tartrolon-b and laulimalide

tartrolon-b has been researched along with laulimalide* in 1 studies

Reviews

1 review(s) available for tartrolon-b and laulimalide

ArticleYear
Lessons learned from macrolide synthesis.
    Chemical record (New York, N.Y.), 2004, Volume: 3, Issue:5

    The highlights of three macrolide syntheses recently completed in our laboratory are described. In the epothilone B synthesis we developed the "early epoxide approach," which resulted in the first completely stereocontrolled synthesis of this natural product. In the laulimalide synthesis our contribution was the auxiliary controlled ene-macrocyclization and Sharpless' kinetic resolution for achieving a regioselective epoxidation of two pseudo-enantiomorphic allylic alcohol subunits. The tartrolon B synthesis was the first to be completed. In this case, a substrate controlled aldol addition was used to assemble the entire carbon skeleton of the compound.

    Topics: Borates; Cyclization; Epothilones; Epoxy Compounds; Macrolides; Stereoisomerism; Taxoids

2004