taurochenodeoxycholic-acid has been researched along with 4-cresol* in 2 studies
2 other study(ies) available for taurochenodeoxycholic-acid and 4-cresol
Article | Year |
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TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model.
Chronic kidney disease (CKD) leads to the loss of kidney function, as well as the dysfunction of several other organs due to the release of uremic toxins into the system. In a murine CKD model, reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress are increased in the hippocampus. Mesenchymal stem cells (MSCs) are one of the candidates for cell-based therapy for CKD; however severe pathophysiological conditions can decrease their therapeutic potential. To address these issues, we established tauroursodeoxycholic acid (TUDCA)-treated MSCs using MSCs isolated from patients with CKD (CKD-hMSCs) and assessed the survival and ROS generation of neural cell line SH-SY5Y cells by co-culturing with TUDCA-treated CKD-hMSCs. In the presence of the uremic toxin Topics: Adenine; Animals; Cell Line; Cell Survival; Coculture Techniques; Cresols; Disease Models, Animal; Endoplasmic Reticulum Stress; Hippocampus; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; PrPC Proteins; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Taurochenodeoxycholic Acid; Up-Regulation | 2019 |
Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein.
Mesenchymal stem cells (MSCs) could be a promising solution in the treatment of various diseases including chronic kidney disease (CKD). However, endoplasmic reticulum (ER) stress induced by ischemia in the area of application limits the integration and survival of MSCs in patients. In our study, we generated ER stress-induced conditions in MSCs using Topics: Adipose Tissue; Antioxidants; Apoptosis; Cells, Cultured; Cresols; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Mesenchymal Stem Cells; Oxidative Stress; PrPC Proteins; Reactive Oxygen Species; Taurochenodeoxycholic Acid | 2018 |