Page last updated: 2024-09-04

tariquidar and verapamil

tariquidar has been researched along with verapamil in 44 studies

Compound Research Comparison

Studies
(tariquidar)
Trials
(tariquidar)
Recent Studies (post-2010)
(tariquidar)
Studies
(verapamil)
Trials
(verapamil)
Recent Studies (post-2010) (verapamil)
2101613817,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomytariquidar (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.27)18.2507
2000's9 (20.45)29.6817
2010's30 (68.18)24.3611
2020's4 (9.09)2.80

Authors

AuthorsStudies
Ashworth, P; Brumwell, J; Charlton, P; Chima, L; Dangerfield, W; Folkes, A; Hunjan, S; Pretswell, I; Roe, M; Ryder, H1
Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H1
Catalano, C; Gaudreault, RC; Labrie, P; Lacroix, J; Lee, DK; Maddaford, SP; Rakhit, S1
Globisch, C; Müller, H; Pajeva, IK; Wiese, M1
Müller, H; Pick, A; Wiese, M1
Globisch, C; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Bönisch, H; Haenisch, B; Mayer, R; Müller, CE; Müller, H; Pajeva, IK; Pick, A; Weigt, M; Wiese, M1
Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U1
Colabufo, NA; Contino, M; Digiacomo, M; Lapucci, A; Macchia, M; Nesi, G; Perrone, MG; Perrone, R; Rapposelli, S1
Bu, X; Li, W; Lou, L; Tang, G; Wang, R; Yin, S; Zhu, J1
Bartolucci, G; Coronnello, M; Dei, S; Floriddia, E; Manetti, D; Romanelli, MN; Salerno, M; Santo Domingo Porqueras, D; Teodori, E1
Cui, J; Ghaleb, H; Huang, W; Jiao, L; Kairuki, M; Liao, C; Lin, H; Pan, M; Qian, H; Zhou, J1
Waghray, D; Zhang, Q1
Bartolucci, G; Coronnello, M; Dei, S; Manetti, D; Romanelli, MN; Salerno, M; Teodori, E; Udomtanakunchai, C1
Bi, X; Cui, J; Gao, Y; Huang, W; Li, Z; Liu, C; Qian, H; Shi, W; Wang, G1
Bi, Y; Liu, XX; Qi, JG; Ren, QW; Tian, JW; Wang, BH; Wang, HB; Wang, X; Yang, YT; Zhai, R1
Ghaleb, H; Huang, W; Jiang, C; Kairuki, M; Li, Q; Pan, M; Qian, H; Qiu, Q; Zhou, J1
Alexiou, P; Chilov, GG; Ivanova, ES; Novikov, FN; Pelecanou, M; Sagnou, M; Shtil, AA; Stroylov, VS; Tatarskiy, VV; Titov, IY; Vagida, MS1
Bi, Y; Chen, X; Huang, W; Li, X; Liang, K; Liu, S; Ma, M; Wang, B; Wang, H; Zeng, W1
Bi, Y; Cheng, H; Huang, W; Liu, S; Qiao, H; Tian, Q; Wang, H; Wang, L; Wang, R; Wang, Y; Xu, S1
Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F1
Litman, T; Skovsgaard, T; Stein, WD1
Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S1
Abrahim, A; Bankstahl, JP; Karch, R; Kletter, K; Kuntner, C; Langer, O; Löscher, W; Müller, M; Stanek, J; Wadsak, W; Wanek, T1
Bauer, M; Chiba, P; Feurstein, T; Karch, R; Kletter, K; Kopp, S; Langer, O; Löscher, W; Müller, M; Wagner, CC; Zeitlinger, M1
Bauer, M; Karch, R; Kletter, K; Langer, O; Löscher, W; Müller, M; Neumann, F; Wagner, CC; Zeitlinger, M1
Bankstahl, JP; Bankstahl, M; Brauner, R; Ding, X; Karch, R; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Stundner, G; Wanek, T1
Bankstahl, JP; Bankstahl, M; Ding, XQ; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Wanek, T1
Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T1
Greenberg, RM; Kasinathan, RS; Morgan, WM1
Bankstahl, JP; Bauer, M; Böhmdorfer, M; Jäger, W; Karch, R; Koepp, M; Kuntner, C; Langer, O; Löscher, W; Matzneller, P; Mitterhauser, M; Müller, M; Stanek, J; Wadsak, W; Zeitlinger, M1
Amano, N; Hirabayashi, H; Moriwaki, T; Sugimoto, H1
Baum, L; Chanteux, H; Kwan, P; Zhang, C; Zuo, Z1
Ambudkar, SV; Ansbro, MR; Li, L; Shukla, S; Yuspa, SH1
Bankstahl, JP; Bankstahl, M; Karch, R; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müllauer, J; Müller, M; Stanek, J; Wanek, T1
McCormick, JW; Vogel, PD; Wise, JG1
Bauer, M; Hacker, M; Haslacher, H; Jäger, W; Jungbauer, C; Karch, R; Langer, O; Löscher, W; Maier-Salamon, A; Philippe, C; Römermann, K; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M1
Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S1
Bauer, M; Hacker, M; Jäger, W; Karch, R; Langer, O; Philippe, C; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M1
Clarke, DM; Loo, TW1
Doligalska, M; Donskow-Łysoniewska, K; Kozłowska, E; Krawczak, K1
Breier, A; Elefantova, K; Kubickova, J; Lakatos, B; Sulova, Z1
Ambudkar, SV; Lusvarghi, S1

