tariquidar has been researched along with verapamil in 44 studies
| Studies (tariquidar) | Trials (tariquidar) | Recent Studies (post-2010) (tariquidar) | Studies (verapamil) | Trials (verapamil) | Recent Studies (post-2010) (verapamil) |
|---|---|---|---|---|---|
| 210 | 16 | 138 | 17,621 | 1,527 | 2,067 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 9 (20.45) | 29.6817 |
| 2010's | 30 (68.18) | 24.3611 |
| 2020's | 4 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ashworth, P; Brumwell, J; Charlton, P; Chima, L; Dangerfield, W; Folkes, A; Hunjan, S; Pretswell, I; Roe, M; Ryder, H | 1 |
| Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H | 1 |
| Catalano, C; Gaudreault, RC; Labrie, P; Lacroix, J; Lee, DK; Maddaford, SP; Rakhit, S | 1 |
| Globisch, C; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| Globisch, C; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Bönisch, H; Haenisch, B; Mayer, R; Müller, CE; Müller, H; Pajeva, IK; Pick, A; Weigt, M; Wiese, M | 1 |
| Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U | 1 |
| Colabufo, NA; Contino, M; Digiacomo, M; Lapucci, A; Macchia, M; Nesi, G; Perrone, MG; Perrone, R; Rapposelli, S | 1 |
| Bu, X; Li, W; Lou, L; Tang, G; Wang, R; Yin, S; Zhu, J | 1 |
| Bartolucci, G; Coronnello, M; Dei, S; Floriddia, E; Manetti, D; Romanelli, MN; Salerno, M; Santo Domingo Porqueras, D; Teodori, E | 1 |
| Cui, J; Ghaleb, H; Huang, W; Jiao, L; Kairuki, M; Liao, C; Lin, H; Pan, M; Qian, H; Zhou, J | 1 |
| Waghray, D; Zhang, Q | 1 |
| Bartolucci, G; Coronnello, M; Dei, S; Manetti, D; Romanelli, MN; Salerno, M; Teodori, E; Udomtanakunchai, C | 1 |
| Bi, X; Cui, J; Gao, Y; Huang, W; Li, Z; Liu, C; Qian, H; Shi, W; Wang, G | 1 |
| Bi, Y; Liu, XX; Qi, JG; Ren, QW; Tian, JW; Wang, BH; Wang, HB; Wang, X; Yang, YT; Zhai, R | 1 |
| Ghaleb, H; Huang, W; Jiang, C; Kairuki, M; Li, Q; Pan, M; Qian, H; Qiu, Q; Zhou, J | 1 |
| Alexiou, P; Chilov, GG; Ivanova, ES; Novikov, FN; Pelecanou, M; Sagnou, M; Shtil, AA; Stroylov, VS; Tatarskiy, VV; Titov, IY; Vagida, MS | 1 |
| Bi, Y; Chen, X; Huang, W; Li, X; Liang, K; Liu, S; Ma, M; Wang, B; Wang, H; Zeng, W | 1 |
| Bi, Y; Cheng, H; Huang, W; Liu, S; Qiao, H; Tian, Q; Wang, H; Wang, L; Wang, R; Wang, Y; Xu, S | 1 |
| Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F | 1 |
| Litman, T; Skovsgaard, T; Stein, WD | 1 |
| Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S | 1 |
| Abrahim, A; Bankstahl, JP; Karch, R; Kletter, K; Kuntner, C; Langer, O; Löscher, W; Müller, M; Stanek, J; Wadsak, W; Wanek, T | 1 |
| Bauer, M; Chiba, P; Feurstein, T; Karch, R; Kletter, K; Kopp, S; Langer, O; Löscher, W; Müller, M; Wagner, CC; Zeitlinger, M | 1 |
| Bauer, M; Karch, R; Kletter, K; Langer, O; Löscher, W; Müller, M; Neumann, F; Wagner, CC; Zeitlinger, M | 1 |
| Bankstahl, JP; Bankstahl, M; Brauner, R; Ding, X; Karch, R; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Stundner, G; Wanek, T | 1 |
| Bankstahl, JP; Bankstahl, M; Ding, XQ; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Wanek, T | 1 |
| Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T | 1 |
| Greenberg, RM; Kasinathan, RS; Morgan, WM | 1 |
| Bankstahl, JP; Bauer, M; Böhmdorfer, M; Jäger, W; Karch, R; Koepp, M; Kuntner, C; Langer, O; Löscher, W; Matzneller, P; Mitterhauser, M; Müller, M; Stanek, J; Wadsak, W; Zeitlinger, M | 1 |
| Amano, N; Hirabayashi, H; Moriwaki, T; Sugimoto, H | 1 |
| Baum, L; Chanteux, H; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Ambudkar, SV; Ansbro, MR; Li, L; Shukla, S; Yuspa, SH | 1 |
| Bankstahl, JP; Bankstahl, M; Karch, R; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müllauer, J; Müller, M; Stanek, J; Wanek, T | 1 |
| McCormick, JW; Vogel, PD; Wise, JG | 1 |
| Bauer, M; Hacker, M; Haslacher, H; Jäger, W; Jungbauer, C; Karch, R; Langer, O; Löscher, W; Maier-Salamon, A; Philippe, C; Römermann, K; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M | 1 |
| Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S | 1 |
| Bauer, M; Hacker, M; Jäger, W; Karch, R; Langer, O; Philippe, C; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M | 1 |
| Clarke, DM; Loo, TW | 1 |
| Doligalska, M; Donskow-Łysoniewska, K; Kozłowska, E; Krawczak, K | 1 |
| Breier, A; Elefantova, K; Kubickova, J; Lakatos, B; Sulova, Z | 1 |
| Ambudkar, SV; Lusvarghi, S | 1 |
2 review(s) available for tariquidar and verapamil
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation | 2018 |
3 trial(s) available for tariquidar and verapamil
| Article | Year |
|---|---|
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine | 2008 |
A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carbon Radioisotopes; Humans; Kinetics; Male; Pilot Projects; Positron-Emission Tomography; Quinolines; Verapamil | 2009 |
Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[
Topics: Adult; Age Factors; Aged; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Drug Interactions; Gray Matter; Healthy Volunteers; Humans; Male; Positron-Emission Tomography; Quinolines; Verapamil | 2017 |
39 other study(ies) available for tariquidar and verapamil
| Article | Year |
|---|---|
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Humans; ortho-Aminobenzoates; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection | 2007 |
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Intestines; ortho-Aminobenzoates; Pyrazines; Quinolines | 2007 |
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Humans; Ligands; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Quantitative Structure-Activity Relationship | 2008 |
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 2008 |
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Models, Molecular | 2009 |
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Hydrogen Bonding; Models, Molecular; Neoplasm Proteins; Quantitative Structure-Activity Relationship | 2011 |
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2014 |
Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Euphorbia; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Molecular Structure; Rats; Structure-Activity Relationship | 2016 |
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy.
