tautomycin and 4-aminophenylphosphate

tautomycin has been researched along with 4-aminophenylphosphate* in 1 studies

Other Studies

1 other study(ies) available for tautomycin and 4-aminophenylphosphate

Article	Year
RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS letters, 1995, Sep-18, Volume: 372, Issue:1 A specific inhibitor of protein tyrosine phosphatase (PTPase), RK-682 (3-hexadecanoyl-5-hydroxymethyl-tetronic acid) was isolated from microbial metabolites. In vitro, RK-682 inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 microM, respectively. In situ, sodium orthovanadate and RK-682 enhanced the phosphotyrosine level of Ball-1 cells, a human B cell leukemia, but not the phosphoserine/threonine level. The PTPase inhibitors, however, had the different arrest point on the cell cycle progression. Sodium orthovanadate inhibited the cell cycle progression at G2/M boundary phase, on the other hand, RK-682 inhibited the G1/S transition. Topics: Aniline Compounds; Antifungal Agents; Blotting, Western; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Dual Specificity Phosphatase 3; Enzyme Inhibitors; Ethers, Cyclic; G1 Phase; Humans; Kinetics; Leukemia, B-Cell; Okadaic Acid; Organophosphorus Compounds; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrans; Spiro Compounds; Streptomyces; Tumor Cells, Cultured; Vanadates	1995

Article

Year

RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase.

FEBS letters, 1995, Sep-18, Volume: 372, Issue:1

A specific inhibitor of protein tyrosine phosphatase (PTPase), RK-682 (3-hexadecanoyl-5-hydroxymethyl-tetronic acid) was isolated from microbial metabolites. In vitro, RK-682 inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 microM, respectively. In situ, sodium orthovanadate and RK-682 enhanced the phosphotyrosine level of Ball-1 cells, a human B cell leukemia, but not the phosphoserine/threonine level. The PTPase inhibitors, however, had the different arrest point on the cell cycle progression. Sodium orthovanadate inhibited the cell cycle progression at G2/M boundary phase, on the other hand, RK-682 inhibited the G1/S transition.

Topics: Aniline Compounds; Antifungal Agents; Blotting, Western; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Dual Specificity Phosphatase 3; Enzyme Inhibitors; Ethers, Cyclic; G1 Phase; Humans; Kinetics; Leukemia, B-Cell; Okadaic Acid; Organophosphorus Compounds; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrans; Spiro Compounds; Streptomyces; Tumor Cells, Cultured; Vanadates

1995