Reviews

2 review(s) available for tariquidar and verapamil

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
    Journal of medicinal chemistry, 2018, 06-28, Volume: 61, Issue:12

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation

2018

Trials

3 trial(s) available for tariquidar and verapamil

ArticleYear
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
    Biochemical pharmacology, 2008, Mar-15, Volume: 75, Issue:6

    Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine

2008
A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:12

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carbon Radioisotopes; Humans; Kinetics; Male; Pilot Projects; Positron-Emission Tomography; Quinolines; Verapamil

2009
Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:9

    Topics: Adult; Age Factors; Aged; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Drug Interactions; Gray Matter; Healthy Volunteers; Humans; Male; Positron-Emission Tomography; Quinolines; Verapamil

2017

Other Studies

39 other study(ies) available for tariquidar and verapamil

ArticleYear
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
    Bioorganic & medicinal chemistry letters, 1999, Feb-22, Volume: 9, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Humans; ortho-Aminobenzoates; Structure-Activity Relationship; Tumor Cells, Cultured

1999
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection

2007
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Intestines; ortho-Aminobenzoates; Pyrazines; Quinolines

2007
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
    Bioorganic & medicinal chemistry, 2008, Mar-01, Volume: 16, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Humans; Ligands; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Quantitative Structure-Activity Relationship

2008
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured

2008
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
    Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Models, Molecular

2009
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
    Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Hydrogen Bonding; Models, Molecular; Neoplasm Proteins; Quantitative Structure-Activity Relationship

2011
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2012
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.
    European journal of medicinal chemistry, 2014, Apr-09, Volume: 76

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2014
Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Euphorbia; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Molecular Structure; Rats; Structure-Activity Relationship

2016
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Amines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclohexanols; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; Esters; Humans; K562 Cells; Rhodamine 123

2017
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.
    Bioorganic & medicinal chemistry, 2017, 08-01, Volume: 25, Issue:15

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Humans; Isoquinolines; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Triazoles

2017
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.
    European journal of medicinal chemistry, 2018, Mar-10, Volume: 147

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; K562 Cells; Molecular Structure; Piperazine; Piperazines; Structure-Activity Relationship; Tumor Cells, Cultured

2018
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors.
    Bioorganic & medicinal chemistry, 2018, 05-15, Volume: 26, Issue:9

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Isoquinolines; K562 Cells; Molecular Docking Simulation; Quinolines; Rhodamine 123; Structure-Activity Relationship

2018
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
    European journal of medicinal chemistry, 2019, Jan-01, Volume: 161

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured

2019
Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.
    Bioorganic & medicinal chemistry, 2019, 08-01, Volume: 27, Issue:15

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; K562 Cells; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tetrahydroisoquinolines; Triazoles

2019
Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin.
    European journal of medicinal chemistry, 2020, Jul-15, Volume: 198

    Topics: Amides; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Survival; Curcumin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; K562 Cells; Leukemia, Myeloid; Models, Molecular; Structure-Activity Relationship

