumaric Acids; Dose-Response Relationship, Drug; Flavonoids; Flavonols; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Jurkat Cells; Keratinocytes; Phosphorylation; Quercetin; RNA, Messenger; Tyrosine

2002
A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production.
    Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:1

    Topics: Administration, Oral; Animals; Anthocyanins; Anti-Inflammatory Agents; Apigenin; Cells, Cultured; Ear, External; Edema; Flavonoids; Flavonols; Lipopolysaccharides; Luteolin; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Quercetin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2004
Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:5

    Topics: Antioxidants; Apigenin; Blotting, Western; Cell Survival; Cytokines; Flavonoids; Flavonols; Glutathione; Hepatocytes; Humans; Inflammation; Kaempferols; Liver; Oxidation-Reduction; Quercetin; Reactive Nitrogen Species; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles

2008
In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.
    Toxicology, 2013, Jun-07, Volume: 308

    Topics: Animals; Apigenin; Catechin; Cattle; Cytochrome-B(5) Reductase; Cytochromes b5; Flavanones; Flavonoids; Microsomes, Liver; Protein Binding; Quercetin; Rabbits

2013
Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.
    Laboratory investigation; a journal of technical methods and pathology, 2014, Volume: 94, Issue:3

    Topics: Antioxidants; Antiviral Agents; Apigenin; Cell Line; Chromones; Down-Regulation; Fatty Acids, Nonesterified; Hepacivirus; Humans; Kaempferols; Lipogenesis; Liver X Receptors; Morpholines; Orphan Nuclear Receptors; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quercetin; Reactive Nitrogen Species; Signal Transduction; Triglycerides; Virus Replication

2014
Interactions of flavonoids and other phytochemicals with adenosine receptors.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Animals; Cell Line; CHO Cells; Cricetinae; Flavonoids; Humans; Magnetic Resonance Spectroscopy; Plants; Protein Binding; Radioligand Assay; Rats; Receptors, Purinergic P1

1996
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
    Journal of natural products, 1998, Volume: 61, Issue:1

    Topics: Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Structure-Activity Relationship; Xanthine Oxidase

1998
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Bacterial Proteins; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Helicobacter pylori; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Urease

2013