Topics: Amines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclohexanols; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; Esters; Humans; K562 Cells; Rhodamine 123 | 2017 |
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Humans; Isoquinolines; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Triazoles | 2017 |
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; K562 Cells; Molecular Structure; Piperazine; Piperazines; Structure-Activity Relationship; Tumor Cells, Cultured | 2018 |
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Isoquinolines; K562 Cells; Molecular Docking Simulation; Quinolines; Rhodamine 123; Structure-Activity Relationship | 2018 |
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; K562 Cells; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tetrahydroisoquinolines; Triazoles | 2019 |
Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin.
Topics: Amides; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Survival; Curcumin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; K562 Cells; Leukemia, Myeloid; Models, Molecular; Structure-Activity Relationship | 2020 |
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2021 |
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Nude; Nitrogen; Oleanolic Acid | 2022 |
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel | 2022 |
Pumping of drugs by P-glycoprotein: a two-step process?
Topics: Algorithms; Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cyclosporine; Daunorubicin; Fluoresceins; Humans; Immunosuppressive Agents; Kinetics; Models, Biological; Pharmaceutical Preparations; Quinolines; Verapamil; Vinblastine | 2003 |
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Calcium Channel Blockers; Carbon Radioisotopes; Female; Models, Biological; Positron-Emission Tomography; Quinolines; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution; Verapamil | 2008 |
Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Drug Resistance, Multiple; Epilepsy; Humans; Image Processing, Computer-Assisted; Infusions, Intravenous; Male; Positron-Emission Tomography; Quinolines; Verapamil | 2010 |
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Blood-Brain Barrier; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrahydroisoquinolines; Verapamil | 2010 |
A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.
Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Calcium Channel Blockers; Carbon Isotopes; Computer Simulation; Disease Models, Animal; Female; Gene Expression Regulation; Heterocyclic Compounds; Magnetic Resonance Imaging; Models, Chemical; Organometallic Compounds; Pilocarpine; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Scopolamine; Seizures; Time Factors; Verapamil | 2011 |
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Mice; Phenotype; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Verapamil | 2012 |
Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Female; Gene Knockdown Techniques; Male; Mice; Multidrug Resistance-Associated Proteins; Ovum; Parasite Load; Quinolines; RNA Interference; Schistosoma mansoni; Verapamil | 2011 |
Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbon Radioisotopes; Dose-Response Relationship, Drug; Humans; Positron-Emission Tomography; Quinolines; Rats; Species Specificity; Verapamil | 2012 |
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Drug Interactions; Humans; LLC-PK1 Cells; Loperamide; Quinolines; Swine; Verapamil | 2013 |
Potential role for human P-glycoprotein in the transport of lacosamide.
Topics: Acetamides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Lacosamide; Quinolines; Rhodamine 123; RNA, Messenger; Swine; Time Factors; Transfection; Tritium; Verapamil | 2013 |
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cyclosporine; Drug Resistance, Multiple; High-Throughput Screening Assays; Humans; Quinolines; Reproducibility of Results; Verapamil | 2013 |
Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Carbon Radioisotopes; Female; Gene Expression Regulation; Kinetics; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil | 2013 |
Multiple Drug Transport Pathways through Human P-Glycoprotein.
Topics: Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biological Transport; Daunorubicin; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Protein Conformation; Quinolines; Verapamil | 2015 |
Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier.
Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Female; Humans; Male; Neoplasm Proteins; Pilot Projects; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Tissue Distribution; Verapamil; Young Adult | 2016 |
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil | 2017 |
Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Detergents; Enzyme Activation; Glucosides; Humans; Micelles; Quinolines; Rhodamines; Verapamil | 2017 |
The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cyclosporine; Host-Parasite Interactions; Interleukin-4; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Nematospiroides dubius; NF-kappa B; Quinolines; Strongylida Infections; T-Lymphocyte Subsets; Verapamil | 2017 |
Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Carbocyanines; Cell Line; Cyclosporine; Fluorescent Dyes; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Quinolines; Verapamil | 2018 |
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil | 2019 |