2020
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
    European journal of medicinal chemistry, 2021, Feb-05, Volume: 211

    Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship

2021
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
    European journal of medicinal chemistry, 2022, Mar-15, Volume: 232

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Nude; Nitrogen; Oleanolic Acid

2022
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
    European journal of medicinal chemistry, 2022, Apr-05, Volume: 233

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel

2022
Pumping of drugs by P-glycoprotein: a two-step process?
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Algorithms; Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cyclosporine; Daunorubicin; Fluoresceins; Humans; Immunosuppressive Agents; Kinetics; Models, Biological; Pharmaceutical Preparations; Quinolines; Verapamil; Vinblastine

2003
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Calcium Channel Blockers; Carbon Radioisotopes; Female; Models, Biological; Positron-Emission Tomography; Quinolines; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution; Verapamil

2008
Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:3

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Drug Resistance, Multiple; Epilepsy; Humans; Image Processing, Computer-Assisted; Infusions, Intravenous; Male; Positron-Emission Tomography; Quinolines; Verapamil

2010
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:5

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Blood-Brain Barrier; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrahydroisoquinolines; Verapamil

2010
A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jun-15, Volume: 31, Issue:24

    Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Calcium Channel Blockers; Carbon Isotopes; Computer Simulation; Disease Models, Animal; Female; Gene Expression Regulation; Heterocyclic Compounds; Magnetic Resonance Imaging; Models, Chemical; Organometallic Compounds; Pilocarpine; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Scopolamine; Seizures; Time Factors; Verapamil

2011
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
    European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:1

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Mice; Phenotype; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Verapamil

2012
Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni.
    PLoS neglected tropical diseases, 2011, Volume: 5, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Female; Gene Knockdown Techniques; Male; Mice; Multidrug Resistance-Associated Proteins; Ovum; Parasite Load; Quinolines; RNA Interference; Schistosoma mansoni; Verapamil

2011
Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data.
    Clinical pharmacology and therapeutics, 2012, Volume: 91, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbon Radioisotopes; Dose-Response Relationship, Drug; Humans; Positron-Emission Tomography; Quinolines; Rats; Species Specificity; Verapamil

2012
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Drug Interactions; Humans; LLC-PK1 Cells; Loperamide; Quinolines; Swine; Verapamil

2013
Potential role for human P-glycoprotein in the transport of lacosamide.
    Epilepsia, 2013, Volume: 54, Issue:7

    Topics: Acetamides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Lacosamide; Quinolines; Rhodamine 123; RNA, Messenger; Swine; Time Factors; Transfection; Tritium; Verapamil

2013
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cyclosporine; Drug Resistance, Multiple; High-Throughput Screening Assays; Humans; Quinolines; Reproducibility of Results; Verapamil

2013
Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
    Nuclear medicine and biology, 2013, Volume: 40, Issue:6

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Carbon Radioisotopes; Female; Gene Expression Regulation; Kinetics; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil

2013
Multiple Drug Transport Pathways through Human P-Glycoprotein.
    Biochemistry, 2015, Jul-21, Volume: 54, Issue:28

    Topics: Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biological Transport; Daunorubicin; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Protein Conformation; Quinolines; Verapamil

2015
Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier.
    Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:2

    Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Female; Humans; Male; Neoplasm Proteins; Pilot Projects; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Tissue Distribution; Verapamil; Young Adult

2016
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
    The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil

2017
Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.
    Biochemical and biophysical research communications, 2017, 07-08, Volume: 488, Issue:4

    Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Detergents; Enzyme Activation; Glucosides; Humans; Micelles; Quinolines; Rhodamines; Verapamil

2017
The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.
    Parasite immunology, 2017, Volume: 39, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cyclosporine; Host-Parasite Interactions; Interleukin-4; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Nematospiroides dubius; NF-kappa B; Quinolines; Strongylida Infections; T-Lymphocyte Subsets; Verapamil

2017
Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter.
    International journal of molecular sciences, 2018, 07-07, Volume: 19, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Carbocyanines; Cell Line; Cyclosporine; Fluorescent Dyes; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Quinolines; Verapamil

2018
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
    The Biochemical journal, 2019, 12-19, Volume: 476, Issue:24

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil

2019